Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TPD52L1 Gene

Aliases for TPD52L1 Gene

  • Tumor Protein D52 Like 1 2 3 5
  • Tumor Protein D52-Like 1 4
  • Tumor Protein D53 3
  • HD53 4
  • D53 3

External Ids for TPD52L1 Gene

Previous GeneCards Identifiers for TPD52L1 Gene

  • GC06P125322
  • GC06P125455
  • GC06P125516
  • GC06P123051

Summaries for TPD52L1 Gene

Entrez Gene Summary for TPD52L1 Gene

  • This gene encodes a member of a family of proteins that contain coiled-coil domains and may form hetero- or homomers. The encoded protein is involved in cell proliferation and calcium signaling. It also interacts with the mitogen-activated protein kinase kinase kinase 5 (MAP3K5/ASK1) and positively regulates MAP3K5-induced apoptosis. Multiple alternatively spliced transcript variants have been observed. [provided by RefSeq, Jan 2016]

GeneCards Summary for TPD52L1 Gene

TPD52L1 (Tumor Protein D52 Like 1) is a Protein Coding gene. Among its related pathways are Vesicle-mediated transport and Clathrin derived vesicle budding. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and protein heterodimerization activity. An important paralog of this gene is TPD52.

Gene Wiki entry for TPD52L1 Gene

Additional gene information for TPD52L1 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TPD52L1 Gene

Genomics for TPD52L1 Gene

GeneHancer (GH) Regulatory Elements for TPD52L1 Gene

Promoters and enhancers for TPD52L1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J125153 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 666.9 +35.3 35321 2.4 HDGF FOXA2 ARNT NEUROD1 SIN3A FEZF1 ZNF2 YY1 ZNF766 ZNF143 TPD52L1 HDDC2 LOC100126584
GH06J125200 Enhancer 1.2 Ensembl ENCODE 5.4 +82.9 82904 2.8 HDGF CLOCK NEUROD1 SIN3A ZNF2 YY1 ZNF766 ZNF213 FOS KLF13 HDDC2 TPD52L1 LOC100126584
GH06J125196 Enhancer 1 Ensembl ENCODE 4.8 +78.7 78667 2.9 PKNOX1 NFIB ZNF766 SMARCC2 RXRA USF2 REST NR2F2 ZNF217 SP1 LOC100126584 TRMT11 HDDC2 TPD52L1
GH06J125218 Enhancer 0.4 Ensembl ENCODE 5.6 +101.1 101109 2.6 HDDC2 TPD52L1 LOC100126584
GH06J125278 Enhancer 0.4 FANTOM5 4.5 +159.4 159382 0.3 OSR2 PRDM6 PRDM1 TPD52L1 HDDC2 LOC100126584
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TPD52L1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TPD52L1 gene promoter:
  • TBP
  • RFX1
  • E2F
  • E2F-1

Genomic Locations for TPD52L1 Gene

Genomic Locations for TPD52L1 Gene
145,359 bases
Plus strand
145,359 bases
Plus strand

Genomic View for TPD52L1 Gene

Genes around TPD52L1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TPD52L1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TPD52L1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TPD52L1 Gene

Proteins for TPD52L1 Gene

  • Protein details for TPD52L1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tumor protein D53
    Protein Accession:
    Secondary Accessions:
    • A8K757
    • A8K772
    • A8MUD2
    • A8MUJ7
    • A8MW70
    • F6V707
    • O43397
    • Q5TC99
    • Q5TDQ0
    • Q9BUQ6
    • Q9C054

    Protein attributes for TPD52L1 Gene

    204 amino acids
    Molecular mass:
    22449 Da
    Quaternary structure:
    • Forms a homodimer or heterodimer with other members of the family.
    • Sequence=AAC98475.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for TPD52L1 Gene


neXtProt entry for TPD52L1 Gene

Post-translational modifications for TPD52L1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Abcam antibodies for TPD52L1
  • Boster Bio Antibodies for TPD52L1
  • Santa Cruz Biotechnology (SCBT) Antibodies for TPD52L1

