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Aliases for TRIM25 Gene

Aliases for TRIM25 Gene

  • Tripartite Motif Containing 25 2 3 5
  • Zinc Finger Protein 147 (Estrogen-Responsive Finger Protein) 2 3
  • Ubiquitin/ISG15-Conjugating Enzyme TRIM25 3 4
  • RING-Type E3 Ubiquitin Transferase TRIM25 3 4
  • Tripartite Motif-Containing Protein 25 3 4
  • Estrogen-Responsive Finger Protein 3 4
  • RING-Type E3 Ubiquitin Transferase 3 4
  • RING Finger Protein 147 3 4
  • ZNF147 3 4
  • RNF147 3 4
  • EFP 3 4
  • E3 Ubiquitin/ISG15 Ligase TRIM25 3
  • Tripartite Motif Protein TRIM25 3
  • Tripartite Motif-Containing 25 2
  • Zinc Finger Protein-147 3
  • Zinc Finger Protein 147 4
  • EC 6.3.2.n3 4
  • EC 2.3.2.27 4
  • Z147 3

External Ids for TRIM25 Gene

Previous HGNC Symbols for TRIM25 Gene

  • ZNF147

Previous GeneCards Identifiers for TRIM25 Gene

  • GC17M055444
  • GC17M052323
  • GC17M054965
  • GC17M050325

Summaries for TRIM25 Gene

Entrez Gene Summary for TRIM25 Gene

  • The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to the cytoplasm. The presence of potential DNA-binding and dimerization-transactivation domains suggests that this protein may act as a transcription factor, similar to several other members of the TRIM family. Expression of the gene is upregulated in response to estrogen, and it is thought to mediate estrogen actions in breast cancer as a primary response gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for TRIM25 Gene

TRIM25 (Tripartite Motif Containing 25) is a Protein Coding gene. Diseases associated with TRIM25 include Influenza and Pericardial Tuberculosis. Among its related pathways are NF-kappa B signaling pathway and RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways. Gene Ontology (GO) annotations related to this gene include acid-amino acid ligase activity. An important paralog of this gene is TRIM47.

UniProtKB/Swiss-Prot for TRIM25 Gene

  • Functions as a ubiquitin E3 ligase and as an ISG15 E3 ligase. Involved in innate immune defense against viruses by mediating ubiquitination of DDX58. Mediates Lys-63-linked polyubiquitination of the DDX58 N-terminal CARD-like region which is crucial for triggering the cytosolic signal transduction that leads to the production of interferons in response to viral infection. Promotes ISGylation of 14-3-3 sigma (SFN), an adapter protein implicated in the regulation of a large spectrum signaling pathway. Mediates estrogen action in various target organs. Mediates the ubiquitination and subsequent proteasomal degradation of ZFHX3 (PubMed:22452784).

Gene Wiki entry for TRIM25 Gene

Additional gene information for TRIM25 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM25 Gene

Genomics for TRIM25 Gene

GeneHancer (GH) Regulatory Elements for TRIM25 Gene

Promoters and enhancers for TRIM25 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J056911 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 675.9 -0.9 -944 6.8 MLX DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC PPARGC1A SSRP1 ZNF610 TRIM25 ENSG00000274213 DGKE ENSG00000262298 SCPEP1
GH17J056909 Enhancer 1.5 FANTOM5 ENCODE dbSUPER 28.2 +3.6 3602 1.3 PKNOX1 ATF1 ARNT ARID4B YY1 TCF12 ZNF121 ZNF766 GATA2 ATF7 TRIM25 SCPEP1 MIR3614
GH17J056918 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 19.9 -5.2 -5153 1.2 MEIS2 PKNOX1 ARNT MAX CEBPG ZNF384 CHAMP1 IRF9 FOSL1 ZNF316 TRIM25 SCPEP1 ENSG00000274213 ENSG00000262298
GH17J057872 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 10 -961.0 -961018 4.9 HDGF PKNOX1 MLX ARID4B NEUROD1 SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B CUEDC1 MRPS23 ENSG00000262298 TRIM25 MKS1 SRSF1 TSPOAP1 GC17P057856 ENSG00000264914
GH17J057897 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 10 -987.9 -987850 8.2 HDGF PKNOX1 CLOCK FOXA2 MLX ZFP64 ARID4B NEUROD1 SIN3A DMAP1 SRSF1 ENSG00000262298 MKS1 CUEDC1 TRIM25 EPX VEZF1 ENSG00000263004 OR4D2 ENSG00000264914
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TRIM25 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TRIM25 gene promoter:
  • STAT1
  • p53
  • FOXJ2 (long isoform)
  • FOXJ2
  • AhR
  • Arnt
  • ATF6
  • Pax-5

Genomic Locations for TRIM25 Gene

Genomic Locations for TRIM25 Gene
chr17:56,887,909-56,914,048
(GRCh38/hg38)
Size:
26,140 bases
Orientation:
Minus strand
chr17:54,965,270-54,991,409
(GRCh37/hg19)
Size:
26,140 bases
Orientation:
Minus strand

Genomic View for TRIM25 Gene

Genes around TRIM25 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRIM25 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRIM25 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM25 Gene

Proteins for TRIM25 Gene

  • Protein details for TRIM25 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14258-TRI25_HUMAN
    Recommended name:
    E3 ubiquitin/ISG15 ligase TRIM25
    Protein Accession:
    Q14258

    Protein attributes for TRIM25 Gene

    Size:
    630 amino acids
    Molecular mass:
    70973 Da
    Quaternary structure:
    • Interacts (via SPRY domain) with DDX58 (via CARD domain). Interacts (via coiled coil) with influenza A virus NS1 protein; this interaction specifically inhibits TRIM25 multimerization and TRIM25-mediated DDX58 CARD ubiquitination, thereby suppressing DDX58 signal transduction. Interacts with ZFHX3.

