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Aliases for CALML3 Gene

Aliases for CALML3 Gene

  • Calmodulin Like 3 2 3 5
  • Calmodulin-Related Protein NB-1 3 4
  • CaM-Like Protein 3 4
  • CLP 3 4
  • Calmodulin-Like Protein 3 3
  • Calmodulin-Like 3 2

External Ids for CALML3 Gene

Previous GeneCards Identifiers for CALML3 Gene

  • GC10M005445
  • GC10P005525
  • GC10P005666
  • GC10P005520

Summaries for CALML3 Gene

GeneCards Summary for CALML3 Gene

CALML3 (Calmodulin Like 3) is a Protein Coding gene. Among its related pathways are Salivary secretion and Aldosterone synthesis and secretion. Gene Ontology (GO) annotations related to this gene include calcium ion binding. An important paralog of this gene is CALM1.

UniProtKB/Swiss-Prot for CALML3 Gene

  • May function as a specific light chain of unconventional myosin-10 (MYO10), also enhances MYO10 translation, possibly by acting as a chaperone for the emerging MYO10 heavy chain protein. May compete with calmodulin by binding, with different affinities, to cellular substrates.

Gene Wiki entry for CALML3 Gene

Additional gene information for CALML3 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CALML3 Gene

Genomics for CALML3 Gene

GeneHancer (GH) Regulatory Elements for CALML3 Gene

Promoters and enhancers for CALML3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10I005524 Promoter/Enhancer 0.7 EPDnew dbSUPER 550.8 +0.9 933 0.1 ENSG00000256462 CALML3-AS1 CALML3
GH10I005444 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 11.2 -76.1 -76076 7 HDGF PKNOX1 CLOCK SMAD1 FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 NET1 LOC105376384 NRBF2P5 TUBAL3 GDI2 FBXO18 FAM208B CALML5 CALML3 CALML3-AS1
GH10I005543 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 15.2 +25.7 25721 11.7 CLOCK FEZF1 DMAP1 E2F8 ZNF143 MCM3 SP3 MEF2D SSRP1 ZNF610 FAM208B FBXO18 LOC105376384 CALML3-AS1 ENSG00000226647 CALML3 NRBF2P5 ENSG00000256462 GDI2 CALML5
GH10I005563 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 18.1 +41.8 41759 4.8 PKNOX1 FOXA2 ETV1 BMI1 ZFHX2 GATA3 ZNF316 POLR2A EGR1 FOS LOC105376381 CALML3 CALML3-AS1 ENSG00000256462 CALML5 LOC105376382 LOC105376380
GH10I005492 Enhancer 0.8 dbSUPER 29.9 -30.4 -30384 1.6 HDGF CLOCK FOXA2 NFIB NEUROD1 SIN3A ZBTB7B RARA FOS RCOR1 CALML3 CALML3-AS1 ENSG00000256462 CALML5 NET1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CALML3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CALML3 gene promoter:

Genomic Locations for CALML3 Gene

Genomic Locations for CALML3 Gene
chr10:5,524,009-5,526,771
(GRCh38/hg38)
Size:
2,763 bases
Orientation:
Plus strand
chr10:5,566,924-5,568,225
(GRCh37/hg19)

Genomic View for CALML3 Gene

Genes around CALML3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CALML3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CALML3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CALML3 Gene

Proteins for CALML3 Gene

  • Protein details for CALML3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P27482-CALL3_HUMAN
    Recommended name:
    Calmodulin-like protein 3
    Protein Accession:
    P27482
    Secondary Accessions:
    • B2R9V6
    • Q5SQI4

    Protein attributes for CALML3 Gene

    Size:
    149 amino acids
    Molecular mass:
    16891 Da
    Quaternary structure:
    • Interacts with MYO10, the interaction is calcium-dependent and essential for MYO10 function in filopodial extension.
    Miscellaneous:
    • Binds four calcium ions.

