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Aliases for TTPAL Gene

Aliases for TTPAL Gene

  • Alpha Tocopherol Transfer Protein Like 2 3 5
  • Tocopherol (Alpha) Transfer Protein-Like 2 3
  • C20orf121 3 4
  • Alpha-Tocopherol Transfer Protein-Like 3
  • Chromosome 20 Open Reading Frame 121 2

External Ids for TTPAL Gene

Previous HGNC Symbols for TTPAL Gene

  • C20orf121

Previous GeneCards Identifiers for TTPAL Gene

  • GC20P042538
  • GC20P043104
  • GC20P039846

Summaries for TTPAL Gene

GeneCards Summary for TTPAL Gene

TTPAL (Alpha Tocopherol Transfer Protein Like) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include transporter activity. An important paralog of this gene is CLVS1.

UniProtKB/Swiss-Prot for TTPAL Gene

  • May act as a protein that binds a hydrophobic ligand.

Additional gene information for TTPAL Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TTPAL Gene

Genomics for TTPAL Gene

GeneHancer (GH) Regulatory Elements for TTPAL Gene

Promoters and enhancers for TTPAL Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20J044475 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 650.7 +0.5 454 2.5 HDGF PKNOX1 SMAD1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 TTPAL SYS1 PIGT PKIG GC20P044473 PIR42438
GH20J044493 Enhancer 1.3 FANTOM5 ENCODE dbSUPER 17.4 +20.1 20072 4.8 PKNOX1 BATF IRF4 SCRT2 ATF7 FOS RUNX3 CREM RXRA JUNB GC20P044495 PIR46342 PKIG TTPAL SERINC3 RPL37AP1 LINC01620 LINC01430 OSER1 ADA
GH20J044530 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 6.1 +56.1 56146 2.3 HDGF MLX ARID4B SIN3A DMAP1 ZNF2 ZBTB7B IRF4 YY1 SLC30A9 PKIG OSER1 PIGT SYS1 TTPAL PIR61280
GH20J044578 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 5.3 +107.6 107618 9.9 HDGF PKNOX1 ATF1 IRF4 ATF7 RUNX3 JUNB ZNF592 ATF4 GLIS1 PKIG TTPAL OSER1 PIR61280 GC20M044554
GH20J044518 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 5.1 +45.5 45491 4.8 HDGF PKNOX1 SMAD1 FOXA2 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 SERINC3 PKIG TTPAL PIR36658 GC20M044500
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TTPAL on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TTPAL gene promoter:
  • Nkx2-5
  • Arnt
  • AhR
  • Tal-1beta
  • COUP
  • COUP-TF1
  • HNF-4alpha1
  • E47
  • c-Myb

Genomic Locations for TTPAL Gene

Genomic Locations for TTPAL Gene
18,721 bases
Plus strand
18,719 bases
Plus strand

Genomic View for TTPAL Gene

Genes around TTPAL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TTPAL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TTPAL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TTPAL Gene

Proteins for TTPAL Gene

  • Protein details for TTPAL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Alpha-tocopherol transfer protein-like
    Protein Accession:
    Secondary Accessions:
    • E1P5X3
    • Q5QPC1
    • Q9H1G2
    • Q9NQG8

    Protein attributes for TTPAL Gene

    342 amino acids
    Molecular mass:
    38515 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TTPAL Gene

Post-translational modifications for TTPAL Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TTPAL Gene

Domains & Families for TTPAL Gene

Gene Families for TTPAL Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for TTPAL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TTPAL: view

No data available for UniProtKB/Swiss-Prot for TTPAL Gene

Function for TTPAL Gene

Molecular function for TTPAL Gene

UniProtKB/Swiss-Prot Function:
May act as a protein that binds a hydrophobic ligand.

Phenotypes From GWAS Catalog for TTPAL Gene

genes like me logo Genes that share phenotypes with TTPAL: view

Animal Model Products

miRNA for TTPAL Gene

miRTarBase miRNAs that target TTPAL

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TTPAL Gene

Localization for TTPAL Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TTPAL gene
Compartment Confidence
cytosol 3
nucleus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Golgi apparatus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TTPAL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane HDA 19946888
genes like me logo Genes that share ontologies with TTPAL: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TTPAL Gene

Pathways & Interactions for TTPAL Gene

SuperPathways for TTPAL Gene

No Data Available

Gene Ontology (GO) - Biological Process for TTPAL Gene


No data available for Pathways by source and SIGNOR curated interactions for TTPAL Gene

Drugs & Compounds for TTPAL Gene

No Compound Related Data Available

Transcripts for TTPAL Gene

Unigene Clusters for TTPAL Gene

Tocopherol (alpha) transfer protein-like:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TTPAL Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5a · 5b
SP1: - -
SP2: -
SP4: -
SP6: - -

Relevant External Links for TTPAL Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TTPAL Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TTPAL Gene

mRNA differential expression in normal tissues according to GTEx for TTPAL Gene

This gene is overexpressed in Liver (x4.1).

