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Aliases for TUT7 Gene

Aliases for TUT7 Gene

  • Terminal Uridylyl Transferase 7 2 3
  • Zinc Finger CCHC-Type Containing 6 2 3 5
  • Zinc Finger CCHC Domain-Containing Protein 6 3 4
  • TUTase 7 3 4
  • ZCCHC6 3 5
  • Zinc Finger, CCHC Domain Containing 6 3
  • PAP Associated Domain Containing 6 3
  • Terminal Uridylyltransferase 7 3
  • EC 2.7.7.52 4
  • KIAA1711 4
  • TUTase7 2
  • TENT3B 3
  • PAPD6 3
  • HS2 4

External Ids for TUT7 Gene

Previous HGNC Symbols for TUT7 Gene

  • ZCCHC6

Summaries for TUT7 Gene

GeneCards Summary for TUT7 Gene

TUT7 (Terminal Uridylyl Transferase 7) is a Protein Coding gene. An important paralog of this gene is TUT4.

UniProtKB/Swiss-Prot for TUT7 Gene

  • Uridylyltransferase that mediates the terminal uridylation of mRNAs with short (less than 25 nucleotides) poly(A) tails, hence facilitating global mRNA decay (PubMed:19703396, PubMed:25480299). Involved in microRNA (miRNA)-induced gene silencing through uridylation of deadenylated miRNA targets (PubMed:25480299). Also acts as a suppressor of miRNA biogenesis by mediating the terminal uridylation of some miRNA precursors, including that of let-7 (pre-let-7). Uridylated pre-let-7 RNA is not processed by Dicer and undergo degradation. Pre-let-7 uridylation is strongly enhanced in the presence of LIN28A (PubMed:22898984). Due to functional redundancy between ZCCHC6 and ZCCHC11, the identification of the specific role of each of these proteins is difficult.

Gene Wiki entry for TUT7 Gene

Additional gene information for TUT7 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TUT7 Gene

Genomics for TUT7 Gene

GeneHancer (GH) Regulatory Elements for TUT7 Gene

Promoters and enhancers for TUT7 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J086349 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 656.9 +1.4 1419 6.2 HDGF PKNOX1 CLOCK ARNT ARID4B NEUROD1 SIN3A DMAP1 ZNF2 IRF4 TUT7 C9orf153 RN7SKP264 LOC389765 GC09M086340
GH09J086405 Enhancer 1.4 FANTOM5 Ensembl ENCODE 13.5 -52.3 -52311 3.2 FOXA2 MLX ARID4B FEZF1 DMAP1 ETS1 YY1 SLC30A9 FOS NFKBIZ TUT7 GOLM1 C9orf153 GC09P086413 RPS6P13
GH09J086280 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 6.1 +72.1 72142 2.8 HDGF PKNOX1 CLOCK ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 ISCA1 GOLM1 C9orf153 RN7SKP264 ENSG00000270688 LOC102724080 LOC100287212 ENSG00000232211 ENSG00000229454 LOC494127
GH09J086337 Enhancer 1 Ensembl ENCODE 7.6 +15.4 15429 4 PKNOX1 INSM2 BACH1 BMI1 BATF POLR2A EED ZNF143 ATF7 FOSL2 TUT7 C9orf153 GC09M086340 ISCA1
GH09J086284 Enhancer 0.7 ENCODE 6.1 +69.3 69297 1.3 SMARCE1 MEIS2 LEF1 PKNOX1 MTA2 TEAD4 TAL1 CBFA2T3 REST DPF2 TUT7 C9orf153 ISCA1 GC09M086340
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TUT7 on UCSC Golden Path with GeneCards custom track

Genomic Locations for TUT7 Gene

Genomic Locations for TUT7 Gene
chr9:86,287,733-86,354,501
(GRCh38/hg38)
Size:
66,769 bases
Orientation:
Minus strand
chr9:88,902,648-88,969,402
(GRCh37/hg19)
Size:
66,755 bases
Orientation:
Minus strand

