Free for academic non-profit institutions. Other users need a Commercial license
The product of this gene belongs to the serine/threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. This enzyme is a multifunctional serine/threonine protein kinase with limited tissue distribution, that has been implicated in transcriptional regulation in lymphocytes, neurons and male germ cells. [provided by RefSeq, Jul 2008] See more...
Aliases for CAMK4 Gene
Aliases for CAMK4 Gene
- Calcium/Calmodulin Dependent Protein Kinase IV 2 3 5
- Calcium/Calmodulin-Dependent Protein Kinase Type IV Catalytic Chain 2 3
- Brain Ca++-Calmodulin-Dependent Protein Kinase Type IV 2 3
- Calcium/Calmodulin-Dependent Protein Kinase Type IV 3 4
- CAM Kinase- GR 2 3
- CAM Kinase IV 2 3
- CaMK IV 3 4
- CaMK-GR 2 3
- CaMKIV 2 3
External Ids for CAMK4 Gene
- HGNC: 1464
- Entrez Gene: 814
- Ensembl: ENSG00000152495
- OMIM: 114080
- UniProtKB: Q16566
Previous GeneCards Identifiers for CAMK4 Gene
- GC05P110183
- GC05P111005
- GC05P110590
- GC05P110636
- GC05P110587
- GC05P105739
Summaries for CAMK4 Gene
-
The product of this gene belongs to the serine/threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. This enzyme is a multifunctional serine/threonine protein kinase with limited tissue distribution, that has been implicated in transcriptional regulation in lymphocytes, neurons and male germ cells. [provided by RefSeq, Jul 2008]
GeneCards Summary for CAMK4 Gene
CAMK4 (Calcium/Calmodulin Dependent Protein Kinase IV) is a Protein Coding gene. Diseases associated with CAMK4 include Cerebral Hypoxia and Gingival Fibromatosis. Among its related pathways are DAG and IP3 signaling and Neuroscience. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MAPKAPK3.
UniProtKB/Swiss-Prot Summary for CAMK4 Gene
-
Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK4 signaling cascade and regulates, mainly by phosphorylation, the activity of several transcription activators, such as CREB1, MEF2D, JUN and RORA, which play pivotal roles in immune response, inflammation, and memory consolidation. In the thymus, regulates the CD4(+)/CD8(+) double positive thymocytes selection threshold during T-cell ontogeny. In CD4 memory T-cells, is required to link T-cell antigen receptor (TCR) signaling to the production of IL2, IFNG and IL4 (through the regulation of CREB and MEF2). Regulates the differentiation and survival phases of osteoclasts and dendritic cells (DCs). Mediates DCs survival by linking TLR4 and the regulation of temporal expression of BCL2. Phosphorylates the transcription activator CREB1 on 'Ser-133' in hippocampal neuron nuclei and contribute to memory consolidation and long term potentiation (LTP) in the hippocampus. Can activate the MAP kinases MAPK1/ERK2, MAPK8/JNK1 and MAPK14/p38 and stimulate transcription through the phosphorylation of ELK1 and ATF2. Can also phosphorylate in vitro CREBBP, PRM2, MEF2A and STMN1/OP18.
Additional gene information for CAMK4 Gene
- HGNC(1464)
- Entrez Gene(814)
- Ensembl(ENSG00000152495)
- OMIM(114080)
- UniProtKB(Q16566)
- Open Targets Platform(ENSG00000152495)
- Monarch Initiative
- Search for CAMK4 at DataMed
- Search for CAMK4 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for CAMK4 Gene
Genomics for CAMK4 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for CAMK4 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around CAMK4 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for CAMK4
- Top Transcription factor binding sites by QIAGEN in the CAMK4 gene promoter:
-
- AhR
- AML1a
- CREB
- deltaCREB
- FAC1
- HFH-1
- Nkx2-5
- Pax-3
- Pax-4a
- Pbx1a
Genomic Locations for CAMK4 Gene
Genomic Locations for CAMK4 Gene
- chr5:111,223,583-111,498,503
- (GRCh38/hg38)
- Size:
- 274,921 bases
- Orientation:
- Plus strand
- chr5:110,559,351-110,830,584
- (GRCh37/hg19)
- Size:
- 271,234 bases
- Orientation:
- Plus strand
Genomic View for CAMK4 Gene
Genes around CAMK4 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 5q22.1 by HGNC
- 5q22.1 by Entrez Gene
- 5q22.1 by Ensembl
CAMK4 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CAMK4 Gene
Proteins for CAMK4 Gene
-
Protein details for CAMK4 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q16566-KCC4_HUMAN
- Recommended name:
- Calcium/calmodulin-dependent protein kinase type IV
- Protein Accession:
- Q16566
- D3DSZ7
Protein attributes for CAMK4 Gene
- Size:
- 473 amino acids
- Molecular mass:
- 51926 Da
- Quaternary structure:
-
- Monomer (By similarity). Interacts with protein phosphatase 2A (PPP2CA/PPP2CB); the interaction is mutually exclusive with binding to Ca(2+)/calmodulin.
