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Aliases for WNT2B Gene

Aliases for WNT2B Gene

  • Wnt Family Member 2B 2 3 5
  • Wingless-Type MMTV Integration Site Family, Member 13 2 3
  • Wingless-Type MMTV Integration Site Family, Member 2B 2 3
  • XWNT2, Xenopus, Homolog Of 2 3
  • WNT13 3 4
  • Protein Wnt-2b 3
  • Protein Wnt-13 4

External Ids for WNT2B Gene

Previous HGNC Symbols for WNT2B Gene

  • WNT13

Previous GeneCards Identifiers for WNT2B Gene

  • GC01P113426
  • GC01P111881
  • GC01P112112
  • GC01P112308
  • GC01P112722
  • GC01P112810
  • GC01P113009
  • GC01P110867

Summaries for WNT2B Gene

Entrez Gene Summary for WNT2B Gene

  • This gene encodes a member of the wingless-type MMTV integration site (WNT) family of highly conserved, secreted signaling factors. WNT family members function in a variety of developmental processes including regulation of cell growth and differentiation and are characterized by a WNT-core domain. This gene may play a role in human development as well as carcinogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

GeneCards Summary for WNT2B Gene

WNT2B (Wnt Family Member 2B) is a Protein Coding gene. Diseases associated with WNT2B include Diarrhea. Among its related pathways are Presynaptic function of Kainate receptors and HTLV-I infection. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and frizzled binding. An important paralog of this gene is WNT2.

UniProtKB/Swiss-Prot for WNT2B Gene

  • Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt/beta-catenin signaling pathway. Plays a redundant role in embryonic lung development.

Gene Wiki entry for WNT2B Gene

Additional gene information for WNT2B Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WNT2B Gene

Genomics for WNT2B Gene

GeneHancer (GH) Regulatory Elements for WNT2B Gene

Promoters and enhancers for WNT2B Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J112507 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 650.3 +42.6 42620 2.9 SIN3A GLI4 ZNF2 YY1 GLIS2 ZNF213 ZNF416 ZNF143 ZNF202 SP3 WNT2B LRIG2 ST7L LOC100421402 DDX20 GC01M112502 GC01P112514
GH01J112462 Promoter/Enhancer 1.6 Ensembl ENCODE 661.7 -1.8 -1774 5 HDGF PKNOX1 CLOCK FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B WNT2B LOC100421402 DDX20 ST7L LRIG2 CTTNBP2NL MIR4256
GH01J112388 Enhancer 1.4 Ensembl ENCODE dbSUPER 20 -76.0 -76003 3.5 PKNOX1 ATF1 ARID4B SIN3A DMAP1 ZNF2 IRF4 ZNF48 E2F8 ARID2 GC01P112392 WNT2B CTTNBP2NL RHOC PPM1J ENSG00000238761
GH01J112696 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 10 +235.9 235912 11.2 CLOCK MLX DMAP1 YY1 ZNF213 E2F8 ZNF143 ZNF263 SP3 MEF2D RHOC PIR32287 PIR38214 ST7L LOC100421402 LRIG2 DDX20 SLC16A1-AS1 CAPZA1 WNT2B
GH01J112617 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10 +153.8 153772 6.2 HDGF PKNOX1 CLOCK SMAD1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 ST7L CAPZA1 LOC100421402 LRIG2 KCND3-AS1 DDX20 RPS15P1 LOC105378910 MOV10 ENSG00000225075
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around WNT2B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the WNT2B gene promoter:
  • AP-1
  • ATF-2
  • c-Jun
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4

Genomic Locations for WNT2B Gene

Genomic Locations for WNT2B Gene
63,625 bases
Plus strand
63,625 bases
Plus strand

Genomic View for WNT2B Gene

Genes around WNT2B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WNT2B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WNT2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WNT2B Gene

Proteins for WNT2B Gene

  • Protein details for WNT2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Wnt-2b
    Protein Accession:
    Secondary Accessions:
    • O14903
    • Q5TEH9
    • Q5TEI2
    • Q9HDC1
    • Q9HDC2

    Protein attributes for WNT2B Gene

    391 amino acids
    Molecular mass:
    43770 Da
    Quaternary structure:
    • Forms a soluble 1:1 complex with AFM; this prevents oligomerization and is required for prolonged biological activity (PubMed:26902720). The complex with AFM may represent the physiological form in body fluids (PubMed:26902720). Interacts with FZD4 and FZD5 (By similarity).

