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Aliases for ZNF23 Gene

Aliases for ZNF23 Gene

  • Zinc Finger Protein 23 2 3 3 5
  • Zinc Finger Protein 359 2 3 4
  • Zinc Finger Protein 612 3 4
  • ZNF359 3 4
  • ZNF612 3 4
  • KOX16 3 4
  • Kruppel-Like Zinc Finger Factor X31 3
  • Zinc Finger Protein 23 (KOX 16) 3
  • Zinc Finger Protein KOX16 4
  • Zinc Finger Protein 32 3
  • Zfp612 3

External Ids for ZNF23 Gene

Previous HGNC Symbols for ZNF23 Gene

  • ZNF359

Previous GeneCards Identifiers for ZNF23 Gene

  • GC16U990062
  • GC16M072204
  • GC16M071216
  • GC16M071257
  • GC16M070039
  • GC16M071481
  • GC16M057249
  • GC16M071449
  • GC16M071450
  • GC16M071452
  • GC16M071455
  • GC16M071457
  • GC16M071459
  • GC16M071461
  • GC16M071463

Summaries for ZNF23 Gene

GeneCards Summary for ZNF23 Gene

ZNF23 (Zinc Finger Protein 23) is a Protein Coding gene. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA binding transcription factor activity. An important paralog of this gene is ZNF184.

UniProtKB/Swiss-Prot for ZNF23 Gene

  • May be involved in transcriptional regulation. May have a role in embryonic development.

Gene Wiki entry for ZNF23 Gene

Additional gene information for ZNF23 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF23 Gene

Genomics for ZNF23 Gene

GeneHancer (GH) Regulatory Elements for ZNF23 Gene

Promoters and enhancers for ZNF23 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J071483 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 674.1 -21.3 -21289 1.7 HDGF MLX ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B IRF4 YY1 ZNF23 ZNF19 DHX38 IST1 AP1G1 COG4 ATXN1L SF3B3 ENSG00000247324 VAC14
GH16J071459 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 662.7 +1.8 1771 3.1 HDGF CLOCK MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B ZNF23 ENSG00000247324 DHX38 IST1 AP1G1 COG4 ATXN1L SF3B3 VAC14 ZNF19
GH16J071454 Promoter 0.5 EPDnew 650.4 +9.0 8952 0.1 ZNF23 ZNF19 ENSG00000247324 GC16M071448 PIR35377 ENSG00000261611
GH16J071425 Enhancer 1.3 Ensembl ENCODE 56.1 +36.5 36483 1.7 PKNOX1 FOXA2 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 SLC30A9 GC16P071427 LINC02136 TRM-CAT2-1 DHX38 ZNF23 SF3B3 ZNF19 ATXN1L ENSG00000247324 PHLPP2
GH16J070522 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 14.1 +939.0 939028 3.5 PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF766 SF3B3 COG4 PDXDC2P-NPIPB14P PDXDC2P NFAT5 NONOP1 DDX19B PDPR DDX19A ZNF23
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF23 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF23 gene promoter:
  • HFH-1
  • COUP
  • COUP-TF
  • COUP-TF1
  • HNF-4alpha1
  • HNF-4alpha2
  • PPAR-gamma2
  • PPAR-gamma1
  • LUN-1
  • AREB6

Genomic Locations for ZNF23 Gene

Genomic Locations for ZNF23 Gene
chr16:71,447,597-71,463,095
(GRCh38/hg38)
Size:
15,499 bases
Orientation:
Minus strand
chr16:71,481,500-71,496,998
(GRCh37/hg19)
Size:
15,499 bases
Orientation:
Minus strand

Genomic View for ZNF23 Gene

Genes around ZNF23 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF23 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF23 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF23 Gene

Proteins for ZNF23 Gene

  • Protein details for ZNF23 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P17027-ZNF23_HUMAN
    Recommended name:
    Zinc finger protein 23
    Protein Accession:
    P17027
    Secondary Accessions:
    • Q8NDP5
    • Q96IT3
    • Q9UG42

    Protein attributes for ZNF23 Gene

    Size:
    643 amino acids
    Molecular mass:
    73059 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ZNF23 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF23 Gene

Post-translational modifications for ZNF23 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF23 Gene

Domains & Families for ZNF23 Gene

Gene Families for ZNF23 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF23 Gene

Suggested Antigen Peptide Sequences for ZNF23 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P17027

UniProtKB/Swiss-Prot:

ZNF23_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF23: view

Function for ZNF23 Gene

Molecular function for ZNF23 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation. May have a role in embryonic development.
GENATLAS Biochemistry:
zinc finger protein 23 (KOX16) (C2H2 type,Kruppel-like)

Phenotypes From GWAS Catalog for ZNF23 Gene

Gene Ontology (GO) - Molecular Function for ZNF23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS 19274049
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity IBA --
GO:0005515 protein binding IPI 21516116
genes like me logo Genes that share ontologies with ZNF23: view
genes like me logo Genes that share phenotypes with ZNF23: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF23

