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Aliases for TNIP2 Gene

Aliases for TNIP2 Gene

  • TNFAIP3 Interacting Protein 2 2 3 5
  • Fetal Liver LKB1-Interacting Protein 3 4
  • ABIN2 3 4
  • FLIP1 3 4
  • A20-Binding Inhibitor Of NF-Kappa-B Activation 2 4
  • A20-Binding Inhibitor Of NF-KappaB Activation-2 3
  • TNFAIP3-Interacting Protein 2 3
  • ABIN-2 4
  • KLIP 3

External Ids for TNIP2 Gene

Previous GeneCards Identifiers for TNIP2 Gene

  • GC04M002726
  • GC04M002602
  • GC04P9I0140
  • GC04M002775
  • GC04M002780

Summaries for TNIP2 Gene

Entrez Gene Summary for TNIP2 Gene

  • This gene encodes a protein which acts as an inhibitor of NFkappaB activation. The encoded protein is also involved in MAP/ERK signaling pathway in specific cell types. It may be involved in apoptosis of endothelial cells. Alternative splicing results in multiple transcript variants. A pseudogene related to this gene is located on the X chromosome.[provided by RefSeq, May 2014]

GeneCards Summary for TNIP2 Gene

TNIP2 (TNFAIP3 Interacting Protein 2) is a Protein Coding gene. Among its related pathways are Activated TLR4 signalling and IL-1 signaling pathway. Gene Ontology (GO) annotations related to this gene include protein kinase binding and polyubiquitin modification-dependent protein binding.

UniProtKB/Swiss-Prot for TNIP2 Gene

  • Inhibits NF-kappa-B activation by blocking the interaction of RIPK1 with its downstream effector NEMO/IKBKG. Forms a ternary complex with NFKB1 and MAP3K8 but appears to function upstream of MAP3K8 in the TLR4 signaling pathway that regulates MAP3K8 activation. Involved in activation of the MEK/ERK signaling pathway during innate immune response; this function seems to be stimulus- and cell type specific. Required for stability of MAP3K8. Involved in regulation of apoptosis in endothelial cells; promotes TEK agonist-stimulated endothelial survival. May act as transcriptional coactivator when translocated to the nucleus. Enhances CHUK-mediated NF-kappa-B activation involving NF-kappa-B p50-p65 and p50-c-Rel complexes.

Gene Wiki entry for TNIP2 Gene

Additional gene information for TNIP2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TNIP2 Gene

Genomics for TNIP2 Gene

GeneHancer (GH) Regulatory Elements for TNIP2 Gene

Promoters and enhancers for TNIP2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J002755 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 661.4 +0.2 215 2.2 HDGF ATF1 ZFP64 ARID4B SIN3A DMAP1 ZNF48 YY1 GLIS2 ELK1 TNIP2 GC04P002755 FAM193A RNF4 NELFA HAUS3 MFSD10 NOP14-AS1 ZFYVE28
GH04J002792 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 15.1 -43.9 -43942 15.2 HDGF PKNOX1 CLOCK MLX ZFP64 ARID4B SIN3A DMAP1 ZBTB7B YY1 SH3BP2 ADD1 TNIP2 NOP14-AS1 GRK4 CFAP99 ZFYVE28 HTT
GH04J002842 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 11.5 -88.1 -88114 3.8 HDGF PKNOX1 FOXA2 ZFP64 ARID4B SIN3A DMAP1 IRF4 POLR2B ZNF213 ADD1 GC04P002844 GC04P002845 GC04P002843 GRK4 FAM193A TNIP2 RNF4 GC04P002904 PIR46708
GH04J002866 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE dbSUPER 11.9 -111.3 -111329 3.4 ATF1 FOXA2 ARNT ARID4B YY1 TCF12 ZNF766 GATA2 E2F8 RXRA ADD1 GRK4 TNIP2 NOP14-AS1 MFSD10 NOP14 GC04P002845 GC04P002844 GC04P002843 GC04P002904
GH04J002833 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE dbSUPER 11.8 -80.6 -80649 7 NFIB STAT5A RAD21 RARA TCF12 ETV6 BCLAF1 RUNX3 CREM RXRA ADD1 NOP14-AS1 TNIP2 ZFYVE28 SH3BP2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TNIP2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TNIP2 gene promoter:
  • c-Myb
  • Egr-1
  • PPAR-alpha
  • HEN1
  • RP58
  • AP-4
  • FOXJ2
  • FOXJ2 (long isoform)
  • c-Myc
  • Max