    Alternative splice isoforms for WNT2B Gene


neXtProt entry for WNT2B Gene

Post-translational modifications for WNT2B Gene

  • Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.
  • Glycosylation at isoforms=2283 and isoforms=2117
  • Modification sites at PhosphoSitePlus

Other Protein References for WNT2B Gene

No data available for DME Specific Peptides for WNT2B Gene

Domains & Families for WNT2B Gene

Gene Families for WNT2B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for WNT2B Gene

Suggested Antigen Peptide Sequences for WNT2B Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the Wnt family.
  • Belongs to the Wnt family.
genes like me logo Genes that share domains with WNT2B: view

Function for WNT2B Gene

Molecular function for WNT2B Gene

UniProtKB/Swiss-Prot Function:
Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt/beta-catenin signaling pathway. Plays a redundant role in embryonic lung development.
GENATLAS Biochemistry:
wingless type 2B,Drosophila wingless (wg),segment polarity gene homolog,expressed in breast,gastric cancer,modulating cell fate and cell behavior during vertebrate development

Phenotypes From GWAS Catalog for WNT2B Gene

Gene Ontology (GO) - Molecular Function for WNT2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 signaling receptor binding IEA --
GO:0005109 frizzled binding IBA --
genes like me logo Genes that share ontologies with WNT2B: view
genes like me logo Genes that share phenotypes with WNT2B: view

Animal Models for WNT2B Gene

MGI Knock Outs for WNT2B:

Animal Model Products

  • Taconic Biosciences Mouse Models for WNT2B

Clone Products

  • Addgene plasmids for WNT2B

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for WNT2B Gene

Localization for WNT2B Gene

Subcellular locations from UniProtKB/Swiss-Prot for WNT2B Gene

Secreted, extracellular space, extracellular matrix. Secreted.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WNT2B gene
Compartment Confidence
extracellular 5
plasma membrane 1
mitochondrion 1
nucleus 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for WNT2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space NAS,IBA 15135146
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with WNT2B: view

Pathways & Interactions for WNT2B Gene

genes like me logo Genes that share pathways with WNT2B: view

SIGNOR curated interactions for WNT2B Gene


Gene Ontology (GO) - Biological Process for WNT2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002062 chondrocyte differentiation IEP 15135146
GO:0002088 lens development in camera-type eye ISS 16258938
GO:0007275 multicellular organism development IEA --
GO:0008584 male gonad development IEP 17848411
GO:0009267 cellular response to starvation IEA --
genes like me logo Genes that share ontologies with WNT2B: view

Drugs & Compounds for WNT2B Gene

No Compound Related Data Available

Transcripts for WNT2B Gene

mRNA/cDNA for WNT2B Gene

Unigene Clusters for WNT2B Gene

Wingless-type MMTV integration site family, member 2B:
Representative Sequences:

Clone Products

  • Addgene plasmids for WNT2B

Alternative Splicing Database (ASD) splice patterns (SP) for WNT2B Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b
SP1: -
SP2: - -

Relevant External Links for WNT2B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for WNT2B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for WNT2B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for WNT2B Gene

This gene is overexpressed in Testis (46.9) and Prostate (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for WNT2B Gene

Protein tissue co-expression partners for WNT2B Gene

NURSA nuclear receptor signaling pathways regulating expression of WNT2B Gene:


SOURCE GeneReport for Unigene cluster for WNT2B Gene:


mRNA Expression by UniProt/SwissProt for WNT2B Gene:

Tissue specificity: Isoform 1 is expressed in adult heart, brain, placenta, lung, prostate, testis, ovary, small intestine and colon. In the adult brain, it is mainly found in the caudate nucleus, subthalamic nucleus and thalamus. Also detected in fetal brain, lung and kidney. Isoform 2 is expressed in fetal brain, fetal lung, fetal kidney, caudate nucleus, testis and cancer cell lines.
genes like me logo Genes that share expression patterns with WNT2B: view

No data available for mRNA differential expression in normal tissues , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for WNT2B Gene

Orthologs for WNT2B Gene

This gene was present in the common ancestor of animals.

