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Aliases for TMEM242 Gene

Aliases for TMEM242 Gene

  • Transmembrane Protein 242 2 3 3 5
  • C6orf35 3 4
  • UPF0463 Transmembrane Protein C6orf35 3
  • Chromosome 6 Open Reading Frame 35 2
  • BM033 3

External Ids for TMEM242 Gene

Previous HGNC Symbols for TMEM242 Gene

  • C6orf35

Previous GeneCards Identifiers for TMEM242 Gene

  • GC06M157714

Summaries for TMEM242 Gene

GeneCards Summary for TMEM242 Gene

TMEM242 (Transmembrane Protein 242) is a Protein Coding gene.

Gene Wiki entry for TMEM242 Gene

Additional gene information for TMEM242 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM242 Gene

Genomics for TMEM242 Gene

GeneHancer (GH) Regulatory Elements for TMEM242 Gene

Promoters and enhancers for TMEM242 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J157322 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE 692.7 +0.0 13 3.3 MLX ZFP64 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF416 ZNF143 TMEM242 ENSG00000271040 ARID1B LOC100420839 ENSG00000271265 ENSG00000271551 LOC105378078 SYNJ2-IT1 LOC105378073 SNX9
GH06J157273 Enhancer 1.5 FANTOM5 Ensembl ENCODE 38.2 +49.1 49110 3.3 PKNOX1 ARNT SIN3A DMAP1 ZNF2 CBX5 ZNF207 ZNF143 SP3 REST TMEM242 LOC105378073 SYNJ2-IT1 LOC105378078 ARID1B LOC100420839 ENSG00000234361 LDHAL6FP LOC105378075
GH06J157304 Enhancer 1.2 FANTOM5 Ensembl ENCODE 41.4 +18.9 18858 2.4 HDAC1 USF1 NFATC3 ARNT JUN MAX YY1 TCF12 GATA2 ZFP91 TMEM242 LDHAL6FP ENSG00000271040
GH06J157316 Enhancer 1.5 FANTOM5 Ensembl ENCODE 27.6 +6.9 6851 2.1 HDGF PKNOX1 SMAD1 ATF1 ARNT YY1 TCF12 ZNF766 E2F8 ATF7 TMEM242 ENSG00000271040 LDHAL6FP
GH06J157268 Enhancer 1 FANTOM5 Ensembl ENCODE 32.8 +54.9 54888 1.6 SP1 RXRA EGR1 IKZF1 REST NR2F2 TMEM242 LOC105378075 LDHAL6FP
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TMEM242 on UCSC Golden Path with GeneCards custom track

Genomic Locations for TMEM242 Gene

Genomic Locations for TMEM242 Gene
chr6:157,289,022-157,324,259
(GRCh38/hg38)
Size:
35,238 bases
Orientation:
Minus strand
chr6:157,710,054-157,745,253
(GRCh37/hg19)
Size:
35,200 bases
Orientation:
Minus strand

Genomic View for TMEM242 Gene

Genes around TMEM242 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM242 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM242 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM242 Gene

Proteins for TMEM242 Gene

  • Protein details for TMEM242 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NWH2-TM242_HUMAN
    Recommended name:
    Transmembrane protein 242
    Protein Accession:
    Q9NWH2
    Secondary Accessions:
    • B9EJD0
    • Q9NZ88
    • Q9P094

    Protein attributes for TMEM242 Gene

    Size:
    141 amino acids
    Molecular mass:
    14758 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAF28965.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAF67621.1; Type=Frameshift; Positions=130; Evidence={ECO:0000305};

neXtProt entry for TMEM242 Gene

Post-translational modifications for TMEM242 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMEM242 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM242 Gene

Domains & Families for TMEM242 Gene

Gene Families for TMEM242 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for TMEM242 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM242 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NWH2

UniProtKB/Swiss-Prot:

TM242_HUMAN :
  • Belongs to the TMEM242 family.
Family:
  • Belongs to the TMEM242 family.
genes like me logo Genes that share domains with TMEM242: view

Function for TMEM242 Gene

Gene Ontology (GO) - Molecular Function for TMEM242 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with TMEM242: view
genes like me logo Genes that share phenotypes with TMEM242: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM242 Gene

Localization for TMEM242 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM242 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM242 gene
Compartment Confidence
nucleus 3
mitochondrion 2
plasma membrane 1
cytoskeleton 1
peroxisome 1
cytosol 1

Gene Ontology (GO) - Cellular Components for TMEM242 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM242: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TMEM242 Gene

Pathways & Interactions for TMEM242 Gene

SuperPathways for TMEM242 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TMEM242 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM242 Gene

