Aliases for UMPS Gene
External Ids for UMPS Gene
Previous GeneCards Identifiers for UMPS Gene
This gene encodes a uridine 5'-monophosphate synthase. The encoded protein is a bifunctional enzyme that catalyzes the final two steps of the de novo pyrimidine biosynthetic pathway. The first reaction is carried out by the N-terminal enzyme orotate phosphoribosyltransferase which converts orotic acid to orotidine-5'-monophosphate. The terminal reaction is carried out by the C-terminal enzyme OMP decarboxylase which converts orotidine-5'-monophosphate to uridine monophosphate. Defects in this gene are the cause of hereditary orotic aciduria. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]
GeneCards Summary for UMPS Gene
UMPS (Uridine Monophosphate Synthetase) is a Protein Coding gene. Diseases associated with UMPS include Orotic Aciduria and Pyrimidine Metabolic Disorder. Among its related pathways are Pyrimidine metabolism (KEGG) and Drug metabolism - cytochrome P450. Gene Ontology (GO) annotations related to this gene include transferase activity and orotidine-5-phosphate decarboxylase activity.