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Aliases for ZNF33B Gene

Aliases for ZNF33B Gene

  • Zinc Finger Protein 33B 2 3 3 5
  • Zinc Finger Protein 33b (KOX 31) 2 3
  • Zinc Finger Protein 11B 2 4
  • ZNF11B 3 4
  • KOX2 3 4
  • Zinc Finger Protein 11b (KOX 2) 3
  • Zinc Finger Protein KOX2 4
  • KOX31 3

External Ids for ZNF33B Gene

Previous HGNC Symbols for ZNF33B Gene

  • ZNF11B

Previous GeneCards Identifiers for ZNF33B Gene

  • GC10M042377
  • GC10U900001
  • GC10P038188
  • GC07P006406
  • GC03P044571
  • GC10M042405
  • GC10M043069
  • GC10M039611
  • GC10M043084

Summaries for ZNF33B Gene

Entrez Gene Summary for ZNF33B Gene

  • This gene encodes a member of the zinc finger family of proteins. This gene shows decreased expression in cumulus cells derived from patients undergoing controlled ovarian stimulation. This gene is present in a gene cluster with several related zinc finger genes in the pericentromeric region of chromosome 10. Pseudogenes have been identified on chromosomes 7 and 10. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]

GeneCards Summary for ZNF33B Gene

ZNF33B (Zinc Finger Protein 33B) is a Protein Coding gene. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA binding transcription factor activity. An important paralog of this gene is ZNF33A.

UniProtKB/Swiss-Prot for ZNF33B Gene

  • May be involved in transcriptional regulation.

Gene Wiki entry for ZNF33B Gene

Additional gene information for ZNF33B Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF33B Gene

Genomics for ZNF33B Gene

GeneHancer (GH) Regulatory Elements for ZNF33B Gene

Promoters and enhancers for ZNF33B Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J042636 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 670.1 +0.5 478 3 HDGF CLOCK FOXA2 ARID4B SIN3A DMAP1 ZBTB7B YY1 SLC30A9 POLR2B ZNF33B PIR61818 LOC105378268 LINC00839 HNRNPF
GH10J042691 Promoter 0.7 EPDnew 650.2 -52.9 -52911 0.1 ZBTB33 CHD2 GC10M042692 PIR50860 LINC01518 ZNF33B
GH10J043392 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 32.2 -762.9 -762853 18.3 CLOCK MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 HNRNPF RASGEF1A BMS1 EIF3LP2 ZNF32-AS2 HNRNPA3P1 ZNF37BP ZNF33B ZNF32-AS1 ZNF32
GH10J043572 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 12.5 -936.0 -935967 3.9 CLOCK ARNT SIN3A YY1 ZNF766 CBX5 ZNF213 E2F8 ZNF143 KLF13 ZNF239 ZNF32-AS2 BMS1 ZNF33B ZNF32-AS1 ZNF487 CAP1P2
GH10J042551 Promoter/Enhancer 1.5 Ensembl ENCODE 14.6 +86.2 86198 2 ARID4B SIN3A DMAP1 YY1 POLR2B ZNF766 E2F8 ZNF143 ZNF548 KLF13 ZNF37BP LINC00839 ZNF33B BMS1 PIR31407
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF33B on UCSC Golden Path with GeneCards custom track

Genomic Locations for ZNF33B Gene

Genomic Locations for ZNF33B Gene
64,652 bases
Minus strand
49,438 bases
Minus strand

Genomic View for ZNF33B Gene

Genes around ZNF33B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF33B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF33B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF33B Gene

Proteins for ZNF33B Gene

  • Protein details for ZNF33B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 33B
    Protein Accession:
    Secondary Accessions:
    • Q06731
    • Q32MA2
    • Q86XY8
    • Q8NDW3

    Protein attributes for ZNF33B Gene

    778 amino acids
    Molecular mass:
    90683 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH48313.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

neXtProt entry for ZNF33B Gene

Post-translational modifications for ZNF33B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF33B Gene

Domains & Families for ZNF33B Gene

Gene Families for ZNF33B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF33B Gene

Suggested Antigen Peptide Sequences for ZNF33B Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF33B: view

Function for ZNF33B Gene

Molecular function for ZNF33B Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.
GENATLAS Biochemistry:
zinc finger protein 33b (KOX31) (C2H2 type,Kruppel-like)

Gene Ontology (GO) - Molecular Function for ZNF33B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding ISA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity IBA --
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF33B: view
genes like me logo Genes that share phenotypes with ZNF33B: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZNF33B Gene

Localization for ZNF33B Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF33B Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF33B gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ZNF33B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF33B: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ZNF33B Gene

Pathways & Interactions for ZNF33B Gene

SuperPathways for ZNF33B Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF33B: view

