Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CORO2A Gene

Aliases for CORO2A Gene

  • Coronin 2A 2 2 3 5
  • WD Repeat-Containing Protein 2 3 4
  • Coronin-Like Protein B 2 3
  • WD-Repeat Protein 2 2 3
  • WD Protein IR10 2 3
  • IR10 3 4
  • WDR2 3 4
  • Coronin, Actin Binding Protein, 2A 3
  • Coronin, Actin-Binding Protein, 2A 2
  • Coronin-2A 3
  • CLIPINB 3

External Ids for CORO2A Gene

Previous GeneCards Identifiers for CORO2A Gene

  • GC09M091711
  • GC09M092629
  • GC09M094343
  • GC09M096266
  • GC09M096263
  • GC09M097966
  • GC09M099923
  • GC09M100883
  • GC09M070483

Summaries for CORO2A Gene

Entrez Gene Summary for CORO2A Gene

  • This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 5 WD repeats, and has a structural similarity with actin-binding proteins: the D. discoideum coronin and the human p57 protein, suggesting that this protein may also be an actin-binding protein that regulates cell motility. Alternative splicing of this gene generates 2 transcript variants. [provided by RefSeq, Jul 2008]

GeneCards Summary for CORO2A Gene

CORO2A (Coronin 2A) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include actin filament binding. An important paralog of this gene is CORO2B.

Gene Wiki entry for CORO2A Gene

Additional gene information for CORO2A Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CORO2A Gene

Genomics for CORO2A Gene

GeneHancer (GH) Regulatory Elements for CORO2A Gene

Promoters and enhancers for CORO2A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J098187 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 667.7 +1.8 1785 6.2 CLOCK ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF213 E2F8 ZNF143 SP3 CORO2A TBC1D2 NCBP1 TRIM14 ZNF322P1 PIR60537
GH09J098117 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 22.7 +72.4 72449 5.6 PKNOX1 FOXA2 MLX ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 SLC30A9 TRIM14 NCBP1 ENSG00000235494 CORO2A ENSG00000254633 LOC100288125 LOC286359 ZNF322P1 ANKS6 TSTD2
GH09J098221 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 17.7 -35.7 -35715 14.8 HDGF PKNOX1 SMAD1 FOXA2 ARNT ARID4B FEZF1 DMAP1 YY1 ZNF766 MIR6854 TBC1D2 CORO2A NCBP1 TSTD2 TRIM14 LOC100131625
GH09J098246 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.2 -59.1 -59130 11 CLOCK DMAP1 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC ZNF610 GLIS1 TBC1D2 COL15A1 CORO2A ENSG00000270412 TGFBR1 NANS TRMO LOC100131625
GH09J098263 Enhancer 1 Ensembl ENCODE 22.5 -71.3 -71326 0.4 HDGF RB1 ARNT ARID4B ZNF2 ZBTB40 RAD21 ZNF614 ARID2 SCRT2 CORO2A TBC1D2 TRIM14 RNU6-918P GC09M098492
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around CORO2A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CORO2A gene promoter:
  • p53
  • C/EBPbeta
  • AP-4
  • HEN1
  • E47
  • MAZR
  • GCNF
  • GCNF-1

Genomic Locations for CORO2A Gene

Genomic Locations for CORO2A Gene
chr9:98,120,975-98,192,674
(GRCh38/hg38)
Size:
71,700 bases
Orientation:
Minus strand
chr9:100,883,257-100,954,956
(GRCh37/hg19)
Size:
71,700 bases
Orientation:
Minus strand

Genomic View for CORO2A Gene

Genes around CORO2A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CORO2A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CORO2A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CORO2A Gene

Proteins for CORO2A Gene

  • Protein details for CORO2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92828-COR2A_HUMAN
    Recommended name:
    Coronin-2A
    Protein Accession:
    Q92828
    Secondary Accessions:
    • Q5TBR5
    • Q92829
    • Q9BWS5

    Protein attributes for CORO2A Gene

    Size:
    525 amino acids
    Molecular mass:
    59763 Da
    Quaternary structure:
    • Binds actin (By similarity). Component of the N-Cor repressor complex, at least composed of NCOR1, NCOR2, HDAC3, TBL1X, TBL1R, CORO2A and GPS2.

neXtProt entry for CORO2A Gene

Post-translational modifications for CORO2A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CORO2A Gene

No data available for DME Specific Peptides for CORO2A Gene

Domains & Families for CORO2A Gene

Gene Families for CORO2A Gene

Suggested Antigen Peptide Sequences for CORO2A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q92828

UniProtKB/Swiss-Prot:

COR2A_HUMAN :
  • Belongs to the WD repeat coronin family.
Family:
  • Belongs to the WD repeat coronin family.
genes like me logo Genes that share domains with CORO2A: view

Function for CORO2A Gene

Molecular function for CORO2A Gene

GENATLAS Biochemistry:
coronin 2A,homolog to Dictyostelium discoideum coronin,a soluble actin-binding protein,mainly expressed in epidermis,brain,putatively involved in protein interactions

Phenotypes From GWAS Catalog for CORO2A Gene

Gene Ontology (GO) - Molecular Function for CORO2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21331046
GO:0051015 actin filament binding IBA --
genes like me logo Genes that share ontologies with CORO2A: view
genes like me logo Genes that share phenotypes with CORO2A: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CORO2A

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CORO2A Gene

Localization for CORO2A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CORO2A gene
Compartment Confidence
cytosol 4
cytoskeleton 3
plasma membrane 2
mitochondrion 1
peroxisome 1
nucleus 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CORO2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015629 actin cytoskeleton IBA --
GO:0017053 transcriptional repressor complex IDA 12628926
genes like me logo Genes that share ontologies with CORO2A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CORO2A Gene

Pathways & Interactions for CORO2A Gene

SuperPathways for CORO2A Gene

No Data Available

Gene Ontology (GO) - Biological Process for CORO2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030036 actin cytoskeleton organization IBA --
GO:0035556 intracellular signal transduction TAS 8985118
genes like me logo Genes that share ontologies with CORO2A: view

No data available for Pathways by source and SIGNOR curated interactions for CORO2A Gene

Drugs & Compounds for CORO2A Gene

No Compound Related Data Available

Transcripts for CORO2A Gene

mRNA/cDNA for CORO2A Gene

(3) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(127) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CORO2A Gene

Coronin, actin binding protein, 2A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for CORO2A

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CORO2A Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a · 14b
SP1: - - -
SP2:
SP3: -
SP4: -
SP5:

Relevant External Links for CORO2A Gene

GeneLoc Exon Structure for
CORO2A
ECgene alternative splicing isoforms for
CORO2A

Expression for CORO2A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CORO2A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CORO2A Gene

This gene is overexpressed in Esophagus - Mucosa (x4.4) and Colon - Transverse (x4.3).

Protein differential expression in normal tissues from HIPED for CORO2A Gene

This gene is overexpressed in Testis (14.7), Peripheral blood mononuclear cells (13.5), and Lung (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CORO2A Gene



Protein tissue co-expression partners for CORO2A Gene

NURSA nuclear receptor signaling pathways regulating expression of CORO2A Gene:

CORO2A

SOURCE GeneReport for Unigene cluster for CORO2A Gene:

Hs.113094

Evidence on tissue expression from TISSUES for CORO2A Gene

  • Eye(4.1)
  • Skin(4.1)
  • Gall bladder(2.3)
genes like me logo Genes that share expression patterns with CORO2A: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CORO2A Gene

Orthologs for CORO2A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CORO2A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CORO2A 34 33
  • 99.37 (n)
OneToOne
cow
(Bos Taurus)
Mammalia CORO2A 34 33
  • 87.68 (n)
OneToOne
dog
(Canis familiaris)
Mammalia CORO2A 34 33
  • 86.38 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Coro2a 33
  • 85.39 (n)
mouse
(Mus musculus)
Mammalia Coro2a 16 34 33
  • 84.96 (n)
oppossum
(Monodelphis domestica)
Mammalia CORO2A 34
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CORO2A 34
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves CORO2A 34 33
  • 71.67 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CORO2A 34
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia coro2a 33
  • 66.86 (n)
zebrafish
(Danio rerio)
Actinopterygii coro2a 34 33
  • 65.3 (n)
OneToMany
CORO2A (2 of 2) 34
  • 52 (a)
OneToMany
wufc02b08 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007525 33
  • 57.53 (n)
fruit fly
(Drosophila melanogaster)
Insecta coro 34
  • 39 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea cor-1 34 35
  • 33 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CRN1 34
  • 30 (a)
OneToMany
Species where no ortholog for CORO2A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CORO2A Gene

ENSEMBL:
Gene Tree for CORO2A (if available)
TreeFam:
Gene Tree for CORO2A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for CORO2A: view image

Paralogs for CORO2A Gene

Paralogs for CORO2A Gene

(6) SIMAP similar genes for CORO2A Gene using alignment to 1 proteins:

  • COR2A_HUMAN
genes like me logo Genes that share paralogs with CORO2A: view

Variants for CORO2A Gene

Sequence variations from dbSNP and Humsavar for CORO2A Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1000063583 -- 98,134,364(-) C/G intron_variant
rs1000065143 -- 98,181,579(-) T/C genic_upstream_transcript_variant, intron_variant
rs1000073095 -- 98,166,250(-) C/T intron_variant
rs1000142073 -- 98,141,132(-) A/G intron_variant
rs1000147714 -- 98,166,626(-) A/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CORO2A Gene

Variant ID Type Subtype PubMed ID
esv2004305 CNV deletion 18987734
esv3573304 CNV loss 25503493
esv3621201 CNV gain 21293372
nsv1077166 CNV deletion 25765185
nsv1115213 CNV deletion 24896259
nsv474352 CNV novel sequence insertion 20440878
nsv520067 CNV gain 19592680
nsv831663 CNV loss 17160897
nsv950915 CNV duplication 24416366

Variation tolerance for CORO2A Gene

Residual Variation Intolerance Score: 35.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.59; 44.91% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CORO2A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CORO2A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CORO2A Gene

Disorders for CORO2A Gene

Additional Disease Information for CORO2A

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for CORO2A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CORO2A Gene

Publications for CORO2A Gene

  1. cDNA cloning of a novel WD repeat protein mapping to the 9q22.3 chromosomal region. (PMID: 8985118) Zaphiropoulos PG … Toftgård R (DNA and cell biology 1996) 2 3 4 22 58
  2. Common variants in FOXP1 are associated with generalized vitiligo. (PMID: 20526340) Jin Y … Spritz RA (Nature genetics 2010) 3 44 58
  3. Coronin 2A regulates a subset of focal-adhesion-turnover events through the cofilin pathway. (PMID: 19654210) Marshall TW … Bear JE (Journal of cell science 2009) 3 22 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Purification and functional characterization of the human N-CoR complex: the roles of HDAC3, TBL1 and TBLR1. (PMID: 12628926) Yoon HG … Wong J (The EMBO journal 2003) 3 4 58

Products for CORO2A Gene

Sources for CORO2A Gene

Content
Loading form....