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Aliases for PVRIG Gene

Aliases for PVRIG Gene

  • PVR Related Immunoglobulin Domain Containing 2 3 5
  • CD112 Receptor 2 3 4
  • Poliovirus Receptor-Related Immunoglobulin Domain-Containing Protein 3 4
  • Poliovirus Receptor Related Immunoglobulin Domain Containing 2 3
  • Nectin-2 Receptor 2 3
  • C7orf15 3 4
  • CD112R 3 4
  • Transmembrane Protein PVRIG 3

External Ids for PVRIG Gene

Previous GeneCards Identifiers for PVRIG Gene

  • GC07P099614
  • GC07P099815
  • GC07P094451

Summaries for PVRIG Gene

GeneCards Summary for PVRIG Gene

PVRIG (PVR Related Immunoglobulin Domain Containing) is a Protein Coding gene.

UniProtKB/Swiss-Prot for PVRIG Gene

  • Cell surface receptor for NECTIN2. May act as a coinhibitory receptor that suppresses T-cell receptor-mediated signals. Following interaction with NECTIN2, inhibits T-cell proliferation. Competes with CD226 for NECTIN2-binding.

Additional gene information for PVRIG Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PVRIG Gene

Genomics for PVRIG Gene

GeneHancer (GH) Regulatory Elements for PVRIG Gene

Promoters and enhancers for PVRIG Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J100215 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE dbSUPER 668 +2.9 2904 9.2 HDGF PKNOX1 SMAD1 SIN3A IRF4 YY1 GLIS2 ZNF207 ZNF143 ATF7 PVRIG PIR47005 PILRB STAG3L5P MBLAC1 AP4M1 GPC2 CNPY4 PILRA ZCWPW1
GH07J100210 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE dbSUPER 666.7 -5.3 -5310 2 PKNOX1 STAT5A BATF IRF4 EGR1 SCRT2 ATF7 ETV6 BCLAF1 IKZF2 PVRIG PIR36589 GC07M100212 AP4M1 GPC2 PILRA LOC102724025 STAG3 CASTOR3 GC07M100182
GH07J100269 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 17.2 +54.2 54237 3.9 HDGF PKNOX1 FOXA2 ARID4B NEUROD1 SIN3A ZNF2 POLR2B ZNF207 ZNF143 CASTOR3 PILRB PVRIG STAG3 AP4M1 LOC105375426 GC07M100182
GH07J100176 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 17.9 -39.2 -39241 1.4 PKNOX1 CLOCK SIN3A YY1 ZNF335 EGR1 FOS ATF7 SP3 NFYA GPC2 STAG3 PVRIG MEPCE SRRT PTCD1 PPP1R35 AP4M1 ZSCAN25 FBXO24
GH07J100190 Enhancer 1 Ensembl ENCODE dbSUPER 29.5 -24.4 -24395 2.8 HDGF MEIS2 L3MBTL2 NFRKB CEBPB MCM7 IKZF1 SCRT2 ZNF512 PRDM1 PVRIG AP4M1 CASTOR3 GAL3ST4 C7orf43 LAMTOR4 RPL7P60 ZCWPW1 LOC102724025 STAG3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PVRIG on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PVRIG gene promoter:
  • AREB6
  • RelA
  • RREB-1
  • NRSF form 2
  • NRSF form 1
  • AML1a
  • CREB
  • deltaCREB
  • Max1

Genomic Locations for PVRIG Gene

Genomic Locations for PVRIG Gene
4,774 bases
Plus strand
3,250 bases
Plus strand

Genomic View for PVRIG Gene

Genes around PVRIG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PVRIG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PVRIG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PVRIG Gene

Proteins for PVRIG Gene

  • Protein details for PVRIG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protein PVRIG
    Protein Accession:
    Secondary Accessions:
    • D6W5U9
    • Q9BVK3

    Protein attributes for PVRIG Gene

    326 amino acids
    Molecular mass:
    34344 Da
    Quaternary structure:
    • Interacts with NECTIN2, hence competing with CD226.
    • Was named PVRIG for the homology observed between its second exon and the variable immunoglobulin domain of the polio virus receptor (PVR/CD155) and polio virus receptor-like (PVRL) genes.

neXtProt entry for PVRIG Gene

Post-translational modifications for PVRIG Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PVRIG Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for PVRIG
  • Boster Bio Antibodies for PVRIG

No data available for DME Specific Peptides for PVRIG Gene

Domains & Families for PVRIG Gene

Gene Families for PVRIG Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for PVRIG Gene


Suggested Antigen Peptide Sequences for PVRIG Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PVRIG: view

No data available for UniProtKB/Swiss-Prot for PVRIG Gene

Function for PVRIG Gene

Molecular function for PVRIG Gene

UniProtKB/Swiss-Prot Function:
Cell surface receptor for NECTIN2. May act as a coinhibitory receptor that suppresses T-cell receptor-mediated signals. Following interaction with NECTIN2, inhibits T-cell proliferation. Competes with CD226 for NECTIN2-binding.
UniProtKB/Swiss-Prot Induction:
In T-cells, up-regulated by activation induced by treatment with anti-CD3 and anti-CD28 antibodies.

