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Aliases for DOK3 Gene

Aliases for DOK3 Gene

  • Docking Protein 3 2 3 3 5
  • Downstream Of Tyrosine Kinase 3 3 4
  • Dok-Like Protein 3
  • DOKL 3

External Ids for DOK3 Gene

Previous GeneCards Identifiers for DOK3 Gene

  • GC00U916977
  • GC05M176861
  • GC05M176928
  • GC05M171849

Summaries for DOK3 Gene

GeneCards Summary for DOK3 Gene

DOK3 (Docking Protein 3) is a Protein Coding gene. Diseases associated with DOK3 include Myeloproliferative/Lymphoproliferative Neoplasms, Familial. Among its related pathways are B Cell Receptor Signaling Pathway (sino) and Innate Immune System. Gene Ontology (GO) annotations related to this gene include insulin receptor binding. An important paralog of this gene is DOK1.

UniProtKB/Swiss-Prot for DOK3 Gene

  • DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK3 is a negative regulator of JNK signaling in B-cells through interaction with INPP5D/SHIP1. May modulate ABL1 function (By similarity).

Gene Wiki entry for DOK3 Gene

Additional gene information for DOK3 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DOK3 Gene

Genomics for DOK3 Gene

GeneHancer (GH) Regulatory Elements for DOK3 Gene

Promoters and enhancers for DOK3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J177507 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 664.2 +1.4 1417 4.8 HDGF PKNOX1 TCF12 ZNF121 GLIS2 RUNX3 NCOA1 ZNF592 SMARCA4 ZNF184 DOK3 LOC105377750 PDLIM7 DDX41 GC05P176931
GH05J177425 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 25.7 +81.9 81902 8.6 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 GRK6 NSD1 FAF2 UIMC1 DOK3 ENSG00000247679 LOC202181 ZNF346-IT1 PFN3 FAM193B
GH05J177542 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 29.2 -34.7 -34729 6.3 PKNOX1 FOXA2 ARID4B SIN3A ETS1 YY1 ATF7 FOS RXRA REST DOK3 LOC105377750 DDX41 TMED9 PDLIM7 MXD3 DBN1 RAB24 GRK6 NSD1
GH05J177552 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 12.6 -42.9 -42910 3.2 FOXA2 ARNT ARID4B SIN3A ZNF2 YY1 ZNF766 E2F8 ZNF143 SP3 GC05P177553 LOC105377750 FAM193B DOK3 DDX41 TMED9 B4GALT7 FAM153A
GH05J177467 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 11.5 +39.8 39762 7.1 HDGF PKNOX1 ARID4B SIN3A YBX1 GLIS2 ZNF143 KLF7 FOS RUNX3 DBN1 MXD3 DOK3 DDX41 FAM193B RPL21P60 PRR7 FGFR4 ENSG00000279821 PIR32965
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around DOK3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DOK3 gene promoter:
  • AP-1
  • STAT3
  • IRF-1
  • E2F

Genomic Locations for DOK3 Gene

Genomic Locations for DOK3 Gene
chr5:177,501,904-177,511,274
(GRCh38/hg38)
Size:
9,371 bases
Orientation:
Minus strand
chr5:176,928,905-176,938,275
(GRCh37/hg19)
Size:
9,371 bases
Orientation:
Minus strand

Genomic View for DOK3 Gene

Genes around DOK3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DOK3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DOK3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DOK3 Gene

Proteins for DOK3 Gene

  • Protein details for DOK3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7L591-DOK3_HUMAN
    Recommended name:
    Docking protein 3
    Protein Accession:
    Q7L591
    Secondary Accessions:
    • E9PAT0
    • H7BXS0
    • Q8N864
    • Q9BQB3
    • Q9H666

    Protein attributes for DOK3 Gene

    Size:
    496 amino acids
    Molecular mass:
    53288 Da
    Quaternary structure:
    • On tyrosine phosphorylation, interacts with CSK and INPP5D/SHIP1 via their SH2 domains. Both Tyr-381 and Tyr-398 are required for interaction with INPP5D. Only Tyr-381 is required for interaction with CSK. Binds ABL1 through the PTB domain and in a kinase-dependent manner. Does not interact with RasGAP (By similarity).

