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Aliases for ZNF19 Gene

Aliases for ZNF19 Gene

  • Zinc Finger Protein 19 2 3 3 5
  • Zinc Finger Protein 19 (KOX 12) 2 3
  • Zinc Finger Protein KOX12 3 4
  • KOX12 3 4

External Ids for ZNF19 Gene

Previous GeneCards Identifiers for ZNF19 Gene

  • GC16U990061
  • GC16M072231
  • GC16M071217
  • GC16M071284
  • GC16M070065
  • GC16M057276

Summaries for ZNF19 Gene

Entrez Gene Summary for ZNF19 Gene

  • The protein encoded by this gene contains a zinc finger, a nucleic acid-binding domain present in many transcription factors. This gene is located in a region next to ZNF23, a gene also encoding a zinc finger protein, on chromosome 16. [provided by RefSeq, Jul 2008]

GeneCards Summary for ZNF19 Gene

ZNF19 (Zinc Finger Protein 19) is a Protein Coding gene. Among its related pathways are Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and DNA binding transcription factor activity. An important paralog of this gene is ZNF7.

UniProtKB/Swiss-Prot for ZNF19 Gene

  • May be involved in transcriptional regulation.

Gene Wiki entry for ZNF19 Gene

Additional gene information for ZNF19 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF19 Gene

Genomics for ZNF19 Gene

GeneHancer (GH) Regulatory Elements for ZNF19 Gene

Promoters and enhancers for ZNF19 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J071483 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 661 +80.7 80705 1.7 HDGF MLX ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B IRF4 YY1 ZNF23 ZNF19 DHX38 IST1 AP1G1 COG4 ATXN1L SF3B3 ENSG00000247324 VAC14
GH16J071563 Promoter/Enhancer 1.5 Ensembl ENCODE 650.7 0.0 -43 3.3 HDGF PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 TAT-AS1 ZNF19 RNU6-1061P DHX38 PHLPP2 ZNF23 IST1 ENSG00000247324 DHODH HPR
GH16J071489 Promoter 0.6 EPDnew 650.2 +75.7 75745 0.1 ZBTB33 ENSG00000261611 ZNF19 TAT-AS1 LOC105371335
GH16J071707 Enhancer 1.2 FANTOM5 Ensembl ENCODE 48.1 -143.8 -143765 3.3 USF1 TEAD4 MAX BACH1 RAD21 FOSL1 ZNF664 ZNF121 GATA3 ZNF316 ZNF19 PMFBP1 PHLPP2 MARVELD3 RNU6-208P HPR HYDIN SNORA70D ENSG00000261513
GH16J071425 Enhancer 1.3 Ensembl ENCODE 41 +138.5 138477 1.7 PKNOX1 FOXA2 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 SLC30A9 GC16P071427 LINC02136 TRM-CAT2-1 DHX38 ZNF23 SF3B3 ZNF19 ATXN1L ENSG00000247324 PHLPP2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF19 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF19 gene promoter:
  • AML1a
  • HNF-1
  • HNF-1A
  • NRSF form 1
  • NRSF form 2

Genomic Locations for ZNF19 Gene

Genomic Locations for ZNF19 Gene
chr16:71,464,555-71,565,089
(GRCh38/hg38)
Size:
100,535 bases
Orientation:
Minus strand
chr16:71,498,453-71,598,992
(GRCh37/hg19)
Size:
100,540 bases
Orientation:
Minus strand

Genomic View for ZNF19 Gene

Genes around ZNF19 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF19 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF19 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF19 Gene

Proteins for ZNF19 Gene

  • Protein details for ZNF19 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P17023-ZNF19_HUMAN
    Recommended name:
    Zinc finger protein 19
    Protein Accession:
    P17023
    Secondary Accessions:
    • A8K895
    • Q86Y66
    • Q8NDE2
    • Q96M79
    • Q96NE5

    Protein attributes for ZNF19 Gene

    Size:
    458 amino acids
    Molecular mass:
    52449 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAA36814.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ZNF19 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ZNF19 Gene

Post-translational modifications for ZNF19 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ZNF19 Gene

Domains & Families for ZNF19 Gene

Gene Families for ZNF19 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF19 Gene

Suggested Antigen Peptide Sequences for ZNF19 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P17023

UniProtKB/Swiss-Prot:

ZNF19_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF19: view

Function for ZNF19 Gene

Molecular function for ZNF19 Gene

UniProtKB/Swiss-Prot Function:
May be involved in transcriptional regulation.
GENATLAS Biochemistry:
zinc finger protein 19 (KOX12) (C2H2 type,Kruppel-like)