No data available for DME Specific Peptides for TPD52L1 Gene

Domains & Families for TPD52L1 Gene

Gene Families for TPD52L1 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for TPD52L1 Gene


Suggested Antigen Peptide Sequences for TPD52L1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TPD52 family.
  • Belongs to the TPD52 family.
genes like me logo Genes that share domains with TPD52L1: view

Function for TPD52L1 Gene

Molecular function for TPD52L1 Gene

GENATLAS Biochemistry:
tumor protein D52-like 1,breast carcinoma associated (hD53)

Gene Ontology (GO) - Molecular Function for TPD52L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 9484778
GO:0042802 identical protein binding IPI 9484778
GO:0042803 protein homodimerization activity IDA 9484778
GO:0046982 protein heterodimerization activity IDA 9484778
genes like me logo Genes that share ontologies with TPD52L1: view
genes like me logo Genes that share phenotypes with TPD52L1: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TPD52L1 Gene

Localization for TPD52L1 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TPD52L1 gene
Compartment Confidence
cytosol 3
nucleus 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cell Junctions (2)
  • Cytosol (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TPD52L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 12963375
GO:0048471 perinuclear region of cytoplasm IDA 12963375
genes like me logo Genes that share ontologies with TPD52L1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TPD52L1 Gene

Pathways & Interactions for TPD52L1 Gene

genes like me logo Genes that share pathways with TPD52L1: view

Gene Ontology (GO) - Biological Process for TPD52L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle IDA 16112108
GO:0043406 positive regulation of MAP kinase activity IDA 14761963
GO:0046330 positive regulation of JNK cascade IDA 14761963
GO:2001235 positive regulation of apoptotic signaling pathway IDA 14761963
genes like me logo Genes that share ontologies with TPD52L1: view

No data available for SIGNOR curated interactions for TPD52L1 Gene

Drugs & Compounds for TPD52L1 Gene

No Compound Related Data Available

Transcripts for TPD52L1 Gene

Unigene Clusters for TPD52L1 Gene

Tumor protein D52-like 1:
Representative Sequences:

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TPD52L1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c · 10d · 10e · 10f · 10g
SP1: - - - - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - -
SP4: - - -
SP5: - - - - - - - - - - -
SP6: - - - -
SP7: - - - - - - - -
SP8: - - - - - - -
SP9: - - - - - -
SP10: - - - - - -
SP11: - - - - -

Relevant External Links for TPD52L1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TPD52L1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TPD52L1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TPD52L1 Gene

This gene is overexpressed in Adrenal Gland (x5.2).

Protein differential expression in normal tissues from HIPED for TPD52L1 Gene

This gene is overexpressed in Skin (46.5) and Salivary gland (11.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TPD52L1 Gene

NURSA nuclear receptor signaling pathways regulating expression of TPD52L1 Gene:


SOURCE GeneReport for Unigene cluster for TPD52L1 Gene:


Evidence on tissue expression from TISSUES for TPD52L1 Gene

  • Lung(4.4)
  • Liver(4.3)
  • Muscle(4.3)
  • Adrenal gland(2.4)
  • Nervous system(2.4)
genes like me logo Genes that share expression patterns with TPD52L1: view