Genomic View for TUT7 Gene

Genes around TUT7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TUT7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TUT7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TUT7 Gene

Proteins for TUT7 Gene

  • Protein details for TUT7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VYS8-TUT7_HUMAN
    Recommended name:
    Terminal uridylyltransferase 7
    Protein Accession:
    Q5VYS8
    Secondary Accessions:
    • Q5H9T0
    • Q5VYS5
    • Q5VYS7
    • Q658Z9
    • Q659A2
    • Q6MZJ3
    • Q8N5F0
    • Q96N57
    • Q96NE8
    • Q9C0F2
    • Q9H8M6

    Protein attributes for TUT7 Gene

    Size:
    1495 amino acids
    Molecular mass:
    171229 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB14584.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB71052.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TUT7 Gene

    Alternative splice isoforms for TUT7 Gene

neXtProt entry for TUT7 Gene

Post-translational modifications for TUT7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TUT7 Gene

Domains & Families for TUT7 Gene

Graphical View of Domain Structure for InterPro Entry

Q5VYS8

UniProtKB/Swiss-Prot:

TUT7_HUMAN :
  • Belongs to the DNA polymerase type-B-like family.
Family:
  • Belongs to the DNA polymerase type-B-like family.
genes like me logo Genes that share domains with TUT7: view

Function for TUT7 Gene

Molecular function for TUT7 Gene

UniProtKB/Swiss-Prot Function:
Uridylyltransferase that mediates the terminal uridylation of mRNAs with short (less than 25 nucleotides) poly(A) tails, hence facilitating global mRNA decay (PubMed:19703396, PubMed:25480299). Involved in microRNA (miRNA)-induced gene silencing through uridylation of deadenylated miRNA targets (PubMed:25480299). Also acts as a suppressor of miRNA biogenesis by mediating the terminal uridylation of some miRNA precursors, including that of let-7 (pre-let-7). Uridylated pre-let-7 RNA is not processed by Dicer and undergo degradation. Pre-let-7 uridylation is strongly enhanced in the presence of LIN28A (PubMed:22898984). Due to functional redundancy between ZCCHC6 and ZCCHC11, the identification of the specific role of each of these proteins is difficult.
UniProtKB/Swiss-Prot CatalyticActivity:
UTP + RNA(n) = diphosphate + RNA(n+1).

Enzyme Numbers (IUBMB) for TUT7 Gene

Phenotypes From GWAS Catalog for TUT7 Gene

Gene Ontology (GO) - Molecular Function for TUT7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding HDA 22658674
GO:0008270 zinc ion binding IEA --
GO:0016740 transferase activity IEA --
GO:0016779 nucleotidyltransferase activity IEA --
genes like me logo Genes that share ontologies with TUT7: view
genes like me logo Genes that share phenotypes with TUT7: view

Animal Model Products

miRNA for TUT7 Gene

miRTarBase miRNAs that target TUT7

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TUT7 Gene

Localization for TUT7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TUT7 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TUT7 gene
Compartment Confidence
nucleus 5
cytosol 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TUT7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with TUT7: view

Pathways & Interactions for TUT7 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TUT7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening TAS --
GO:0031123 RNA 3-end processing IDA 17353264
GO:0071044 NOT histone mRNA catabolic process IMP 18172165
genes like me logo Genes that share ontologies with TUT7: view

No data available for Pathways by source and SIGNOR curated interactions for TUT7 Gene

Drugs & Compounds for TUT7 Gene

(1) Drugs for TUT7 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Uridine triphosphate Experimental, Investigational Pharma 0

(1) Additional Compounds for TUT7 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pyrophosphate
  • [(ho)2P(O)OP(O)(OH)2]
  • Acide diphosphorique
  • Diphosphorsaeure
  • H4P2O7
  • PYROphosphATE
14000-31-8
genes like me logo Genes that share compounds with TUT7: view

Transcripts for TUT7 Gene

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TUT7 Gene

No ASD Table

Relevant External Links for TUT7 Gene

GeneLoc Exon Structure for
TUT7
ECgene alternative splicing isoforms for
TUT7

Expression for TUT7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of TUT7 Gene:

TUT7

Evidence on tissue expression from TISSUES for TUT7 Gene

  • Nervous system(4.7)
  • Liver(4.3)
  • Muscle(4.3)
genes like me logo Genes that share expression patterns with TUT7: view

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TUT7 Gene

Orthologs for TUT7 Gene

This gene was present in the common ancestor of animals.

