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Aliases for PCGF2 Gene

Aliases for PCGF2 Gene

  • Polycomb Group Ring Finger 2 2 3 5
  • DNA-Binding Protein Mel-18 3 4
  • Zinc Finger Protein 144 3 4
  • Ring Finger Protein 110 2 3
  • RNF110 3 4
  • ZNF144 3 4
  • Polycomb Group RING Finger Protein 2 3
  • RING Finger Protein 110 4
  • MEL-18 3
  • MEL18 4

External Ids for PCGF2 Gene

Previous HGNC Symbols for PCGF2 Gene

  • ZNF144
  • RNF110

Previous GeneCards Identifiers for PCGF2 Gene

  • GC17M034144
  • GC17M036890
  • GC17M032686

Summaries for PCGF2 Gene

Entrez Gene Summary for PCGF2 Gene

  • The protein encoded by this gene contains a RING finger motif and is similar to the polycomb group (PcG) gene products. PcG gene products form complexes via protein-protein interaction and maintain the transcription repression of genes involved in embryogenesis, cell cycles, and tumorigenesis. This protein was shown to act as a negative regulator of transcription and has tumor suppressor activity. The expression of this gene was detected in various tumor cells, but is limited in neural organs in normal tissues. Knockout studies in mice suggested that this protein may negatively regulate the expression of different cytokines, chemokines, and chemokine receptors, and thus plays an important role in lymphocyte differentiation and migration, as well as in immune responses. [provided by RefSeq, Jul 2008]

GeneCards Summary for PCGF2 Gene

PCGF2 (Polycomb Group Ring Finger 2) is a Protein Coding gene. Among its related pathways are SUMOylation and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and ubiquitin-protein transferase activity. An important paralog of this gene is BMI1.

UniProtKB/Swiss-Prot for PCGF2 Gene

  • Transcriptional repressor. Binds specifically to the DNA sequence 5-GACTNGACT-3. Has tumor suppressor activity. May play a role in control of cell proliferation and/or neural cell development. Regulates proliferation of early T progenitor cells by maintaining expression of HES1. Also plays a role in antero-posterior specification of the axial skeleton and negative regulation of the self-renewal activity of hematopoietic stem cells (By similarity). Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A Lys-119, rendering chromatin heritably changed in its expressibility (PubMed:26151332). Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity (PubMed:26151332).

Gene Wiki entry for PCGF2 Gene

Additional gene information for PCGF2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PCGF2 Gene

Genomics for PCGF2 Gene

GeneHancer (GH) Regulatory Elements for PCGF2 Gene

Promoters and enhancers for PCGF2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J038745 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 688.1 +0.0 44 8.6 MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 PCGF2 PSMB3 LOC100287808 CDK12 MED1 LOC105371762 SNORA21 RPL19 RPL23 STARD3
GH17J038724 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 34.5 +20.4 20355 10.8 HDGF CLOCK SMAD1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 CISD3 ENSG00000279119 LASP1 CDK12 MED1 PCGF2 LOC105371762 RPL23 RPL19 FBXL20
GH17J038699 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 24.9 +46.2 46159 7.8 MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 ZNF143 SP3 MLLT6 MIR4734 GC17P038706 LOC105371764 ENSG00000277969 CDK12 LOC105371762 SNORA21 MED1 PCGF2
GH17J038673 Promoter/Enhancer 1.5 Ensembl ENCODE 29 +75.1 75095 1.7 CLOCK MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143 EPOP GC17M038673 PCGF2 PIP4K2B MLLT6 CISD3 PSMB3 CWC25
GH17J038740 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 23.2 +7.3 7262 3.6 KLF1 PKNOX1 FOXA2 NFIB ZSCAN4 BMI1 ZIC2 ZNF48 ZNF121 GLIS2 C17orf98 PCGF2 MLLT6 FBXO47 PIP4K2B SOCS7 PSMB3 CISD3 LOC100287808 RNA5SP440
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PCGF2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PCGF2 gene promoter:
  • YY1
  • p300
  • LCR-F1
  • AREB6
  • HOXA9
  • HOXA9B
  • Meis-1
  • Meis-1b
  • MyoD
  • Ik-3

