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Aliases for GCC1 Gene

Aliases for GCC1 Gene

  • GRIP And Coiled-Coil Domain Containing 1 2 3 5
  • Golgi Coiled-Coil Protein 1 3 4
  • Golgi Coiled-Coil 1 2 3
  • GRIP And Coiled-Coil Domain-Containing Protein 1 3
  • Peripheral Membrane Golgi Protein 3
  • GCC1P 3
  • GCC88 3

External Ids for GCC1 Gene

Previous GeneCards Identifiers for GCC1 Gene

  • GC07M125698
  • GC07M126761
  • GC07M126775
  • GC07M126814
  • GC07M127008
  • GC07M127220
  • GC07M121581

Summaries for GCC1 Gene

Entrez Gene Summary for GCC1 Gene

  • The protein encoded by this gene is a peripheral membrane protein. It is sensitive to brefeldin A. This encoded protein contains a GRIP domain which is thought to be used in targeting. It may play a role in the organization of trans-Golgi network subcompartment involved with membrane transport. [provided by RefSeq, Jul 2008]

GeneCards Summary for GCC1 Gene

GCC1 (GRIP And Coiled-Coil Domain Containing 1) is a Protein Coding gene. Diseases associated with GCC1 include Phencyclidine Abuse. Among its related pathways are Vesicle-mediated transport and Golgi-to-ER retrograde transport. Gene Ontology (GO) annotations related to this gene include binding.

UniProtKB/Swiss-Prot for GCC1 Gene

  • Probably involved in maintaining Golgi structure.

Gene Wiki entry for GCC1 Gene

Additional gene information for GCC1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GCC1 Gene

Genomics for GCC1 Gene

GeneHancer (GH) Regulatory Elements for GCC1 Gene

Promoters and enhancers for GCC1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J127584 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 656 +8.2 8218 2.1 HDGF ARNT ARID4B SIN3A ZNF2 YY1 POLR2B E2F8 KLF13 SP3 GCC1 GC07P127584 PIR62659 RBM28 ENSG00000273270 LOC105375490
GH07J127594 Enhancer 0.6 ENCODE 650.7 -1.2 -1182 0.8 NFIA RXRA RAD21 SP1 POLR2A TARDBP IKZF1 HNF4G HNF4A IKZF2 GCC1 FSCN3 PAX4
GH07J127593 Promoter 0.5 EPDnew 650.7 0.0 -29 0.1 FSCN3 GCC1 LOC105375489 PAX4
GH07J128341 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 50.2 -749.6 -749630 2.6 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 RBM28 GC07P128370 RNU7-27P ZNF800 GCC1 ENSG00000243679 ENSG00000230715 ENSG00000243302 ENSG00000224138 ENSG00000242588
GH07J127391 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 29.1 +201.1 201103 3 HDGF PKNOX1 SMAD1 SIN3A FEZF1 ZNF2 YY1 POLR2B CBX5 ZNF207 ZNF800 ENSG00000224138 GCC1 RBM28 FSCN3 LOC101928333 LOC100196944 ENSG00000224981 GC07M127372 GC07M127373
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around GCC1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GCC1 gene promoter:
  • ATF-2
  • c-Jun
  • Hand1
  • E47
  • GATA-3
  • Nkx2-5
  • Chx10
  • AP-1
  • USF-1:USF-2
  • USF-1

Genomic Locations for GCC1 Gene

Genomic Locations for GCC1 Gene
12,994 bases
Minus strand
12,994 bases
Minus strand

Genomic View for GCC1 Gene

Genes around GCC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GCC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GCC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GCC1 Gene

Proteins for GCC1 Gene

  • Protein details for GCC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    GRIP and coiled-coil domain-containing protein 1
    Protein Accession:
    Secondary Accessions:
    • Q9H6N7

    Protein attributes for GCC1 Gene

    775 amino acids
    Molecular mass:
    87811 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH08902.2; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305}; Sequence=BAB15218.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for GCC1 Gene

Post-translational modifications for GCC1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for GCC1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for GCC1 Gene

Domains & Families for GCC1 Gene

Gene Families for GCC1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for GCC1 Gene


Suggested Antigen Peptide Sequences for GCC1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Extended rod-like protein with coiled-coil domains.
  • Extended rod-like protein with coiled-coil domains.
genes like me logo Genes that share domains with GCC1: view

Function for GCC1 Gene

Molecular function for GCC1 Gene

UniProtKB/Swiss-Prot Function:
Probably involved in maintaining Golgi structure.

