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Aliases for WNT8B Gene

Aliases for WNT8B Gene

  • Wnt Family Member 8B 2 3 5
  • Wingless-Type MMTV Integration Site Family, Member 8B 2 3
  • Protein Wnt-8b 3

External Ids for WNT8B Gene

Previous GeneCards Identifiers for WNT8B Gene

  • GC10P101116
  • GC10P101456
  • GC10P102354
  • GC10P101887
  • GC10P102212
  • GC10P095851

Summaries for WNT8B Gene

Entrez Gene Summary for WNT8B Gene

  • The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 95%, 86% and 71% amino acid identity to the mouse, zebrafish and Xenopus Wnt8B proteins, respectively. The expression patterns of the human and mouse genes appear identical and are restricted to the developing brain. The chromosomal location of this gene to 10q24 suggests it as a candidate gene for partial epilepsy. [provided by RefSeq, Jul 2008]

GeneCards Summary for WNT8B Gene

WNT8B (Wnt Family Member 8B) is a Protein Coding gene. Among its related pathways are Presynaptic function of Kainate receptors and HTLV-I infection. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and frizzled binding. An important paralog of this gene is WNT8A.

UniProtKB/Swiss-Prot for WNT8B Gene

  • Ligand for members of the frizzled family of seven transmembrane receptors. May play an important role in the development and differentiation of certain forebrain structures, notably the hippocampus.

Gene Wiki entry for WNT8B Gene

Additional gene information for WNT8B Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WNT8B Gene

Genomics for WNT8B Gene

GeneHancer (GH) Regulatory Elements for WNT8B Gene

Promoters and enhancers for WNT8B Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J100518 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE 11.3 +56.6 56557 1.6 CTCF SAP130 ARID4B SIN3A ZNF48 RAD21 RFX5 ZNF664 GATAD1 SCRT2 SEC31B WNT8B BLOC1S2 CWF19L1 ENSG00000255339 GC10M100501 GC10M100502
GH10J100341 Enhancer 1.4 Ensembl ENCODE dbSUPER 11 -121.0 -121019 2 HDGF FOXA2 ARID4B DMAP1 ZNF2 ZNF48 ETS1 YY1 ARID2 ZNF143 PKD2L1 WNT8B CWF19L1 RNU6-422P ENSG00000231188 BLOC1S2
GH10J100434 Enhancer 1 ENCODE 11.6 -29.1 -29082 0.2 HDGF ATF1 ARNT ARID4B SIN3A ZNF2 ZNF48 SLC30A9 ZNF213 ARID2 SEC31B SCD ENSG00000231188 WNT8B NDUFB8 HIF1AN ENSG00000255339 ENSG00000212325 OLMALINC
GH10J100433 Enhancer 0.9 Ensembl 11.6 -29.3 -29340 0.2 HDGF ATF1 ARNT SIN3A ZNF48 SLC30A9 ZNF213 ZNF143 ATF7 SP3 SCD ENSG00000231188 WNT8B SEC31B ENSG00000255339 NDUFB8 HIF1AN ENSG00000212325 OLMALINC
GH10J100019 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 1.9 -442.6 -442607 2.9 ELF3 PKNOX1 FOXA2 ZSCAN4 KLF17 DMAP1 BATF ZBTB7B IRF4 RAD21 DNMBP CUTC WNT8B CPN1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around WNT8B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the WNT8B gene promoter:
  • GATA-3
  • POU2F1
  • oct-B2
  • oct-B3
  • POU2F1a
  • POU2F2
  • POU2F2 (Oct-2.1)
  • POU2F2B
  • POU2F2C
  • Oct-B1

Genomic Locations for WNT8B Gene

Genomic Locations for WNT8B Gene
20,704 bases
Plus strand
20,704 bases
Plus strand

Genomic View for WNT8B Gene

Genes around WNT8B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WNT8B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WNT8B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WNT8B Gene