    Alternative splice isoforms for DOK3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DOK3 Gene

Post-translational modifications for DOK3 Gene

  • Constitutively tyrosine-phosphorylated.
  • On IL2 stimulation, phosphorylated on C-terminal tyrosine residues possibly by Src kinases. Can also be phosphorylated by ABL1 kinase (By similarity).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for DOK3 Gene

Domains & Families for DOK3 Gene

Gene Families for DOK3 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for DOK3 Gene

Suggested Antigen Peptide Sequences for DOK3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7L591

UniProtKB/Swiss-Prot:

DOK3_HUMAN :
  • PTB domain mediates receptor interaction.
  • Belongs to the DOK family. Type A subfamily.
Domain:
  • PTB domain mediates receptor interaction.
Family:
  • Belongs to the DOK family. Type A subfamily.
genes like me logo Genes that share domains with DOK3: view

Function for DOK3 Gene

Molecular function for DOK3 Gene

UniProtKB/Swiss-Prot Function:
DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK3 is a negative regulator of JNK signaling in B-cells through interaction with INPP5D/SHIP1. May modulate ABL1 function (By similarity).

Phenotypes From GWAS Catalog for DOK3 Gene

Gene Ontology (GO) - Molecular Function for DOK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17290227
genes like me logo Genes that share ontologies with DOK3: view
genes like me logo Genes that share phenotypes with DOK3: view

Animal Models for DOK3 Gene

MGI Knock Outs for DOK3:

Animal Model Products

miRNA for DOK3 Gene

miRTarBase miRNAs that target DOK3

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DOK3 Gene

Localization for DOK3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DOK3 Gene

Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DOK3 gene
Compartment Confidence
plasma membrane 5
nucleus 2
mitochondrion 1
peroxisome 1
cytosol 1

Gene Ontology (GO) - Cellular Components for DOK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0030667 secretory granule membrane TAS --
GO:0101003 ficolin-1-rich granule membrane TAS --
genes like me logo Genes that share ontologies with DOK3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for DOK3 Gene

Pathways & Interactions for DOK3 Gene

genes like me logo Genes that share pathways with DOK3: view

Pathways by source for DOK3 Gene

1 Sino Biological pathway for DOK3 Gene
3 Reactome pathways for DOK3 Gene

Gene Ontology (GO) - Biological Process for DOK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007265 Ras protein signal transduction IEA --
GO:0043312 neutrophil degranulation TAS --
genes like me logo Genes that share ontologies with DOK3: view

No data available for SIGNOR curated interactions for DOK3 Gene

Drugs & Compounds for DOK3 Gene

No Compound Related Data Available

Transcripts for DOK3 Gene

Unigene Clusters for DOK3 Gene

Docking protein 3:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DOK3 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c · 3d · 3e ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b
SP1: - - - - - - - - - - - -
SP2: - - - - - - - - - -
SP3: - - - -
SP4: - - - - - - - - - - - -
SP5: - - - - - -
SP6: - - - - - - -
SP7: - - -
SP8: - - - - -
SP9: - - - -
SP10: - -
SP11: - - - -
SP12: - - -
SP13:

Relevant External Links for DOK3 Gene

GeneLoc Exon Structure for
DOK3
ECgene alternative splicing isoforms for
DOK3

Expression for DOK3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DOK3 Gene

mRNA differential expression in normal tissues according to GTEx for DOK3 Gene

This gene is overexpressed in Whole Blood (x35.0) and Spleen (x4.2).

Protein differential expression in normal tissues from HIPED for DOK3 Gene

This gene is overexpressed in Lavage (25.9), Peripheral blood mononuclear cells (17.1), Platelet (10.3), and Stomach (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DOK3 Gene



Protein tissue co-expression partners for DOK3 Gene

NURSA nuclear receptor signaling pathways regulating expression of DOK3 Gene:

DOK3

SOURCE GeneReport for Unigene cluster for DOK3 Gene:

Hs.720849

mRNA Expression by UniProt/SwissProt for DOK3 Gene:

Q7L591-DOK3_HUMAN
Tissue specificity: Expressed in spleen.