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TPD52L1 Gene

Orthologs for TPD52L1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TPD52L1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TPD52L1 34 33
  • 99.35 (n)
(Canis familiaris)
Mammalia TPD52L1 34 33
  • 90.86 (n)
(Bos Taurus)
Mammalia TPD52L1 34 33
  • 89.87 (n)
(Rattus norvegicus)
Mammalia Tpd52l1 33
  • 88.75 (n)
(Mus musculus)
Mammalia Tpd52l1 16 34 33
  • 88.4 (n)
(Monodelphis domestica)
Mammalia TPD52L1 34
  • 77 (a)
(Ornithorhynchus anatinus)
Mammalia TPD52L1 34
  • 46 (a)
(Gallus gallus)
Aves TPD52L1 34 33
  • 78.43 (n)
(Anolis carolinensis)
Reptilia TPD52L1 34
  • 76 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tpd52l1 33
  • 66.34 (n)
(Danio rerio)
Actinopterygii tpd52l1 34 33
  • 63.79 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG5174 34
  • 15 (a)
(Caenorhabditis elegans)
Secernentea F13E6.1 34
  • 26 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9626 34
  • 32 (a)
Species where no ortholog for TPD52L1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TPD52L1 Gene

Gene Tree for TPD52L1 (if available)
Gene Tree for TPD52L1 (if available)
Evolutionary constrained regions (ECRs) for TPD52L1: view image

Paralogs for TPD52L1 Gene

Paralogs for TPD52L1 Gene

(5) SIMAP similar genes for TPD52L1 Gene using alignment to 6 proteins:

  • F6V707_HUMAN
genes like me logo Genes that share paralogs with TPD52L1: view

Variants for TPD52L1 Gene

Sequence variations from dbSNP and Humsavar for TPD52L1 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000027106 -- 125,230,362(+) G/T intron_variant
rs1000084038 -- 125,229,782(+) G/T intron_variant
rs1000090963 -- 125,224,016(+) G/T intron_variant
rs1000118764 -- 125,222,688(+) T/C intron_variant
rs1000142717 -- 125,180,579(+) C/T genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TPD52L1 Gene

Variant ID Type Subtype PubMed ID
dgv3382n106 CNV deletion 24896259
esv2677911 CNV deletion 23128226
esv2732675 CNV deletion 23290073
esv2732676 CNV deletion 23290073
esv2732677 CNV deletion 23290073
esv2732678 CNV deletion 23290073
esv3302861 CNV tandem duplication 20981092
esv3363615 CNV insertion 20981092
esv3424415 CNV insertion 20981092
esv3540430 CNV deletion 23714750
esv3576230 CNV gain 25503493
esv3610682 CNV gain 21293372
esv3610683 CNV gain 21293372
esv3610684 CNV loss 21293372
esv3890943 CNV gain 25118596
nsv1029255 CNV gain 25217958
nsv1123267 CNV deletion 24896259
nsv1140692 CNV deletion 24896259
nsv1161450 CNV duplication 26073780
nsv604600 CNV gain 21841781
nsv830795 CNV loss 17160897
nsv950503 CNV deletion 24416366

Variation tolerance for TPD52L1 Gene

Residual Variation Intolerance Score: 53.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.50; 29.22% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TPD52L1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TPD52L1 Gene

Disorders for TPD52L1 Gene

Additional Disease Information for TPD52L1

No disorders were found for TPD52L1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TPD52L1 Gene

Publications for TPD52L1 Gene

  1. Definition of the tumor protein D52 (TPD52) gene family through cloning of D52 homologues in human (hD53) and mouse (mD52). (PMID: 8812487) Byrne JA … Basset P (Genomics 1996) 2 3 4 22 58
  2. D53 (TPD52L1) is a cell cycle-regulated protein maximally expressed at the G2-M transition in breast cancer cells. (PMID: 16112108) Boutros R … Byrne JA (Experimental cell research 2005) 2 3 22 58
  3. Identification of homo- and heteromeric interactions between members of the breast carcinoma-associated D52 protein family using the yeast two-hybrid system. (PMID: 9484778) Byrne JA … Gunning P (Oncogene 1998) 3 4 22 58
  4. A testis-specific and testis developmentally regulated tumor protein D52 (TPD52)-like protein TPD52L3/hD55 interacts with TPD52 family proteins. (PMID: 16631610) Cao Q … Li J (Biochemical and biophysical research communications 2006) 3 22 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58

Products for TPD52L1 Gene

Sources for TPD52L1 Gene

Loading form....