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Aliases for ZNF35 Gene

Aliases for ZNF35 Gene

  • Zinc Finger Protein 35 2 3 5
  • Zinc Finger Protein 35 (Clone HF.10) 2 3
  • Zinc Finger Protein HF.10 3 4
  • Zfp105 3
  • HF.10 3
  • HF10 3

External Ids for ZNF35 Gene

Previous GeneCards Identifiers for ZNF35 Gene

  • GC03P044155
  • GC03P043870
  • GC03P044509
  • GC03P044650
  • GC03P044665
  • GC03P044690
  • GC03P044684
  • GC03P044807
  • GC03P044832
  • GC03P044906
  • GC03P044941
  • GC03P044985
  • GC03P045020

Summaries for ZNF35 Gene

GeneCards Summary for ZNF35 Gene

ZNF35 (Zinc Finger Protein 35) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is ZNF660.

UniProtKB/Swiss-Prot for ZNF35 Gene

  • May be involved in transcriptional regulation. Involved in cell differentiation and/or proliferation.

Gene Wiki entry for ZNF35 Gene

Additional gene information for ZNF35 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF35 Gene

Genomics for ZNF35 Gene

GeneHancer (GH) Regulatory Elements for ZNF35 Gene

Promoters and enhancers for ZNF35 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03I044648 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 561.5 +0.2 228 1.7 PKNOX1 ARNT SIN3A IRF4 YY1 ETS1 POLR2B CBX5 E2F8 ELK1 ZNF35 ZNF852 RPS24P8 ZNF501 ZNF197 ZNF502 ZDHHC3 KIAA1143 ENSG00000272077 ENSG00000236869
GH03I044624 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 21.8 -23.4 -23430 2.2 PKNOX1 ARNT ARID4B SIN3A YY1 POLR2B ZNF766 CBX5 E2F8 ZNF143 ZNF197 ZNF197-AS1 ZNF35 ZNF852 KIAA1143 ZNF660 ZDHHC3 ZNF502 ZNF445 ENSG00000236869
GH03I045130 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 19.2 +487.3 487264 11.1 HDGF PKNOX1 SMAD1 ARNT POLR2B ZNF766 CBX5 E2F8 FOS REST ZNF502 ZNF852 RN7SL145P ZNF35 ZNF197 RNU5B-3P CLEC3B TMEM158 SACM1L ZDHHC3
GH03I045052 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 19.2 +410.8 410802 13.7 HDGF PKNOX1 ARNT YY1 POLR2B ZNF766 E2F8 ZNF143 FOS REST ZNF502 ZNF852 RN7SL145P CLEC3B ZNF35 CDCP1 ZNF197 ZNF660 EXOSC7 RNU5B-3P
GH03I043689 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 13.1 -954.3 -954308 10.4 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A FEZF1 DMAP1 YY1 POLR2B ABHD5 ZNF35 ZNF852 ZNF660 ENSG00000261786 ANO10 PIR40588 GC03M043165
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around ZNF35 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF35 gene promoter:

Genomic Locations for ZNF35 Gene

Genomic Locations for ZNF35 Gene
chr3:44,648,727-44,660,791
(GRCh38/hg38)
Size:
12,065 bases
Orientation:
Plus strand
chr3:44,690,219-44,702,283
(GRCh37/hg19)

Genomic View for ZNF35 Gene

Genes around ZNF35 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF35 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF35 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF35 Gene

Proteins for ZNF35 Gene

  • Protein details for ZNF35 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P13682-ZNF35_HUMAN
    Recommended name:
    Zinc finger protein 35
    Protein Accession:
    P13682
    Secondary Accessions:
    • B2RBU6
    • Q53Y54
    • Q96D01

    Protein attributes for ZNF35 Gene

    Size:
    527 amino acids
    Molecular mass:
    59089 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAA85451.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAG37343.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAA30268.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for ZNF35 Gene

Post-translational modifications for ZNF35 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF35 Gene

Domains & Families for ZNF35 Gene

Gene Families for ZNF35 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF35 Gene

Suggested Antigen Peptide Sequences for ZNF35 Gene

Graphical View of Domain Structure for InterPro Entry

P13682

UniProtKB/Swiss-Prot:

ZNF35_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF35: view

Function for ZNF35 Gene

Molecular function for ZNF35 Gene

GENATLAS Biochemistry:
zinc finger protein 35,cHF.10 (C2H2 type,Kruppel-like),expressed in testis,involved in germ cell differentiation process
UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation. Involved in cell differentiation and/or proliferation.

