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Aliases for ZP3 Gene

Aliases for ZP3 Gene

  • Zona Pellucida Glycoprotein 3 2 3 4 5
  • Zona Pellucida Protein C 3 4
  • Sperm Receptor 3 4
  • ZP3A/ZP3B 3 4
  • ZP3A 3 4
  • ZP3B 3 4
  • Zp-3 3 4
  • ZPC 3 4
  • Zona Pellucida Glycoprotein 3A (Sperm Receptor) 2
  • Zona Pellucida Sperm-Binding Protein 3 3
  • Zona Pellucida Glycoprotein ZP3 3
  • Zona Pellucida Glycoprotein 3B 3
  • OOMD3 3

External Ids for ZP3 Gene

Previous HGNC Symbols for ZP3 Gene

  • ZP3A
  • ZP3B

Previous GeneCards Identifiers for ZP3 Gene

  • GC07P074589
  • GC07P071749
  • GC07P071763
  • GC07P075638
  • GC07P075671
  • GC07P075864
  • GC07P076026
  • GC07P071113

Summaries for ZP3 Gene

Entrez Gene Summary for ZP3 Gene

  • The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed primarily of three or four glycoproteins with various functions during fertilization and preimplantation development. The protein encoded by this gene is a structural component of the zona pellucida and functions in primary binding and induction of the sperm acrosome reaction. The nascent protein contains a N-terminal signal peptide sequence, a conserved ZP domain, a C-terminal consensus furin cleavage site, and a transmembrane domain. It is hypothesized that furin cleavage results in release of the mature protein from the plasma membrane for subsequent incorporation into the zona pellucida matrix. However, the requirement for furin cleavage in this process remains controversial based on mouse studies. A variation in the last exon of this gene has previously served as the basis for an additional ZP3 locus; however, sequence and literature review reveals that there is only one full-length ZP3 locus in the human genome. Another locus encoding a bipartite transcript designated POMZP3 contains a duplication of the last four exons of ZP3, including the above described variation, and maps closely to this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for ZP3 Gene

ZP3 (Zona Pellucida Glycoprotein 3) is a Protein Coding gene. Diseases associated with ZP3 include Oocyte Maturation Defect 3 and Female Infertility Due To Zona Pellucida Defect. Among its related pathways are Fertilization and Ovarian Infertility Genes. Gene Ontology (GO) annotations related to this gene include obsolete signal transducer activity and store-operated calcium channel activity. An important paralog of this gene is POMZP3.

UniProtKB/Swiss-Prot for ZP3 Gene

  • The mammalian zona pellucida, which mediates species-specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP3 is essential for sperm binding and zona matrix formation.

Gene Wiki entry for ZP3 Gene

Additional gene information for ZP3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZP3 Gene

Genomics for ZP3 Gene

GeneHancer (GH) Regulatory Elements for ZP3 Gene

Promoters and enhancers for ZP3 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J076395 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 650.7 -0.6 -613 2.8 HDGF PKNOX1 SMAD1 ARNT SIN3A YY1 POLR2B ZNF263 SP3 REST ZP3 PMS2P3 SPDYE5 NSUN5P1 POMZP3 SPDYE18 FAM185BP LOC100133091 UPK3B PMS2P9
GH07J076400 Promoter 0.5 EPDnew 650.7 +3.0 3012 0.1 ZP3 SSC4D
GH07J076626 Promoter/Enhancer 2 EPDnew Ensembl ENCODE dbSUPER 65.9 +229.8 229783 1.8 HDGF HDAC1 PKNOX1 ATF1 TAF9B RB1 ARNT NFRKB SIN3A ZNF335 POMZP3 ZP3 GC07P076622 GC07P076623 GC07P076625 PIR56287 LOC100133091
GH07J076548 Promoter/Enhancer 1.5 Ensembl ENCODE 58.7 +152.1 152095 2 HDGF ARNT ARID4B SIN3A DMAP1 YY1 POLR2B ZNF207 ZNF143 SP3 LOC100133091 ZP3 UPK3B POMZP3 PIR43157
GH07J076568 Enhancer 0.8 ENCODE dbSUPER 67.1 +171.5 171461 0.3 SOX5 SOX13 JUND PRDM6 FOXA2 TEAD1 JUN FOS ZP3 LOC100133091 PIR43157
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZP3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZP3 gene promoter:
  • SRY
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4

Genomic Locations for ZP3 Gene

Genomic Locations for ZP3 Gene
44,554 bases
Plus strand
44,554 bases
Plus strand

Genomic View for ZP3 Gene

Genes around ZP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZP3 Gene

Proteins for ZP3 Gene

  • Protein details for ZP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zona pellucida sperm-binding protein 3
    Protein Accession:
    Secondary Accessions:
    • Q06633
    • Q29RW0

    Protein attributes for ZP3 Gene

    424 amino acids
    Molecular mass:
    47018 Da
    Quaternary structure:
    • Polymers of ZP2 and ZP3 organized into long filaments cross-linked by ZP1 homodimers (By similarity). Interacts with ZP1 and ZP2 (PubMed:28886344).

