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Aliases for DOCK5 Gene

Aliases for DOCK5 Gene

  • Dedicator Of Cytokinesis 5 2 3 5
  • Dedicator Of Cytokinesis Protein 5 3

External Ids for DOCK5 Gene

Previous GeneCards Identifiers for DOCK5 Gene

  • GC08P025247
  • GC08P025098
  • GC08P023646

Summaries for DOCK5 Gene

Entrez Gene Summary for DOCK5 Gene

  • This gene encodes a member of the dedicator of cytokinesis protein family. Members of this family act as guanine nucleotide exchange factors for small Rho family G proteins. The protein encoded by this gene is thought to associate with adaptors CRK and CRKL, and function in regulation of intestinal epithelial cell spreading and migration on collagen IV. Similar proteins in mouse and zebrafish also function in myoblast fusion. [provided by RefSeq, Oct 2016]

GeneCards Summary for DOCK5 Gene

DOCK5 (Dedicator Of Cytokinesis 5) is a Protein Coding gene. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Factors involved in megakaryocyte development and platelet production. Gene Ontology (GO) annotations related to this gene include binding and guanyl-nucleotide exchange factor activity. An important paralog of this gene is DOCK1.

UniProtKB/Swiss-Prot for DOCK5 Gene

  • Guanine nucleotide exchange factor (GEF) for Rho and Rac. GEF proteins activate small GTPases by exchanging bound GDP for free GTP (By similarity). Along with DOCK1, mediates CRK/CRKL regulation of epithelial and endothelial cell spreading and migration on type IV collagen (PubMed:19004829).

Gene Wiki entry for DOCK5 Gene

Additional gene information for DOCK5 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DOCK5 Gene

Genomics for DOCK5 Gene

GeneHancer (GH) Regulatory Elements for DOCK5 Gene

Promoters and enhancers for DOCK5 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J025183 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 666.2 +1.8 1820 6.7 FOXA2 MLX ARID4B SIN3A FEZF1 DMAP1 YY1 FOS KLF13 DEK DOCK5 CDCA2 KCTD9 ENSG00000284858
GH08J025236 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 37.6 +53.8 53755 3.3 ELF3 FOXA2 ZSCAN4 ARID4B RAD21 THRB ZSCAN9 RARA ATF7 CREM DOCK5 KCTD9 CDCA2 ENSG00000284858
GH08J025201 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 29.1 +17.0 16977 1 ELF3 SOX13 GATAD2A FOXA2 RXRA SAP130 ARID4B ELF1 ETV5 ATF2 DOCK5 ENSG00000284858
GH08J025197 Enhancer 1.3 Ensembl ENCODE dbSUPER 17.5 +14.0 14043 2.7 FOXA2 MLX ARID4B SIN3A DMAP1 ZNF48 ETS1 ATF7 NFKBIZ RXRA DOCK5 ENSG00000284858
GH08J025194 Enhancer 1.2 Ensembl ENCODE dbSUPER 16.6 +10.8 10822 2.5 KLF1 MXI1 JUN MAX SIN3A RAD21 RARA RFX5 ZKSCAN1 CTBP1 DOCK5 ENSG00000284858
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DOCK5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DOCK5 gene promoter:
  • Egr-1
  • AML1a
  • Arnt
  • AhR
  • HNF-3beta
  • NF-1
  • NF-1/L
  • Sox5
  • Nkx2-5
  • STAT5A

Genomic Locations for DOCK5 Gene

Genomic Locations for DOCK5 Gene
233,360 bases
Plus strand
233,361 bases
Plus strand

Genomic View for DOCK5 Gene

Genes around DOCK5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DOCK5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DOCK5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DOCK5 Gene

Proteins for DOCK5 Gene

  • Protein details for DOCK5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Dedicator of cytokinesis protein 5
    Protein Accession:
    Secondary Accessions:
    • B2RNY0
    • Q5XKD5
    • Q6AI11
    • Q6PJS6
    • Q6ZTS6

    Protein attributes for DOCK5 Gene

    1870 amino acids
    Molecular mass:
    215309 Da
    Quaternary structure:
    • Interacts with CRK and CRKL.
    • Sequence=BAB14962.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC86503.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for DOCK5 Gene


neXtProt entry for DOCK5 Gene

Post-translational modifications for DOCK5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for DOCK5 Gene

Domains & Families for DOCK5 Gene

Gene Families for DOCK5 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for DOCK5 Gene

Graphical View of Domain Structure for InterPro Entry



  • The DHR-2 domain may mediate some GEF activity.
  • Belongs to the DOCK family.
  • The DHR-2 domain may mediate some GEF activity.
  • Belongs to the DOCK family.
genes like me logo Genes that share domains with DOCK5: view

Function for DOCK5 Gene

Molecular function for DOCK5 Gene

UniProtKB/Swiss-Prot Function:
Guanine nucleotide exchange factor (GEF) for Rho and Rac. GEF proteins activate small GTPases by exchanging bound GDP for free GTP (By similarity). Along with DOCK1, mediates CRK/CRKL regulation of epithelial and endothelial cell spreading and migration on type IV collagen (PubMed:19004829).