Protein differential expression in normal tissues from HIPED for TTPAL Gene

This gene is overexpressed in Frontal cortex (42.5), Spleen (8.5), and Blymphocyte (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TTPAL Gene

NURSA nuclear receptor signaling pathways regulating expression of TTPAL Gene:


SOURCE GeneReport for Unigene cluster for TTPAL Gene:


Evidence on tissue expression from TISSUES for TTPAL Gene

  • Liver(4.4)
genes like me logo Genes that share expression patterns with TTPAL: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TTPAL Gene

Orthologs for TTPAL Gene

This gene was present in the common ancestor of animals.

Orthologs for TTPAL Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TTPAL 34 33
  • 99.42 (n)
(Canis familiaris)
Mammalia TTPAL 34 33
  • 90.45 (n)
(Bos Taurus)
Mammalia TTPAL 34 33
  • 87.52 (n)
(Mus musculus)
Mammalia Ttpal 16 34 33
  • 87.33 (n)
(Monodelphis domestica)
Mammalia TTPAL 34
  • 87 (a)
(Rattus norvegicus)
Mammalia Ttpal 33
  • 85.87 (n)
(Ornithorhynchus anatinus)
Mammalia TTPAL 34
  • 82 (a)
(Gallus gallus)
Aves TTPAL 34 33
  • 76.81 (n)
(Anolis carolinensis)
Reptilia TTPAL 34
  • 76 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ttpal 33
  • 66.86 (n)
(Danio rerio)
Actinopterygii ttpal 34 33
  • 64.87 (n)
Dr.26556 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009314 33
  • 48.35 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG5958 34
  • 31 (a)
CG12926 34
  • 29 (a)
CG10237 34
  • 29 (a)
CG31636 34
  • 29 (a)
CG2663 34
  • 27 (a)
pinta 34
  • 27 (a)
CG33966 34
  • 26 (a)
CG10657 34
  • 26 (a)
CG33965 34
  • 26 (a)
Cralbp 34
  • 26 (a)
CG5973 34
  • 26 (a)
CG33514 34
  • 26 (a)
CG10026 34
  • 25 (a)
CG30339 34
  • 24 (a)
CG1902 34
  • 24 (a)
CG10300 34
  • 24 (a)
CG11550 34
  • 23 (a)
CG3823 34
  • 22 (a)
CG3191 34
  • 22 (a)
CG10301 34
  • 20 (a)
CG3091 34
  • 20 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 31 (a)
Species where no ortholog for TTPAL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TTPAL Gene

Gene Tree for TTPAL (if available)
Gene Tree for TTPAL (if available)
Evolutionary constrained regions (ECRs) for TTPAL: view image

Paralogs for TTPAL Gene

Paralogs for TTPAL Gene

(5) SIMAP similar genes for TTPAL Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TTPAL: view

Variants for TTPAL Gene

Sequence variations from dbSNP and Humsavar for TTPAL Gene

SNP ID Clin Chr 20 pos Variation AA Info Type
rs1000009529 -- 44,477,068(+) G/A intron_variant
rs1000027553 -- 44,474,772(+) C/T upstream_transcript_variant
rs1000104577 -- 44,485,944(+) CT/ intron_variant
rs1001005752 -- 44,490,443(+) T/C 3_prime_UTR_variant
rs1001226701 -- 44,476,322(+) C/T 5_prime_UTR_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TTPAL Gene

Variant ID Type Subtype PubMed ID
nsv1061719 CNV gain 25217958
nsv586065 CNV gain 21841781

Variation tolerance for TTPAL Gene

Residual Variation Intolerance Score: 35.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.53; 55.66% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TTPAL Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TTPAL Gene

Disorders for TTPAL Gene

Additional Disease Information for TTPAL

No disorders were found for TTPAL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TTPAL Gene

Publications for TTPAL Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  2. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P … Rogers J (Nature 2001) 3 4 58
  3. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y … Zou H (Journal of proteomics 2014) 4 58
  4. Defining the membrane proteome of NK cells. (PMID: 19946888) Ghosh D … Wilkins JA (Journal of mass spectrometry : JMS 2010) 3 58
  5. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K … Gorospe M (The EMBO journal 2009) 3 58

Products for TTPAL Gene

Sources for TTPAL Gene

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