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Aliases for ZNF8 Gene

Aliases for ZNF8 Gene

  • Zinc Finger Protein 8 2 3 3 5
  • Zinc Finger Protein 8 (Clone HF.18) 2 3
  • Zinc Finger Protein HF.18 3 4
  • Zinc Finger Protein 272 3
  • Zfp128 3
  • HF.18 3

External Ids for ZNF8 Gene

Previous GeneCards Identifiers for ZNF8 Gene

  • GC19P059695
  • GC19P059244
  • GC19P063466
  • GC19P063482
  • GC19P058790
  • GC19P055099

Summaries for ZNF8 Gene

GeneCards Summary for ZNF8 Gene

ZNF8 (Zinc Finger Protein 8) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is FEZF1.

UniProtKB/Swiss-Prot for ZNF8 Gene

  • Transcriptional repressor. May modulate BMP and TGF-beta signal transduction, through its interaction with SMAD proteins.

Gene Wiki entry for ZNF8 Gene

Additional gene information for ZNF8 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ZNF8 Gene

Genomics for ZNF8 Gene

GeneHancer (GH) Regulatory Elements for ZNF8 Gene

Promoters and enhancers for ZNF8 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J058277 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 650.7 +0.2 173 2.6 HDGF PKNOX1 MLX ARID4B SIN3A DMAP1 ZBTB7B YY1 POLR2B ZNF766 LOC105372482 ENSG00000267216 ZNF8 TRIM28 ZNF543 ZNF417 ZNF548 ZNF550 ZNF17 ZNF606
GH19J058300 Promoter 0.6 EPDnew 650.3 +21.8 21806 0.1 REST GC19P058302 PIR53955 ZNF8 ZNF544 ZNF446 RNU6-1337P ZNF329 ERVK3-1 ENSG00000267216 GC19P058237
GH19J058298 Promoter 0.5 EPDnew 650.4 +19.9 19898 0.1 GC19P058302 PIR53955 ZNF8 ZNF544 ZNF446 RNU6-1337P ZNF329 ENSG00000267216 GC19P058237 ENSG00000283515
GH19J058400 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 3.9 +122.5 122503 2.2 HDGF PKNOX1 ARID4B NEUROD1 SIN3A YY1 SLC30A9 POLR2B E2F8 ZNF207 ZNF584 LINC02560 GC19P058413 ZNF132 TRIM28 ZNF606 ZNF549 ENSG00000232098 MZF1 ZNF417
GH19J058537 Promoter/Enhancer 1.5 FANTOM5 Ensembl ENCODE 4.1 +259.4 259368 2.3 SOX13 USF1 RB1 BACH1 ETS1 POLR2A NR2F6 SOX5 ZNF687 RNF2 ZBTB45 ZNF584 ZSCAN18 ENSG00000232098 ZNF8 ZNF544 TRIM28 ZNF329 ZNF497 ZNF324
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around ZNF8 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the ZNF8 gene promoter:
  • STAT5A
  • Pax-2
  • Pax-2a
  • Sox9
  • CBF(2)
  • NF-Y
  • Pbx1a
  • Zic1

Genomic Locations for ZNF8 Gene

Genomic Locations for ZNF8 Gene
23,855 bases
Plus strand
16,937 bases
Plus strand

Genomic View for ZNF8 Gene

Genes around ZNF8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ZNF8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ZNF8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ZNF8 Gene

Proteins for ZNF8 Gene

  • Protein details for ZNF8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc finger protein 8
    Protein Accession:
    Secondary Accessions:
    • Q6PI99

    Protein attributes for ZNF8 Gene

    575 amino acids
    Molecular mass:
    64970 Da
    Quaternary structure:
    • Interacts with SMAD1 (via MH1 and MH2 domains) (By similarity). Interacts with SMAD5 (PubMed:12370310). Interacts weakly with SMAD2 (By similarity). Interacts weakly with SMAD3 and SMAD4 (PubMed:12370310).

neXtProt entry for ZNF8 Gene

Post-translational modifications for ZNF8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ZNF8 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ZNF8 Gene

Domains & Families for ZNF8 Gene

Gene Families for ZNF8 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for ZNF8 Gene

Suggested Antigen Peptide Sequences for ZNF8 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the krueppel C2H2-type zinc-finger protein family.
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with ZNF8: view