Phenotypes From GWAS Catalog for DOCK5 Gene

Gene Ontology (GO) - Molecular Function for DOCK5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005085 guanyl-nucleotide exchange factor activity ISS --
GO:0005488 binding IEA --
GO:0005515 protein binding IPI 19004829
genes like me logo Genes that share ontologies with DOCK5: view
genes like me logo Genes that share phenotypes with DOCK5: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DOCK5 Gene

Localization for DOCK5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DOCK5 Gene

Cytoplasm. Cell membrane. Note=Associated with the edge of the plasma membrane in Caco-2 intestinal epithelial cells spreading on type IV collagen. {ECO:0000269 PubMed:19004829}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DOCK5 gene
Compartment Confidence
plasma membrane 5
cytosol 5
nucleus 2
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for DOCK5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005737 cytoplasm ISS --
GO:0005829 cytosol IDA --
GO:0005886 plasma membrane IEA,IDA 19004829
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with DOCK5: view

Pathways & Interactions for DOCK5 Gene

genes like me logo Genes that share pathways with DOCK5: view

Pathways by source for DOCK5 Gene

Gene Ontology (GO) - Biological Process for DOCK5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0010634 positive regulation of epithelial cell migration IMP 19004829
GO:0065009 regulation of molecular function IEA --
GO:1900026 positive regulation of substrate adhesion-dependent cell spreading IMP 19004829
GO:1904694 negative regulation of vascular smooth muscle contraction IMP 22158624
genes like me logo Genes that share ontologies with DOCK5: view

No data available for SIGNOR curated interactions for DOCK5 Gene

Drugs & Compounds for DOCK5 Gene

(3) Drugs for DOCK5 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0
Guanosine monophosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with DOCK5: view

Transcripts for DOCK5 Gene

Unigene Clusters for DOCK5 Gene

Dedicator of cytokinesis 5:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DOCK5 Gene

No ASD Table

Relevant External Links for DOCK5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DOCK5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DOCK5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DOCK5 Gene

This gene is overexpressed in Whole Blood (x5.6).

Protein differential expression in normal tissues from HIPED for DOCK5 Gene

This gene is overexpressed in Serum (41.7) and Bone marrow stromal cell (9.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for DOCK5 Gene

NURSA nuclear receptor signaling pathways regulating expression of DOCK5 Gene:


SOURCE GeneReport for Unigene cluster for DOCK5 Gene:


Evidence on tissue expression from TISSUES for DOCK5 Gene

  • Nervous system(4.3)
  • Heart(4.2)
  • Liver(4.2)
  • Muscle(4.1)
  • Skin(4.1)
genes like me logo Genes that share expression patterns with DOCK5: view

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DOCK5 Gene

Orthologs for DOCK5 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DOCK5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DOCK5 34 33
  • 99.57 (n)
(Canis familiaris)
Mammalia DOCK5 34 33
  • 90.96 (n)
(Bos Taurus)
Mammalia DOCK5 34 33
  • 89.83 (n)
(Monodelphis domestica)
Mammalia DOCK5 34
  • 88 (a)
(Mus musculus)
Mammalia Dock5 16 34 33
  • 87.13 (n)
(Rattus norvegicus)
Mammalia Dock5 33
  • 87.1 (n)
(Ornithorhynchus anatinus)
Mammalia DOCK5 34
  • 81 (a)
(Gallus gallus)
Aves DOCK5 34 33
  • 78 (n)
(Anolis carolinensis)
Reptilia DOCK5 34
  • 80 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dock5 33
  • 69.3 (n)
(Danio rerio)
Actinopterygii dock5 34 33
  • 69.3 (n)
fruit fly
(Drosophila melanogaster)
Insecta mbc 34
  • 35 (a)
(Caenorhabditis elegans)
Secernentea ced-5 34
  • 27 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 34
  • 17 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 50 (a)
Species where no ortholog for DOCK5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DOCK5 Gene

Gene Tree for DOCK5 (if available)
Gene Tree for DOCK5 (if available)
Evolutionary constrained regions (ECRs) for DOCK5: view image

Paralogs for DOCK5 Gene

Paralogs for DOCK5 Gene

(6) SIMAP similar genes for DOCK5 Gene using alignment to 5 proteins:

  • B9A015_HUMAN
  • H0Y7N4_HUMAN
  • H0YB14_HUMAN
genes like me logo Genes that share paralogs with DOCK5: view