Genomic Locations for TNIP2 Gene

Genomic Locations for TNIP2 Gene
chr4:2,741,648-2,756,376
(GRCh38/hg38)
Size:
14,729 bases
Orientation:
Minus strand
chr4:2,743,375-2,758,103
(GRCh37/hg19)
Size:
14,729 bases
Orientation:
Minus strand

Genomic View for TNIP2 Gene

Genes around TNIP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TNIP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TNIP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TNIP2 Gene

Proteins for TNIP2 Gene

  • Protein details for TNIP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NFZ5-TNIP2_HUMAN
    Recommended name:
    TNFAIP3-interacting protein 2
    Protein Accession:
    Q8NFZ5
    Secondary Accessions:
    • B1AKS4
    • B3KTY8
    • D3DVQ9
    • Q7L5L2
    • Q9BQR6
    • Q9H682

    Protein attributes for TNIP2 Gene

    Size:
    429 amino acids
    Molecular mass:
    48700 Da
    Quaternary structure:
    • Interacts with STK11/LKB1, TNFAIP3, IKBKG, NFKB1, MAP3K8, TEK, RIPK1, CHUK, IKBKB and SMARCD1. Interacts with polyubiquitin.

    Three dimensional structures from OCA and Proteopedia for TNIP2 Gene

    Alternative splice isoforms for TNIP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TNIP2 Gene

Post-translational modifications for TNIP2 Gene

  • In vitro phosphorylated by CHUK.
  • Ubiquitinated; undergoes Lys-48-linked polyubiquitination probably leading to constitutive proteasomal degradation which can be impaired by IKK-A/CHUK or IKBKB probably involving deubiquitination.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TNIP2 Gene

No data available for DME Specific Peptides for TNIP2 Gene

Domains & Families for TNIP2 Gene

Gene Families for TNIP2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TNIP2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TNIP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TNIP2: view

No data available for UniProtKB/Swiss-Prot for TNIP2 Gene

Function for TNIP2 Gene

Molecular function for TNIP2 Gene

UniProtKB/Swiss-Prot Function:
Inhibits NF-kappa-B activation by blocking the interaction of RIPK1 with its downstream effector NEMO/IKBKG. Forms a ternary complex with NFKB1 and MAP3K8 but appears to function upstream of MAP3K8 in the TLR4 signaling pathway that regulates MAP3K8 activation. Involved in activation of the MEK/ERK signaling pathway during innate immune response; this function seems to be stimulus- and cell type specific. Required for stability of MAP3K8. Involved in regulation of apoptosis in endothelial cells; promotes TEK agonist-stimulated endothelial survival. May act as transcriptional coactivator when translocated to the nucleus. Enhances CHUK-mediated NF-kappa-B activation involving NF-kappa-B p50-p65 and p50-c-Rel complexes.

Phenotypes From GWAS Catalog for TNIP2 Gene

Gene Ontology (GO) - Molecular Function for TNIP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11389905
GO:0019901 protein kinase binding IDA 21784860
GO:0031593 polyubiquitin modification-dependent protein binding IDA 18212736
GO:0046872 metal ion binding IEA --
GO:0070530 K63-linked polyubiquitin modification-dependent protein binding IEA --
genes like me logo Genes that share ontologies with TNIP2: view
genes like me logo Genes that share phenotypes with TNIP2: view

Animal Models for TNIP2 Gene

MGI Knock Outs for TNIP2:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TNIP2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TNIP2 Gene

Localization for TNIP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TNIP2 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TNIP2 gene
Compartment Confidence
nucleus 5
cytosol 5
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (4)
  • Nucleoplasm (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TNIP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IBA --
GO:0005829 cytosol TAS,IDA --
genes like me logo Genes that share ontologies with TNIP2: view

Pathways & Interactions for TNIP2 Gene

genes like me logo Genes that share pathways with TNIP2: view

Pathways by source for TNIP2 Gene

1 GeneGo (Thomson Reuters) pathway for TNIP2 Gene

SIGNOR curated interactions for TNIP2 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for TNIP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006915 apoptotic process IEA --
GO:0006954 inflammatory response IEA --
GO:0007249 I-kappaB kinase/NF-kappaB signaling IEA --
genes like me logo Genes that share ontologies with TNIP2: view

Drugs & Compounds for TNIP2 Gene

(1) Drugs for TNIP2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with TNIP2: view

Transcripts for TNIP2 Gene

mRNA/cDNA for TNIP2 Gene

Unigene Clusters for TNIP2 Gene

TNFAIP3 interacting protein 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TNIP2