    Three dimensional structures from OCA and Proteopedia for CALML3 Gene

neXtProt entry for CALML3 Gene

Post-translational modifications for CALML3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CALML3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CALML3 Gene

Domains & Families for CALML3 Gene

Gene Families for CALML3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for CALML3 Gene

Suggested Antigen Peptide Sequences for CALML3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P27482

UniProtKB/Swiss-Prot:

CALL3_HUMAN :
  • Belongs to the calmodulin family.
Family:
  • Belongs to the calmodulin family.
genes like me logo Genes that share domains with CALML3: view

Function for CALML3 Gene

Molecular function for CALML3 Gene

GENATLAS Biochemistry:
calmodulin-like 1,calcium modulated protein
UniProtKB/Swiss-Prot Function:
May function as a specific light chain of unconventional myosin-10 (MYO10), also enhances MYO10 translation, possibly by acting as a chaperone for the emerging MYO10 heavy chain protein. May compete with calmodulin by binding, with different affinities, to cellular substrates.
UniProtKB/Swiss-Prot Induction:
By TGFB1.

Phenotypes From GWAS Catalog for CALML3 Gene

Gene Ontology (GO) - Molecular Function for CALML3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IPI 16189514
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with CALML3: view
genes like me logo Genes that share phenotypes with CALML3: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CALML3 Gene

Localization for CALML3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CALML3 gene
Compartment Confidence
extracellular 5
cytosol 3
nucleus 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CALML3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome HDA,IDA 19056867
genes like me logo Genes that share ontologies with CALML3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for CALML3 Gene

Pathways & Interactions for CALML3 Gene

genes like me logo Genes that share pathways with CALML3: view

Gene Ontology (GO) - Biological Process for CALML3 Gene

None

No data available for SIGNOR curated interactions for CALML3 Gene

Drugs & Compounds for CALML3 Gene

(1) Drugs for CALML3 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Approved Nutra 0
genes like me logo Genes that share compounds with CALML3: view

Transcripts for CALML3 Gene

mRNA/cDNA for CALML3 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(55) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CALML3 Gene

Calmodulin-like 3:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CALML3 Gene

No ASD Table

Relevant External Links for CALML3 Gene

GeneLoc Exon Structure for
CALML3
ECgene alternative splicing isoforms for
CALML3

Expression for CALML3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CALML3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CALML3 Gene

This gene is overexpressed in Esophagus - Mucosa (x18.6), Skin - Not Sun Exposed (Suprapubic) (x9.4), Vagina (x7.5), Skin - Sun Exposed (Lower leg) (x5.7), Cervix - Ectocervix (x5.1), and Minor Salivary Gland (x5.0).

Protein differential expression in normal tissues from HIPED for CALML3 Gene

This gene is overexpressed in Hair follicle (25.6), Cervix (12.6), Nasal epithelium (11.6), and Urinary Bladder (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CALML3 Gene



Protein tissue co-expression partners for CALML3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CALML3 Gene:

CALML3

SOURCE GeneReport for Unigene cluster for CALML3 Gene:

Hs.239600

mRNA Expression by UniProt/SwissProt for CALML3 Gene:

P27482-CALL3_HUMAN
Tissue specificity: Expressed in normal mammary, prostate, cervical, and epidermal tissues. It is greatly reduced or undetectable in transformed cells.