- SequenceCaution:
-
- Sequence=AAH16695.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
Protein Expression for CAMK4 Gene
Selected DME Specific Peptides for CAMK4 Gene
- Q16566:
-
- AKDLVRK
- HPNIIKL
- VTGGELF
- GGELFDR
- LKPENLL
- RDLKPEN
- FNARRKL
- VHRDLKP
- IVHRDLK
Post-translational modifications for CAMK4 Gene
- Phosphorylated by CaMKK1 and CaMKK2 on Thr-200. Dephosphorylated by protein phosphatase 2A. Autophosphorylated on Ser-12 and Ser-13.
- Glycosylation at Ser-189 modulates the phosphorylation of CaMK4 at Thr-200 and negatively regulates its activity toward CREB1 in basal conditions and during early inomycin stimulation.
-
Glycosylation at Thr57, Ser58, Ser137, Ser189, Ser344, Ser345, and Ser356
- NX_Q16566 (NX_Q16566-1)
-
Ubiquitination at Lys190 and Lys303
- NX_Q16566 (NX_Q16566-1)
- Modification sites at PhosphoSitePlus
Other Protein References for CAMK4 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- LifeSpan BioSciences CAMK4 / CaMK IV Antibody and CAMK4 / CaMK IV Monoclonal Antibody
- GeneTex Anti-CaMKIV antibody [N1C3] and Anti-CaMKIV antibody
- BioLegend CAMK IV Antibody
-
Custom Antibody ServicesOriGene Antibodies for CAMK4
- Novus Biologicals Antibodies for CAMK4
-
Abcam antibodies for CAMK4
- Invitrogen Antibodies for CAMK4 (AFLGC-CAMK4)
- antibodies-online: Show 45 available CAMK4 Antibodies ranked by validation data
- Compare Top CAMK4 Antibodies
-
Recommended
- 111 WB Antibodies (anti-human)
- 24 IF (p) Antibodies (anti-human)
- 3 IHC Antibodies (anti-human)
- 2 IHC (p) Antibodies (anti-human)
- 1 IF/ICC Antibody (anti-human)
- 77 WB Antibodies (anti-mouse)
- 24 IF (p) Antibodies (anti-mouse)
- 3 IHC Antibodies (anti-mouse)
- 1 IHC (p) Antibody (anti-mouse)
- 50 WB Antibodies (anti-rat)
- 24 IF (p) Antibodies (anti-rat)
- 3 IHC Antibodies (anti-rat)
-
Boster Bio Antibodies for CAMK4
-
Santa Cruz Biotechnology (SCBT) Antibodies for CAMK4
- Sino Biological Antibodies for CAMK4
Protein Products
-
OriGene Purified Proteins for CAMK4
- Search Origene for MassSpec and Protein Over-expression Lysates for CAMK4
- Origene Custom Protein Services for CAMK4
- Sino Biological Recombinant Proteins for CAMK4
- Sino Biological Cell Lysates for CAMK4
- ProSpec Recombinant Proteins for CAMK4
-
Signalway Proteins for CAMK4
-
Abcam proteins for CAMK4
Assay Products
- antibodies-online: Show 5 available CAMK4 Elisa Kits ranked by validation data
- Compare Top CAMK4 Elisa Kits
-
Quality Products:
Domains & Families for CAMK4 Gene
Gene Families for CAMK4 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted intracellular proteins
- Predicted membrane proteins
Protein Domains for CAMK4 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for CAMK4 Gene
- GenScript: Design optimal peptide antigens:
-
- CaM kinase-GR (KCC4_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q16566UniProtKB/Swiss-Prot:
KCC4_HUMAN :- The autoinhibitory domain overlaps with the calmodulin binding region and interacts in the inactive folded state with the catalytic domain as a pseudosubstrate.
- Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
- Domain:
-
- The autoinhibitory domain overlaps with the calmodulin binding region and interacts in the inactive folded state with the catalytic domain as a pseudosubstrate.
- Family:
-
- Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
Function for CAMK4 Gene
Molecular function for CAMK4 Gene
- UniProtKB/Swiss-Prot Function:
- Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK4 signaling cascade and regulates, mainly by phosphorylation, the activity of several transcription activators, such as CREB1, MEF2D, JUN and RORA, which play pivotal roles in immune response, inflammation, and memory consolidation. In the thymus, regulates the CD4(+)/CD8(+) double positive thymocytes selection threshold during T-cell ontogeny. In CD4 memory T-cells, is required to link T-cell antigen receptor (TCR) signaling to the production of IL2, IFNG and IL4 (through the regulation of CREB and MEF2). Regulates the differentiation and survival phases of osteoclasts and dendritic cells (DCs). Mediates DCs survival by linking TLR4 and the regulation of temporal expression of BCL2. Phosphorylates the transcription activator CREB1 on 'Ser-133' in hippocampal neuron nuclei and contribute to memory consolidation and long term potentiation (LTP) in the hippocampus. Can activate the MAP kinases MAPK1/ERK2, MAPK8/JNK1 and MAPK14/p38 and stimulate transcription through the phosphorylation of ELK1 and ATF2. Can also phosphorylate in vitro CREBBP, PRM2, MEF2A and STMN1/OP18.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.17;.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.17;.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Activated by Ca(2+)/calmodulin. Binding of calmodulin results in conformational change that relieves intrasteric autoinhibition and allows phosphorylation of Thr-200 within the activation loop by CaMKK1 or CaMKK2. Phosphorylation of Thr-200 results in a 10-20-fold increase in total activity to generate Ca(2+)/calmodulin-independent activity. Autophosphorylation of the N-terminus Ser-12 and Ser-13 is required for full activation. Inactivated by protein phosphatase 2A (PPP2CA/PPP2CB) which dephosphorylates Thr-200, thereby terminating autonomous activity and helping to maintain the enzyme in its autoinhibited state.
- GENATLAS Biochemistry:
- protein kinase,type IV,calcium/calmodulin dependent,brain
Enzyme Numbers (IUBMB) for CAMK4 Gene
Phenotypes From GWAS Catalog for CAMK4 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000166 | nucleotide binding | IEA | -- |
| GO:0004672 | protein kinase activity | IEA | -- |
| GO:0004674 | protein serine/threonine kinase activity | IEA | -- |
| GO:0004683 | calmodulin-dependent protein kinase activity | IDA | 8107230 |
| GO:0005516 | calmodulin binding | IBA | 21873635 |
Phenotypes for CAMK4 Gene
- MGI mutant phenotypes for CAMK4:
-
inferred from 5 alleles
- nervous system phenotype
- immune system phenotype
- normal phenotype
- cellular phenotype
- behavior/neurological phenotype
- mortality/aging
- homeostasis/metabolism phenotype
- growth/size/body region phenotype
- endocrine/exocrine gland phenotype
- reproductive system phenotype
- skeleton phenotype
- hematopoietic system phenotype
- integument phenotype
- GenomeRNAi human phenotypes for CAMK4:
-
- Increased vaccinia virus (VACV) infection
- no effect
- Decreased viability ratio
- shRNA abundance <= 25%
- Reduced mammosphere formation
- Increased epidermal growth factor (EGF) endocytosis, decreased transferrin (TF) endocytosis
- Decreased viability
- Increased shRNA abundance (Z-score > 2)
- Decreased shRNA abundance (Z-score < -2)
- Decreased substrate adherent cell growth
- Increased cell viability after pRB stimulation
- Decreased vesicular stomatitis virus (VSV) infection
- Decreased human cytomegalovirus (HCMV) strain AD169 replication
- Decreased Cdk9 T-loop phosphorylation
- Decreased simian virus 40 (SV40) infection