Proteins for WNT8B Gene

  • Protein details for WNT8B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Wnt-8b
    Protein Accession:
    Secondary Accessions:
    • O00771
    • Q5VX55
    • Q8WYK9

    Protein attributes for WNT8B Gene

    351 amino acids
    Molecular mass:
    38721 Da
    Quaternary structure:
    No Data Available

neXtProt entry for WNT8B Gene

Post-translational modifications for WNT8B Gene

  • Palmitoleoylation is required for efficient binding to frizzled receptors (By similarity). Depalmitoleoylation leads to Wnt signaling pathway inhibition (By similarity).
  • Proteolytic processing by TIKI1 and TIKI2 promotes oxidation and formation of large disulfide-bond oligomers, leading to inactivation of WNT8B.
  • Glycosylation at isoforms=259 and posLast=103103
  • Modification sites at PhosphoSitePlus

Other Protein References for WNT8B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for WNT8B Gene

Domains & Families for WNT8B Gene

Gene Families for WNT8B Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for WNT8B Gene

Suggested Antigen Peptide Sequences for WNT8B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the Wnt family.
  • Belongs to the Wnt family.
genes like me logo Genes that share domains with WNT8B: view

Function for WNT8B Gene

Molecular function for WNT8B Gene

UniProtKB/Swiss-Prot Function:
Ligand for members of the frizzled family of seven transmembrane receptors. May play an important role in the development and differentiation of certain forebrain structures, notably the hippocampus.
GENATLAS Biochemistry:
wingless-type MMTV integration site 8B,member of the WNT family encoding intercellular signaling molecules,expressed in the developing forebrain,Drosophila wingless (Wg) segment polarity gene homolog,modulating cell fate and cell behavior during vertebrate development

Phenotypes From GWAS Catalog for WNT8B Gene

Gene Ontology (GO) - Molecular Function for WNT8B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005109 frizzled binding IBA --
GO:0048018 receptor ligand activity IDA 28733458
genes like me logo Genes that share ontologies with WNT8B: view
genes like me logo Genes that share phenotypes with WNT8B: view

Animal Models for WNT8B Gene

MGI Knock Outs for WNT8B:

Animal Model Products

  • Taconic Biosciences Mouse Models for WNT8B

Clone Products

  • Addgene plasmids for WNT8B

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for WNT8B Gene

Localization for WNT8B Gene

Subcellular locations from UniProtKB/Swiss-Prot for WNT8B Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WNT8B gene
Compartment Confidence
extracellular 5
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for WNT8B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IBA --
genes like me logo Genes that share ontologies with WNT8B: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for WNT8B Gene

Pathways & Interactions for WNT8B Gene

genes like me logo Genes that share pathways with WNT8B: view

SIGNOR curated interactions for WNT8B Gene


Gene Ontology (GO) - Biological Process for WNT8B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction TAS 9536085
GO:0007275 multicellular organism development IEA --
GO:0007369 gastrulation ISS 7635061
GO:0007399 nervous system development TAS 9536085
GO:0010469 regulation of signaling receptor activity IEA --
genes like me logo Genes that share ontologies with WNT8B: view

Drugs & Compounds for WNT8B Gene

No Compound Related Data Available

Transcripts for WNT8B Gene

mRNA/cDNA for WNT8B Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for WNT8B Gene

Wingless-type MMTV integration site family, member 8B:
Representative Sequences:

Clone Products

  • Addgene plasmids for WNT8B

Alternative Splicing Database (ASD) splice patterns (SP) for WNT8B Gene

No ASD Table

Relevant External Links for WNT8B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for WNT8B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for WNT8B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for WNT8B Gene

This gene is overexpressed in Testis (x8.3) and Kidney - Cortex (x4.2).

Protein differential expression in normal tissues from HIPED for WNT8B Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for WNT8B Gene

Protein tissue co-expression partners for WNT8B Gene

NURSA nuclear receptor signaling pathways regulating expression of WNT8B Gene:


SOURCE GeneReport for Unigene cluster for WNT8B Gene:


mRNA Expression by UniProt/SwissProt for WNT8B Gene:

Tissue specificity: Expression is restricted to the brain, and more specifically to the forebrain.

