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Aliases for WNT8A Gene

Aliases for WNT8A Gene

  • Wnt Family Member 8A 2 3 5
  • Wingless-Type MMTV Integration Site Family, Member 8A 2 3
  • Protein Wnt-8d 3 4
  • WNT8D 3 4
  • Protein Wnt-8a 3
  • WNT8d 3

External Ids for WNT8A Gene

Previous GeneCards Identifiers for WNT8A Gene

  • GC05P137294
  • GC05P137450
  • GC05P137495
  • GC05P137447
  • GC05P132610

Summaries for WNT8A Gene

Entrez Gene Summary for WNT8A Gene

  • The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family, and may be implicated in development of early embryos as well as germ cell tumors. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2014]

GeneCards Summary for WNT8A Gene

WNT8A (Wnt Family Member 8A) is a Protein Coding gene. Among its related pathways are Presynaptic function of Kainate receptors and HTLV-I infection. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and receptor ligand activity. An important paralog of this gene is WNT8B.

UniProtKB/Swiss-Prot for WNT8A Gene

  • Ligand for members of the frizzled family of seven transmembrane receptors. Plays a role in embryonic patterning.

Additional gene information for WNT8A Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for WNT8A Gene

Genomics for WNT8A Gene

GeneHancer (GH) Regulatory Elements for WNT8A Gene

Promoters and enhancers for WNT8A Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J138083 Promoter 0.6 EPDnew 650.7 +0.0 3 0.1 ZNF335 WNT8A PIR31393
GH05J138027 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 11.1 -52.6 -52594 6.8 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF213 ZNF207 LOC100130172 FAM13B BRD8 CDC23 HNRNPA0 RNU6-1148P NME5 WNT8A RNU6-888P KDM3B
GH05J138035 Enhancer 1.1 Ensembl ENCODE 11.2 -47.8 -47795 1 PKNOX1 FOXA2 ARNT ARID4B ZNF2 YY1 ZNF121 ZNF143 ATF7 DEK RNU6-1148P WNT8A NME5 RNU6-888P ENSG00000250260 LOC100130172 FAM13B
GH05J138540 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 2 +459.8 459786 7 CLOCK DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC ZNF610 ETF1 LOC105379193 GC05P138544 CDC23 HNRNPA0 BRD8 ENSG00000232174 KDM3B WNT8A FAM53C
GH05J138034 Enhancer 0.4 FANTOM5 11.2 -49.0 -48956 0.2 ZNF362 ZNF384 NME5 RNU6-1148P WNT8A RNU6-888P FAM53C PKD2L2 FAM13B KDM3B LOC100130172 ENSG00000250260
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around WNT8A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the WNT8A gene promoter:
  • HNF-4alpha2
  • HNF-4alpha1
  • AREB6
  • SRF (504 AA)
  • SRF
  • AML1a
  • p53
  • Egr-2
  • Lmo2
  • Pax-2a

Genomic Locations for WNT8A Gene

Genomic Locations for WNT8A Gene
12,839 bases
Plus strand
8,474 bases
Plus strand

Genomic View for WNT8A Gene

Genes around WNT8A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
WNT8A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for WNT8A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for WNT8A Gene

Proteins for WNT8A Gene

  • Protein details for WNT8A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Wnt-8a
    Protein Accession:
    Secondary Accessions:
    • Q96S51

    Protein attributes for WNT8A Gene

    351 amino acids
    Molecular mass:
    38849 Da
    Quaternary structure:
    • Forms a soluble 1:1 complex with AFM; this prevents oligomerization and is required for prolonged biological activity (PubMed:26902720). The complex with AFM may represent the physiological form in body fluids (PubMed:26902720).

    Alternative splice isoforms for WNT8A Gene


neXtProt entry for WNT8A Gene

Post-translational modifications for WNT8A Gene

  • Palmitoleoylation is required for efficient binding to frizzled receptors (By similarity). Depalmitoleoylation leads to Wnt signaling pathway inhibition (By similarity).
  • Proteolytic processing by TIKI1 and TIKI2 promotes oxidation and formation of large disulfide-bond oligomers, leading to inactivation of WNT8A.
  • Glycosylation at posLast=281281, isoforms=2262, and isoforms=2103
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for WNT8A Gene

Domains & Families for WNT8A Gene

Gene Families for WNT8A Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for WNT8A Gene

Suggested Antigen Peptide Sequences for WNT8A Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the Wnt family.
  • Belongs to the Wnt family.
genes like me logo Genes that share domains with WNT8A: view

Function for WNT8A Gene

Molecular function for WNT8A Gene

UniProtKB/Swiss-Prot Function:
Ligand for members of the frizzled family of seven transmembrane receptors. Plays a role in embryonic patterning.

Phenotypes From GWAS Catalog for WNT8A Gene

Gene Ontology (GO) - Molecular Function for WNT8A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 signaling receptor binding IEA --
GO:0005109 frizzled binding NAS,IBA 11408932
GO:0048018 receptor ligand activity IDA,NAS 11408932
genes like me logo Genes that share ontologies with WNT8A: view
genes like me logo Genes that share phenotypes with WNT8A: view

Animal Models for WNT8A Gene

MGI Knock Outs for WNT8A:
  • Wnt8a Wnt8a<tm1(KOMP)Vlcg>

Animal Model Products

miRNA for WNT8A Gene

miRTarBase miRNAs that target WNT8A

Clone Products

  • Addgene plasmids for WNT8A

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for WNT8A Gene

Localization for WNT8A Gene

Subcellular locations from UniProtKB/Swiss-Prot for WNT8A Gene

Secreted, extracellular space, extracellular matrix. Secreted.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for WNT8A gene
Compartment Confidence
extracellular 5
plasma membrane 2
cytosol 2
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (1)
  • Plasma membrane (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for WNT8A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 colocalizes_with extracellular space ISS --
genes like me logo Genes that share ontologies with WNT8A: view