Function for ZNF8 Gene

Molecular function for ZNF8 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional repressor. May modulate BMP and TGF-beta signal transduction, through its interaction with SMAD proteins.
GENATLAS Biochemistry:
zinc finger protein 8 (clone ZFP.18) (C2H2,Kruppel-like)

Gene Ontology (GO) - Molecular Function for ZNF8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding NAS 2106481
GO:0003700 DNA binding transcription factor activity IBA --
GO:0008270 zinc ion binding NAS 2106481
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ZNF8: view
genes like me logo Genes that share phenotypes with ZNF8: view

Animal Model Products

CRISPR Products

miRNA for ZNF8 Gene

miRTarBase miRNAs that target ZNF8

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF8

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ZNF8 Gene

Localization for ZNF8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ZNF8 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ZNF8 gene
Compartment Confidence
nucleus 5
cytosol 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ZNF8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with ZNF8: view

Pathways & Interactions for ZNF8 Gene

No Data Available

Interacting Proteins for ZNF8 Gene

Gene Ontology (GO) - Biological Process for ZNF8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IBA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA,IBA --
GO:0030509 BMP signaling pathway IEA --
genes like me logo Genes that share ontologies with ZNF8: view

No data available for Pathways by source and SIGNOR curated interactions for ZNF8 Gene

Drugs & Compounds for ZNF8 Gene

No Compound Related Data Available

Transcripts for ZNF8 Gene

mRNA/cDNA for ZNF8 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(253) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ZNF8 Gene

Zinc finger protein 8:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for ZNF8

Alternative Splicing Database (ASD) splice patterns (SP) for ZNF8 Gene

No ASD Table

Relevant External Links for ZNF8 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ZNF8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ZNF8 Gene

Protein differential expression in normal tissues from HIPED for ZNF8 Gene

This gene is overexpressed in Heart (30.7), Islet of Langerhans (15.9), and Saliva (13.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ZNF8 Gene

NURSA nuclear receptor signaling pathways regulating expression of ZNF8 Gene:


SOURCE GeneReport for Unigene cluster for ZNF8 Gene:


mRNA Expression by UniProt/SwissProt for ZNF8 Gene:

Tissue specificity: Ubiquitously present in many human cell lines of different embryological derivation.
genes like me logo Genes that share expression patterns with ZNF8: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ZNF8 Gene

Orthologs for ZNF8 Gene

This gene was present in the common ancestor of mammals.

Orthologs for ZNF8 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ZNF8 33
  • 99.25 (n)
(Canis familiaris)
Mammalia ZNF8 33
  • 83.28 (n)
(Mus musculus)
Mammalia Zfp128 16 33
  • 79.09 (n)
(Rattus norvegicus)
Mammalia LOC102553002 33
  • 79.02 (n)
Species where no ortholog for ZNF8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ZNF8 Gene

Gene Tree for ZNF8 (if available)
Gene Tree for ZNF8 (if available)
Evolutionary constrained regions (ECRs) for ZNF8: view image

Paralogs for ZNF8 Gene

Paralogs for ZNF8 Gene

(375) SIMAP similar genes for ZNF8 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ZNF8: view

Variants for ZNF8 Gene

Sequence variations from dbSNP and Humsavar for ZNF8 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000019488 -- 58,286,804(+) G/A intron_variant
rs1000233911 -- 58,290,822(+) G/A intron_variant
rs1000256372 -- 58,284,205(+) C/T intron_variant
rs1000280390 -- 58,293,444(+) G/A intron_variant
rs1000289380 -- 58,277,760(+) A/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for ZNF8 Gene

Variant ID Type Subtype PubMed ID
nsv1058109 CNV gain 25217958
nsv1066059 CNV gain 25217958
nsv833886 CNV gain 17160897
nsv833887 CNV loss 17160897

Variation tolerance for ZNF8 Gene

Residual Variation Intolerance Score: 70.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.08; 22.08% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for ZNF8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ZNF8 Gene

Disorders for ZNF8 Gene

Additional Disease Information for ZNF8

No disorders were found for ZNF8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ZNF8 Gene

Publications for ZNF8 Gene

  1. cDNA isolation, expression analysis, and chromosomal localization of two human zinc finger genes. (PMID: 2106481) Lania L … Pelicci PG (Genomics 1990) 2 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Identification of mZnf8, a mouse Krüppel-like transcriptional repressor, as a novel nuclear interaction partner of Smad1. (PMID: 12370310) Jiao K … Hogan BL (Molecular and cellular biology 2002) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 58

Products for ZNF8 Gene

Sources for ZNF8 Gene

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