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Aliases for SLC35G2 Gene

Aliases for SLC35G2 Gene

  • Solute Carrier Family 35 Member G2 2 3 3 5
  • Transmembrane Protein 22 2 3 4
  • TMEM22 3 4
  • Solute Carrier Family 35, Member G2 2

External Ids for SLC35G2 Gene

Previous HGNC Symbols for SLC35G2 Gene

  • TMEM22

Previous GeneCards Identifiers for SLC35G2 Gene

  • GC03P136538

Summaries for SLC35G2 Gene

GeneCards Summary for SLC35G2 Gene

SLC35G2 (Solute Carrier Family 35 Member G2) is a Protein Coding gene. An important paralog of this gene is SLC35G6.

UniProtKB/Swiss-Prot for SLC35G2 Gene

  • May play a role in cell proliferation.

Gene Wiki entry for SLC35G2 Gene

Additional gene information for SLC35G2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC35G2 Gene

Genomics for SLC35G2 Gene

GeneHancer (GH) Regulatory Elements for SLC35G2 Gene

Promoters and enhancers for SLC35G2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J136817 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 650.7 +0.5 539 2.8 PKNOX1 ATF1 ZFP64 ARID4B SIN3A DMAP1 ZNF48 YY1 GLIS2 ZNF143 SLC35G2 NCK1 ENSG00000273486 NCK1-DT
GH03J136851 Promoter 0.5 EPDnew 661.9 +33.1 33091 0.1 SLC35G2 ENSG00000242968 IL20RB-AS1 IL20RB NCK1-DT ENSG00000273486
GH03J136860 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 19.8 +43.5 43494 3.3 HDGF PKNOX1 SMAD1 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 SLC30A9 NCK1 NCK1-DT STAG1 IL20RB MSL2 SLC35G2 ENSG00000273486 ENSG00000242968
GH03J136748 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 14.8 -66.8 -66811 6.2 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 STAG1 ENSG00000261758 MSL2 IL20RB SLC35G2 NCK1 ENSG00000242968 ENSG00000273486 PCCB LOC100421438
GH03J136954 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE dbSUPER 10.9 +139.8 139833 7.9 FOXA2 ARNT BRCA1 POLR2B FOS ATF7 RXRA ATF4 MIER3 STAT3 IL20RB IL20RB-AS1 SLC35G2 ENSG00000242968 GC03P136873
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SLC35G2 on UCSC Golden Path with GeneCards custom track

Genomic Locations for SLC35G2 Gene

Genomic Locations for SLC35G2 Gene
37,246 bases
Plus strand
37,246 bases
Plus strand

Genomic View for SLC35G2 Gene

Genes around SLC35G2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC35G2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC35G2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC35G2 Gene

Proteins for SLC35G2 Gene

  • Protein details for SLC35G2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Solute carrier family 35 member G2
    Protein Accession:
    Secondary Accessions:
    • B2RA80
    • D3DNE1
    • Q9BWN4
    • Q9H0S6

    Protein attributes for SLC35G2 Gene

    412 amino acids
    Molecular mass:
    46422 Da
    Quaternary structure:
    • Interacts with RAB37.
    • Sequence=AAH00111.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for SLC35G2 Gene

Post-translational modifications for SLC35G2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for SLC35G2 Gene

Domains & Families for SLC35G2 Gene

Gene Families for SLC35G2 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for SLC35G2 Gene


Suggested Antigen Peptide Sequences for SLC35G2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SLC35G solute transporter family.
  • Belongs to the SLC35G solute transporter family.
genes like me logo Genes that share domains with SLC35G2: view

Function for SLC35G2 Gene

Molecular function for SLC35G2 Gene

UniProtKB/Swiss-Prot Function:
May play a role in cell proliferation.