Drugs & Compounds for TMEM242 Gene

No Compound Related Data Available

Transcripts for TMEM242 Gene

mRNA/cDNA for TMEM242 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMEM242 Gene

Transmembrane protein 242:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM242 Gene

No ASD Table

Relevant External Links for TMEM242 Gene

GeneLoc Exon Structure for
TMEM242
ECgene alternative splicing isoforms for
TMEM242

Expression for TMEM242 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM242 Gene

Protein differential expression in normal tissues from HIPED for TMEM242 Gene

This gene is overexpressed in Bone (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TMEM242 Gene



Protein tissue co-expression partners for TMEM242 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TMEM242 Gene:

TMEM242

SOURCE GeneReport for Unigene cluster for TMEM242 Gene:

Hs.157212

Evidence on tissue expression from TISSUES for TMEM242 Gene

  • Nervous system(4.7)
  • Bone marrow(4.1)
  • Blood(4)
  • Heart(2.4)
  • Liver(2.4)
  • Stomach(2.2)
  • Muscle(2)
genes like me logo Genes that share expression patterns with TMEM242: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM242 Gene

Orthologs for TMEM242 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM242 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM242 34 33
  • 97.64 (n)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM242 34 33
  • 87.71 (n)
OneToOne
cow
(Bos Taurus)
Mammalia TMEM242 33
  • 85.05 (n)
C9H6ORF35 34
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem242 16 34 33
  • 83.33 (n)
rat
(Rattus norvegicus)
Mammalia C1H6orf35 33
  • 81.67 (n)
oppossum
(Monodelphis domestica)
Mammalia TMEM242 34
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves C3H6ORF35 33
  • 74.04 (n)
TMEM242 34
  • 60 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMEM242 34
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem242 33
  • 65.25 (n)
zebrafish
(Danio rerio)
Actinopterygii tmem242 34 33
  • 61.03 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009165 33
  • 48.92 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG11699 34 33
  • 47.62 (n)
OneToOne
Species where no ortholog for TMEM242 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM242 Gene

ENSEMBL:
Gene Tree for TMEM242 (if available)
TreeFam:
Gene Tree for TMEM242 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TMEM242: view image

Paralogs for TMEM242 Gene

Pseudogenes.org Pseudogenes for TMEM242 Gene

genes like me logo Genes that share paralogs with TMEM242: view

No data available for Paralogs for TMEM242 Gene

Variants for TMEM242 Gene

Sequence variations from dbSNP and Humsavar for TMEM242 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000187484 -- 157,314,394(-) T/A intron_variant
rs1000245605 -- 157,321,419(-) T/C intron_variant
rs1000314135 -- 157,306,942(-) A/G intron_variant
rs1000647045 -- 157,305,587(-) A/G intron_variant
rs1000767174 -- 157,313,405(-) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM242 Gene

Variant ID Type Subtype PubMed ID
dgv1026e201 CNV deletion 23290073
esv2127993 CNV deletion 18987734
esv22447 CNV loss 19812545
esv2732977 CNV deletion 23290073
esv2732978 CNV deletion 23290073
esv2732979 CNV deletion 23290073
esv2763603 CNV gain 21179565
esv33003 CNV loss 17666407
esv3990 OTHER complex 18987735
esv4246 OTHER complex 18987735
esv5900 CNV loss 19470904
nsv1074438 CNV deletion 25765185
nsv1076604 CNV duplication 25765185
nsv1112440 CNV deletion 24896259
nsv1114885 CNV deletion 24896259
nsv1115728 CNV duplication 24896259
nsv1153539 CNV duplication 26484159
nsv349114 CNV deletion 16902084
nsv349208 CNV deletion 16902084
nsv349327 CNV deletion 16902084
nsv509155 CNV insertion 20534489
nsv820493 CNV duplication 20802225
nsv956953 CNV deletion 24416366
nsv970182 CNV duplication 23825009

Variation tolerance for TMEM242 Gene

Residual Variation Intolerance Score: 88.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.56; 55.92% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM242 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM242

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM242 Gene

Disorders for TMEM242 Gene

Additional Disease Information for TMEM242

No disorders were found for TMEM242 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM242 Gene

Publications for TMEM242 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  3. RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination. (PMID: 29117863) Choudhury NR … Michlewski G (BMC biology 2017) 3 58
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58
  5. N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. (PMID: 22814378) Van Damme P … Aldabe R (Proceedings of the National Academy of Sciences of the United States of America 2012) 4 58

Products for TMEM242 Gene

Sources for TMEM242 Gene

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