    Three dimensional structures from OCA and Proteopedia for TRIM25 Gene

neXtProt entry for TRIM25 Gene

Post-translational modifications for TRIM25 Gene

  • Auto-ISGylated.
  • Ubiquitination at isoforms=567, posLast=447447, posLast=439439, posLast=320320, posLast=273273, and posLast=117117
  • Modification sites at PhosphoSitePlus

Other Protein References for TRIM25 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TRIM25 Gene

Domains & Families for TRIM25 Gene

Gene Families for TRIM25 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for TRIM25 Gene

Graphical View of Domain Structure for InterPro Entry

Q14258

UniProtKB/Swiss-Prot:

TRI25_HUMAN :
  • The RING-type zinc finger is important for ISG15 E3 ligase activity and autoISGylation. AutoISGylation negatively regulates ISG15 E3 ligase activity.
Domain:
  • The RING-type zinc finger is important for ISG15 E3 ligase activity and autoISGylation. AutoISGylation negatively regulates ISG15 E3 ligase activity.
  • The C-terminal B30.2/SPRY domain interacts with the first N-terminal CARD domain of DDX58.
genes like me logo Genes that share domains with TRIM25: view

Function for TRIM25 Gene

Molecular function for TRIM25 Gene

UniProtKB/Swiss-Prot Function:
Functions as a ubiquitin E3 ligase and as an ISG15 E3 ligase. Involved in innate immune defense against viruses by mediating ubiquitination of DDX58. Mediates Lys-63-linked polyubiquitination of the DDX58 N-terminal CARD-like region which is crucial for triggering the cytosolic signal transduction that leads to the production of interferons in response to viral infection. Promotes ISGylation of 14-3-3 sigma (SFN), an adapter protein implicated in the regulation of a large spectrum signaling pathway. Mediates estrogen action in various target organs. Mediates the ubiquitination and subsequent proteasomal degradation of ZFHX3 (PubMed:22452784).
UniProtKB/Swiss-Prot CatalyticActivity:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + [ISG15] + [protein]-lysine = AMP + diphosphate + [protein]-N-ISGyllysine.
UniProtKB/Swiss-Prot Induction:
By interferons.

Enzyme Numbers (IUBMB) for TRIM25 Gene

Gene Ontology (GO) - Molecular Function for TRIM25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003700 DNA binding transcription factor activity TAS 8248217
GO:0003723 RNA binding HDA 22658674
GO:0004842 ubiquitin-protein transferase activity EXP 17392790
GO:0005515 protein binding IPI 19454348
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with TRIM25: view
genes like me logo Genes that share phenotypes with TRIM25: view

Animal Models for TRIM25 Gene

MGI Knock Outs for TRIM25:

Animal Model Products

  • Taconic Biosciences Mouse Models for TRIM25

Clone Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TRIM25 Gene

Localization for TRIM25 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRIM25 Gene

Cytoplasm. Note=Colocalized with DDX58 at cytoplasmic perinuclear bodies.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRIM25 gene
Compartment Confidence
nucleus 5
cytosol 5
extracellular 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nuclear bodies (2)
  • Nucleoplasm (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TRIM25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0016604 nuclear body IDA --
genes like me logo Genes that share ontologies with TRIM25: view

Pathways & Interactions for TRIM25 Gene

genes like me logo Genes that share pathways with TRIM25: view

Pathways by source for TRIM25 Gene

UniProtKB/Swiss-Prot Q14258-TRI25_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for TRIM25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006511 ubiquitin-dependent protein catabolic process IMP 22452784
GO:0006513 protein monoubiquitination IMP 24810856
GO:0016032 viral process IEA --
GO:0016567 protein ubiquitination IEA --
GO:0016579 protein deubiquitination TAS --
genes like me logo Genes that share ontologies with TRIM25: view

No data available for SIGNOR curated interactions for TRIM25 Gene

Drugs & Compounds for TRIM25 Gene

(5) Drugs for TRIM25 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine monophosphate Approved, Investigational Nutra 0
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Potentiation, Pore Blocker 0

(1) Additional Compounds for TRIM25 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pyrophosphate
  • [(ho)2P(O)OP(O)(OH)2]
  • Acide diphosphorique
  • Diphosphorsaeure
  • H4P2O7
  • PYROphosphATE
14000-31-8
genes like me logo Genes that share compounds with TRIM25: view

Transcripts for TRIM25 Gene

mRNA/cDNA for TRIM25 Gene

(1) REFSEQ mRNAs :
(13) Additional mRNA sequences :
(332) Selected AceView cDNA sequences:
(9) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TRIM25 Gene

Tripartite motif containing 25:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM25 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11
SP1: - - -
SP2:
SP3: -
SP4:
SP5:

Relevant External Links for TRIM25 Gene

GeneLoc Exon Structure for
TRIM25
ECgene alternative splicing isoforms for
TRIM25

Expression for TRIM25 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TRIM25 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TRIM25 Gene

This gene is overexpressed in Whole Blood (x12.1).