Orthologs for WNT2B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia WNT2B 34 33
  • 99.6 (n)
(Canis familiaris)
Mammalia WNT2B 34
  • 99 (a)
LOC483220 33
  • 92.63 (n)
(Bos Taurus)
Mammalia WNT2B 34 33
  • 92.5 (n)
(Monodelphis domestica)
Mammalia WNT2B 34
  • 91 (a)
(Rattus norvegicus)
Mammalia Wnt2b 33
  • 88.32 (n)
(Mus musculus)
Mammalia Wnt2b 16 34 33
  • 87.49 (n)
(Ornithorhynchus anatinus)
Mammalia WNT2B 34
  • 87 (a)
(Gallus gallus)
Aves WNT2B 34 33
  • 75.27 (n)
(Anolis carolinensis)
Reptilia WNT2B 34
  • 82 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100491761 33
  • 70.62 (n)
African clawed frog
(Xenopus laevis)
Amphibia wnt2b-A 33
(Danio rerio)
Actinopterygii wnt2bb 34 33
  • 70.62 (n)
wnt2ba 34
  • 70 (a)
wnt2b 33
fruit fly
(Drosophila melanogaster)
Insecta Wnt5 35
  • 50 (a)
Wnt6 35
  • 45 (a)
Wnt2 35
  • 42 (a)
Wnt4 35
  • 31 (a)
(Caenorhabditis elegans)
Secernentea cwn-2 35
  • 43 (a)
egl-20 35
  • 39 (a)
mom-2 35
  • 34 (a)
lin-44 35
  • 29 (a)
Species where no ortholog for WNT2B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WNT2B Gene

Gene Tree for WNT2B (if available)
Gene Tree for WNT2B (if available)
Evolutionary constrained regions (ECRs) for WNT2B: view image

Paralogs for WNT2B Gene

Paralogs for WNT2B Gene

(18) SIMAP similar genes for WNT2B Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with WNT2B: view

Variants for WNT2B Gene

Sequence variations from dbSNP and Humsavar for WNT2B Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs879255420 uncertain-significance, not specified 112,515,004(+) C/T coding_sequence_variant, stop_gained
rs1000148190 -- 112,499,473(+) A/G genic_upstream_transcript_variant, intron_variant
rs1000193999 -- 112,474,517(+) A/G genic_upstream_transcript_variant, intron_variant
rs1000216159 -- 112,496,568(+) G/C genic_upstream_transcript_variant, intron_variant
rs1000256537 -- 112,487,184(+) A/G genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for WNT2B Gene

Variant ID Type Subtype PubMed ID
esv1009068 CNV deletion 20482838
esv2659003 CNV deletion 23128226
esv27061 CNV gain+loss 19812545
esv3587213 CNV loss 21293372
nsv1008375 CNV loss 25217958
nsv831081 CNV loss 17160897
nsv951397 CNV deletion 24416366

Variation tolerance for WNT2B Gene

Residual Variation Intolerance Score: 16.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.63; 31.28% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for WNT2B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WNT2B Gene

Disorders for WNT2B Gene

MalaCards: The human disease database

(1) MalaCards diseases for WNT2B Gene - From: ClinVar

Disorder Aliases PubMed IDs
  • diarrhea of presumed infectious origin
- elite association - COSMIC cancer census association via MalaCards
Search WNT2B in MalaCards View complete list of genes associated with diseases

Additional Disease Information for WNT2B

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with WNT2B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for WNT2B Gene

Publications for WNT2B Gene

  1. Alternative splicing of the WNT-2B/WNT-13 gene. (PMID: 10944466) Katoh M … Koike J (Biochemical and biophysical research communications 2000) 2 3 4 22 58
  2. CLC- a novel susceptibility gene for allergic rhinitis? (PMID: 19650845) Bryborn M … Cardell LO (Allergy 2010) 3 22 44 58
  3. Cloning, expression and chromosomal localization of Wnt-13, a novel member of the Wnt gene family. (PMID: 8761309) Katoh M … Terada M (Oncogene 1996) 2 3 4 58
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  5. MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer. (PMID: 20819778) Zhang X … Wu X (Carcinogenesis 2010) 3 44 58

Products for WNT2B Gene

Sources for WNT2B Gene

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