Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ZSCAN21 Gene

Aliases for ZSCAN21 Gene

  • Zinc Finger And SCAN Domain Containing 21 2 3 5
  • Renal Carcinoma Antigen NY-REN-21 3 4
  • Zinc Finger Protein 38 (KOX 25) 2 3
  • Zinc Finger Protein 38 Homolog 3 4
  • Zfp-38 3 4
  • ZNF38 3 4
  • Zinc Finger And SCAN Domain-Containing Protein 21 3
  • Zinc Finger Protein NY-REN-21 Antigen 3
  • Zinc Finger Protein 38 2
  • NY-REN-21 3
  • Zipro1 3
  • ZFP38 4

External Ids for ZSCAN21 Gene

Previous HGNC Symbols for ZSCAN21 Gene

  • ZNF38

Previous GeneCards Identifiers for ZSCAN21 Gene

  • GC07P099486
  • GC07P099647
  • GC07P094282

Summaries for ZSCAN21 Gene

GeneCards Summary for ZSCAN21 Gene

ZSCAN21 (Zinc Finger And SCAN Domain Containing 21) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding. An important paralog of this gene is ZKSCAN8.

UniProtKB/Swiss-Prot for ZSCAN21 Gene

  • Strong transcriptional activator.

Gene Wiki entry for ZSCAN21 Gene

Additional gene information for ZSCAN21 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZSCAN21 Gene

Genomics for ZSCAN21 Gene

GeneHancer (GH) Regulatory Elements for ZSCAN21 Gene

Promoters and enhancers for ZSCAN21 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J100049 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 666 +0.3 334 2.3 HDGF SMAD1 ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 POLR2B ZNF766 ZSCAN21 PIR43713 AP4M1 ZSCAN25 SRRT PPP1R35 MEPCE GIGYF1 PTCD1 TRIM4
GH07J100048 Enhancer 0.3 ENCODE 650.7 -0.8 -844 0 ZNF610 PIR43713 ZSCAN21 ZKSCAN1 MIR93 COPS6 MIR25 MIR106B MCM7 GC07P100039
GH07J100704 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 69.3 +656.5 656473 2.9 CLOCK MLX DMAP1 YY1 ZNF213 ZNF143 SP3 NFYC ZFP41 ZNF610 POP7 ZSCAN21 SRRT STAG3L5P GIGYF1 ENSG00000242798 ZNF3 AP4M1 TRIM4 PILRB
GH07J100427 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 34.4 +383.4 383432 10.8 CLOCK ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 PPP1R35 MEPCE ZCWPW1 PIR54054 ZSCAN25 SRRT TRIM4 GIGYF1 ZNF3 PILRA
GH07J100672 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 34.8 +627.2 627225 8.6 CLOCK MLX ZFP64 FEZF1 DMAP1 YY1 ZNF213 E2F8 ZNF143 ZNF548 GNB2 GC07P100676 TRIM4 ZNF3 GIGYF1 SRRT PCOLCE STAG3L5P PPP1R35 ENSG00000242798
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZSCAN21 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZSCAN21 gene promoter:
  • FOXJ2
  • FOXJ2 (long isoform)
  • AML1a
  • MEF-2A
  • aMEF-2
  • FOXD3
  • ITF-2
  • Tal-1beta
  • TBP
  • CP2

Genomic Locations for ZSCAN21 Gene

Genomic Locations for ZSCAN21 Gene
chr7:100,049,767-100,065,042
(GRCh38/hg38)
Size:
15,276 bases
Orientation:
Plus strand
chr7:99,647,390-99,662,663
(GRCh37/hg19)
Size:
15,274 bases
Orientation:
Plus strand

Genomic View for ZSCAN21 Gene

Genes around ZSCAN21 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZSCAN21 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZSCAN21 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZSCAN21 Gene

Proteins for ZSCAN21 Gene

  • Protein details for ZSCAN21 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y5A6-ZSC21_HUMAN
    Recommended name:
    Zinc finger and SCAN domain-containing protein 21
    Protein Accession:
    Q9Y5A6
    Secondary Accessions:
    • A4D2A6
    • D6W5T9
    • Q9H0B5

    Protein attributes for ZSCAN21 Gene

    Size:
    473 amino acids
    Molecular mass:
    53658 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ZSCAN21 Gene

Post-translational modifications for ZSCAN21 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZSCAN21 Gene

Domains & Families for ZSCAN21 Gene

Gene Families for ZSCAN21 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZSCAN21 Gene

Suggested Antigen Peptide Sequences for ZSCAN21 Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y5A6

UniProtKB/Swiss-Prot:

ZSC21_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZSCAN21: view

Function for ZSCAN21 Gene

Molecular function for ZSCAN21 Gene

UniProtKB/Swiss-Prot Function:
Strong transcriptional activator.