- Transferrin accumulation in enlarged cytoplasmic structures
Animal Models for CAMK4 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for CAMK4 - Select products 50% OFF >
- * CAMK4 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for CAMK4
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CAMK4
-
Santa Cruz Biotechnology (SCBT) CRISPR for CAMK4
miRNA for CAMK4 Gene
- miRTarBase miRNAs that target CAMK4
-
- mmu-miR-190a-5p (MIRT013692)
- hsa-miR-215-5p (MIRT024679)
- hsa-miR-192-5p (MIRT026869)
- hsa-miR-26b-5p (MIRT030257)
- hsa-miR-185-5p (MIRT437481)
- hsa-miR-6792-3p (MIRT460330)
- hsa-miR-4691-5p (MIRT460331)
- hsa-miR-6509-3p (MIRT460332)
- hsa-miR-196a-3p (MIRT460333)
- hsa-miR-3128 (MIRT460334)
- hsa-miR-4746-5p (MIRT460335)
- hsa-miR-1273g-3p (MIRT460336)
- hsa-miR-181a-2-3p (MIRT460337)
- hsa-miR-6807-5p (MIRT496932)
- hsa-miR-922 (MIRT496933)
- hsa-miR-1245b-3p (MIRT496934)
- mmu-miR-150-5p (MIRT590479)
- mmu-miR-5127 (MIRT590480)
- mmu-miR-3087-3p (MIRT590481)
- mmu-miR-3470b (MIRT590482)
- mmu-miR-5125 (MIRT590483)
- mmu-miR-3110-5p (MIRT590484)
- mmu-miR-384-5p (MIRT595037)
- mmu-miR-30c-5p (MIRT595038)
- mmu-miR-30d-5p (MIRT595039)
- mmu-miR-30e-5p (MIRT595040)
- mmu-miR-30b-5p (MIRT595041)
- mmu-miR-30a-5p (MIRT595042)
- mmu-miR-3964 (MIRT595043)
- mmu-miR-1191a (MIRT595395)
- mmu-miR-3064-5p (MIRT599548)
- mmu-miR-3085-3p (MIRT599549)
- mmu-miR-290a-5p (MIRT599550)
- mmu-miR-292a-5p (MIRT599551)
- mmu-miR-1964-5p (MIRT599552)
- mmu-miR-105 (MIRT602680)
- mmu-miR-302b-3p (MIRT602681)
- mmu-miR-294-3p (MIRT602682)
- mmu-miR-302d-3p (MIRT602683)
- mmu-miR-302a-3p (MIRT602684)
- mmu-miR-291a-3p (MIRT602685)
- mmu-miR-295-3p (MIRT602686)
- mmu-miR-1186a (MIRT602687)
- mmu-miR-1186b (MIRT602688)
- mmu-miR-1981-5p (MIRT602689)
- mmu-miR-1971 (MIRT602690)
- hsa-miR-574-5p (MIRT628363)
- hsa-miR-4455 (MIRT628364)
- hsa-miR-30e-3p (MIRT628365)
- hsa-miR-30d-3p (MIRT628366)
- hsa-miR-30a-3p (MIRT628367)
- hsa-miR-6867-5p (MIRT628368)
- hsa-miR-622 (MIRT628369)
- hsa-miR-629-3p (MIRT719212)
- hsa-miR-6867-3p (MIRT719213)
- hsa-miR-4713-5p (MIRT719214)
- hsa-miR-3156-3p (MIRT719215)
- hsa-miR-1255b-5p (MIRT719216)
- hsa-miR-1255a (MIRT719217)
- hsa-miR-3605-5p (MIRT719218)
- hsa-miR-6770-5p (MIRT719219)
- hsa-miR-1253 (MIRT719220)
- hsa-miR-2116-3p (MIRT719221)
- hsa-miR-532-3p (MIRT719222)
- hsa-miR-150-5p (MIRT719223)
- hsa-miR-4301 (MIRT719224)
- hsa-miR-329-5p (MIRT719225)
- hsa-miR-5197-3p (MIRT719226)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CAMK4
- Browse OriGene Inhibitory RNA Products For CAMK4
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CAMK4
Clone Products
- Applied Biological Materials (abm): Clones for CAMK4 - Select products 50% OFF >
- * CAMK4 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for CAMK4
- Addgene plasmids for CAMK4
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CAMK4
Cell Line Products
-
Horizon Cell Lines for CAMK4
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CAMK4 Gene
Localization for CAMK4 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CAMK4 Gene
- Cytoplasm. Nucleus. Note=Localized in hippocampal neuron nuclei. In spermatids, associated with chromatin and nuclear matrix (By similarity). {ECO:0000250}.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| extracellular | 4 |
| cytosol | 4 |
| mitochondrion | 3 |
| plasma membrane | 2 |
| cytoskeleton | 2 |
| endoplasmic reticulum | 2 |
| peroxisome | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Nucleoli fibrillar center (3)
- Nucleoplasm (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001650 | fibrillar center | IDA | -- |
| GO:0005634 | nucleus | IBA | 21873635 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005737 | cytoplasm | IBA | 21873635 |
| GO:0070062 | extracellular exosome | HDA | 19056867 |
Pathways & Interactions for CAMK4 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | DAG and IP3 signaling |
.93
