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Aliases for UGP2 Gene

Aliases for UGP2 Gene

  • UDP-Glucose Pyrophosphorylase 2 2 3 5
  • UTP--Glucose-1-Phosphate Uridylyltransferase 2 3
  • UDP-Glucose Pyrophosphorylase 1 2 3
  • UDPGP 3 4
  • UGP1 3 4
  • UTP--Glucose-1-Phosphate Uridylyltransferase 2 3
  • Uridyl Diphosphate Glucose Pyrophosphorylase-1 3
  • Uridyl Diphosphate Glucose Pyrophosphorylase 2 3
  • Testis Tissue Sperm-Binding Protein Li 58p 3
  • UTP-Glucose-1-Phosphate Uridyltransferase 3
  • UDP-Glucose Pyrophosphorylase 4
  • UDP-Glucose Diphosphorylase 3
  • EC 4
  • UGPase 2 3
  • UDPGP2 3
  • PHC379 3
  • UGPase 4
  • UGPP1 3
  • UGPP2 3
  • UDPG 3

External Ids for UGP2 Gene

Previous HGNC Symbols for UGP2 Gene

  • UGP1

Previous GeneCards Identifiers for UGP2 Gene

  • GC02P064197
  • GC02P064025
  • GC02P064042
  • GC02P063979
  • GC02P063921
  • GC02P063807
  • GC02P064068

Summaries for UGP2 Gene

Entrez Gene Summary for UGP2 Gene

  • The enzyme encoded by this gene is an important intermediary in mammalian carbohydrate interconversions. It transfers a glucose moiety from glucose-1-phosphate to MgUTP and forms UDP-glucose and MgPPi. In liver and muscle tissue, UDP-glucose is a direct precursor of glycogen; in lactating mammary gland it is converted to UDP-galactose which is then converted to lactose. The eukaryotic enzyme has no significant sequence similarity to the prokaryotic enzyme. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for UGP2 Gene

UGP2 (UDP-Glucose Pyrophosphorylase 2) is a Protein Coding gene. Among its related pathways are Metabolism and Porphyrin and chlorophyll metabolism. Gene Ontology (GO) annotations related to this gene include identical protein binding and uridylyltransferase activity.

UniProtKB/Swiss-Prot for UGP2 Gene

  • Plays a central role as a glucosyl donor in cellular metabolic pathways.

Additional gene information for UGP2 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for UGP2 Gene

Genomics for UGP2 Gene

GeneHancer (GH) Regulatory Elements for UGP2 Gene

Promoters and enhancers for UGP2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J063839 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 656.4 +1.3 1250 4.5 MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC ZNF610 GLIS1 UGP2 WDPCP VPS54 MDH1 LOC100507006 ENSG00000251775
GH02J063698 Enhancer 1.1 Ensembl ENCODE 17.3 -141.9 -141852 1.8 ARID4B SIN3A ZNF2 ZNF48 YY1 SLC30A9 ZNF143 FOS DEK RXRA UGP2 VPS54 GC02P063684 LOC100418973 WDPCP
GH02J063819 Enhancer 1.3 Ensembl ENCODE dbSUPER 11.2 -20.7 -20739 1.2 FOXA2 MLX ZFP64 ARID4B DMAP1 ZNF48 ETS1 YY1 SLC30A9 ATF7 GC02M063810 WDPCP UGP2 GC02M063754
GH02J063871 Enhancer 1.3 Ensembl ENCODE dbSUPER 10.8 +30.4 30354 0.2 ELF3 FOXA2 ARID4B ZNF48 ZSCAN9 RARA SLC30A9 FOS THAP11 NFKBIZ WDPCP UGP2 MDH1 ENSG00000251775
GH02J063813 Enhancer 0.6 dbSUPER 18.1 -25.4 -25393 3.3 USF1 NFIA ZNF384 RAD21 MITF SP1 NFIC ATF3 PRDM10 HNF4A UGP2 MDH1 LOC100507006 GC02M063810 WDPCP GC02M063754
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around UGP2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the UGP2 gene promoter:
  • HFH-1
  • Lhx3a
  • LHX3b
  • IRF-1
  • aMEF-2
  • MEF-2A

Genomic Locations for UGP2 Gene

Genomic Locations for UGP2 Gene
50,623 bases
Plus strand
50,623 bases
Plus strand

Genomic View for UGP2 Gene

Genes around UGP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
UGP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for UGP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for UGP2 Gene

Proteins for UGP2 Gene

  • Protein details for UGP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    UTP--glucose-1-phosphate uridylyltransferase
    Protein Accession:
    Secondary Accessions:
    • Q07131
    • Q0P6K2
    • Q86Y81
    • Q9BU15

    Protein attributes for UGP2 Gene

    508 amino acids
    Molecular mass:
    56940 Da
    Quaternary structure:
    • Homooctamer.