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TNIP2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d
SP1: - - - - -
SP2: - - -
SP3: -
SP4: - - - - - - -
SP5: - - -
SP6: - - -
SP7:

Relevant External Links for TNIP2 Gene

GeneLoc Exon Structure for
TNIP2
ECgene alternative splicing isoforms for
TNIP2

Expression for TNIP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TNIP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TNIP2 Gene

This gene is overexpressed in Placenta (15.8), Liver (13.6), Monocytes (9.0), Blymphocyte (8.6), and Peripheral blood mononuclear cells (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TNIP2 Gene



Protein tissue co-expression partners for TNIP2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TNIP2 Gene:

TNIP2

SOURCE GeneReport for Unigene cluster for TNIP2 Gene:

Hs.368551

mRNA Expression by UniProt/SwissProt for TNIP2 Gene:

Q8NFZ5-TNIP2_HUMAN
Tissue specificity: Ubiquitously expressed in all tissues examined.

Evidence on tissue expression from TISSUES for TNIP2 Gene

  • Liver(4.3)
genes like me logo Genes that share expression patterns with TNIP2: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TNIP2 Gene

Orthologs for TNIP2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TNIP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TNIP2 34 33
  • 86.26 (n)
OneToOne
dog
(Canis familiaris)
Mammalia TNIP2 34 33
  • 80.61 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Tnip2 16 34 33
  • 80.14 (n)
cow
(Bos Taurus)
Mammalia TNIP2 34 33
  • 79.57 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tnip2 33
  • 79.25 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 53 (a)
OneToMany
-- 34
  • 48 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia TNIP2 34
  • 50 (a)
OneToOne
chicken
(Gallus gallus)
Aves TNIP2 34 33
  • 61.55 (n)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tnip2 33
  • 59.16 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC564279 33
  • 48.08 (n)
TNIP2 34
  • 32 (a)
OneToOne
Species where no ortholog for TNIP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TNIP2 Gene

ENSEMBL:
Gene Tree for TNIP2 (if available)
TreeFam:
Gene Tree for TNIP2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TNIP2: view image

Paralogs for TNIP2 Gene

Pseudogenes.org Pseudogenes for TNIP2 Gene

genes like me logo Genes that share paralogs with TNIP2: view

No data available for Paralogs for TNIP2 Gene

Variants for TNIP2 Gene

Sequence variations from dbSNP and Humsavar for TNIP2 Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs1000097423 -- 2,758,349(-) C/A upstream_transcript_variant
rs1000189091 -- 2,746,858(-) C/A intron_variant
rs1000205122 -- 2,752,867(-) G/A intron_variant
rs1000257257 -- 2,752,531(-) C/T intron_variant
rs1000335260 -- 2,742,047(-) C/T 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for TNIP2 Gene

Variant ID Type Subtype PubMed ID
esv2189823 CNV deletion 18987734
esv2664337 CNV deletion 23128226
esv2726835 CNV deletion 23290073
nsv1128023 CNV deletion 24896259
nsv470002 CNV loss 18288195
nsv516797 CNV loss 19592680

Variation tolerance for TNIP2 Gene

Residual Variation Intolerance Score: 72.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.53; 85.96% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TNIP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TNIP2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TNIP2 Gene

Disorders for TNIP2 Gene

Additional Disease Information for TNIP2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for TNIP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TNIP2 Gene

Publications for TNIP2 Gene

  1. ABIN-2 protects endothelial cells from death and has a role in the antiapoptotic effect of angiopoietin-1. (PMID: 12933576) Tadros A … Brindle NP (Blood 2003) 2 3 4 22 58
  2. Identification of a novel A20-binding inhibitor of nuclear factor-kappa B activation termed ABIN-2. (PMID: 11390377) Van Huffel S … Beyaert R (The Journal of biological chemistry 2001) 2 3 4 22 58
  3. ABIN-2 forms a ternary complex with TPL-2 and NF-kappa B1 p105 and is essential for TPL-2 protein stability. (PMID: 15169888) Lang V … Ley SC (Molecular and cellular biology 2004) 3 4 22 58
  4. The inhibitor ABIN-2 disrupts the interaction of receptor-interacting protein with the kinase subunit IKKgamma to block activation of the transcription factor NF-kappaB and potentiate apoptosis. (PMID: 14653779) Liu WK … Chou CK (The Biochemical journal 2004) 3 4 22 58
  5. The A20-binding protein ABIN-2 exerts unexpected function in mediating transcriptional coactivation. (PMID: 12753905) Chien CY … Su JY (FEBS letters 2003) 3 4 22 58

Products for TNIP2 Gene

Sources for TNIP2 Gene

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