Protein differential expression in normal tissues from HIPED for TRIM25 Gene

This gene is overexpressed in Lymph node (13.8) and Peripheral blood mononuclear cells (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TRIM25 Gene



Protein tissue co-expression partners for TRIM25 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TRIM25 Gene:

TRIM25

SOURCE GeneReport for Unigene cluster for TRIM25 Gene:

Hs.528952

mRNA Expression by UniProt/SwissProt for TRIM25 Gene:

Q14258-TRI25_HUMAN
Tissue specificity: Expressed in breast tumors (at protein level). Ubiquitous.

Evidence on tissue expression from TISSUES for TRIM25 Gene

  • Liver(4.4)
  • Lung(2.7)
genes like me logo Genes that share expression patterns with TRIM25: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for TRIM25 Gene

Orthologs for TRIM25 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TRIM25 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRIM25 34 33
  • 99.21 (n)
OneToOne
dog
(Canis familiaris)
Mammalia TRIM25 34 33
  • 83.17 (n)
OneToOne
cow
(Bos Taurus)
Mammalia TRIM25 34 33
  • 82.85 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Trim25 33
  • 78.48 (n)
mouse
(Mus musculus)
Mammalia Trim25 16 34 33
  • 77.58 (n)
oppossum
(Monodelphis domestica)
Mammalia TRIM25 34
  • 59 (a)
OneToOne
chicken
(Gallus gallus)
Aves TRIM25 34 33
  • 58.87 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TRIM25 34
  • 48 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii trim25 34 33
  • 47.43 (n)
OneToOne
-- 33
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PSH1 36
Species where no ortholog for TRIM25 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TRIM25 Gene

ENSEMBL:
Gene Tree for TRIM25 (if available)
TreeFam:
Gene Tree for TRIM25 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TRIM25: view image

Paralogs for TRIM25 Gene

Paralogs for TRIM25 Gene

(2) SIMAP similar genes for TRIM25 Gene using alignment to 4 proteins:

  • TRI25_HUMAN
  • D3DTY9_HUMAN
  • I3L2W4_HUMAN
  • L0R8K6_HUMAN

Pseudogenes.org Pseudogenes for TRIM25 Gene

genes like me logo Genes that share paralogs with TRIM25: view

Variants for TRIM25 Gene

Sequence variations from dbSNP and Humsavar for TRIM25 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000007940 -- 56,915,558(-) C/G upstream_transcript_variant
rs1000032272 -- 56,906,631(-) C/A intron_variant
rs1000109223 -- 56,894,047(-) T/C intron_variant
rs1000120344 -- 56,915,737(-) G/A upstream_transcript_variant
rs1000250769 -- 56,909,608(-) C/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TRIM25 Gene

Variant ID Type Subtype PubMed ID
esv1004959 CNV gain 20482838
esv32884 CNV loss 17666407
nsv524499 CNV loss 19592680

Variation tolerance for TRIM25 Gene

Residual Variation Intolerance Score: 41.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.54; 55.73% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TRIM25 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRIM25

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIM25 Gene

Disorders for TRIM25 Gene

MalaCards: The human disease database

(3) MalaCards diseases for TRIM25 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
influenza
  • flu
pericardial tuberculosis
  • tuberculous pericarditis
breast cancer
  • breast cancer, familial
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for TRIM25

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with TRIM25: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TRIM25 Gene

Publications for TRIM25 Gene

  1. Systemic distribution of estrogen-responsive finger protein (Efp) in human tissues. (PMID: 15130519) Shimada N … Sasano H (Molecular and cellular endocrinology 2004) 3 4 22 58
  2. Chromosome mapping of human (ZNF147) and mouse genes for estrogen-responsive finger protein (efp), a member of the RING finger family. (PMID: 7789997) Inoue S … Muramatsu M (Genomics 1995) 2 3 22 58
  3. Genomic binding-site cloning reveals an estrogen-responsive gene that encodes a RING finger protein. (PMID: 8248217) Inoue S … Muramatsu M (Proceedings of the National Academy of Sciences of the United States of America 1993) 3 4 22 58
  4. Oestrogen causes ATBF1 protein degradation through the oestrogen-responsive E3 ubiquitin ligase EFP. (PMID: 22452784) Dong XY … Dong JT (The Biochemical journal 2012) 3 4 58
  5. The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature. (PMID: 20546612) Zhao J … Grant SF (BMC medical genetics 2010) 3 44 58

Products for TRIM25 Gene

Sources for TRIM25 Gene

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