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Aliases for TPM3 Gene

Aliases for TPM3 Gene

  • Tropomyosin 3 2 3 5
  • Tropomyosin-5 3 4
  • Epididymis Secretory Sperm Binding Protein Li 82p 3
  • Heat-Stable Cytoskeletal Protein 30 KDa 3
  • Alpha-Tropomyosin, Slow Skeletal 3
  • Epididymis Luminal Protein 189 3
  • Cytoskeletal Tropomyosin TM30 3
  • Tropomyosin Alpha-3 Chain 3
  • Tropomyosin Gamma 3
  • Gamma-Tropomyosin 4
  • Tropomyosin-3 4
  • OK/SW-Cl.5 3
  • HEL-S-82p 3
  • HEL-189 3
  • TM30nm 3
  • TPMsk3 3
  • Hscp30 3
  • CAPM1 3
  • CFTD 3
  • NEM1 3
  • TM-5 3
  • TM30 3
  • HTM5 4
  • TRK 3
  • TM3 3
  • TM5 3

External Ids for TPM3 Gene

Previous HGNC Symbols for TPM3 Gene

  • NEM1

Previous GeneCards Identifiers for TPM3 Gene

  • GC01U990171
  • GC01M149859
  • GC01M150904
  • GC01M151345
  • GC01M150941
  • GC01M152395
  • GC01M125491

Summaries for TPM3 Gene

Entrez Gene Summary for TPM3 Gene

  • This gene encodes a member of the tropomyosin family of actin-binding proteins. Tropomyosins are dimers of coiled-coil proteins that provide stability to actin filaments and regulate access of other actin-binding proteins. Mutations in this gene result in autosomal dominant nemaline myopathy and other muscle disorders. This locus is involved in translocations with other loci, including anaplastic lymphoma receptor tyrosine kinase (ALK) and neurotrophic tyrosine kinase receptor type 1 (NTRK1), which result in the formation of fusion proteins that act as oncogenes. There are numerous pseudogenes for this gene on different chromosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]

GeneCards Summary for TPM3 Gene

TPM3 (Tropomyosin 3) is a Protein Coding gene. Diseases associated with TPM3 include Nemaline Myopathy 1 and Myopathy, Congenital, With Fiber-Type Disproportion. Among its related pathways are Cardiac conduction and Aldosterone synthesis and secretion. Gene Ontology (GO) annotations related to this gene include actin binding. An important paralog of this gene is TPM4.

UniProtKB/Swiss-Prot for TPM3 Gene

  • Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments.

Gene Wiki entry for TPM3 Gene

Additional gene information for TPM3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TPM3 Gene

Genomics for TPM3 Gene

GeneHancer (GH) Regulatory Elements for TPM3 Gene

Promoters and enhancers for TPM3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I154177 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 551.9 +13.8 13768 6.8 CLOCK ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 TPM3 UBAP2L CRTC2 CHTOP LOC101928120 SLC27A3 FLAD1 ILF2 INTS3 CREB3L4
GH01I154190 Promoter/Enhancer 1.7 EPDnew FANTOM5 Ensembl ENCODE 550.8 +2.3 2340 4.3 PKNOX1 NFIB NEUROD1 BMI1 ELK1 RCOR1 ZNF362 CEBPB ELF1 KAT8 MIR190B TPM3 HAX1 C1orf189 TDRD10 NUP210L CHRNB2 GC01M154167 RN7SL431P
GH01I154175 Promoter/Enhancer 0.9 EPDnew ENCODE dbSUPER 550.4 +18.3 18261 1.6 TPM3 NUP210L C1orf189 UBAP2L SNORA58B ATP8B2 RNU7-57P CREB3L4 GC01M154167 RN7SL431P
GH01I154333 Enhancer 1.3 Ensembl ENCODE dbSUPER 10.3 -140.0 -140042 2.2 PKNOX1 FOXA2 ARID4B SIN3A ZNF48 YY1 ZNF121 ELK1 ZNF143 FOS UBE2Q1 IL6R-AS1 IL6R SNORA58B UBAP2L MIR190B TPM3 C1orf189 UBE2Q1-AS1 ATP8B2
GH01I154479 Enhancer 1.3 Ensembl ENCODE dbSUPER 9.2 -285.4 -285353 0.8 RB1 ARNT ARID4B ZNF2 RAD21 RFX5 YY1 CHAMP1 ZNF335 ZNF121 ENSG00000273110 IL6R UBE2Q1-AS1 UBE2Q1 TDRD10 SHE IL6R-AS1 CHRNB2 ILF2 CHTOP
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TPM3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TPM3 gene promoter:

