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Aliases for IRX6 Gene

Aliases for IRX6 Gene

  • Iroquois Homeobox 6 2 3 5
  • Iroquois Homeobox Protein 6 2 3 4
  • Iroquois Homeobox Protein 7 2 3
  • Homeodomain Protein IRXB3 3 4
  • IRXB3 3 4
  • IRX7 3 4
  • Iroquois-Class Homeodomain Protein IRX-6 3
  • IRX-3 3

External Ids for IRX6 Gene

Previous HGNC Symbols for IRX6 Gene

  • IRX7

Previous GeneCards Identifiers for IRX6 Gene

  • GC16M055413
  • GC16P055096
  • GC16P055137
  • GC16P055136
  • GC16P053915
  • GC16P041244

Summaries for IRX6 Gene

GeneCards Summary for IRX6 Gene

IRX6 (Iroquois Homeobox 6) is a Protein Coding gene. Diseases associated with IRX6 include Brugada Syndrome. Gene Ontology (GO) annotations related to this gene include sequence-specific DNA binding. An important paralog of this gene is IRX4.

Gene Wiki entry for IRX6 Gene

Additional gene information for IRX6 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for IRX6 Gene

Genomics for IRX6 Gene

GeneHancer (GH) Regulatory Elements for IRX6 Gene

Promoters and enhancers for IRX6 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J055323 Enhancer 1 Ensembl ENCODE 656.4 +0.7 687 2.2 ZSCAN4 MZF1 SIN3A KLF14 ZNF2 ZNF335 ZNF366 ZNF143 ATF7 EGR2 IRX6 ENSG00000283423 ENSG00000259283 ENSG00000263207
GH16J055295 Enhancer 0.8 VISTA UCNEbase 12 -27.6 -27647 1.5 IRX6 RN7SL841P ENSG00000283423 ENSG00000259283
GH16J055372 Enhancer 0.5 ENCODE 16.5 +49.5 49494 1.4 ZSCAN21 ZFP36 ZMYM3 ATF7 ATF2 IRX6 LOC105371279 GC16M055346
GH16J055444 Enhancer 0.8 Ensembl ENCODE 9.8 +121.1 121141 1.4 NR2F1 MAX EBF1 DPF2 POLR2A IKZF1 EED ATF7 MYC PRDM4 MMP2-AS1 MMP2 LPCAT2 IRX6 GC16P055429
GH16J055443 Enhancer 0.7 Ensembl 9.8 +119.7 119741 0.6 HDGF ZNF777 SMAD1 BMI1 MCM2 ZNF316 NFATC1 EED ATF7 IKZF2 MMP2-AS1 LPCAT2 IRX6 GC16P055429 MMP2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around IRX6 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the IRX6 gene promoter:
  • Nkx6-1
  • HFH-3
  • FOXI1
  • FOXL1
  • POU3F1
  • SRY
  • AP-2gamma
  • ATF6
  • Bach1

Genomic Locations for IRX6 Gene

Genomic Locations for IRX6 Gene
7,001 bases
Plus strand
7,001 bases
Plus strand

Genomic View for IRX6 Gene

Genes around IRX6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
IRX6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for IRX6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for IRX6 Gene

Proteins for IRX6 Gene

  • Protein details for IRX6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Iroquois-class homeodomain protein IRX-6
    Protein Accession:
    Secondary Accessions:
    • B2RN06
    • Q7Z2K0

    Protein attributes for IRX6 Gene

    446 amino acids
    Molecular mass:
    48240 Da
    Quaternary structure:
    No Data Available

neXtProt entry for IRX6 Gene

Post-translational modifications for IRX6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for IRX6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for IRX6 Gene

Domains & Families for IRX6 Gene

Gene Families for IRX6 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Suggested Antigen Peptide Sequences for IRX6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TALE/IRO homeobox family.
  • Belongs to the TALE/IRO homeobox family.
genes like me logo Genes that share domains with IRX6: view

Function for IRX6 Gene

Phenotypes From GWAS Catalog for IRX6 Gene

Gene Ontology (GO) - Molecular Function for IRX6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS 19274049
GO:0003677 DNA binding IEA --
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with IRX6: view
genes like me logo Genes that share phenotypes with IRX6: view

Animal Models for IRX6 Gene

MGI Knock Outs for IRX6:
  • Irx6 Irx6<tm1Chow>

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IRX6

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for IRX6 Gene

Localization for IRX6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for IRX6 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for IRX6 gene
Compartment Confidence
nucleus 5
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for IRX6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with IRX6: view