Pathways & Interactions for WNT8A Gene

genes like me logo Genes that share pathways with WNT8A: view

SIGNOR curated interactions for WNT8A Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for WNT8A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003002 regionalization IEA --
GO:0007275 multicellular organism development IEA --
GO:0007492 endoderm development IEA --
GO:0009949 polarity specification of anterior/posterior axis IEA --
GO:0010085 polarity specification of proximal/distal axis IEA --
genes like me logo Genes that share ontologies with WNT8A: view

Drugs & Compounds for WNT8A Gene

No Compound Related Data Available

Transcripts for WNT8A Gene

mRNA/cDNA for WNT8A Gene

(8) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for WNT8A Gene

Wingless-type MMTV integration site family, member 8A:
Representative Sequences:

Clone Products

  • Addgene plasmids for WNT8A

Alternative Splicing Database (ASD) splice patterns (SP) for WNT8A Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7

Relevant External Links for WNT8A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for WNT8A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for WNT8A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for WNT8A Gene

This gene is overexpressed in Brain - Putamen (basal ganglia) (x8.5), Brain - Nucleus accumbens (basal ganglia) (x7.8), Brain - Caudate (basal ganglia) (x6.6), and Testis (x6.1).

Protein differential expression in normal tissues from HIPED for WNT8A Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (68.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for WNT8A Gene

Protein tissue co-expression partners for WNT8A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of WNT8A Gene:


SOURCE GeneReport for Unigene cluster for WNT8A Gene:

genes like me logo Genes that share expression patterns with WNT8A: view

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for WNT8A Gene

Orthologs for WNT8A Gene

This gene was present in the common ancestor of animals.

Orthologs for WNT8A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia WNT8A 34 33
  • 99.43 (n)
(Canis familiaris)
Mammalia WNT8A 34 33
  • 89.74 (n)
(Bos Taurus)
Mammalia WNT8A 34 33
  • 88.79 (n)
(Rattus norvegicus)
Mammalia Wnt8a 33
  • 84.53 (n)
(Mus musculus)
Mammalia Wnt8a 16 34 33
  • 83.86 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 20 (a)
(Gallus gallus)
Aves WNT8A 33
  • 72.53 (n)
WNT8C 34
  • 71 (a)
(Anolis carolinensis)
Reptilia WNT8A 34
  • 68 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia wnt8a 33
  • 71.35 (n)
Str.15027 33
African clawed frog
(Xenopus laevis)
Amphibia Xwnt-8 33
(Danio rerio)
Actinopterygii wnt8a 34 34 33
  • 68.09 (n)
-- 33
fruit fly
(Drosophila melanogaster)
Insecta Wnt4 34
  • 17 (a)
(Caenorhabditis elegans)
Secernentea egl-20 34
  • 28 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 20 (a)
Species where no ortholog for WNT8A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for WNT8A Gene

Gene Tree for WNT8A (if available)
Gene Tree for WNT8A (if available)
Evolutionary constrained regions (ECRs) for WNT8A: view image

Paralogs for WNT8A Gene

Paralogs for WNT8A Gene

(16) SIMAP similar genes for WNT8A Gene using alignment to 3 proteins:

  • D6RF47_HUMAN
  • D6RF94_HUMAN
genes like me logo Genes that share paralogs with WNT8A: view

Variants for WNT8A Gene

Sequence variations from dbSNP and Humsavar for WNT8A Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000010025 -- 138,088,385(+) C/G intron_variant
rs1000515504 -- 138,083,156(+) C/G genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000576408 -- 138,075,509(+) G/A upstream_transcript_variant
rs1000620912 -- 138,089,939(+) G/A intron_variant
rs1000658499 -- 138,076,560(+) A/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for WNT8A Gene

Variant ID Type Subtype PubMed ID
esv3575884 CNV gain 25503493
esv3606913 CNV gain 21293372
nsv830502 CNV gain 17160897

Variation tolerance for WNT8A Gene

Residual Variation Intolerance Score: 65.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.14; 23.03% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for WNT8A Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for WNT8A Gene

Disorders for WNT8A Gene

Additional Disease Information for WNT8A

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for WNT8A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for WNT8A Gene

Publications for WNT8A Gene

  1. Molecular cloning and characterization of human WNT8A. (PMID: 11408932) Saitoh T … Katoh M (International journal of oncology 2001) 2 3 4 58
  2. Studies with Wnt genes and nonsyndromic cleft lip and palate. (PMID: 20890934) Menezes R … Vieira AR (Birth defects research. Part A, Clinical and molecular teratology 2010) 3 44 58
  3. Variation in WNT genes is associated with non-syndromic cleft lip with or without cleft palate. (PMID: 18413325) Chiquet BT … Hecht JT (Human molecular genetics 2008) 3 44 58
  4. Mapping of Wnt-Frizzled interactions by multiplex CRISPR targeting of receptor gene families. (PMID: 28733458) Voloshanenko O … Boutros M (FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2017) 3 58
  5. Active and water-soluble form of lipidated Wnt protein is maintained by a serum glycoprotein afamin/α-albumin. (PMID: 26902720) Mihara E … Takagi J (eLife 2016) 4 58

Products for WNT8A Gene

Sources for WNT8A Gene

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