Phenotypes From GWAS Catalog for SLC35G2 Gene

Gene Ontology (GO) - Molecular Function for SLC35G2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0022857 transmembrane transporter activity IBA --
genes like me logo Genes that share ontologies with SLC35G2: view
genes like me logo Genes that share phenotypes with SLC35G2: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SLC35G2 Gene

Localization for SLC35G2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC35G2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC35G2 gene
Compartment Confidence
plasma membrane 5
golgi apparatus 5
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SLC35G2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005794 Golgi apparatus IDA --
GO:0005886 plasma membrane IEA,IDA 19148500
GO:0005887 integral component of plasma membrane TAS 19148500
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA,IBA --
genes like me logo Genes that share ontologies with SLC35G2: view

Pathways & Interactions for SLC35G2 Gene

SuperPathways for SLC35G2 Gene

No Data Available

Interacting Proteins for SLC35G2 Gene

Gene Ontology (GO) - Biological Process for SLC35G2 Gene


No data available for Pathways by source and SIGNOR curated interactions for SLC35G2 Gene

Drugs & Compounds for SLC35G2 Gene

No Compound Related Data Available

Transcripts for SLC35G2 Gene

mRNA/cDNA for SLC35G2 Gene

Unigene Clusters for SLC35G2 Gene

Solute carrier family 35, member G2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC35G2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b
SP2: - -
SP3: -

Relevant External Links for SLC35G2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC35G2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC35G2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of SLC35G2 Gene:


SOURCE GeneReport for Unigene cluster for SLC35G2 Gene:


Evidence on tissue expression from TISSUES for SLC35G2 Gene

  • Nervous system(4.5)
genes like me logo Genes that share expression patterns with SLC35G2: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC35G2 Gene

Orthologs for SLC35G2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for SLC35G2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SLC35G2 34 33
  • 99.43 (n)
(Canis familiaris)
Mammalia SLC35G2 34 33
  • 94.5 (n)
(Bos Taurus)
Mammalia TMEM22 34 33
  • 93.43 (n)
(Monodelphis domestica)
Mammalia SLC35G2 34
  • 90 (a)
(Mus musculus)
Mammalia Slc35g2 16 34 33
  • 88.27 (n)
(Rattus norvegicus)
Mammalia Slc35g2 33
  • 87.62 (n)
(Ornithorhynchus anatinus)
Mammalia SLC35G2 34
  • 81 (a)
(Gallus gallus)
Aves SLC35G2 34 33
  • 76.16 (n)
(Anolis carolinensis)
Reptilia SLC35G2 34
  • 79 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia slc35g2 33
  • 74.27 (n)
(Danio rerio)
Actinopterygii slc35g2b 33
  • 67.73 (n)
Species where no ortholog for SLC35G2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SLC35G2 Gene

Gene Tree for SLC35G2 (if available)
Gene Tree for SLC35G2 (if available)
Evolutionary constrained regions (ECRs) for SLC35G2: view image

Paralogs for SLC35G2 Gene

Paralogs for SLC35G2 Gene

(2) SIMAP similar genes for SLC35G2 Gene using alignment to 1 proteins:

  • S35G2_HUMAN
genes like me logo Genes that share paralogs with SLC35G2: view

Variants for SLC35G2 Gene

Sequence variations from dbSNP and Humsavar for SLC35G2 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000002543 -- 136,844,135(+) T/C genic_upstream_transcript_variant, intron_variant
rs1000014872 -- 136,834,437(+) G/A/T genic_upstream_transcript_variant, intron_variant
rs1000056942 -- 136,830,835(+) C/A 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant
rs1000133801 -- 136,817,594(+) C/T upstream_transcript_variant
rs1000146391 -- 136,850,694(+) A/G genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for SLC35G2 Gene

Variant ID Type Subtype PubMed ID
nsv4027 CNV insertion 18451855
nsv507125 OTHER sequence alteration 20534489

Variation tolerance for SLC35G2 Gene

Residual Variation Intolerance Score: 53% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.01; 37.08% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLC35G2 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC35G2 Gene

Disorders for SLC35G2 Gene

Additional Disease Information for SLC35G2

No disorders were found for SLC35G2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SLC35G2 Gene

Publications for SLC35G2 Gene

  1. Involvement of TMEM22 overexpression in the growth of renal cell carcinoma cells. (PMID: 19148500) Dobashi S … Nakamura Y (Oncology reports 2009) 3 4 22 58
  2. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 2 3 4 58
  3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for SLC35G2 Gene

Sources for SLC35G2 Gene

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