Pathways & Interactions for IRX6 Gene

No Data Available

Gene Ontology (GO) - Biological Process for IRX6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with IRX6: view

No data available for Pathways by source and SIGNOR curated interactions for IRX6 Gene

Drugs & Compounds for IRX6 Gene

No Compound Related Data Available

Transcripts for IRX6 Gene

mRNA/cDNA for IRX6 Gene

(2) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(22) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for IRX6 Gene

Iroquois homeobox 6:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for IRX6

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for IRX6 Gene

No ASD Table

Relevant External Links for IRX6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for IRX6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for IRX6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for IRX6 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x7.2), Skin - Sun Exposed (Lower leg) (x7.1), Adipose - Visceral (Omentum) (x7.1), Heart - Left Ventricle (x6.6), and Adipose - Subcutaneous (x6.1).

NURSA nuclear receptor signaling pathways regulating expression of IRX6 Gene:


SOURCE GeneReport for Unigene cluster for IRX6 Gene:


Evidence on tissue expression from TISSUES for IRX6 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with IRX6: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for IRX6 Gene

Orthologs for IRX6 Gene

This gene was present in the common ancestor of animals.

Orthologs for IRX6 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia IRX6 34 33
  • 98.35 (n)
(Bos Taurus)
Mammalia IRX6 34 33
  • 85.33 (n)
(Canis familiaris)
Mammalia IRX6 34 33
  • 84.5 (n)
(Mus musculus)
Mammalia Irx6 16 34 33
  • 79.35 (n)
(Rattus norvegicus)
Mammalia Irx6 33
  • 78.86 (n)
(Monodelphis domestica)
Mammalia IRX6 34
  • 54 (a)
(Ornithorhynchus anatinus)
Mammalia IRX6 34
  • 38 (a)
(Gallus gallus)
Aves IRX6 34
  • 70 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia irx6 33
  • 53.89 (n)
(Danio rerio)
Actinopterygii irx6a 34 33
  • 62.56 (n)
fruit fly
(Drosophila melanogaster)
Insecta caup 34
  • 19 (a)
ara 34
  • 18 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 20 (a)
-- 34
  • 4 (a)
Species where no ortholog for IRX6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for IRX6 Gene

Gene Tree for IRX6 (if available)
Gene Tree for IRX6 (if available)
Evolutionary constrained regions (ECRs) for IRX6: view image

Paralogs for IRX6 Gene

Paralogs for IRX6 Gene

(3) SIMAP similar genes for IRX6 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with IRX6: view

Variants for IRX6 Gene

Sequence variations from dbSNP and Humsavar for IRX6 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000101716 -- 55,329,968(+) C/G intron_variant
rs1000983083 -- 55,324,626(+) G/C 5_prime_UTR_variant
rs1001267972 -- 55,324,850(+) C/G 5_prime_UTR_variant
rs1001532066 -- 55,327,735(+) T/C coding_sequence_variant, missense_variant
rs1002719303 -- 55,323,478(+) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for IRX6 Gene

Variant ID Type Subtype PubMed ID
nsv833239 CNV gain 17160897
nsv952680 CNV deletion 24416366

Variation tolerance for IRX6 Gene

Residual Variation Intolerance Score: 75.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.18; 61.80% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for IRX6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for IRX6 Gene

Disorders for IRX6 Gene

MalaCards: The human disease database

(1) MalaCards diseases for IRX6 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
brugada syndrome
  • right bundle branch block, st segment elevation, and sudden death syndrome
- elite association - COSMIC cancer census association via MalaCards
Search IRX6 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for IRX6

genes like me logo Genes that share disorders with IRX6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for IRX6 Gene

Publications for IRX6 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. Genome-wide association analyses identify variants in developmental genes associated with hypospadias. (PMID: 25108383) Geller F … Melbye M (Nature genetics 2014) 3 58
  3. Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. (PMID: 22589738) Fox CS … Borecki IB (PLoS genetics 2012) 3 58
  4. A census of human transcription factors: function, expression and evolution. (PMID: 19274049) Vaquerizas JM … Luscombe NM (Nature reviews. Genetics 2009) 3 58
  5. Identification of biomarkers in Dupuytren's disease by comparative analysis of fibroblasts versus tissue biopsies in disease-specific phenotypes. (PMID: 19121738) Shih B … Bayat A (The Journal of hand surgery 2009) 22 58

Products for IRX6 Gene

Sources for IRX6 Gene

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