Phenotypes From GWAS Catalog for GCC1 Gene

Gene Ontology (GO) - Molecular Function for GCC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with GCC1: view
genes like me logo Genes that share phenotypes with GCC1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GCC1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GCC1 Gene

Localization for GCC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GCC1 Gene

Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GCC1 gene
Compartment Confidence
plasma membrane 5
cytosol 5
golgi apparatus 5
nucleus 2
endosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (4)
  • Golgi apparatus (4)
  • Plasma membrane (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GCC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005737 cytoplasm IEA --
GO:0005794 Golgi apparatus IBA,IDA --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with GCC1: view

Pathways & Interactions for GCC1 Gene

genes like me logo Genes that share pathways with GCC1: view

Gene Ontology (GO) - Biological Process for GCC1 Gene


No data available for SIGNOR curated interactions for GCC1 Gene

Drugs & Compounds for GCC1 Gene

No Compound Related Data Available

Transcripts for GCC1 Gene

mRNA/cDNA for GCC1 Gene

(1) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(134) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for GCC1 Gene

GRIP and coiled-coil domain containing 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for GCC1

Alternative Splicing Database (ASD) splice patterns (SP) for GCC1 Gene

No ASD Table

Relevant External Links for GCC1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for GCC1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GCC1 Gene

Protein differential expression in normal tissues from HIPED for GCC1 Gene

This gene is overexpressed in Lymph node (19.1), Salivary gland (10.2), and Stomach (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GCC1 Gene

Protein tissue co-expression partners for GCC1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GCC1 Gene:


SOURCE GeneReport for Unigene cluster for GCC1 Gene:


Evidence on tissue expression from TISSUES for GCC1 Gene

  • Gall bladder(5)
  • Intestine(5)
  • Pancreas(5)
  • Nervous system(5)
  • Skin(4.3)
  • Kidney(2.2)
genes like me logo Genes that share expression patterns with GCC1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GCC1 Gene

Orthologs for GCC1 Gene

This gene was present in the common ancestor of animals.

Orthologs for GCC1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia GCC1 34 33
  • 99.57 (n)
(Canis familiaris)
Mammalia GCC1 34 33
  • 89.55 (n)
(Bos Taurus)
Mammalia GCC1 34 33
  • 89.08 (n)
(Mus musculus)
Mammalia Gcc1 16 34 33
  • 88.09 (n)
(Rattus norvegicus)
Mammalia Gcc1 33
  • 87.57 (n)
(Monodelphis domestica)
Mammalia GCC1 34
  • 84 (a)
(Ornithorhynchus anatinus)
Mammalia GCC1 34
  • 80 (a)
(Gallus gallus)
Aves GCC1 34 33
  • 72.13 (n)
(Anolis carolinensis)
Reptilia GCC1 34
  • 54 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.19283 33
(Danio rerio)
Actinopterygii gcc1 34 33
  • 60.63 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG10703 34 33
  • 47.81 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012521 33
  • 39.76 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 40 (a)
-- 34
  • 36 (a)
Species where no ortholog for GCC1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GCC1 Gene

Gene Tree for GCC1 (if available)
Gene Tree for GCC1 (if available)
Evolutionary constrained regions (ECRs) for GCC1: view image

Paralogs for GCC1 Gene

No data available for Paralogs for GCC1 Gene

Variants for GCC1 Gene

Sequence variations from dbSNP and Humsavar for GCC1 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000402305 -- 127,584,548(-) T/C coding_sequence_variant, missense_variant
rs1001030731 -- 127,585,638(-) G/A upstream_transcript_variant
rs1001082739 -- 127,585,779(-) A/C/T upstream_transcript_variant
rs1001203478 -- 127,580,975(-) T/A 3_prime_UTR_variant
rs1001426199 -- 127,587,445(-) A/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for GCC1 Gene

Variant ID Type Subtype PubMed ID
nsv831122 CNV gain 17160897

Variation tolerance for GCC1 Gene

Residual Variation Intolerance Score: 16.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.44; 64.05% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GCC1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GCC1 Gene

Disorders for GCC1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for GCC1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
phencyclidine abuse
  • pcp abuse
- elite association - COSMIC cancer census association via MalaCards
Search GCC1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for GCC1

genes like me logo Genes that share disorders with GCC1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for GCC1 Gene

Publications for GCC1 Gene

  1. GRIP domain-mediated targeting of two new coiled-coil proteins, GCC88 and GCC185, to subcompartments of the trans-Golgi network. (PMID: 12446665) Luke MR … Gleeson PA (The Journal of biological chemistry 2003) 3 4 22 58
  2. A novel Golgi-localisation domain shared by a class of coiled-coil peripheral membrane proteins. (PMID: 10209125) Kjer-Nielsen L … Gleeson PA (Current biology : CB 1999) 2 3 4 58
  3. The golgin GCC88 is required for efficient retrograde transport of cargo from the early endosomes to the trans-Golgi network. (PMID: 17914056) Lieu ZZ … Gleeson PA (Molecular biology of the cell 2007) 3 22 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for GCC1 Gene

Sources for GCC1 Gene

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