Evidence on tissue expression from TISSUES for WNT8B Gene

  • Nervous system(4.3)
  • Blood(2.1)
genes like me logo Genes that share expression patterns with WNT8B: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for WNT8B Gene

Orthologs for WNT8B Gene

This gene was present in the common ancestor of animals.

Orthologs for WNT8B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia WNT8B 34 33
  • 99.72 (n)
(Bos Taurus)
Mammalia WNT8B 34 33
  • 93.69 (n)
(Canis familiaris)
Mammalia WNT8B 34 33
  • 93.56 (n)
(Rattus norvegicus)
Mammalia Wnt8b 33
  • 91.1 (n)
(Ornithorhynchus anatinus)
Mammalia WNT8B 34
  • 91 (a)
(Monodelphis domestica)
Mammalia WNT8B 34
  • 90 (a)
(Mus musculus)
Mammalia Wnt8b 16 34 33
  • 89.08 (n)
(Gallus gallus)
Aves WNT8B 34 33
  • 79.71 (n)
(Anolis carolinensis)
Reptilia WNT8B 34
  • 85 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia wnt8b 33
  • 72.38 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xwnt-8b 33
(Danio rerio)
Actinopterygii wnt8b 34 33 33
  • 75.17 (n)
fruit fly
(Drosophila melanogaster)
Insecta wntD 34
  • 26 (a)
(Caenorhabditis elegans)
Secernentea lin-44 34
  • 25 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 31 (a)
-- 34
  • 29 (a)
Species where no ortholog for WNT8B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WNT8B Gene

Gene Tree for WNT8B (if available)
Gene Tree for WNT8B (if available)
Evolutionary constrained regions (ECRs) for WNT8B: view image

Paralogs for WNT8B Gene

Paralogs for WNT8B Gene

(16) SIMAP similar genes for WNT8B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with WNT8B: view

Variants for WNT8B Gene

Sequence variations from dbSNP and Humsavar for WNT8B Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
VAR_036288 A colorectal cancer sample p.Glu53Gln
rs1000191400 -- 100,464,335(+) T/G intron_variant
rs1000287935 -- 100,463,862(+) G/A intron_variant
rs1000383006 -- 100,475,067(+) C/G intron_variant
rs1000623963 -- 100,462,093(+) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for WNT8B Gene

Variant ID Type Subtype PubMed ID
esv2759779 CNV gain+loss 17122850
esv34217 CNV gain 17911159
esv3624362 CNV gain 21293372
nsv818783 CNV gain 17921354
nsv819434 CNV loss 19587683
nsv831962 CNV gain 17160897
nsv831963 CNV loss 17160897
nsv8723 CNV gain 18304495

Variation tolerance for WNT8B Gene

Residual Variation Intolerance Score: 35.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.95; 79.84% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for WNT8B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WNT8B Gene

Disorders for WNT8B Gene

Additional Disease Information for WNT8B

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for WNT8B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WNT8B Gene

Publications for WNT8B Gene

  1. Isolation and characterization of WNT8B, a novel human Wnt gene that maps to 10q24. (PMID: 8661156) Lako M … Lindsay S (Genomics 1996) 2 3 4 22 58
  2. Up-regulation of WNT8B mRNA in human gastric cancer. (PMID: 11788899) Saitoh T … Katoh M (International journal of oncology 2002) 3 4 22 58
  3. A novel mammalian wnt gene, WNT8B, shows brain-restricted expression in early development, with sharply delimited expression boundaries in the developing forebrain. (PMID: 9536085) Lako M … Strachan T (Human molecular genetics 1998) 3 4 22 58
  4. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A … Goate A (American journal of human genetics 2006) 3 44 58
  5. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P … Rogers J (Nature 2004) 3 4 58

Products for WNT8B Gene

Sources for WNT8B Gene

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