Genomic Locations for TPM3 Gene

Genomic Locations for TPM3 Gene
chr1:154,155,304-154,194,648
(GRCh38/hg38)
Size:
39,345 bases
Orientation:
Minus strand
chr1:154,127,780-154,167,124
(GRCh37/hg19)

Genomic View for TPM3 Gene

Genes around TPM3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TPM3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TPM3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TPM3 Gene

Proteins for TPM3 Gene

  • Protein details for TPM3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P06753-TPM3_HUMAN
    Recommended name:
    Tropomyosin alpha-3 chain
    Protein Accession:
    P06753
    Secondary Accessions:
    • D3DV71
    • P12324
    • Q2QD06
    • Q5VU58
    • Q5VU63
    • Q5VU66
    • Q5VU71
    • Q5VU72
    • Q8TCG3
    • Q969Q2
    • Q9NQH8

    Protein attributes for TPM3 Gene

    Size:
    285 amino acids
    Molecular mass:
    32950 Da
    Quaternary structure:
    • Homodimer. Heterodimer of an alpha (TPM1, TPM3 or TPM4) and a beta (TPM2) chain (By similarity). Interacts with TMOD1 (PubMed:8002995).

    Alternative splice isoforms for TPM3 Gene

neXtProt entry for TPM3 Gene

Post-translational modifications for TPM3 Gene

  • Ubiquitination at posLast=1313, isoforms=3, 6169, and isoforms=5, 7228
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TPM3 Gene

Domains & Families for TPM3 Gene

Gene Families for TPM3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for TPM3 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

P06753

UniProtKB/Swiss-Prot:

TPM3_HUMAN :
  • The molecule is in a coiled coil structure that is formed by 2 polypeptide chains. The sequence exhibits a prominent seven-residues periodicity.
  • Belongs to the tropomyosin family.
Domain:
  • The molecule is in a coiled coil structure that is formed by 2 polypeptide chains. The sequence exhibits a prominent seven-residues periodicity.
Family:
  • Belongs to the tropomyosin family.
genes like me logo Genes that share domains with TPM3: view

Function for TPM3 Gene

Molecular function for TPM3 Gene

GENATLAS Biochemistry:
tropomyosin 3,alpha,skeletal muscle and non muscle isoforms (involved in the generation of the TRK oncogene by fusion with NTRK1,dimerizing to form a helical coiled coil binding to actin in the troponin complex (thin filamant) that regulates calcium-dependent binding of actin and myosin and muscle contraction
UniProtKB/Swiss-Prot Function:
Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments.

Phenotypes From GWAS Catalog for TPM3 Gene

Gene Ontology (GO) - Molecular Function for TPM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0003779 actin binding IEA --
GO:0005515 protein binding IPI 16189514
GO:0008307 structural constituent of muscle IBA --
GO:0051015 actin filament binding IBA --
genes like me logo Genes that share ontologies with TPM3: view
genes like me logo Genes that share phenotypes with TPM3: view

Human Phenotype Ontology for TPM3 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for TPM3 Gene

MGI Knock Outs for TPM3:

miRNA for TPM3 Gene

miRTarBase miRNAs that target TPM3

Clone Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for TPM3 Gene

Localization for TPM3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TPM3 Gene

Cytoplasm, cytoskeleton.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TPM3 gene
Compartment Confidence
extracellular 5
cytoskeleton 5
cytosol 5
nucleus 2
plasma membrane 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Actin filaments (2)
  • Cytosol (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TPM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001725 stress fiber IDA 16236705
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton TAS 16130169
GO:0005862 muscle thin filament tropomyosin TAS 3018581
genes like me logo Genes that share ontologies with TPM3: view

Pathways & Interactions for TPM3 Gene

genes like me logo Genes that share pathways with TPM3: view

Gene Ontology (GO) - Biological Process for TPM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006928 movement of cell or subcellular component TAS 16130169
GO:0006936 muscle contraction IBA,TAS --
GO:0007015 actin filament organization IBA --
GO:0030049 muscle filament sliding TAS --
genes like me logo Genes that share ontologies with TPM3: view

No data available for SIGNOR curated interactions for TPM3 Gene

Drugs & Compounds for TPM3 Gene

(3) Drugs for TPM3 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Approved Nutra 0
Phenethyl isothiocyanate Investigational Pharma Target 12
genes like me logo Genes that share compounds with TPM3: view

Transcripts for TPM3 Gene

Unigene Clusters for TPM3 Gene

Tropomyosin 3:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TPM3 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13
SP1: - - -
SP2:
SP3: -
SP4: -
SP5: -
SP6:

Relevant External Links for TPM3 Gene

GeneLoc Exon Structure for
TPM3
ECgene alternative splicing isoforms for
TPM3

Expression for TPM3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TPM3 Gene

mRNA differential expression in normal tissues according to GTEx for TPM3 Gene

This gene is overexpressed in Muscle - Skeletal (x16.2) and Whole Blood (x4.4).

