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Aliases for ZYG11B Gene

Aliases for ZYG11B Gene

  • Zyg-11 Family Member B, Cell Cycle Regulator 2 3 5
  • Zyg-11 Homolog B (C. Elegans) 2
  • Zyg-11 Homolog (C. Elegans) 2
  • Protein Zyg-11 Homolog B 3
  • Zyg-11 Homolog B 3
  • KIAA1730 4
  • ZYG11 3

External Ids for ZYG11B Gene

Previous HGNC Symbols for ZYG11B Gene

  • ZYG11

Previous GeneCards Identifiers for ZYG11B Gene

  • GC01P052904
  • GC01P052964
  • GC01P053192
  • GC01P051337

Summaries for ZYG11B Gene

GeneCards Summary for ZYG11B Gene

ZYG11B (Zyg-11 Family Member B, Cell Cycle Regulator) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include binding. An important paralog of this gene is ZYG11A.

UniProtKB/Swiss-Prot for ZYG11B Gene

  • Probably acts as target recruitment subunit in the E3 ubiquitin ligase complex ZYG11B-CUL2-Elongin BC.

Additional gene information for ZYG11B Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZYG11B Gene

Genomics for ZYG11B Gene

GeneHancer (GH) Regulatory Elements for ZYG11B Gene

Promoters and enhancers for ZYG11B Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J052725 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 660.9 +0.4 442 2.2 HDGF PKNOX1 ARNT ARID4B SIN3A YBX1 ZNF2 YY1 E2F8 SP3 ZYG11B ORC1 MAGOH RPS13P2 ECHDC2 ENSG00000230953 PRPF38A ENSG00000266993 ZYG11A GC01P052729
GH01J052697 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 10.1 -28.3 -28310 2.2 HDGF FOXA2 PKNOX1 CLOCK SMAD1 MLX ARNT ARID4B SIN3A DMAP1 COA7 GC01P052696 ENSG00000228838 MAGOH TUT4 LOC100652967 ENSG00000226938 TXNDC12-AS1 SLC25A6P3 GAPDHP51
GH01J052842 Promoter/Enhancer 1.5 Ensembl ENCODE 11.2 +117.4 117375 3.4 PKNOX1 ARNT SIN3A FEZF1 ZNF2 YY1 POLR2B ZNF213 ZNF207 ZNF143 ZYG11A MAGOH PRPF38A NDC1 TUT4 KTI12 ECHDC2 ENSG00000230953 ZFYVE9 ZYG11B
GH01J052706 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE 10.4 -18.3 -18291 2.6 MEIS2 FOXA2 MAX RAD21 YY1 GATA3 FOSL2 ZNF189 RXRA HLF COA7 GC01P052710 NDUFS5P3 ZYG11B SCP2
GH01J052702 Enhancer 1.3 Ensembl ENCODE 10.1 -23.1 -23104 1.7 HDGF PKNOX1 CLOCK FOXA2 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZYG11B COA7 NDUFS5P3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZYG11B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZYG11B gene promoter:
  • YY1
  • Evi-1
  • POU2F1a
  • POU2F1
  • POU2F1b
  • POU2F1c
  • Pax-4a
  • HNF-1A

Genomic Locations for ZYG11B Gene

Genomic Locations for ZYG11B Gene
100,884 bases
Plus strand
100,889 bases
Plus strand

Genomic View for ZYG11B Gene

Genes around ZYG11B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZYG11B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZYG11B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZYG11B Gene

Proteins for ZYG11B Gene

  • Protein details for ZYG11B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein zyg-11 homolog B
    Protein Accession:
    Secondary Accessions:
    • Q8N2X3
    • Q9H8L8

    Protein attributes for ZYG11B Gene

    744 amino acids
    Molecular mass:
    83921 Da
    Quaternary structure:
    • Interacts with TCEB1/Elongin C. Part of an E3 ubiquitin ligase complex including ZYG11B, CUL2 and Elongin BC.
    • Sequence=BAB21821.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ZYG11B Gene


neXtProt entry for ZYG11B Gene

Post-translational modifications for ZYG11B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZYG11B Gene

No data available for DME Specific Peptides for ZYG11B Gene

Domains & Families for ZYG11B Gene

Gene Families for ZYG11B Gene

Protein Domains for ZYG11B Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the zyg-11 family.
  • Belongs to the zyg-11 family.
genes like me logo Genes that share domains with ZYG11B: view

Function for ZYG11B Gene

Molecular function for ZYG11B Gene

UniProtKB/Swiss-Prot Function:
Probably acts as target recruitment subunit in the E3 ubiquitin ligase complex ZYG11B-CUL2-Elongin BC.