    Three dimensional structures from OCA and Proteopedia for UGP2 Gene

    Alternative splice isoforms for UGP2 Gene


neXtProt entry for UGP2 Gene

Post-translational modifications for UGP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for UGP2 Gene

Domains & Families for UGP2 Gene

Gene Families for UGP2 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for UGP2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the UDPGP type 1 family.
  • Belongs to the UDPGP type 1 family.
genes like me logo Genes that share domains with UGP2: view

Function for UGP2 Gene

Molecular function for UGP2 Gene

UniProtKB/Swiss-Prot Function:
Plays a central role as a glucosyl donor in cellular metabolic pathways.
UniProtKB/Swiss-Prot CatalyticActivity:
UTP + alpha-D-glucose 1-phosphate = diphosphate + UDP-glucose.
GENATLAS Biochemistry:
UDP glucose pyrophosphorylase 2,muscle isoform,may be the same as GLAT

Enzyme Numbers (IUBMB) for UGP2 Gene

Phenotypes From GWAS Catalog for UGP2 Gene

Gene Ontology (GO) - Molecular Function for UGP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003983 UTP:glucose-1-phosphate uridylyltransferase activity TAS 8354390
GO:0005515 protein binding IPI 16189514
GO:0005536 glucose binding IEA --
GO:0016740 transferase activity IEA --
GO:0016779 nucleotidyltransferase activity IEA --
genes like me logo Genes that share ontologies with UGP2: view
genes like me logo Genes that share phenotypes with UGP2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for UGP2

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for UGP2

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for UGP2 Gene

Localization for UGP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for UGP2 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for UGP2 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Centrosome (2)
  • Mitochondria (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for UGP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus HDA 21630459
GO:0005737 cytoplasm IBA --
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome HDA 19056867
genes like me logo Genes that share ontologies with UGP2: view

Pathways & Interactions for UGP2 Gene

genes like me logo Genes that share pathways with UGP2: view

Gene Ontology (GO) - Biological Process for UGP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005977 glycogen metabolic process IBA --
GO:0005978 glycogen biosynthetic process TAS --
GO:0006011 UDP-glucose metabolic process IBA,IEA --
GO:0006065 UDP-glucuronate biosynthetic process TAS --
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with UGP2: view

No data available for SIGNOR curated interactions for UGP2 Gene

Drugs & Compounds for UGP2 Gene

(4) Drugs for UGP2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Glucose 1-phosphate Experimental Pharma 0
Uridine diphosphate glucose Experimental Pharma 0
Uridine triphosphate Experimental, Investigational Pharma 0

(1) Additional Compounds for UGP2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • [(ho)2P(O)OP(O)(OH)2]
  • Acide diphosphorique
  • Diphosphorsaeure
  • H4P2O7
  • PYROphosphATE
genes like me logo Genes that share compounds with UGP2: view

Transcripts for UGP2 Gene

Unigene Clusters for UGP2 Gene

UDP-glucose pyrophosphorylase 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for UGP2

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for UGP2 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c · 12d ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17
SP1: - - - - - - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - - - - - -
SP4: - - -
SP5: - - - - - -
SP6: - - - -
SP7: - - - - - - -
SP8: - - - - -
SP9: - -
SP10: - - - - - - - - -
SP11: - - - - - -
SP12: - - - - - - - - - - - -
SP13: - - - - - - - - - - -

Relevant External Links for UGP2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for UGP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for UGP2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for UGP2 Gene

This gene is overexpressed in Muscle - Skeletal (x4.5).

Protein differential expression in normal tissues from HIPED for UGP2 Gene

This gene is overexpressed in Liver, secretome (16.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for UGP2 Gene

Protein tissue co-expression partners for UGP2 Gene

NURSA nuclear receptor signaling pathways regulating expression of UGP2 Gene:


SOURCE GeneReport for Unigene cluster for UGP2 Gene:


Evidence on tissue expression from TISSUES for UGP2 Gene

  • Liver(4.9)
  • Nervous system(4.8)
  • Muscle(4.7)
  • Skin(4.6)
  • Heart(3.4)
  • Kidney(3.4)
  • Intestine(3.3)
  • Lung(3.1)
genes like me logo Genes that share expression patterns with UGP2: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for UGP2 Gene