Signal transduction Calcium signaling
.35
|
|
| 2 | RET signaling |
.92
|
|
| 3 | Post NMDA receptor activation events | ||
| 4 | Activation of cAMP-Dependent PKA |
Activation of cAMP-Dependent PKA
.77
cAMP Pathway
.77
|
PKA Signaling
.56
|
| 5 | CREB Pathway |
CREB Pathway
.68
IP3 Pathway
.68
|
Intracellular Calcium Signaling
.50
|
Pathways by source for CAMK4 Gene
4 Sino Biological pathways for CAMK4 Gene
8 BioSystems pathways for CAMK4 Gene
28 Reactome pathways for CAMK4 Gene
13 KEGG pathways for CAMK4 Gene
6 GeneGo (Thomson Reuters) pathways for CAMK4 Gene
- Development Role of HDAC and calcium/calmodulin-dependent kinase (CaMK) in control of skeletal myogenesis
- Immune response Function of MEF2 in T lymphocytes
- Signal transduction Calcium signaling
- Signal transduction cAMP signaling
- Signal transduction IP3 signaling
16 Qiagen pathways for CAMK4 Gene
- Activation of cAMP-Dependent PKA
- Alpha-Adrenergic Signaling
- BMP Pathway
- Breast Cancer Regulation by Stathmin1
- cAMP Pathway
2 Cell Signaling Technology pathways for CAMK4 Gene
Interacting Proteins for CAMK4 Gene
GPS-Prot Interaction Network for CAMK4
SIGNOR curated interactions for CAMK4 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002250 | adaptive immune response | IEA | -- |
| GO:0002372 | NOT myeloid dendritic cell cytokine production | IMP | 17909078 |
| GO:0002376 | immune system process | IEA | -- |
| GO:0006468 | protein phosphorylation | IEA,TAS | 8089075 |
| GO:0006954 | inflammatory response | IEA | -- |
Drugs & Compounds for CAMK4 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| 3-({[(3S)-3,4-dihydroxybutyl]oxy}amino)-1H,2'H-2,3'-biindol-2'-one | Experimental | Pharma | Target | 0 | ||
| K-00546 | Experimental | Pharma | Target | 0 | ||
| ATP | Investigational | Nutra | Agonist, Activator, Partial agonist, Antagonist, Full agonist, Gating inhibitor, Pore Blocker, Potentiation | 0 | ||
| Calcium | Nutra | 6556 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| ADP |
|
Agonist, Full agonist, Partial agonist, Gating inhibitor, Antagonist | 58-64-0 |
|
Transcripts for CAMK4 Gene
mRNA/cDNA for CAMK4 Gene
- 5 REFSEQ mRNAs :
- 13 NCBI additional mRNA sequence :
- 13 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000508074 557 nts (view in UCSC)
- ENST00000512453 1640 nts (view in UCSC)
- ENST00000282356 11942 nts (view in UCSC)
- ENST00000504544 571 nts (view in UCSC)
- ENST00000515231 1678 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for CAMK4 - Select products 50% OFF >
- * CAMK4 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for CAMK4
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CAMK4
-
Santa Cruz Biotechnology (SCBT) CRISPR for CAMK4
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CAMK4
- Browse OriGene Inhibitory RNA Products For CAMK4
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CAMK4
Clone Products
- Applied Biological Materials (abm): Clones for CAMK4 - Select products 50% OFF >
- * CAMK4 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for CAMK4
- Addgene plasmids for CAMK4
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CAMK4
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | · | 5c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||
| SP2: | |||||||||||||||
| SP3: |
Relevant External Links for CAMK4 Gene
- GeneLoc Exon Structure for
- CAMK4
Expression for CAMK4 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Testis (Reproductive System)
- Elongated Spermatid Seminiferous Tubules
- Spermatid Seminiferous Tubules
-
Gonad
- Elongated Spermatid Seminiferous Tubules
- Spermatid Seminiferous Tubules
-
Blood (Hematopoietic System)
- Small Pre B-Cells Hematopoietic Bone Marrow
-
Lung (Respiratory System)
- Basal Cells Trachea
-
Epithelial Cells
- Basal Cells Trachea
-
Hair (Integumentary System)
- Bulge Stem Cells Bulge
-
Eye (Sensory Organs)
- GABAergic Amacrine Cells Inner Nuclear Layer
-
Neurons
- GABAergic Amacrine Cells Inner Nuclear Layer
-