Phenotypes From GWAS Catalog for PVRIG Gene

Gene Ontology (GO) - Molecular Function for PVRIG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 26755705
GO:0019902 phosphatase binding IPI 26755705
GO:0038023 signaling receptor activity IMP 26755705
genes like me logo Genes that share ontologies with PVRIG: view
genes like me logo Genes that share phenotypes with PVRIG: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PVRIG Gene

Localization for PVRIG Gene

Subcellular locations from UniProtKB/Swiss-Prot for PVRIG Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PVRIG gene
Compartment Confidence
plasma membrane 5
extracellular 1
peroxisome 1
nucleus 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (2)
  • Nucleoli (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PVRIG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA,IDA 26755705
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PVRIG: view

Pathways & Interactions for PVRIG Gene

SuperPathways for PVRIG Gene

No Data Available

Gene Ontology (GO) - Biological Process for PVRIG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0050860 negative regulation of T cell receptor signaling pathway IMP 26755705
genes like me logo Genes that share ontologies with PVRIG: view

No data available for Pathways by source and SIGNOR curated interactions for PVRIG Gene

Drugs & Compounds for PVRIG Gene

No Compound Related Data Available

Transcripts for PVRIG Gene

mRNA/cDNA for PVRIG Gene

(2) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PVRIG Gene

Poliovirus receptor related immunoglobulin domain containing:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PVRIG Gene

No ASD Table

Relevant External Links for PVRIG Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PVRIG Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PVRIG Gene

NURSA nuclear receptor signaling pathways regulating expression of PVRIG Gene:


SOURCE GeneReport for Unigene cluster for PVRIG Gene:


mRNA Expression by UniProt/SwissProt for PVRIG Gene:

Tissue specificity: Expressed in some types of immune cells. Expressed at low levels on the surface of freshly isolated T-cells and natural killer (NK) cells, predominantly on CD8+ T-cells (mainly memory/effector, but not naive cells) and on both CD16+ and CD16- NK cells. T-cell expression levels are variable among individuals. Not detected in B-cells, naive or helper T-cells, monocytes, nor neutrophils (at protein level). Not detected in dendritic cells.

Evidence on tissue expression from TISSUES for PVRIG Gene

  • Pancreas(4.2)
genes like me logo Genes that share expression patterns with PVRIG: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for PVRIG Gene

Orthologs for PVRIG Gene

This gene was present in the common ancestor of mammals.

Orthologs for PVRIG Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PVRIG 34 33
  • 98.77 (n)
(Canis familiaris)
Mammalia PVRIG 34 33
  • 73.15 (n)
(Bos Taurus)
Mammalia PVRIG 34 33
  • 72.28 (n)
(Rattus norvegicus)
Mammalia LOC680923 33
  • 70.39 (n)
(Mus musculus)
Mammalia LOC102640920 33
  • 67.79 (n)
Pvrig 16
Species where no ortholog for PVRIG was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PVRIG Gene

Gene Tree for PVRIG (if available)
Gene Tree for PVRIG (if available)
Evolutionary constrained regions (ECRs) for PVRIG: view image

Paralogs for PVRIG Gene

No data available for Paralogs for PVRIG Gene

Variants for PVRIG Gene

Sequence variations from dbSNP and Humsavar for PVRIG Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000344522 -- 100,220,389(+) T/A coding_sequence_variant, missense_variant
rs1000608811 -- 100,219,275(+) A/T 5_prime_UTR_variant
rs1000632331 -- 100,219,475(+) A/G intron_variant
rs1002212119 -- 100,217,818(+) A/G upstream_transcript_variant
rs1002265872 -- 100,218,061(+) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for PVRIG Gene

Variant ID Type Subtype PubMed ID
esv26986 CNV gain 19812545
esv2734888 CNV deletion 23290073
esv2734890 CNV deletion 23290073
esv3614292 CNV gain 21293372
esv3614293 CNV gain 21293372
nsv428180 CNV gain 18775914
nsv436898 CNV insertion 17901297
nsv8182 CNV gain 18304495

Variation tolerance for PVRIG Gene

Residual Variation Intolerance Score: 85% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.27; 52.93% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PVRIG Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PVRIG Gene

Disorders for PVRIG Gene

Additional Disease Information for PVRIG

No disorders were found for PVRIG Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PVRIG Gene

Publications for PVRIG Gene

  1. Comparative analysis of the paired immunoglobulin-like receptor (PILR) locus in six mammalian genomes: duplication, conversion, and the birth of new genes. (PMID: 16926269) Wilson MD … Koop BF (Physiological genomics 2006) 2 3 4 58
  2. Identification of CD112R as a novel checkpoint for human T cells. (PMID: 26755705) Zhu Y … Edil BH (The Journal of experimental medicine 2016) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. Blockade of CD112R and TIGIT signaling sensitizes human natural killer cell functions. (PMID: 28623459) Xu F … Zhu Y (Cancer immunology, immunotherapy : CII 2017) 3 58
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58

Products for PVRIG Gene

Sources for PVRIG Gene

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