Free for academic non-profit institutions. Other users need a Commercial license

Aliases for C1orf21 Gene

Aliases for C1orf21 Gene

  • Chromosome 1 Open Reading Frame 21 2 3 5
  • Cell Proliferation-Inducing Gene 13 Protein 3 4
  • Proliferation-Inducing Protein 13 2 3
  • Uncharacterized Protein C1orf21 3
  • PIG13 3

External Ids for C1orf21 Gene

Previous GeneCards Identifiers for C1orf21 Gene

  • GC01P181882
  • GC01P179784
  • GC01P180876
  • GC01P181595
  • GC01P181087
  • GC01P182622
  • GC01P155591

Summaries for C1orf21 Gene

GeneCards Summary for C1orf21 Gene

C1orf21 (Chromosome 1 Open Reading Frame 21) is a Protein Coding gene.

Gene Wiki entry for C1orf21 Gene

Additional gene information for C1orf21 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C1orf21 Gene

Genomics for C1orf21 Gene

GeneHancer (GH) Regulatory Elements for C1orf21 Gene

Promoters and enhancers for C1orf21 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J184385 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE 650.7 +1.1 1092 4.6 PKNOX1 SIN3A FEZF1 ZNF2 ZNF213 ZNF416 SP3 ZNF662 REST CBX8 ENSG00000271387 C1orf21 SMG7-AS1 SWT1 ENSG00000273004 FTH1P25 ENSG00000227554 ENSG00000252612 SMG7 EDEM3
GH01J184453 Promoter 0.6 EPDnew 650.2 +65.3 65255 0.1 MZF1 C1orf21 GC01P184462 ENSG00000230470
GH01J184415 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 17 +31.2 31203 5 NFIB NEUROD1 ZNF664 CTBP1 GATA3 ZSCAN5C FOS SMARCE1 YY2 ZNF189 C1orf21 COLGALT2 ENSG00000230470 GC01P184462
GH01J184490 Enhancer 1.3 Ensembl ENCODE dbSUPER 16.5 +105.4 105435 4.5 PKNOX1 ATF1 FOXA2 DMAP1 YY1 ZNF766 ATF7 FOS RUNX3 RXRA C1orf21 EDEM3 GC01P184462 LOC102724857
GH01J184478 Enhancer 1.1 Ensembl ENCODE dbSUPER 18.1 +96.2 96204 8.9 NCOA3 CTCF ESRRA ZSCAN4 ZNF384 CTBP1 GATA3 FOS ZNF202 SMARCE1 C1orf21 GC01P184462 LOC102724857
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around C1orf21 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the C1orf21 gene promoter:
  • Meis-1b
  • Meis-1
  • HOXA9B
  • HOXA9
  • AP-1
  • aMEF-2
  • NF-kappaB1
  • HFH-1
  • RORalpha1
  • MEF-2A

Genomic Locations for C1orf21 Gene

Genomic Locations for C1orf21 Gene
242,006 bases
Plus strand
242,006 bases
Plus strand

Genomic View for C1orf21 Gene

Genes around C1orf21 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C1orf21 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C1orf21 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C1orf21 Gene

Proteins for C1orf21 Gene

  • Protein details for C1orf21 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Uncharacterized protein C1orf21
    Protein Accession:
    Secondary Accessions:
    • B2R551

    Protein attributes for C1orf21 Gene

    121 amino acids
    Molecular mass:
    13865 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C1orf21 Gene

Post-translational modifications for C1orf21 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C1orf21 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C1orf21 Gene

Domains & Families for C1orf21 Gene

Gene Families for C1orf21 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C1orf21 Gene


Suggested Antigen Peptide Sequences for C1orf21 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C1orf21: view

No data available for UniProtKB/Swiss-Prot for C1orf21 Gene

Function for C1orf21 Gene

Phenotypes From GWAS Catalog for C1orf21 Gene

Gene Ontology (GO) - Molecular Function for C1orf21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with C1orf21: view
genes like me logo Genes that share phenotypes with C1orf21: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C1orf21 Gene

Localization for C1orf21 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C1orf21 gene
Compartment Confidence
nucleus 3
cytosol 3
mitochondrion 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C1orf21 Gene

Pathways & Interactions for C1orf21 Gene

SuperPathways for C1orf21 Gene

No Data Available

Interacting Proteins for C1orf21 Gene

Gene Ontology (GO) - Biological Process for C1orf21 Gene


No data available for Pathways by source and SIGNOR curated interactions for C1orf21 Gene

Drugs & Compounds for C1orf21 Gene

No Compound Related Data Available

Transcripts for C1orf21 Gene

mRNA/cDNA for C1orf21 Gene

(1) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(243) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for C1orf21 Gene

Chromosome 1 open reading frame 21:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C1orf21 Gene

No ASD Table

Relevant External Links for C1orf21 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C1orf21 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C1orf21 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for C1orf21 Gene

This gene is overexpressed in Muscle - Skeletal (x5.1).

