Aliases for SNIP1 Gene
External Ids for SNIP1 Gene
Previous GeneCards Identifiers for SNIP1 Gene
This gene encodes a protein that contains a coiled-coil motif and C-terminal forkhead-associated (FHA) domain. The encoded protein functions as a transcriptional coactivator that increases c-Myc activity and inhibits transforming growth factor beta (TGF-beta) and nuclear factor kappa-B (NF-kB) signaling. The encoded protein also regulates the stability of cyclin D1 mRNA, and may play a role in cell proliferation and cancer progression. Mutations in this gene are a cause of psychomotor retardation, epilepsy, and craniofacial dysmorphism (PMRED). [provided by RefSeq, Mar 2012]
GeneCards Summary for SNIP1 Gene
SNIP1 (Smad Nuclear Interacting Protein 1) is a Protein Coding gene. Diseases associated with SNIP1 include Psychomotor Retardation, Epilepsy, And Craniofacial Dysmorphism and Benign Epilepsy With Centrotemporal Spikes. Among its related pathways are Regulation of nuclear SMAD2/3 signaling and TGF-beta Signaling Pathway (WikiPathways). An important paralog of this gene is SLC4A1AP.
UniProtKB/Swiss-Prot for SNIP1 Gene
Down-regulates NF-kappa-B signaling by competing with RELA for CREBBP/EP300 binding. Involved in the microRNA (miRNA) biogenesis. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3end of the CCND1 gene and its mRNA.