Variants for DOCK5 Gene

Sequence variations from dbSNP and Humsavar for DOCK5 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs864622027 uncertain-significance, Malignant tumor of prostate 25,408,014(+) G/T coding_sequence_variant, genic_downstream_transcript_variant, missense_variant
rs1000022392 -- 25,227,851(+) C/A genic_upstream_transcript_variant, intron_variant
rs1000028175 -- 25,261,048(+) G/C genic_upstream_transcript_variant, intron_variant
rs1000031420 -- 25,266,648(+) A/G genic_upstream_transcript_variant, intron_variant
rs1000035683 -- 25,313,679(+) G/A genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for DOCK5 Gene

Variant ID Type Subtype PubMed ID
dgv1176n67 CNV loss 20364138
dgv12066n54 CNV gain 21841781
dgv12067n54 CNV gain+loss 21841781
dgv12068n54 CNV loss 21841781
dgv12069n54 CNV loss 21841781
dgv12070n54 CNV loss 21841781
dgv208n73 CNV deletion 24416366
dgv243n6 CNV deletion 16902084
dgv3797n106 CNV deletion 24896259
dgv453n21 CNV loss 19592680
dgv7147n100 CNV loss 25217958
dgv7148n100 CNV gain 25217958
esv1007835 CNV gain 20482838
esv2232393 CNV deletion 18987734
esv22943 CNV loss 19812545
esv2376511 CNV deletion 18987734
esv2468745 CNV loss 19546169
esv25667 CNV gain 19812545
esv2623034 CNV deletion 19546169
esv2657736 CNV deletion 23128226
esv2665846 CNV deletion 23128226
esv2676779 CNV deletion 23128226
esv2736770 CNV deletion 23290073
esv2736771 CNV deletion 23290073
esv2736772 CNV deletion 23290073
esv2736774 CNV deletion 23290073
esv2736775 CNV deletion 23290073
esv2736776 CNV deletion 23290073
esv2759606 CNV loss 17122850
esv3273051 CNV deletion 24192839
esv3543249 CNV deletion 23714750
esv3543251 CNV deletion 23714750
esv3616666 OTHER inversion 21293372
esv3616674 CNV loss 21293372
esv3616675 CNV loss 21293372
esv3616676 CNV loss 21293372
esv3616677 CNV loss 21293372
esv3616678 CNV loss 21293372
esv3891378 CNV loss 25118596
esv4966 CNV loss 18987735
esv6383 CNV loss 19470904
esv6612 CNV loss 19470904
esv989370 CNV deletion 20482838
esv994520 CNV deletion 20482838
nsv1017110 CNV gain 25217958
nsv1028475 CNV gain 25217958
nsv1075126 CNV deletion 25765185
nsv1076072 CNV deletion 25765185
nsv1077030 CNV deletion 25765185
nsv1120559 CNV tandem duplication 24896259
nsv1132136 CNV deletion 24896259
nsv1137355 CNV deletion 24896259
nsv396824 CNV deletion 16902084
nsv397748 CNV insertion 16902084
nsv436568 CNV deletion 17901297
nsv499572 CNV loss 21111241
nsv508500 CNV deletion 20534489
nsv511383 CNV loss 21212237
nsv511393 CNV gain 21212237
nsv512036 CNV loss 21212237
nsv514486 CNV loss 21397061
nsv527803 CNV loss 19592680
nsv610822 CNV gain 21841781
nsv610829 CNV gain 21841781
nsv610833 CNV gain+loss 21841781
nsv6124 CNV deletion 18451855
nsv6125 CNV insertion 18451855
nsv819560 CNV loss 19587683
nsv820034 CNV gain 19587683
nsv820928 CNV deletion 20802225
nsv824578 CNV loss 20364138
nsv951115 CNV duplication 24416366

Variation tolerance for DOCK5 Gene

Residual Variation Intolerance Score: 33.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.71; 91.51% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DOCK5 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DOCK5 Gene

Disorders for DOCK5 Gene

Additional Disease Information for DOCK5

No disorders were found for DOCK5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DOCK5 Gene

Publications for DOCK5 Gene

  1. Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity. (PMID: 12432077) Côté JF … Vuori K (Journal of cell science 2002) 2 3 4 58
  2. DOCK5 and DOCK1 regulate Caco-2 intestinal epithelial cell spreading and migration on collagen IV. (PMID: 19004829) Sanders MA … Basson MD (The Journal of biological chemistry 2009) 3 4 58
  3. DNA sequence and analysis of human chromosome 8. (PMID: 16421571) Nusbaum C … Lander ES (Nature 2006) 3 4 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for DOCK5 Gene

Sources for DOCK5 Gene

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