    Alternative splice isoforms for ZP3 Gene


neXtProt entry for ZP3 Gene

Post-translational modifications for ZP3 Gene

  • Proteolytically cleaved before the transmembrane segment to yield the secreted ectodomain incorporated in the zona pellucida.
  • N-glycosylated.
  • O-glycosylated; removal of O-linked glycans may play an important role in the post-fertilization block to polyspermy.
  • Glycosylation at isoforms=3, 2272, isoforms=3, 2226, isoforms=3, 2163, isoforms=3, 2162, posLast=156156, posLast=147147, and posLast=125125
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • ZP3_HUMAN (634)

Other Protein References for ZP3 Gene

Antibody Products

  • Abcam antibodies for ZP3
  • Boster Bio Antibodies for ZP3
  • Santa Cruz Biotechnology (SCBT) Antibodies for ZP3

No data available for DME Specific Peptides for ZP3 Gene

Domains & Families for ZP3 Gene

Gene Families for ZP3 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for ZP3 Gene


Suggested Antigen Peptide Sequences for ZP3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • The ZP domain is involved in the polymerization of the ZP proteins to form the zona pellucida.
  • The ZP domain is involved in the polymerization of the ZP proteins to form the zona pellucida.
  • Belongs to the ZP domain family. ZPC subfamily.
genes like me logo Genes that share domains with ZP3: view

Function for ZP3 Gene

Molecular function for ZP3 Gene

UniProtKB/Swiss-Prot Function:
The mammalian zona pellucida, which mediates species-specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP3 is essential for sperm binding and zona matrix formation.

Phenotypes From GWAS Catalog for ZP3 Gene

Gene Ontology (GO) - Molecular Function for ZP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19945174
GO:0030246 carbohydrate binding IDA 19246320
GO:0032190 acrosin binding IPI 15950651
GO:0042802 identical protein binding IPI 26879157
GO:0048018 receptor ligand activity ISS --
genes like me logo Genes that share ontologies with ZP3: view
genes like me logo Genes that share phenotypes with ZP3: view

Animal Models for ZP3 Gene

MGI Knock Outs for ZP3:
  • Zp3 Zp3<tm1Pmw>
  • Zp3 Zp3<tm1Dean>

Animal Model Products

CRISPR Products

miRNA for ZP3 Gene

miRTarBase miRNAs that target ZP3

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZP3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZP3 Gene

Localization for ZP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZP3 Gene

Processed zona pellucida sperm-binding protein 3: Secreted, extracellular space, extracellular matrix. Note=The glycoproteinaceous translucent extracellular matrix that surrounds the mammalian oocyte is called zona pellucida. {ECO:0000305}.
Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZP3 gene
Compartment Confidence
plasma membrane 5
extracellular 5
peroxisome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for ZP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IMP 19246320
GO:0005622 intracellular IEA --
GO:0005886 plasma membrane ISS --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with ZP3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZP3 Gene

Pathways & Interactions for ZP3 Gene

genes like me logo Genes that share pathways with ZP3: view

Pathways by source for ZP3 Gene

1 BioSystems pathway for ZP3 Gene
1 Qiagen pathway for ZP3 Gene

Gene Ontology (GO) - Biological Process for ZP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001809 positive regulation of type IV hypersensitivity ISS --
GO:0001825 blastocyst formation ISS --
GO:0002455 humoral immune response mediated by circulating immunoglobulin ISS --
GO:0002687 positive regulation of leukocyte migration ISS --
GO:0002922 positive regulation of humoral immune response IDA 19004505
genes like me logo Genes that share ontologies with ZP3: view

No data available for SIGNOR curated interactions for ZP3 Gene

Drugs & Compounds for ZP3 Gene

(7) Drugs for ZP3 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for ZP3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ZP3: view

Transcripts for ZP3 Gene

mRNA/cDNA for ZP3 Gene

Unigene Clusters for ZP3 Gene

Zona pellucida glycoprotein 3 (sperm receptor):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZP3

Alternative Splicing Database (ASD) splice patterns (SP) for ZP3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b
SP3: - -

Relevant External Links for ZP3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZP3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZP3 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZP3 Gene

Protein tissue co-expression partners for ZP3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZP3 Gene:


SOURCE GeneReport for Unigene cluster for ZP3 Gene:


mRNA Expression by UniProt/SwissProt for ZP3 Gene:

Tissue specificity: Oocytes.