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF23 Gene

Localization for ZNF23 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF23 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF23 gene
Compartment Confidence
nucleus 5
cytosol 3

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF23: view

Pathways & Interactions for ZNF23 Gene

SuperPathways for ZNF23 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF23: view

Pathways by source for ZNF23 Gene

2 Reactome pathways for ZNF23 Gene

Gene Ontology (GO) - Biological Process for ZNF23 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IBA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with ZNF23: view

No data available for SIGNOR curated interactions for ZNF23 Gene

Drugs & Compounds for ZNF23 Gene

No Compound Related Data Available

Transcripts for ZNF23 Gene

mRNA/cDNA for ZNF23 Gene

Unigene Clusters for ZNF23 Gene

Zinc finger protein 23:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF23

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF23 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b · 4c · 4d ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e ^ 8 ^ 9a · 9b · 9c · 9d
SP1: - - - - - -
SP2: - - - - -
SP3: - - - - - -
SP4: - - - - - - -
SP5: - - - - - - -
SP6: - - - - - -
SP7: - - - - -
SP8:
SP9: - - - -
SP10: - -
SP11: -

Relevant External Links for ZNF23 Gene

GeneLoc Exon Structure for
ZNF23
ECgene alternative splicing isoforms for
ZNF23

Expression for ZNF23 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF23 Gene

Protein differential expression in normal tissues from HIPED for ZNF23 Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ZNF23 Gene



Protein tissue co-expression partners for ZNF23 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ZNF23 Gene:

ZNF23

SOURCE GeneReport for Unigene cluster for ZNF23 Gene:

Hs.656643

Evidence on tissue expression from TISSUES for ZNF23 Gene

  • Nervous system(4.4)
  • Muscle(4.2)
genes like me logo Genes that share expression patterns with ZNF23: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF23 Gene

Orthologs for ZNF23 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF23 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF23 34 33
  • 99.64 (n)
OneToOne
dog
(Canis familiaris)
Mammalia ZNF23 34 33
  • 89.74 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ZNF23 33
  • 88.85 (n)
ZNF19 34
  • 54 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Zfp612 33
  • 81.88 (n)
mouse
(Mus musculus)
Mammalia Zfp612 16 34 33
  • 79.65 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 55 (a)
OneToMany
-- 34
  • 54 (a)
OneToMany
-- 34
  • 53 (a)
OneToMany
-- 34
  • 52 (a)
OneToMany
-- 34
  • 52 (a)
OneToMany
-- 34
  • 50 (a)
OneToMany
Species where no ortholog for ZNF23 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF23 Gene

ENSEMBL:
Gene Tree for ZNF23 (if available)
TreeFam:
Gene Tree for ZNF23 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for ZNF23: view image

Paralogs for ZNF23 Gene

(502) SIMAP similar genes for ZNF23 Gene using alignment to 5 proteins:

  • ZNF23_HUMAN
  • H0Y310_HUMAN
  • H3BMC6_HUMAN
  • H3BPE6_HUMAN
  • J3QLW9_HUMAN
genes like me logo Genes that share paralogs with ZNF23: view

Variants for ZNF23 Gene

Sequence variations from dbSNP and Humsavar for ZNF23 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000379998 -- 71,458,483(-) G/A/C intron_variant
rs1000411217 -- 71,458,726(-) G/A intron_variant
rs1000490315 -- 71,451,892(-) A/G intron_variant
rs1000591883 -- 71,452,180(-) G/A/C intron_variant
rs1000869773 -- 71,447,293(-) A/G downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF23 Gene

Variant ID Type Subtype PubMed ID
nsv1064435 CNV loss 25217958
nsv7285 OTHER inversion 18451855

Variation tolerance for ZNF23 Gene

Residual Variation Intolerance Score: 43.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.36; 26.88% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF23 Gene

Human Gene Mutation Database (HGMD)
ZNF23
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF23

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF23 Gene

Disorders for ZNF23 Gene

Additional Disease Information for ZNF23

No disorders were found for ZNF23 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF23 Gene

Publications for ZNF23 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  2. Identification and characterization of two novel zinc finger genes, ZNF359 and ZFP28, in human development. (PMID: 12127974) Zhou L … Wu X (Biochemical and biophysical research communications 2002) 3 4 58
  3. Human zinc finger gene ZNF23 (Kox16) maps to a zinc finger gene cluster on chromosome 16q22, and ZNF32 (Kox30) to chromosome region 10q23-q24. (PMID: 8500793) Cannizzaro LA … Thiesen HJ (Human genetics 1993) 3 22 58
  4. Multiple genes encoding zinc finger domains are expressed in human T cells. (PMID: 2288909) Thiesen HJ (The New biologist 1990) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for ZNF23 Gene

Sources for ZNF23 Gene

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