Protein differential expression in normal tissues from HIPED for TPM3 Gene

This gene is overexpressed in Liver, secretome (6.8) and Peripheral blood mononuclear cells (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TPM3 Gene



Protein tissue co-expression partners for TPM3 Gene

NURSA nuclear receptor signaling pathways regulating expression of TPM3 Gene:

TPM3

SOURCE GeneReport for Unigene cluster for TPM3 Gene:

Hs.644306

Evidence on tissue expression from TISSUES for TPM3 Gene

  • Muscle(5)
  • Skin(4.8)
  • Kidney(4.7)
  • Nervous system(4.7)
  • Blood(4.6)
  • Liver(4.5)
  • Bone(4.4)
  • Lung(4.4)
  • Eye(3.8)
  • Pancreas(3.8)
  • Intestine(3.7)
  • Heart(2.6)
  • Spleen(2.5)
  • Bone marrow(2.3)
  • Lymph node(2.2)
  • Stomach(2.2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for TPM3 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • immune
  • integumentary
  • nervous
  • reproductive
  • respiratory
  • skeletal muscle
  • skeleton
Regions:
Head and neck:
  • brain
  • cheek
  • chin
  • cranial nerve
  • ear
  • eye
  • eyelid
  • face
  • forehead
  • head
  • jaw
  • larynx
  • mandible
  • maxilla
  • mouth
  • neck
  • nose
  • pharynx
  • skull
  • tongue
  • vocal cord
Thorax:
  • chest wall
  • clavicle
  • esophagus
  • heart
  • heart valve
  • lung
  • rib
  • rib cage
  • scapula
  • sternum
Abdomen:
  • stomach
Pelvis:
  • pelvis
  • placenta
  • uterus
Limb:
  • ankle
  • arm
  • digit
  • elbow
  • finger
  • foot
  • hand
  • hip
  • humerus
  • knee
  • lower limb
  • shoulder
  • toe
  • upper limb
  • wrist
General:
  • peripheral nerve
  • peripheral nervous system
  • skin
  • spinal column
  • spinal cord
  • vertebrae
genes like me logo Genes that share expression patterns with TPM3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for TPM3 Gene

Orthologs for TPM3 Gene

This gene was present in the common ancestor of animals.

Orthologs for TPM3 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia TPM3 34
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TPM3 34
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TPM3 34
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TPM3 33 34
  • 96.24 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TPM3 34
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tpm3 33 16 34
  • 84.74 (n)
chicken
(Gallus gallus)
Aves TPM3 34
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 100 (a)
OneToMany
-- 34
  • 88 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia Xl.34726 33
zebrafish
(Danio rerio)
Actinopterygii tpma 34
  • 93 (a)
OneToOne
tpm3 33
  • 81.69 (n)
fruit fly
(Drosophila melanogaster)
Insecta Tm2 34
  • 46 (a)
ManyToMany
Tm1 34
  • 22 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea lev-11 34
  • 59 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11015 34
  • 74 (a)
ManyToMany
CSA.10371 34
  • 67 (a)
ManyToMany
Species where no ortholog for TPM3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TPM3 Gene

ENSEMBL:
Gene Tree for TPM3 (if available)
TreeFam:
Gene Tree for TPM3 (if available)

Paralogs for TPM3 Gene

Variants for TPM3 Gene

Sequence variations from dbSNP and Humsavar for TPM3 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1001577539 uncertain-significance, Nemaline myopathy, Congenital fiber-type disproportion 154,167,654(-) C/G 3_prime_UTR_variant, genic_downstream_transcript_variant, intron_variant
rs1034745952 uncertain-significance, Nemaline myopathy, Congenital fiber-type disproportion 154,164,379(-) C/T 3_prime_UTR_variant, genic_downstream_transcript_variant, intron_variant
rs1044378492 uncertain-significance, Nemaline myopathy, Congenital fiber-type disproportion 154,165,973(-) T/C 3_prime_UTR_variant, genic_downstream_transcript_variant, intron_variant
rs10908723 benign, Congenital fiber-type disproportion, Nemaline myopathy 154,165,752(-) G/A 3_prime_UTR_variant, genic_downstream_transcript_variant, intron_variant
rs11265201 benign, Nemaline myopathy, Congenital fiber-type disproportion 154,165,218(-) C/T 3_prime_UTR_variant, genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TPM3 Gene