Phenotypes From GWAS Catalog for ZSCAN21 Gene

Gene Ontology (GO) - Molecular Function for ZSCAN21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA 19549071
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding ISA --
GO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA 19549071
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with ZSCAN21: view
genes like me logo Genes that share phenotypes with ZSCAN21: view

Animal Models for ZSCAN21 Gene

MGI Knock Outs for ZSCAN21:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZSCAN21

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ZSCAN21 Gene

Localization for ZSCAN21 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZSCAN21 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZSCAN21 gene
Compartment Confidence
nucleus 5
endoplasmic reticulum 3
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZSCAN21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZSCAN21: view

Pathways & Interactions for ZSCAN21 Gene

SuperPathways for ZSCAN21 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZSCAN21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA,IMP 19549071
GO:0006366 transcription by RNA polymerase II IEA --
GO:0045893 positive regulation of transcription, DNA-templated IEA --
GO:0045944 positive regulation of transcription by RNA polymerase II IDA 19549071
genes like me logo Genes that share ontologies with ZSCAN21: view

No data available for Pathways by source and SIGNOR curated interactions for ZSCAN21 Gene

Drugs & Compounds for ZSCAN21 Gene

No Compound Related Data Available

Transcripts for ZSCAN21 Gene

Unigene Clusters for ZSCAN21 Gene

Zinc finger and SCAN domain containing 21:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZSCAN21

Alternative Splicing Database (ASD) splice patterns (SP) for ZSCAN21 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c · 3d · 3e ^ 4a · 4b · 4c · 4d ^ 5
SP1: -
SP2:
SP3: -
SP4:
SP5:
SP6:

Relevant External Links for ZSCAN21 Gene

GeneLoc Exon Structure for
ZSCAN21
ECgene alternative splicing isoforms for
ZSCAN21

Expression for ZSCAN21 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZSCAN21 Gene

Protein differential expression in normal tissues from HIPED for ZSCAN21 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZSCAN21 Gene



Protein tissue co-expression partners for ZSCAN21 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZSCAN21 Gene:

ZSCAN21

SOURCE GeneReport for Unigene cluster for ZSCAN21 Gene:

Hs.632294

Evidence on tissue expression from TISSUES for ZSCAN21 Gene

  • Nervous system(2.2)
genes like me logo Genes that share expression patterns with ZSCAN21: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZSCAN21 Gene

Orthologs for ZSCAN21 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZSCAN21 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZSCAN21 34 33
  • 99.86 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ZSCAN21 34
  • 85 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ZSCAN21 34 33
  • 84.99 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zscan21 33
  • 82.56 (n)
mouse
(Mus musculus)
Mammalia Zscan21 16 34 33
  • 81.28 (n)
oppossum
(Monodelphis domestica)
Mammalia ZSCAN21 34
  • 44 (a)
OneToOne
Species where no ortholog for ZSCAN21 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZSCAN21 Gene

ENSEMBL:
Gene Tree for ZSCAN21 (if available)
TreeFam:
Gene Tree for ZSCAN21 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZSCAN21: view image

Paralogs for ZSCAN21 Gene

(566) SIMAP similar genes for ZSCAN21 Gene using alignment to 4 proteins:

  • ZSC21_HUMAN
  • C9JHD9_HUMAN
  • G3V1M0_HUMAN
  • Q8N506_HUMAN
genes like me logo Genes that share paralogs with ZSCAN21: view

Variants for ZSCAN21 Gene

Sequence variations from dbSNP and Humsavar for ZSCAN21 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000174343 -- 100,060,508(+) G/A intron_variant
rs1000547772 -- 100,058,223(+) G/A intron_variant
rs1000637003 -- 100,052,921(+) G/A intron_variant
rs1000798357 -- 100,052,790(+) G/A intron_variant
rs1000911406 -- 100,059,165(+) G/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZSCAN21 Gene

Variant ID Type Subtype PubMed ID
esv2667101 CNV deletion 23128226
esv2734888 CNV deletion 23290073
esv3614288 CNV loss 21293372
esv3614289 CNV loss 21293372
nsv469687 CNV loss 16826518
nsv507405 OTHER sequence alteration 20534489
nsv510966 OTHER complex 20534489

Variation tolerance for ZSCAN21 Gene

Residual Variation Intolerance Score: 34.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.50; 29.13% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZSCAN21 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZSCAN21

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZSCAN21 Gene

Disorders for ZSCAN21 Gene

Additional Disease Information for ZSCAN21

No disorders were found for ZSCAN21 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZSCAN21 Gene

Publications for ZSCAN21 Gene

  1. Spectroscopic characterization of the tumor antigen NY-REN-21 and identification of heterodimer formation with SCAND1. (PMID: 16540086) Carneiro FR … Zanchin NI (Biochemical and biophysical research communications 2006) 3 22 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer SW … Tsui LC (Science (New York, N.Y.) 2003) 3 4 58
  4. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 3 4 58
  5. Antigens recognized by autologous antibody in patients with renal-cell carcinoma. (PMID: 10508479) Scanlan MJ … Old LJ (International journal of cancer 1999) 3 4 58

Products for ZSCAN21 Gene

Sources for ZSCAN21 Gene

Content
Loading form....