Phenotypes From GWAS Catalog for ZNF19 Gene

Gene Ontology (GO) - Molecular Function for ZNF19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS 19274049
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity NAS 7557990
GO:0043565 sequence-specific DNA binding IBA --
genes like me logo Genes that share ontologies with ZNF19: view
genes like me logo Genes that share phenotypes with ZNF19: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ZNF19 Gene

Localization for ZNF19 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF19 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF19 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for ZNF19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus NAS 7557990
genes like me logo Genes that share ontologies with ZNF19: view

Pathways & Interactions for ZNF19 Gene

SuperPathways for ZNF19 Gene

SuperPathway Contained pathways
1 Gene Expression
genes like me logo Genes that share pathways with ZNF19: view

Pathways by source for ZNF19 Gene

2 Reactome pathways for ZNF19 Gene

Gene Ontology (GO) - Biological Process for ZNF19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA,NAS 7557990
GO:0006357 regulation of transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with ZNF19: view

No data available for SIGNOR curated interactions for ZNF19 Gene

Drugs & Compounds for ZNF19 Gene

No Compound Related Data Available

Transcripts for ZNF19 Gene

mRNA/cDNA for ZNF19 Gene

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF19 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c
SP1: - - -
SP2: - - - -
SP3:
SP4: -
SP5: - -
SP6: -

Relevant External Links for ZNF19 Gene

GeneLoc Exon Structure for
ZNF19
ECgene alternative splicing isoforms for
ZNF19

Expression for ZNF19 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF19 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF19 Gene:

ZNF19

Evidence on tissue expression from TISSUES for ZNF19 Gene

  • Lung(4.1)
  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with ZNF19: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF19 Gene

Orthologs for ZNF19 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF19 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ZNF19 33
  • 99.34 (n)
-- 34
  • 99 (a)
OneToMany
dog
(Canis familiaris)
Mammalia ZNF19 33
  • 87.82 (n)
-- 34
  • 85 (a)
OneToMany
cow
(Bos Taurus)
Mammalia ZNF19 33
  • 84.62 (n)
Species where no ortholog for ZNF19 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF19 Gene

ENSEMBL:
Gene Tree for ZNF19 (if available)
TreeFam:
Gene Tree for ZNF19 (if available)

Paralogs for ZNF19 Gene

(546) SIMAP similar genes for ZNF19 Gene using alignment to 10 proteins:

  • ZNF19_HUMAN
  • H3BMU5_HUMAN
  • H3BNH9_HUMAN
  • H3BNI0_HUMAN
  • H3BQ26_HUMAN
  • H3BQI6_HUMAN
  • H3BR98_HUMAN
  • J3KRI7_HUMAN
  • J3KSN3_HUMAN
  • J3KT56_HUMAN

Pseudogenes.org Pseudogenes for ZNF19 Gene

genes like me logo Genes that share paralogs with ZNF19: view

Variants for ZNF19 Gene

Sequence variations from dbSNP and Humsavar for ZNF19 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000058973 -- 71,488,985(-) C/T intron_variant
rs1000300451 -- 71,488,579(-) G/A/C intron_variant
rs1000317683 -- 71,488,343(-) G/A intron_variant
rs1000328498 -- 71,488,681(-) C/T intron_variant
rs1000532036 -- 71,477,145(-) G/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF19 Gene

Variant ID Type Subtype PubMed ID
nsv7285 OTHER inversion 18451855

Variation tolerance for ZNF19 Gene

Residual Variation Intolerance Score: 34% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.24; 40.24% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF19 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ZNF19

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF19 Gene

Disorders for ZNF19 Gene

Additional Disease Information for ZNF19

No disorders were found for ZNF19 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF19 Gene

Publications for ZNF19 Gene

  1. Characterization and mapping of human genes encoding zinc finger proteins. (PMID: 1946370) Bray P … Dawid IB (Proceedings of the National Academy of Sciences of the United States of America 1991) 2 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Clustering of C2-H2 zinc finger motif sequences within telomeric and fragile site regions of human chromosomes. (PMID: 1505991) Lichter P … Ward DC (Genomics 1992) 2 3 58
  5. Multiple genes encoding zinc finger domains are expressed in human T cells. (PMID: 2288909) Thiesen HJ (The New biologist 1990) 3 4 58

Products for ZNF19 Gene

Sources for ZNF19 Gene

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