Orthologs for TUT7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZCCHC6 34 33
  • 99.82 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ZCCHC6 34 33
  • 89.99 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ZCCHC6 34 33
  • 89.6 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Zcchc6 34 33
  • 82.53 (n)
OneToOne
Tut7 16
rat
(Rattus norvegicus)
Mammalia Zcchc6 33
  • 82 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ZCCHC6 34
  • 79 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ZCCHC6 34
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves ZCCHC6 34 33
  • 71.25 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ZCCHC6 34
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia zcchc6 33
  • 63.19 (n)
Str.756 33
zebrafish
(Danio rerio)
Actinopterygii LOC562358 33
  • 55.18 (n)
ZCCHC6 34
  • 49 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta mkg-p 34
  • 14 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea pup-2 34
  • 25 (a)
ManyToMany
Y34F4.3 34
  • 20 (a)
ManyToMany
cid-1 34
  • 20 (a)
ManyToMany
K05C4.4 34
  • 15 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5065 34
  • 42 (a)
OneToMany
Species where no ortholog for TUT7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TUT7 Gene

ENSEMBL:
Gene Tree for TUT7 (if available)
TreeFam:
Gene Tree for TUT7 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TUT7: view image

Paralogs for TUT7 Gene

Paralogs for TUT7 Gene

genes like me logo Genes that share paralogs with TUT7: view

Variants for TUT7 Gene

Sequence variations from dbSNP and Humsavar for TUT7 Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1000064801 -- 86,336,013(-) A/T intron_variant
rs1000075016 -- 86,342,883(-) T/G intron_variant
rs1000076465 -- 86,351,099(-) A/C intron_variant
rs1000086092 -- 86,295,550(-) A/G 3_prime_UTR_variant, genic_downstream_transcript_variant, intron_variant
rs1000117655 -- 86,352,708(-) G/A 5_prime_UTR_variant, coding_sequence_variant, non_coding_transcript_variant, synonymous_variant

Structural Variations from Database of Genomic Variants (DGV) for TUT7 Gene

Variant ID Type Subtype PubMed ID
nsv518696 CNV loss 19592680

Variation tolerance for TUT7 Gene

Residual Variation Intolerance Score: 15.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.94; 59.65% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TUT7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TUT7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TUT7 Gene

Disorders for TUT7 Gene

Additional Disease Information for TUT7

No disorders were found for TUT7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TUT7 Gene

Publications for TUT7 Gene

  1. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 2 3 4 58
  2. Uridylation by TUT4 and TUT7 marks mRNA for degradation. (PMID: 25480299) Lim J … Kim VN (Cell 2014) 3 4 58
  3. Lin28-mediated control of let-7 microRNA expression by alternative TUTases Zcchc11 (TUT4) and Zcchc6 (TUT7). (PMID: 22898984) Thornton JE … Gregory RI (RNA (New York, N.Y.) 2012) 3 4 58
  4. Degradation of histone mRNA requires oligouridylation followed by decapping and simultaneous degradation of the mRNA both 5' to 3' and 3' to 5'. (PMID: 18172165) Mullen TE … Marzluff WF (Genes & development 2008) 3 4 58
  5. Efficient RNA polyuridylation by noncanonical poly(A) polymerases. (PMID: 17353264) Rissland OS … Norbury CJ (Molecular and cellular biology 2007) 3 4 58

Products for TUT7 Gene

Sources for TUT7 Gene

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