Thymus (Hematopoietic System)
mRNA differential expression in normal tissues according to GTEx for CAMK4 Gene
This gene is overexpressed in Brain - Cerebellar Hemisphere (x12.4), Brain - Cerebellum (x11.3), Brain - Nucleus accumbens (basal ganglia) (x5.0), and Brain - Putamen (basal ganglia) (x4.1).
This gene is overexpressed in Peripheral blood mononuclear cells (34.8), Lymph node (14.7), and Frontal cortex (6.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CAMK4 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for CAMK4
SOURCE GeneReport for Unigene cluster for CAMK4 Gene:
Hs.591269mRNA Expression by UniProt/SwissProt for CAMK4 Gene:
Q16566-KCC4_HUMAN
Tissue specificity:
Expressed in brain, thymus, CD4 T-cells, testis and epithelial ovarian cancer tissue.
Evidence on tissue expression from TISSUES for CAMK4 Gene
- Nervous system(4.7)
- Blood(4.5)
- Liver(4.3)
- Lung(4.3)
- Spleen(2.1)
- Muscle(2)
- Lymph node(2)
Primer Products
-
OriGene qPCR primer pairs for CAMK4
-
OriGene qPCR primer pairs and template standards for CAMK4
Gene Expression Assay Products
No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CAMK4 Gene
Orthologs for CAMK4 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | CAMK4 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | CAMK4 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | CAMK4 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Camk4 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Camk4 30 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | CAMK4 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | CAMK4 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | CAMK4 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | CAMK4 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | camk4 30 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | camk4-A 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | camk4 30 31 |
|
OneToOne | |
| Fruit Fly (Drosophila melanogaster) |
Insecta | CaMKI 31 |
|
OneToOne | |
| Worm (Caenorhabditis elegans) |
Secernentea | cmk-1 31 |
|
OneToOne | |
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | CMK1 31 |
|
ManyToMany | |
| CMK2 31 |
|
ManyToMany | |||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToOne | |
| Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.9956 30 |
|
- Species where no ortholog for CAMK4 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for CAMK4 Gene
- ENSEMBL:
- Gene Tree for CAMK4 (if available)
- TreeFam:
- Gene Tree for CAMK4 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for CAMK4: view image
Paralogs for CAMK4 Gene
(42) SIMAP similar genes for CAMK4 Gene using alignment to 4 proteins:
- KCC4_HUMAN
- D6RCD6_HUMAN
- D6RE65_HUMAN
- D6REY7_HUMAN
Variants for CAMK4 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for CAMK4 Gene
| SNP ID | Clinical significance and condition | Chr 05 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 729717 | Benign: not provided | 111,446,758(+) | G/A | MISSENSE_VARIANT,FIVE_PRIME_UTR_VARIANT | |
| 776053 | Benign: not provided | 111,484,438(+) | A/G | MISSENSE_VARIANT | |
| 783442 | Benign: not provided | 111,484,418(+) | T/G | SYNONYMOUS_VARIANT | |
| rs1239950009 | A lung large cell carcinoma sample | p.Ile469Met | |||
| rs1561515242 | Conflicting Interpretations: Intellectual disability; Involuntary movements; not provided | 111,482,938(+) | G/A | SPLICE_DONOR_VARIANT |
Residual Variation Intolerance Score:
28.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.89;
48.62% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for CAMK4 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CAMK4 Gene
Disorders for CAMK4 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| cerebral hypoxia |
|
|
| gingival fibromatosis |
|
|
| lung large cell carcinoma |
|
|
| crouzon syndrome with acanthosis nigricans |
|
|
| systemic lupus erythematosus |
|
|
Search CAMK4 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for CAMK4