Genomic Locations for PCGF2 Gene

Genomic Locations for PCGF2 Gene
chr17:38,733,897-38,749,817
(GRCh38/hg38)
Size:
15,921 bases
Orientation:
Minus strand
chr17:36,890,150-36,906,070
(GRCh37/hg19)
Size:
15,921 bases
Orientation:
Minus strand

Genomic View for PCGF2 Gene

Genes around PCGF2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PCGF2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PCGF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PCGF2 Gene

Proteins for PCGF2 Gene

  • Protein details for PCGF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P35227-PCGF2_HUMAN
    Recommended name:
    Polycomb group RING finger protein 2
    Protein Accession:
    P35227
    Secondary Accessions:
    • A6NGD8

    Protein attributes for PCGF2 Gene

    Size:
    344 amino acids
    Molecular mass:
    37788 Da
    Quaternary structure:
    • Exists as both a monomer and homodimer (By similarity). Component of a PRC1-like complex (PubMed:19636380, PubMed:21282530, PubMed:26151332). Interacts with CBX8, RING1 AND RNF2 (PubMed:19636380). Interacts with CBX7 (By similarity). Interacts with PHC2 (By similarity).

neXtProt entry for PCGF2 Gene

Post-translational modifications for PCGF2 Gene

  • Phosphorylated. Homodimer formation is regulated by phosphorylation with only unphosphorylated proteins forming homodimers.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for PCGF2 Gene

Domains & Families for PCGF2 Gene

Gene Families for PCGF2 Gene

Protein Domains for PCGF2 Gene

Suggested Antigen Peptide Sequences for PCGF2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PCGF2: view

No data available for UniProtKB/Swiss-Prot for PCGF2 Gene

Function for PCGF2 Gene

Molecular function for PCGF2 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional repressor. Binds specifically to the DNA sequence 5-GACTNGACT-3. Has tumor suppressor activity. May play a role in control of cell proliferation and/or neural cell development. Regulates proliferation of early T progenitor cells by maintaining expression of HES1. Also plays a role in antero-posterior specification of the axial skeleton and negative regulation of the self-renewal activity of hematopoietic stem cells (By similarity). Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A Lys-119, rendering chromatin heritably changed in its expressibility (PubMed:26151332). Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity (PubMed:26151332).

Phenotypes From GWAS Catalog for PCGF2 Gene

Gene Ontology (GO) - Molecular Function for PCGF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003682 chromatin binding IEA --
GO:0003700 DNA binding transcription factor activity TAS 8325509
GO:0005515 protein binding IPI 16182291
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with PCGF2: view
genes like me logo Genes that share phenotypes with PCGF2: view

Animal Models for PCGF2 Gene

MGI Knock Outs for PCGF2:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PCGF2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PCGF2 Gene

Localization for PCGF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PCGF2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PCGF2 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for PCGF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin IDA 19636380
GO:0001739 sex chromatin IEA --
GO:0005634 nucleus IEA,IDA 21282530
GO:0005654 nucleoplasm TAS --
GO:0016604 nuclear body IEA --
genes like me logo Genes that share ontologies with PCGF2: view

Pathways & Interactions for PCGF2 Gene

genes like me logo Genes that share pathways with PCGF2: view

Gene Ontology (GO) - Biological Process for PCGF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IMP 19636380
GO:0001701 in utero embryonic development IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0009952 anterior/posterior pattern specification IEA --
genes like me logo Genes that share ontologies with PCGF2: view

No data available for SIGNOR curated interactions for PCGF2 Gene

Drugs & Compounds for PCGF2 Gene

No Compound Related Data Available

Transcripts for PCGF2 Gene

Unigene Clusters for PCGF2 Gene

Polycomb group ring finger 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PCGF2

Alternative Splicing Database (ASD) splice patterns (SP) for PCGF2 Gene

No ASD Table

Relevant External Links for PCGF2 Gene

GeneLoc Exon Structure for
PCGF2
ECgene alternative splicing isoforms for
PCGF2

Expression for PCGF2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PCGF2 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PCGF2 Gene



NURSA nuclear receptor signaling pathways regulating expression of PCGF2 Gene:

PCGF2

SOURCE GeneReport for Unigene cluster for PCGF2 Gene:

Hs.371617

mRNA Expression by UniProt/SwissProt for PCGF2 Gene:

P35227-PCGF2_HUMAN
Tissue specificity: Detected in all tissues examined with high expression found in placenta lung and kidney and low expression, in liver, pancreas and skeletal muscle.