Phenotypes From GWAS Catalog for ZNF35 Gene

Gene Ontology (GO) - Molecular Function for ZNF35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding TAS 2108922
GO:0003700 DNA binding transcription factor activity IDA 1572646
GO:0043565 sequence-specific DNA binding IDA 8477855
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF35: view
genes like me logo Genes that share phenotypes with ZNF35: view

Animal Model Products

CRISPR Products

miRNA for ZNF35 Gene

miRTarBase miRNAs that target ZNF35

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF35 Gene

Localization for ZNF35 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF35 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF35 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005623 cell ISS --
GO:0005634 nucleus IEA,IDA 20186958
GO:0048471 perinuclear region of cytoplasm IDA 20186958
genes like me logo Genes that share ontologies with ZNF35: view

Pathways & Interactions for ZNF35 Gene

SuperPathways for ZNF35 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ZNF35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated TAS,IEA --
GO:0007283 spermatogenesis ISS 20186958
GO:0071300 cellular response to retinoic acid ISS 20186958
genes like me logo Genes that share ontologies with ZNF35: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF35 Gene

Drugs & Compounds for ZNF35 Gene

No Compound Related Data Available

Transcripts for ZNF35 Gene

Unigene Clusters for ZNF35 Gene

Zinc finger protein 35:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF35 Gene

No ASD Table

Relevant External Links for ZNF35 Gene

GeneLoc Exon Structure for
ZNF35
ECgene alternative splicing isoforms for
ZNF35

Expression for ZNF35 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF35 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ZNF35 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ZNF35 Gene



Protein tissue co-expression partners for ZNF35 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF35 Gene:

ZNF35

SOURCE GeneReport for Unigene cluster for ZNF35 Gene:

Hs.288658

Evidence on tissue expression from TISSUES for ZNF35 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with ZNF35: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF35 Gene

Orthologs for ZNF35 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF35 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF35 33 34
  • 99.68 (n)
dog
(Canis familiaris)
Mammalia ZNF35 33 34
  • 90.64 (n)
cow
(Bos Taurus)
Mammalia ZNF35 33 34
  • 86.78 (n)
rat
(Rattus norvegicus)
Mammalia Zfp105 33
  • 85.56 (n)
mouse
(Mus musculus)
Mammalia Zfp105 33 16 34
  • 84.48 (n)
zebrafish
(Danio rerio)
Actinopterygii BX004879.1 34
  • 39 (a)
ManyToMany
BX005448.1 34
  • 39 (a)
ManyToMany
BX890548.2 34
  • 39 (a)
ManyToMany
gb:am422109 34
  • 39 (a)
ManyToMany
si:ch211-283l16.1 34
  • 39 (a)
ManyToMany
si:dkey-56m15.3 34
  • 39 (a)
ManyToMany
zgc:174700 34
  • 39 (a)
ManyToMany
CABZ01008480.1 34
  • 38 (a)
ManyToMany
CT573263.3 34
  • 38 (a)
ManyToMany
si:ch211-226o13.2 34
  • 38 (a)
ManyToMany
si:dkey-22h13.2 34
  • 38 (a)
ManyToMany
si:dkey-237m9.1 34
  • 37 (a)
ManyToMany
si:dkey-54j5.2 34
  • 37 (a)
ManyToMany
CR293532.1 34
  • 36 (a)
ManyToMany
si:dkey-16b10.2 34
  • 36 (a)
ManyToMany
zgc:173714 34
  • 36 (a)
ManyToMany
zgc:174694 34
  • 36 (a)
ManyToMany
BX005448.2 34
  • 32 (a)
ManyToMany
Species where no ortholog for ZNF35 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF35 Gene

ENSEMBL:
Gene Tree for ZNF35 (if available)
TreeFam:
Gene Tree for ZNF35 (if available)

Paralogs for ZNF35 Gene

Paralogs for ZNF35 Gene

(523) SIMAP similar genes for ZNF35 Gene using alignment to 5 proteins:

Pseudogenes.org Pseudogenes for ZNF35 Gene

genes like me logo Genes that share paralogs with ZNF35: view

Variants for ZNF35 Gene

Sequence variations from dbSNP and Humsavar for ZNF35 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000148749 -- 44,655,788(+) G/A intron_variant
rs1000256620 -- 44,653,048(+) T/C intron_variant
rs1000490268 -- 44,652,498(+) G/C intron_variant
rs1000924911 -- 44,647,486(+) AAAAA/AAAA upstream_transcript_variant
rs1000953859 -- 44,647,912(+) A/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF35 Gene

Variant ID Type Subtype PubMed ID
esv3596037 CNV gain 21293372

Variation tolerance for ZNF35 Gene

Residual Variation Intolerance Score: 51.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.43; 90.93% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF35 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF35

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF35 Gene

Disorders for ZNF35 Gene

Additional Disease Information for ZNF35

No disorders were found for ZNF35 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF35 Gene

Publications for ZNF35 Gene

  1. Structural and functional organization of the HF.10 human zinc finger gene (ZNF35) located on chromosome 3p21-p22. (PMID: 1572646) Lanfrancone L … Pelicci PG (Genomics 1992) 2 3 4 22 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Localization of the human HF.10 finger gene on a chromosome region (3p21-22) frequently deleted in human cancers. (PMID: 2108922) Donti E … Pelicci PG (Human genetics 1990) 2 3 58
  4. Isolation of cDNAs encoding finger proteins and measurement of the corresponding mRNA levels during myeloid terminal differentiation. (PMID: 3380682) Pannuti A … Lania L (Nucleic acids research 1988) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for ZNF35 Gene

Sources for ZNF35 Gene

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