Evidence on tissue expression from TISSUES for CALML3 Gene

  • Skin(4.3)
genes like me logo Genes that share expression patterns with CALML3: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CALML3 Gene

Orthologs for CALML3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CALML3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CALML3 33 34
  • 100 (n)
rat
(Rattus norvegicus)
Mammalia Calml3 33
  • 85.91 (n)
mouse
(Mus musculus)
Mammalia Calml3 33 16 34
  • 84.34 (n)
oppossum
(Monodelphis domestica)
Mammalia CALML3 34
  • 83 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CALML3 34
  • 58 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CALML3 34
  • 32 (a)
OneToOne
chicken
(Gallus gallus)
Aves CALML3 33 34
  • 78.97 (n)
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 73 (a)
OneToMany
-- 34
  • 73 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Cam 35
  • 85 (a)
And 35
  • 63 (a)
CG31960 34
  • 49 (a)
ManyToMany
CG11165 35 34
  • 45 (a)
CG31958 34
  • 40 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea cmd-1 35
  • 85 (a)
Y73B3A.12 35
  • 82 (a)
cal-1 35 34
  • 60 (a)
cal-2 35 34
  • 60 (a)
cal-3 35 34
  • 54 (a)
cal-4 35 34
  • 54 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CMD1 34
  • 56 (a)
OneToMany
MLC2 36
thale cress
(Arabidopsis thaliana)
eudicotyledons CAM1 33
  • 72.93 (n)
rice
(Oryza sativa)
Liliopsida Os05g0491100 33
  • 76.51 (n)
Os.2226 33
barley
(Hordeum vulgare)
Liliopsida Hv.12866 33
wheat
(Triticum aestivum)
Liliopsida Ta.1018 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7047 34
  • 47 (a)
ManyToMany
Species where no ortholog for CALML3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • zebrafish (Danio rerio)

Evolution for CALML3 Gene

ENSEMBL:
Gene Tree for CALML3 (if available)
TreeFam:
Gene Tree for CALML3 (if available)

Paralogs for CALML3 Gene

Variants for CALML3 Gene

Sequence variations from dbSNP and Humsavar for CALML3 Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1000009372 -- 5,523,959(+) G/A/C upstream_transcript_variant
rs1002148596 -- 5,522,918(+) AAAAAA/AAAAA upstream_transcript_variant
rs1002503067 -- 5,525,778(+) CTCCCCACTC/CTCCCCACTCCCCACTC 3_prime_UTR_variant
rs1002555584 -- 5,525,999(+) T/C 3_prime_UTR_variant
rs1002749925 -- 5,526,008(+) G/A 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for CALML3 Gene

Variant ID Type Subtype PubMed ID
dgv664n100 CNV gain 25217958
esv2759729 CNV gain 17122850
nsv1051283 CNV gain 25217958
nsv523491 CNV gain 19592680
nsv549886 CNV loss 21841781
nsv831774 CNV gain 17160897

Variation tolerance for CALML3 Gene

Residual Variation Intolerance Score: 59.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.19; 39.67% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CALML3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CALML3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CALML3 Gene

Disorders for CALML3 Gene

Additional Disease Information for CALML3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for CALML3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CALML3 Gene

Publications for CALML3 Gene

  1. The tumor-sensitive calmodulin-like protein is a specific light chain of human unconventional myosin X. (PMID: 11278607) Rogers MS … Strehler EE (The Journal of biological chemistry 2001) 3 4 22 58
  2. Functional analysis of the promoters of the human CaMIII calmodulin gene and of the intronless gene coding for a calmodulin-like protein. (PMID: 8476923) Koller M … Strehler EE (Biochimica et biophysica acta 1993) 2 3 22 58
  3. Calmodulin-like protein upregulates myosin-10 in human keratinocytes and is regulated during epidermal wound healing in vivo. (PMID: 18818677) Bennett RD … Strehler EE (The Journal of investigative dermatology 2009) 3 22 58
  4. Human calmodulin-like protein (CLP) expression in oral squamous mucosa and in malignant transformation. (PMID: 19166543) Brooks MD … Carr AB (Journal of prosthodontics : official journal of the American College of Prosthodontists 2009) 3 22 58
  5. Interaction with the IQ3 motif of myosin-10 is required for calmodulin-like protein-dependent filopodial extension. (PMID: 18570893) Bennett RD … Strehler EE (FEBS letters 2008) 3 22 58

Products for CALML3 Gene

Sources for CALML3 Gene

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