Aliases for TMX1 Gene
External Ids for TMX1 Gene
Previous HGNC Symbols for TMX1 Gene
Previous GeneCards Identifiers for TMX1 Gene
This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, a catalytically active thioredoxin domain, and one transmembrane domain. Unlike most members of this gene family, it lacks a C-terminal ER-retention sequence. The mature membrane-bound protein can both oxidize and reduce disulfide bonds and acts selectively on membrane-associated polypeptides. [provided by RefSeq, Jan 2017]
GeneCards Summary for TMX1 Gene
TMX1 (Thioredoxin Related Transmembrane Protein 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include protein disulfide isomerase activity and disulfide oxidoreductase activity. An important paralog of this gene is TMX4.
UniProtKB/Swiss-Prot for TMX1 Gene
May participate in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyze dithiol-disulfide exchange reactions.