Evidence on tissue expression from TISSUES for PCGF2 Gene

  • Intestine(4.2)
  • Nervous system(2.2)
  • Kidney(2.1)
genes like me logo Genes that share expression patterns with PCGF2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for PCGF2 Gene

Orthologs for PCGF2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PCGF2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PCGF2 33
  • 99.61 (n)
cow
(Bos Taurus)
Mammalia PCGF2 33
  • 92.15 (n)
dog
(Canis familiaris)
Mammalia PCGF2 33
  • 92.15 (n)
rat
(Rattus norvegicus)
Mammalia Pcgf2 33
  • 88.79 (n)
mouse
(Mus musculus)
Mammalia Pcgf2 16 33
  • 88.5 (n)
chicken
(Gallus gallus)
Aves PCGF2 33
  • 76.86 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia pcgf2 33
  • 69.41 (n)
Species where no ortholog for PCGF2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PCGF2 Gene

ENSEMBL:
Gene Tree for PCGF2 (if available)
TreeFam:
Gene Tree for PCGF2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PCGF2: view image

Paralogs for PCGF2 Gene

Paralogs for PCGF2 Gene

(8) SIMAP similar genes for PCGF2 Gene using alignment to 4 proteins:

  • PCGF2_HUMAN
  • J3KSL0_HUMAN
  • J3KT13_HUMAN
  • J3QS42_HUMAN
genes like me logo Genes that share paralogs with PCGF2: view

Variants for PCGF2 Gene

Sequence variations from dbSNP and Humsavar for PCGF2 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000304779 -- 38,736,662(-) G/A intron_variant
rs1000440255 -- 38,736,764(-) G/A intron_variant
rs1000556927 -- 38,747,616(-) G/C genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000572430 -- 38,736,518(-) G/A intron_variant
rs1000621822 -- 38,741,542(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PCGF2 Gene

Variant ID Type Subtype PubMed ID
nsv1146669 OTHER inversion 26484159
nsv470585 CNV loss 18288195
nsv833438 CNV loss 17160897
nsv833439 CNV loss 17160897

Variation tolerance for PCGF2 Gene

Residual Variation Intolerance Score: 29.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.88; 18.24% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PCGF2 Gene

Human Gene Mutation Database (HGMD)
PCGF2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PCGF2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PCGF2 Gene

Disorders for PCGF2 Gene

Additional Disease Information for PCGF2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for PCGF2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PCGF2 Gene

Publications for PCGF2 Gene

  1. Cloning and chromosome mapping of the human Mel-18 gene which encodes a DNA-binding protein with a new 'RING-finger' motif. (PMID: 8325509) Ishida A … Kanno M (Gene 1993) 2 3 4 22 58
  2. Several distinct polycomb complexes regulate and co-localize on the INK4a tumor suppressor locus. (PMID: 19636380) Maertens GN … Peters G (PloS one 2009) 3 4 22 58
  3. The novel tumor-suppressor Mel-18 in prostate cancer: its functional polymorphism, expression and clinical significance. (PMID: 19585577) Wang W … Habuchi T (International journal of cancer 2009) 3 22 44 58
  4. BMI1-RING1B is an autoinhibited RING E3 ubiquitin ligase. (PMID: 26151332) Taherbhoy AM … Cochran AG (Nature communications 2015) 3 4 58
  5. Interaction proteomics analysis of polycomb proteins defines distinct PRC1 complexes in mammalian cells. (PMID: 21282530) Vandamme J … Angrand PO (Molecular & cellular proteomics : MCP 2011) 3 4 58

Products for PCGF2 Gene

Sources for PCGF2 Gene

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