Evidence on tissue expression from TISSUES for ZP3 Gene

  • Nervous system(4.5)
  • Lung(4.1)
genes like me logo Genes that share expression patterns with ZP3: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZP3 Gene

Orthologs for ZP3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZP3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZP3 34 33
  • 99.46 (n)
(Bos Taurus)
Mammalia ZP3 34 33
  • 79.63 (n)
(Canis familiaris)
Mammalia ZP3 34 33
  • 79.17 (n)
(Mus musculus)
Mammalia Zp3 16 34 33
  • 74.54 (n)
(Rattus norvegicus)
Mammalia Zp3 33
  • 73.99 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 52 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 51 (a)
(Gallus gallus)
Aves ZP3 33
  • 61.78 (n)
-- 34
  • 46 (a)
-- 34
  • 42 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 44 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC394444 33
  • 55.95 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.3715 33
(Danio rerio)
Actinopterygii zp3a.2 34 33
  • 52.13 (n)
zgc:171779 34
  • 27 (a)
zgc:173556 34
  • 27 (a)
zp3a.1 34
  • 27 (a)
zp3.2 34 34
  • 26 (a)
zp3b 34
  • 22 (a)
Species where no ortholog for ZP3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZP3 Gene

Gene Tree for ZP3 (if available)
Gene Tree for ZP3 (if available)
Evolutionary constrained regions (ECRs) for ZP3: view image

Paralogs for ZP3 Gene

Paralogs for ZP3 Gene

(2) SIMAP similar genes for ZP3 Gene using alignment to 3 proteins:

  • H0Y3M4_HUMAN Pseudogenes for ZP3 Gene

genes like me logo Genes that share paralogs with ZP3: view

Variants for ZP3 Gene

Sequence variations from dbSNP and Humsavar for ZP3 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
VAR_079712 Oocyte maturation defect 3 (OOMD3) [MIM:617712] p.Ala134Thr
rs1000029426 -- 76,414,463(+) C/G genic_upstream_transcript_variant, intron_variant
rs1000104374 -- 76,427,838(+) G/A intron_variant
rs1000116853 -- 76,414,070(+) C/G genic_upstream_transcript_variant, intron_variant
rs1000193036 -- 76,420,027(+) C/G genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZP3 Gene

Variant ID Type Subtype PubMed ID
dgv120n16 CNV deletion 17901297
dgv21n31 CNV gain 19718026
dgv232e55 CNV gain 17911159
dgv233e55 CNV loss 17911159
dgv234e55 CNV gain 17911159
dgv235e55 CNV loss 17911159
esv23516 CNV gain 19812545
esv2422494 CNV duplication 17116639
esv2584656 CNV insertion 19546169
esv2669174 CNV deletion 23128226
esv33074 CNV gain 17666407
esv3541928 CNV deletion 23714750
esv3613762 CNV loss 21293372
esv3613763 CNV loss 21293372
nsv1028665 CNV gain 25217958
nsv1119226 CNV duplication 24896259
nsv1128344 CNV deletion 24896259
nsv428174 CNV gain 18775914
nsv517634 CNV gain+loss 19592680
nsv528969 CNV gain 19592680
nsv607585 CNV gain 21841781
nsv7403 OTHER inversion 18451855
nsv970893 CNV duplication 23825009

Variation tolerance for ZP3 Gene

Residual Variation Intolerance Score: 93.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.75; 73.38% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZP3 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZP3 Gene

Disorders for ZP3 Gene

MalaCards: The human disease database

(10) MalaCards diseases for ZP3 Gene - From: HGMD, OMIM, ClinVar, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search ZP3 in MalaCards View complete list of genes associated with diseases


  • Oocyte maturation defect 3 (OOMD3) [MIM:617712]: An autosomal dominant infertility disorder characterized by abnormal oocytes that lack the zona pellucida, and oocytes degeneration. {ECO:0000269 PubMed:28886344}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Additional Disease Information for ZP3

genes like me logo Genes that share disorders with ZP3: view

No data available for Genatlas for ZP3 Gene

Publications for ZP3 Gene

  1. Cloning and characterization of the human sperm receptor ligand ZP3: evidence for a second polymorphic allele with a different frequency in the Caucasian and Japanese populations. (PMID: 1478648) van Duin M … Aitken RJ (Genomics 1992) 2 3 4 22 58
  2. Mass spectrometry analysis of recombinant human ZP3 expressed in glycosylation-deficient CHO cells. (PMID: 15379548) Zhao M … Dean J (Biochemistry 2004) 3 4 22 58
  3. Human homolog of the mouse sperm receptor. (PMID: 2385582) Chamberlin ME … Dean J (Proceedings of the National Academy of Sciences of the United States of America 1990) 3 4 22 58
  4. A Recurrent Missense Mutation in ZP3 Causes Empty Follicle Syndrome and Female Infertility. (PMID: 28886344) Chen T … Chen ZJ (American journal of human genetics 2017) 3 4 58
  5. Functional activity of human ZP3 primary sperm receptor resides toward its C-terminus. (PMID: 19246320) Bansal P … Gupta SK (Biology of reproduction 2009) 3 22 58

Products for ZP3 Gene

Sources for ZP3 Gene

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