Variant ID Type Subtype PubMed ID
esv2663393 CNV deletion 23128226
esv29020 CNV loss 19812545
esv3587601 CNV loss 21293372
nsv1000153 CNV gain 25217958
nsv1119725 CNV deletion 24896259
nsv520398 CNV gain+loss 19592680
nsv946404 CNV duplication 23825009

Variation tolerance for TPM3 Gene

Residual Variation Intolerance Score: 26.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.14; 23.07% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TPM3 Gene

Human Gene Mutation Database (HGMD)
TPM3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TPM3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TPM3 Gene

Disorders for TPM3 Gene

MalaCards: The human disease database

(19) MalaCards diseases for TPM3 Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search TPM3 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

TPM3_HUMAN
  • Cap myopathy 1 (CAPM1) [MIM:609284]: A rare congenital skeletal muscle disorder characterized by the presence of cap-like structures which are well demarcated and peripherally located under the sarcolemma and show abnormal accumulation of sarcomeric proteins. Clinical features are early onset of hypotonia and slowly progressive muscle weakness. Respiratory problems are common. {ECO:0000269 PubMed:18300303, ECO:0000269 PubMed:19487656, ECO:0000269 PubMed:19553118, ECO:0000269 PubMed:24239060, ECO:0000269 PubMed:24692096}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Myopathy, congenital, with fiber-type disproportion (CFTD) [MIM:255310]: A genetically heterogeneous disorder in which there is relative hypotrophy of type 1 muscle fibers compared to type 2 fibers on skeletal muscle biopsy. However, these findings are not specific and can be found in many different myopathic and neuropathic conditions. {ECO:0000269 PubMed:18300303, ECO:0000269 PubMed:19953533, ECO:0000269 PubMed:20951040, ECO:0000269 PubMed:24692096}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Nemaline myopathy 1 (NEM1) [MIM:609284]: A form of nemaline myopathy with autosomal dominant or recessive inheritance. Nemaline myopathies are disorders characterized by muscle weakness of varying onset and severity, and abnormal thread-like or rod-shaped structures in muscle fibers on histologic examination. Autosomal dominant NEM1 is characterized by a moderate phenotype with onset between birth and early second decade of life. Weakness is diffuse and symmetric with slow progression often with need for a wheelchair in adulthood. The autosomal recessive form has onset at birth with moderate to severe hypotonia and diffuse weakness. In the most severe cases, death can occur before 2 years. Less severe cases have delayed major motor milestones, and these patients may walk, but often need a wheelchair before 10 years. {ECO:0000269 PubMed:10587521, ECO:0000269 PubMed:17376686, ECO:0000269 PubMed:24692096, ECO:0000269 PubMed:7704029}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Note=A chromosomal aberration involving TPM3 is found in papillary thyroid carcinomas (PTCs). A rearrangement with NTRK1 generates the TRK fusion transcript by fusing the amino end of isoform 2 of TPM3 to the 3-end of NTRK1. {ECO:0000269 PubMed:2869410}.

Additional Disease Information for TPM3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with TPM3: view

No data available for Genatlas for TPM3 Gene

Publications for TPM3 Gene

  1. Mutations of tropomyosin 3 (TPM3) are common and associated with type 1 myofiber hypotrophy in congenital fiber type disproportion. (PMID: 19953533) Lawlor MW … Beggs AH (Human mutation 2010) 3 4 22 58
  2. A mutation in the alpha tropomyosin gene TPM3 associated with autosomal dominant nemaline myopathy. (PMID: 7704029) Laing NG … Love DR (Nature genetics 1995) 3 4 22 58
  3. A systematic nomenclature for mammalian tropomyosin isoforms. (PMID: 25369766) Geeves MA … Gunning PW (Journal of muscle research and cell motility 2015) 2 3 58
  4. Mutation update and genotype-phenotype correlations of novel and previously described mutations in TPM2 and TPM3 causing congenital myopathies. (PMID: 24692096) Marttila M … Wallgren-Pettersson C (Human mutation 2014) 3 4 58
  5. Novel TPM3 mutation in a family with cap myopathy and review of the literature. (PMID: 24239060) Schreckenbach T … Claeys KG (Neuromuscular disorders : NMD 2014) 3 4 58

Products for TPM3 Gene

Sources for TPM3 Gene

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