Protein differential expression in normal tissues from HIPED for C1orf21 Gene

This gene is overexpressed in Frontal cortex (35.0), Oral epithelium (11.7), Urinary Bladder (6.7), and Prostate (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for C1orf21 Gene

NURSA nuclear receptor signaling pathways regulating expression of C1orf21 Gene:


SOURCE GeneReport for Unigene cluster for C1orf21 Gene:


mRNA Expression by UniProt/SwissProt for C1orf21 Gene:

Tissue specificity: Expressed in spleen, prostate, testis and uterus.

Evidence on tissue expression from TISSUES for C1orf21 Gene

  • Nervous system(3.9)
  • Skin(2)
genes like me logo Genes that share expression patterns with C1orf21: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for C1orf21 Gene

Orthologs for C1orf21 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C1orf21 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia C1H1ORF21 34
  • 100 (a)
C1H1orf21 33
  • 99.72 (n)
(Bos Taurus)
Mammalia C16H1ORF21 34
  • 99 (a)
C16H1orf21 33
  • 96.69 (n)
-- 34
  • 95 (a)
(Canis familiaris)
Mammalia C1orf21 34
  • 99 (a)
C7H1orf21 33
  • 96.97 (n)
(Monodelphis domestica)
Mammalia C1orf21 34
  • 96 (a)
(Mus musculus)
Mammalia 1700025G04Rik 16 34 33
  • 93.94 (n)
(Rattus norvegicus)
Mammalia RGD1309104 33
  • 93.11 (n)
(Ornithorhynchus anatinus)
Mammalia C1orf21 34
  • 92 (a)
(Gallus gallus)
Aves C1orf21 34
  • 93 (a)
C8H1ORF21 33
  • 92.84 (n)
(Anolis carolinensis)
Reptilia C1orf21 34
  • 93 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia c1orf21 33
  • 75.21 (n)
African clawed frog
(Xenopus laevis)
Amphibia MGC69115 33
(Danio rerio)
Actinopterygii zgc:92140 33
  • 64.64 (n)
C2H1orf21 34
  • 59 (a)
Dr.20974 33
Species where no ortholog for C1orf21 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C1orf21 Gene

Gene Tree for C1orf21 (if available)
Gene Tree for C1orf21 (if available)

Paralogs for C1orf21 Gene

No data available for Paralogs for C1orf21 Gene

Variants for C1orf21 Gene

Sequence variations from dbSNP and Humsavar for C1orf21 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000005984 -- 184,551,706(+) C/T intron_variant
rs1000014650 -- 184,491,466(+) T/C intron_variant
rs1000034846 -- 184,607,031(+) T/C intron_variant
rs1000037812 -- 184,563,608(+) T/G intron_variant
rs1000039758 -- 184,388,196(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for C1orf21 Gene

Variant ID Type Subtype PubMed ID
dgv20n21 CNV loss 19592680
esv2668015 CNV deletion 23128226
esv2674731 CNV deletion 23128226
esv2720162 CNV deletion 23290073
esv3543567 CNV deletion 23714750
esv3588125 CNV loss 21293372
esv3588126 CNV loss 21293372
esv3588127 CNV loss 21293372
nsv1008237 CNV gain 25217958
nsv3821 CNV deletion 18451855
nsv478651 CNV novel sequence insertion 20440878
nsv832037 CNV gain 17160897

Variation tolerance for C1orf21 Gene

Residual Variation Intolerance Score: 55.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.15; 3.34% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C1orf21 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C1orf21 Gene

Disorders for C1orf21 Gene

Additional Disease Information for C1orf21

No disorders were found for C1orf21 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C1orf21 Gene

Publications for C1orf21 Gene

  1. Cloning and characterization of 13 novel transcripts and the human RGS8 gene from the 1q25 region encompassing the hereditary prostate cancer (HPC1) locus. (PMID: 11318611) Sood R … Carpten JD (Genomics 2001) 2 3 4 58
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for C1orf21 Gene

Sources for C1orf21 Gene

Loading form....