Aliases for TRH Gene
External Ids for TRH Gene
Previous GeneCards Identifiers for TRH Gene
This gene encodes a member of the thyrotropin-releasing hormone family. Cleavage of the encoded proprotein releases mature thyrotropin-releasing hormone, which is a tripeptide hypothalamic regulatory hormone. The human proprotein contains six thyrotropin-releasing hormone tripeptides. Thyrotropin-releasing hormone is involved in the regulation and release of thyroid-stimulating hormone, as well as prolactin. Deficiency of this hormone has been associated with hypothalamic hypothyroidism. [provided by RefSeq, May 2013]
GeneCards Summary for TRH Gene
TRH (Thyrotropin Releasing Hormone) is a Protein Coding gene. Diseases associated with TRH include Thyrotropin-Releasing Hormone Deficiency and Endogenous Depression. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include neuropeptide hormone activity and thyrotropin-releasing hormone activity.
UniProtKB/Swiss-Prot for TRH Gene
Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems. May promote hair shaft elongation, prolonge the hair cycle growth phase (anagen) and antagonized its termination by TGFB2. May also increase proliferation and inhibited apoptosis of hair matrix keratinocytes.