Evidence on tissue expression from TISSUES for DOK3 Gene

  • Blood(4.6)
  • Intestine(4.3)
  • Liver(4.1)
  • Bone marrow(2.1)
genes like me logo Genes that share expression patterns with DOK3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for DOK3 Gene

Orthologs for DOK3 Gene

This gene was present in the common ancestor of animals.

Orthologs for DOK3 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia DOK3 34 33
  • 82.42 (n)
OneToOne
cow
(Bos Taurus)
Mammalia DOK3 34 33
  • 82.25 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Dok3 16 34 33
  • 79.77 (n)
rat
(Rattus norvegicus)
Mammalia Dok3 33
  • 79.24 (n)
oppossum
(Monodelphis domestica)
Mammalia DOK3 34
  • 62 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DOK3 34
  • 50 (a)
OneToOne
chicken
(Gallus gallus)
Aves DOK3 34 33
  • 60.02 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DOK3 34
  • 40 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii CABZ01072950.1 34
  • 42 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Dok 34
  • 13 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4936 34
  • 20 (a)
OneToMany
Species where no ortholog for DOK3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DOK3 Gene

ENSEMBL:
Gene Tree for DOK3 (if available)
TreeFam:
Gene Tree for DOK3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for DOK3: view image

Paralogs for DOK3 Gene

Paralogs for DOK3 Gene

(2) SIMAP similar genes for DOK3 Gene using alignment to 8 proteins:

  • DOK3_HUMAN
  • D6R951_HUMAN
  • D6R977_HUMAN
  • D6RAM3_HUMAN
  • D6RAV2_HUMAN
  • D6RAZ9_HUMAN
  • D6RC22_HUMAN
  • D6RF29_HUMAN
genes like me logo Genes that share paralogs with DOK3: view

Variants for DOK3 Gene

Sequence variations from dbSNP and Humsavar for DOK3 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs869312828 risk-factor, Myeloproliferative/lymphoproliferative neoplasms, familial (multiple types), susceptibility to 177,512,369(-) C/T upstream_transcript_variant
rs78923296 likely-benign, not specified 177,511,717(-) G/A upstream_transcript_variant
rs140652745 benign, not specified 177,512,145(-) G/A upstream_transcript_variant
rs1000621375 -- 177,507,446(-) C/T intron_variant
rs1001407768 -- 177,508,708(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for DOK3 Gene

Variant ID Type Subtype PubMed ID
nsv1161311 CNV duplication 26073780

Variation tolerance for DOK3 Gene

Residual Variation Intolerance Score: 95% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.60; 65.36% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DOK3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DOK3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DOK3 Gene

Disorders for DOK3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for DOK3 Gene - From: GeneCards

Disorder Aliases PubMed IDs
myeloproliferative/lymphoproliferative neoplasms, familial
  • myeloproliferative/lymphoproliferative neoplasms, familial , susceptibility to
- elite association - COSMIC cancer census association via MalaCards
Search DOK3 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for DOK3

genes like me logo Genes that share disorders with DOK3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DOK3 Gene

Publications for DOK3 Gene

  1. DOK4 and DOK5: new Dok-related genes expressed in human T cells. (PMID: 12595900) Favre C … Nunès JA (Genes and immunity 2003) 2 3 4 58
  2. Proteomic analysis of integrin alphaIIbbeta3 outside-in signaling reveals Src-kinase-independent phosphorylation of Dok-1 and Dok-3 leading to SHIP-1 interactions. (PMID: 19682241) Senis YA … García A (Journal of thrombosis and haemostasis : JTH 2009) 3 22 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Dok-3, a novel adapter molecule involved in the negative regulation of immunoreceptor signaling. (PMID: 10733577) Lemay S … Veillette A (Molecular and cellular biology 2000) 2 3 58

Products for DOK3 Gene

Sources for DOK3 Gene

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