Phenotypes From GWAS Catalog for ZYG11B Gene

Gene Ontology (GO) - Molecular Function for ZYG11B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IBA --
GO:0005488 binding IEA --
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with ZYG11B: view
genes like me logo Genes that share phenotypes with ZYG11B: view

Animal Model Products

CRISPR Products

miRNA for ZYG11B Gene

miRTarBase miRNAs that target ZYG11B

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZYG11B

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZYG11B Gene

Localization for ZYG11B Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZYG11B gene
Compartment Confidence
cytoskeleton 2
nucleus 2
cytosol 2
golgi apparatus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
  • Intermediate filaments (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZYG11B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031462 Cul2-RING ubiquitin ligase complex IBA --
genes like me logo Genes that share ontologies with ZYG11B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ZYG11B Gene

Pathways & Interactions for ZYG11B Gene

SuperPathways for ZYG11B Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZYG11B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
GO:0051438 regulation of ubiquitin-protein transferase activity IBA --
genes like me logo Genes that share ontologies with ZYG11B: view

No data available for Pathways by source and SIGNOR curated interactions for ZYG11B Gene

Drugs & Compounds for ZYG11B Gene

No Compound Related Data Available

Transcripts for ZYG11B Gene

mRNA/cDNA for ZYG11B Gene

Unigene Clusters for ZYG11B Gene

Zyg-11 family member B, cell cycle regulator:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZYG11B

Alternative Splicing Database (ASD) splice patterns (SP) for ZYG11B Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b
SP1: -
SP4: -

Relevant External Links for ZYG11B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZYG11B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZYG11B Gene

mRNA differential expression in normal tissues according to GTEx for ZYG11B Gene

This gene is overexpressed in Muscle - Skeletal (x6.3).

Protein differential expression in normal tissues from HIPED for ZYG11B Gene

This gene is overexpressed in Fetal Brain (13.4), Frontal cortex (9.0), Lymph node (7.3), Spleen (6.8), and Testis (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZYG11B Gene

NURSA nuclear receptor signaling pathways regulating expression of ZYG11B Gene:


SOURCE GeneReport for Unigene cluster for ZYG11B Gene:


Evidence on tissue expression from TISSUES for ZYG11B Gene

  • Nervous system(4.7)
  • Muscle(2)
genes like me logo Genes that share expression patterns with ZYG11B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZYG11B Gene

Orthologs for ZYG11B Gene

This gene was present in the common ancestor of animals.

Orthologs for ZYG11B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZYG11B 34 33
  • 99.82 (n)
(Canis familiaris)
Mammalia ZYG11B 34 33
  • 95.01 (n)
(Bos Taurus)
Mammalia ZYG11B 34 33
  • 94.27 (n)
(Monodelphis domestica)
Mammalia ZYG11B 34
  • 94 (a)
(Rattus norvegicus)
Mammalia Zyg11b 33
  • 89.78 (n)
(Mus musculus)
Mammalia Zyg11b 16 34 33
  • 89.25 (n)
(Ornithorhynchus anatinus)
Mammalia ZYG11B 34
  • 62 (a)
(Gallus gallus)
Aves ZYG11B 34 33
  • 81.5 (n)
(Anolis carolinensis)
Reptilia ZYG11B 34
  • 92 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100496980 33
  • 75.05 (n)
(Danio rerio)
Actinopterygii zyg11 34 33
  • 66.3 (n)
si:ch1073-82l19.1 34
  • 51 (a)
(Caenorhabditis elegans)
Secernentea zyg-11 34 33
  • 46.48 (n)
Species where no ortholog for ZYG11B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ZYG11B Gene

Gene Tree for ZYG11B (if available)
Gene Tree for ZYG11B (if available)
Evolutionary constrained regions (ECRs) for ZYG11B: view image

Paralogs for ZYG11B Gene

Paralogs for ZYG11B Gene

(1) SIMAP similar genes for ZYG11B Gene using alignment to 3 proteins:

  • B4DK95_HUMAN
genes like me logo Genes that share paralogs with ZYG11B: view

Variants for ZYG11B Gene

Sequence variations from dbSNP and Humsavar for ZYG11B Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000060559 -- 52,779,390(+) T/C intron_variant
rs1000077170 -- 52,824,077(+) C/T 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1000095681 -- 52,816,788(+) T/C genic_downstream_transcript_variant, intron_variant
rs1000101320 -- 52,727,557(+) A/G genic_upstream_transcript_variant, intron_variant
rs1000102763 -- 52,813,006(+) G/C genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZYG11B Gene

Variant ID Type Subtype PubMed ID
esv1751396 CNV insertion 17803354
esv2758934 CNV loss 17122850
esv3381752 CNV insertion 20981092
esv6479 CNV gain 19470904
nsv1000097 CNV gain 25217958
nsv1001535 CNV gain 25217958
nsv1122344 CNV deletion 24896259
nsv1133851 CNV deletion 24896259
nsv829859 CNV loss 17160897
nsv866 CNV deletion 18451855
nsv945948 CNV duplication 23825009

Variation tolerance for ZYG11B Gene

Residual Variation Intolerance Score: 14.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.38; 8.36% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZYG11B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZYG11B Gene

Disorders for ZYG11B Gene

Additional Disease Information for ZYG11B

No disorders were found for ZYG11B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZYG11B Gene

Publications for ZYG11B Gene

  1. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 2 3 4 58
  2. The Caenorhabditis elegans cell-cycle regulator ZYG-11 defines a conserved family of CUL-2 complex components. (PMID: 17304241) Vasudevan S … Kipreos ET (EMBO reports 2007) 3 4 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. CHK2-BRCA1 tumor-suppressor axis restrains oncogenic Aurora-A kinase to ensure proper mitotic microtubule assembly. (PMID: 26831064) Ertych N … Bastians H (Proceedings of the National Academy of Sciences of the United States of America 2016) 3 58

Products for ZYG11B Gene

Sources for ZYG11B Gene

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