Orthologs for UGP2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for UGP2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia UGP2 34 33
  • 99.74 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 98 (a)
-- 34
  • 90 (a)
(Ornithorhynchus anatinus)
Mammalia UGP2 34
  • 96 (a)
(Bos Taurus)
Mammalia UGP2 34 33
  • 93.57 (n)
(Canis familiaris)
Mammalia UGP2 34 33
  • 93.44 (n)
(Mus musculus)
Mammalia Ugp2 16 34 33
  • 92.19 (n)
(Rattus norvegicus)
Mammalia Ugp2 33
  • 91.34 (n)
(Gallus gallus)
Aves UGP2 34 33
  • 81.1 (n)
(Anolis carolinensis)
Reptilia UGP2 34
  • 93 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ugp2 33
  • 75.79 (n)
African clawed frog
(Xenopus laevis)
Amphibia MGC68615 33
(Danio rerio)
Actinopterygii ugp2b 34
  • 84 (a)
ugp2a 34
  • 82 (a)
wufi53h10 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10939 33
fruit fly
(Drosophila melanogaster)
Insecta CG4347 35
  • 63 (a)
UGP 34
  • 61 (a)
(Caenorhabditis elegans)
Secernentea K08E3.5a 35
  • 66 (a)
K08E3.5c 35
  • 66 (a)
K08E3.5b 35
  • 64 (a)
K08E3.5d 35
  • 62 (a)
K08E3.5 34 33
  • 59.96 (n)
D1005.2 35
  • 39 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UGP1 36 34
  • 53 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.7436 33
(Glycine max)
eudicotyledons Gma.6257 33
(Zea mays)
Liliopsida Zm.9568 33
(Triticum aestivum)
Liliopsida Ta.542 33
(Oryza sativa)
Liliopsida Os.10118 33
(Hordeum vulgare)
Liliopsida Hv.19 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6144 34
  • 63 (a)
Cin.4853 33
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4853 33
Species where no ortholog for UGP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for UGP2 Gene

Gene Tree for UGP2 (if available)
Gene Tree for UGP2 (if available)
Evolutionary constrained regions (ECRs) for UGP2: view image

Paralogs for UGP2 Gene

No data available for Paralogs for UGP2 Gene

Variants for UGP2 Gene

Sequence variations from dbSNP and Humsavar for UGP2 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000006071 -- 63,847,918(+) A/C intron_variant
rs1000009855 -- 63,861,376(+) C/G intron_variant
rs1000220156 -- 63,885,296(+) T/A intron_variant
rs1000257615 -- 63,847,635(+) G/T intron_variant
rs1000270514 -- 63,891,657(+) C/T downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for UGP2 Gene

Variant ID Type Subtype PubMed ID
esv21925 CNV loss 19812545
esv2470969 CNV deletion 19546169
esv2658650 CNV deletion 23128226
esv2720141 CNV deletion 23290073
esv2720142 CNV deletion 23290073
esv2720143 CNV deletion 23290073
esv2720144 CNV deletion 23290073
esv2720145 CNV deletion 23290073
esv2720146 CNV deletion 23290073
esv2720147 CNV deletion 23290073
esv2741858 CNV deletion 23290073
esv3591066 CNV loss 21293372
nsv521717 CNV gain 19592680
nsv582126 CNV gain 21841781
nsv582127 CNV gain 21841781
nsv7313 OTHER inversion 18451855

Variation tolerance for UGP2 Gene

Residual Variation Intolerance Score: 12.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.81; 16.95% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for UGP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for UGP2 Gene

Disorders for UGP2 Gene

Additional Disease Information for UGP2

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for UGP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for UGP2 Gene

Publications for UGP2 Gene

  1. The crystal structure of human UDP-glucose pyrophosphorylase reveals a latch effect that influences enzymatic activity. (PMID: 22132858) Yu Q … Zheng X (The Biochemical journal 2012) 3 4 58
  2. Hypoxia promotes glycogen accumulation through hypoxia inducible factor (HIF)-mediated induction of glycogen synthase 1. (PMID: 20300197) Pescador N … del Peso L (PloS one 2010) 3 22 58
  3. Variants of organic anion transporter polypeptide 2 gene are not risk factors associated with severe neonatal hyperbilirubinemia. (PMID: 20514852) Wong FL … Wang MK (The Malaysian journal of pathology 2009) 3 44 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. The importance of conserved residues in human liver UDPglucose pyrophosphorylase. (PMID: 8612650) Chang HY … Duggleby RG (European journal of biochemistry 1996) 3 4 58

Products for UGP2 Gene

Sources for UGP2 Gene

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