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for CAMK4 Gene
Publications for CAMK4 Gene
- Regulation and function of the calcium/calmodulin-dependent protein kinase IV/protein serine/threonine phosphatase 2A signaling complex. (PMID: 15143065) Anderson KA … Means AR (The Journal of biological chemistry 2004) 3 4 23
- Regulation of mitogen-activated protein kinases by a calcium/calmodulin-dependent protein kinase cascade. (PMID: 8855261) Enslen H … Soderling TR (Proceedings of the National Academy of Sciences of the United States of America 1996) 3 4 23
- A Ca2+/calmodulin-dependent protein kinase, CaM kinase-Gr, expressed after transformation of primary human B lymphocytes by Epstein-Barr virus (EBV) is induced by the EBV oncogene LMP1. (PMID: 8107230) Mosialos G … Chatila TA (Journal of virology 1994) 3 4 23
- The cDNA sequence and characterization of the Ca2+/calmodulin-dependent protein kinase-Gr from human brain and thymus. (PMID: 8194751) Bland MM … Ohmstede CA (Gene 1994) 3 4 23
- cDNA cloning and expression of human calmodulin-dependent protein kinase IV. (PMID: 8089075) Kitani T … Fujisawa H (Journal of biochemistry 1994) 3 4 23
ExternalLinks
Products for CAMK4 Gene
- Custom Antibody ServicesOriGene Antibodies for CAMK4
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for CAMK4
- Search Origene for MassSpec and Protein Over-expression Lysates for CAMK4
- Origene Custom Protein Services for CAMK4
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CAMK4
- Browse OriGene Inhibitory RNA Products For CAMK4
- OriGene qPCR primer pairs for CAMK4
- OriGene qPCR primer pairs and template standards for CAMK4
- OriGene CRISPR knockouts for CAMK4
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For CAMK4
- Sino Biological Human cDNA Clone for CAMK4
- Sino Biological Recombinant Proteins for CAMK4
- Sino Biological Cell Lysates for CAMK4
- Sino Biological Antibodies for CAMK4
- Browse Sino Biological Assays
- Browse Recombinant Proteins
- Browse Antibodies
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for CAMK4
- Novus Biologicals proteins and lysates for CAMK4
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for CAMK4
- Abcam proteins for CAMK4
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- VectorBuilder Custom and pre-made DNA vectors for CAMK4 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for CAMK4 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for CAMK4 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for CAMK4 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for CAMK4
- Addgene plasmids for CAMK4
- antibodies-online: Show 45 available CAMK4 Antibodies ranked by validation data
- Compare Top CAMK4 Antibodies
- Recommended
- 111 WB Antibodies (anti-human)
- 24 IF (p) Antibodies (anti-human)
- 3 IHC Antibodies (anti-human)
- 2 IHC (p) Antibodies (anti-human)
- 1 IF/ICC Antibody (anti-human)
- 77 WB Antibodies (anti-mouse)
- 24 IF (p) Antibodies (anti-mouse)
- 3 IHC Antibodies (anti-mouse)
- 1 IHC (p) Antibody (anti-mouse)
- 50 WB Antibodies (anti-rat)
- 24 IF (p) Antibodies (anti-rat)
- 3 IHC Antibodies (anti-rat)
- antibodies-online: Show 5 available CAMK4 Elisa Kits ranked by validation data
- Compare Top CAMK4 Elisa Kits
- Quality Products:
- antibodies-online: Show 16 available CAMK4 Proteins ranked by validation data
- Compare Top CAMK4 Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for CAMK4
- Search Santa Cruz Biotechnology (SCBT) for CAMK4 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for CAMK4
- Horizon Cell Lines for CAMK4
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for CAMK4
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for CAMK4
- Search GeneCopoeia for miRNA 3'UTR Target clone products for CAMK4
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CAMK4
- Boster Bio Antibodies for CAMK4
- Signalway Proteins for CAMK4
Sources for CAMK4 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB