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Aliases for UPK2 Gene

Aliases for UPK2 Gene

  • Uroplakin 2 2 3 5
  • Uroplakin II 2 3 4
  • Uroplakin-2 2 3
  • UPII 3 4
  • UP2 3 4

External Ids for UPK2 Gene

Previous GeneCards Identifiers for UPK2 Gene

  • GC11P134018
  • GC11P120338
  • GC11P118829
  • GC11P118364
  • GC11P118332
  • GC11P114766
  • GC11P118795

Summaries for UPK2 Gene

Entrez Gene Summary for UPK2 Gene

  • This gene encodes one of the proteins of the highly conserved urothelium-specific integral membrane proteins of the asymmetric unit membrane which forms urothelium apical plaques in mammals. The asymmetric unit membrane is believed to strengthen the urothelium by preventing cell rupture during bladder distention. The encoded protein is expressed in the peripheral blood of bladder cancer patients with transitional cell carcinomas.[provided by RefSeq, Sep 2009]

GeneCards Summary for UPK2 Gene

UPK2 (Uroplakin 2) is a Protein Coding gene. Diseases associated with UPK2 include Transitional Cell Carcinoma and Gastric Signet Ring Cell Adenocarcinoma.

UniProtKB/Swiss-Prot for UPK2 Gene

  • Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in regulating the assembly of the AUM (By similarity).

Gene Wiki entry for UPK2 Gene

Additional gene information for UPK2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UPK2 Gene

Genomics for UPK2 Gene

GeneHancer (GH) Regulatory Elements for UPK2 Gene

Promoters and enhancers for UPK2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J118906 Promoter/Enhancer 2.9 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 653.4 -6.4 -6371 24.6 CLOCK MLX ZFP64 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 BCL9L UPK2 ARCN1 DPAGT1 CCDC84 RNF26 UBE4A ENSG00000254909 VPS11 KMT2A
GH11J118956 Promoter 0.7 EPDnew 650.3 +31.1 31115 0.1 CTCF SMARCE1 POLR2A GC11M118949 UPK2 ENSG00000222529
GH11J118787 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10.9 -134.5 -134522 6.4 HDGF PKNOX1 FOXA2 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B DDX6 ENSG00000278376 GC11M118786 GC11P118793 GC11P118796 PIR33268 PIR35418 LOC105369519 BCL9L HINFP
GH11J119015 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 11.1 +92.9 92897 4.6 HDGF PKNOX1 CLOCK SMAD1 ARNT ARID4B SIN3A FEZF1 DMAP1 YY1 TRAPPC4 PIR32149 RPS25 PIR60932 MIR3656 GC11P119047 RNF26 ARCN1 VPS11 CCDC84
GH11J119066 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 10.1 +142.5 142522 2.2 HDGF PKNOX1 CLOCK MLX ARNT ZFP64 ARID4B SIN3A DMAP1 YY1 VPS11 ENSG00000272186 HYOU1 DPAGT1 HMBS ARCN1 H2AFX C2CD2L KMT2A ENSG00000254909
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around UPK2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the UPK2 gene promoter:
  • p53
  • MAZR
  • Pax-4a
  • S8
  • AML1a
  • NF-kappaB
  • NF-kappaB1
  • RelA
  • CUTL1
  • Spz1

Genomic Locations for UPK2 Gene

Genomic Locations for UPK2 Gene
33,396 bases
Plus strand
33,397 bases
Plus strand

Genomic View for UPK2 Gene

Genes around UPK2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UPK2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UPK2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UPK2 Gene

Proteins for UPK2 Gene

  • Protein details for UPK2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • B0YJ92
    • O00457
    • Q53YV0

    Protein attributes for UPK2 Gene

    184 amino acids
    Molecular mass:
    19438 Da
    Quaternary structure:
    • Interacts with uroplakin-1a (UPK1A).

neXtProt entry for UPK2 Gene

Post-translational modifications for UPK2 Gene

  • Glycosylation at isoforms=66, posLast=5757, and posLast=2828
  • Modification sites at PhosphoSitePlus

Other Protein References for UPK2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for UPK2 Gene

Domains & Families for UPK2 Gene

Gene Families for UPK2 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for UPK2 Gene


Suggested Antigen Peptide Sequences for UPK2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the uroplakin-2 family.
  • Belongs to the uroplakin-2 family.
genes like me logo Genes that share domains with UPK2: view

Function for UPK2 Gene

Molecular function for UPK2 Gene

UniProtKB/Swiss-Prot Function:
Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in regulating the assembly of the AUM (By similarity).
GENATLAS Biochemistry:
uroplakin 2,urothelium specific transmembrane protein forming 12nm protein particles in association with other UPKs,at the asymetric unit membrane of the bladder epithelium,strenghthening and stabilizing the urothelial epithelial surface trough its interactions with the underlying cytoskeleton,continuously expressed by the majority of transitional cell carcinoma of the bladder (TCC), in a region of partial synteny to chromosome 11

Phenotypes From GWAS Catalog for UPK2 Gene

Gene Ontology (GO) - Molecular Function for UPK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with UPK2: view
genes like me logo Genes that share phenotypes with UPK2: view

Animal Models for UPK2 Gene

MGI Knock Outs for UPK2:
  • Upk2 Upk2<tm1Tsun>

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for UPK2 Gene

Localization for UPK2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UPK2 Gene

Cell membrane; Single-pass type I membrane protein. Note=Heterodimer formation with UPK1A is a prerequisite to exit out of the endoplasmic reticulum (ER). {ECO:0000250}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UPK2 gene
Compartment Confidence
plasma membrane 5
extracellular 5
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for UPK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0005887 integral component of plasma membrane TAS 8175808
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0016324 apical plasma membrane IBA --
genes like me logo Genes that share ontologies with UPK2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for UPK2 Gene

Pathways & Interactions for UPK2 Gene

No Data Available

Interacting Proteins for UPK2 Gene

Gene Ontology (GO) - Biological Process for UPK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development TAS 9515818
GO:0030855 epithelial cell differentiation IDA 10514386
genes like me logo Genes that share ontologies with UPK2: view

No data available for Pathways by source and SIGNOR curated interactions for UPK2 Gene

Drugs & Compounds for UPK2 Gene

(1) Drugs for UPK2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with UPK2: view

Transcripts for UPK2 Gene

mRNA/cDNA for UPK2 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(9) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for UPK2 Gene

Uroplakin 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for UPK2 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5
SP1: -

Relevant External Links for UPK2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for UPK2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for UPK2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for UPK2 Gene

This gene is overexpressed in Bladder (x43.8).

Protein differential expression in normal tissues from HIPED for UPK2 Gene

This gene is overexpressed in Urine (66.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for UPK2 Gene

Protein tissue co-expression partners for UPK2 Gene

NURSA nuclear receptor signaling pathways regulating expression of UPK2 Gene:


SOURCE GeneReport for Unigene cluster for UPK2 Gene:


mRNA Expression by UniProt/SwissProt for UPK2 Gene:

Tissue specificity: Expressed in ureter.
genes like me logo Genes that share expression patterns with UPK2: view

No data available for Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for UPK2 Gene

Orthologs for UPK2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for UPK2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia UPK2 34
  • 99 (a)
(Canis familiaris)
Mammalia UPK2 34 33
  • 90.58 (n)
(Bos Taurus)
Mammalia UPK2 34 33
  • 87.68 (n)
(Rattus norvegicus)
Mammalia Upk2 33
  • 84.96 (n)
(Mus musculus)
Mammalia Upk2 16 34 33
  • 84.24 (n)
(Monodelphis domestica)
Mammalia UPK2 34
  • 65 (a)
Species where no ortholog for UPK2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for UPK2 Gene

Gene Tree for UPK2 (if available)
Gene Tree for UPK2 (if available)
Evolutionary constrained regions (ECRs) for UPK2: view image

Paralogs for UPK2 Gene

No data available for Paralogs for UPK2 Gene

Variants for UPK2 Gene

Sequence variations from dbSNP and Humsavar for UPK2 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000392173 -- 118,955,449(+) A/C upstream_transcript_variant
rs1000903628 -- 118,955,502(+) C/T upstream_transcript_variant
rs1002093358 -- 118,954,811(+) C/T upstream_transcript_variant
rs1002160285 -- 118,954,397(+) C/A upstream_transcript_variant
rs1002445686 -- 118,956,138(+) T/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for UPK2 Gene

Variant ID Type Subtype PubMed ID
nsv819166 CNV loss 19587683

Variation tolerance for UPK2 Gene

Residual Variation Intolerance Score: 80.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.25; 62.44% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for UPK2 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UPK2 Gene

Disorders for UPK2 Gene

MalaCards: The human disease database

(12) MalaCards diseases for UPK2 Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
transitional cell carcinoma
  • transitional carcinoma
gastric signet ring cell adenocarcinoma
  • signet ring cell adenocarcinoma of the stomach
bladder squamous cell carcinoma
  • epidermoid carcinoma of the urinary bladder
bladder carcinoma in situ
  • bladder ca in situ
cystitis cystica
- elite association - COSMIC cancer census association via MalaCards
Search UPK2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for UPK2

genes like me logo Genes that share disorders with UPK2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for UPK2 Gene

Publications for UPK2 Gene

  1. Uroplakin gene expression by normal and neoplastic human urothelium. (PMID: 9846985) Lobban ED … Southgate J (The American journal of pathology 1998) 2 3 4 22 58
  2. Genetic detection for hematogenous micrometastasis in patients with various types of malignant tumors using Uroplakin II derived primers in polymerase chain reaction. (PMID: 12792753) Hirata H … Kanamaru T (Oncology reports 2003) 3 4 22 58
  3. Prostate stem cell antigen enhancer and uroplakin II promoter based bladder cancer targeted tissue-specific vector. (PMID: 18440837) Wang D … Rodriguez R (Urologic oncology 2010) 3 22 58
  4. Mutation analyses of Uroplakin II in children with renal tract malformations. (PMID: 17012268) Jenkins D … Woolf AS (Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2006) 3 22 58
  5. Cloning of human uroplakin II gene from Chinese transitional cell carcinoma of bladder and construction of its eukaryotic expression vector. (PMID: 16116969) Chen F … Lu G (Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 2005) 3 22 58

Products for UPK2 Gene

Sources for UPK2 Gene

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