Pathways by source for ZNF33B Gene

2 Reactome pathways for ZNF33B Gene

Gene Ontology (GO) - Biological Process for ZNF33B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA,IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with ZNF33B: view

No data available for SIGNOR curated interactions for ZNF33B Gene

Drugs & Compounds for ZNF33B Gene

(1) Drugs for ZNF33B Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Zinc Approved, Investigational Pharma 2430
genes like me logo Genes that share compounds with ZNF33B: view

Transcripts for ZNF33B Gene

mRNA/cDNA for ZNF33B Gene

(8) REFSEQ mRNAs :
(17) Additional mRNA sequences :
(8) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF33B Gene

Zinc finger protein 33B:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF33B Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d
SP1: - - -
SP2: - - -
SP3: -
SP4: - - -
SP5: - - - -
SP6: - - -
SP7: - - - -
SP8: - - - - -

Relevant External Links for ZNF33B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF33B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF33B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ZNF33B Gene

This gene is overexpressed in Pancreas (x4.1).

Protein differential expression in normal tissues from HIPED for ZNF33B Gene

This gene is overexpressed in Ovary (54.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF33B Gene

Protein tissue co-expression partners for ZNF33B Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF33B Gene:


SOURCE GeneReport for Unigene cluster for ZNF33B Gene:


Evidence on tissue expression from TISSUES for ZNF33B Gene

  • Intestine(4.1)
  • Nervous system(2.9)
genes like me logo Genes that share expression patterns with ZNF33B: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF33B Gene

Orthologs for ZNF33B Gene

This gene was present in the common ancestor of chordates.

Orthologs for ZNF33B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF33B 34 33
  • 99.4 (n)
(Bos Taurus)
Mammalia -- 34
  • 86 (a)
(Canis familiaris)
Mammalia -- 34
  • 83 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 55 (a)
(Mus musculus)
Mammalia Zfp35 34
  • 46 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 41 (a)
(Gallus gallus)
Aves -- 34
  • 37 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 37 (a)
(Danio rerio)
Actinopterygii BX004873.2 34
  • 45 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 43 (a)
-- 34
  • 41 (a)
-- 34
  • 38 (a)
-- 34
  • 32 (a)
Species where no ortholog for ZNF33B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ZNF33B Gene

Gene Tree for ZNF33B (if available)
Gene Tree for ZNF33B (if available)
Evolutionary constrained regions (ECRs) for ZNF33B: view image

Paralogs for ZNF33B Gene

(487) SIMAP similar genes for ZNF33B Gene using alignment to 3 proteins:

  • Q3B799_HUMAN
  • Q6P1A4_HUMAN Pseudogenes for ZNF33B Gene

genes like me logo Genes that share paralogs with ZNF33B: view

Variants for ZNF33B Gene

Sequence variations from dbSNP and Humsavar for ZNF33B Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1000003382 -- 42,629,870(-) T/C intron_variant
rs1000007341 -- 42,588,827(-) T/C downstream_transcript_variant, genic_downstream_transcript_variant, intron_variant
rs1000059373 -- 42,623,481(-) T/C intron_variant
rs1000137349 -- 42,620,689(-) G/A intron_variant
rs1000147841 -- 42,589,119(-) A/G 3_prime_UTR_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF33B Gene

Variant ID Type Subtype PubMed ID
dgv1098n54 CNV gain 21841781
esv2669368 CNV deletion 23128226
esv2759746 CNV loss 17122850
esv34929 CNV loss 17911159
esv3623017 CNV loss 21293372
esv3623018 CNV gain 21293372
esv3623019 CNV loss 21293372
esv3891795 CNV gain 25118596
nsv1042764 CNV gain 25217958
nsv469725 CNV gain 16826518
nsv550672 CNV gain 21841781

Variation tolerance for ZNF33B Gene

Residual Variation Intolerance Score: 89% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.67; 57.07% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF33B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF33B Gene

Disorders for ZNF33B Gene

Additional Disease Information for ZNF33B

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for ZNF33B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF33B Gene

Publications for ZNF33B Gene

  1. Duplicated KOX zinc finger gene clusters flank the centromere of human chromosome 10: evidence for a pericentric inversion during primate evolution. (PMID: 8464732) Tunnacliffe A … Ponder BA (Nucleic acids research 1993) 3 4 22 58
  2. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A … Goate A (American journal of human genetics 2006) 3 44 58
  3. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P … Rogers J (Nature 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Genomic sequence and transcriptional profile of the boundary between pericentromeric satellites and genes on human chromosome arm 10p. (PMID: 12566394) Guy J … Jackson MS (Genome research 2003) 3 4 58

Products for ZNF33B Gene

Sources for ZNF33B Gene

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