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Aliases for TPD52 Gene

Aliases for TPD52 Gene

  • Tumor Protein D52 2 3 3 5
  • Protein N8 3 4
  • Prostate And Colon Associated Protein 3
  • Prostate Leucine Zipper 3
  • PC-1 3
  • PrLZ 3
  • HD52 3
  • D52 3
  • N8L 3

External Ids for TPD52 Gene

Previous GeneCards Identifiers for TPD52 Gene

  • GC08M079835
  • GC08M080995
  • GC08M080670
  • GC08M080997
  • GC08M081110
  • GC08M076436
  • GC08M080870

Summaries for TPD52 Gene

GeneCards Summary for TPD52 Gene

TPD52 (Tumor Protein D52) is a Protein Coding gene. Diseases associated with TPD52 include Lung Squamous Cell Carcinoma and Nodular Malignant Melanoma. Among its related pathways are Vesicle-mediated transport and Clathrin derived vesicle budding. Gene Ontology (GO) annotations related to this gene include calcium ion binding and protein heterodimerization activity. An important paralog of this gene is ENSG00000276418.

Gene Wiki entry for TPD52 Gene

Additional gene information for TPD52 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TPD52 Gene

Genomics for TPD52 Gene

GeneHancer (GH) Regulatory Elements for TPD52 Gene

Promoters and enhancers for TPD52 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J080167 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 673.4 +61.4 61368 5.6 HDGF SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B ZNF213 ZNF207 ZNF143 FOS TPD52 MRPS28 ENSG00000254205 RN7SL41P
GH08J080078 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 672.9 +148.8 148834 8.5 HDGF PKNOX1 FOXA2 ZFP64 ARID4B NEUROD1 SIN3A DMAP1 IRF4 ZNF207 TPD52 LOC105375918 ENSG00000276418 MRPS28 ENSG00000254162 LOC105375919 ENSG00000254205
GH08J080038 Promoter/Enhancer 1.2 EPDnew Ensembl dbSUPER 660.6 +193.0 193031 0.4 ZNF316 MAFF MAFG EMSY MAFK TPD52 ENSG00000272264 LOC105375919 ENSG00000276418
GH08J080230 Enhancer 1.1 Ensembl ENCODE 657.8 +0.4 414 1.5 ELF3 RB1 ARID4B SIN3A ZNF2 ZBTB40 RAD21 RFX5 SLC30A9 ZNF143 TPD52 LOC105375920 RN7SL41P GC08M080196
GH08J080043 Promoter/Enhancer 1 EPDnew Ensembl dbSUPER 660 +187.5 187531 0.6 ZNF692 TPD52 ENSG00000272264 ENSG00000276418 LOC105375919
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TPD52 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TPD52 gene promoter:
  • Tal-1beta
  • ITF-2
  • YY1
  • AML1a
  • MyoD
  • GR
  • GR-alpha
  • GR-beta
  • Brachyury
  • Lmo2

Genomic Locations for TPD52 Gene

Genomic Locations for TPD52 Gene
196,488 bases
Minus strand
272,897 bases
Minus strand

Genomic View for TPD52 Gene

Genes around TPD52 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TPD52 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TPD52 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TPD52 Gene

Proteins for TPD52 Gene

  • Protein details for TPD52 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tumor protein D52
    Protein Accession:
    Secondary Accessions:
    • B7Z414
    • C9J502
    • D0UFD1
    • D0UFD2
    • D0UFD3
    • D0UFD4
    • D0UFD5
    • E5RKB4
    • Q13056
    • Q53EK8
    • Q6FGP3
    • Q6FGS3
    • Q86YZ2
    • Q9UCX8

    Protein attributes for TPD52 Gene

    224 amino acids
    Molecular mass:
    24327 Da
    Quaternary structure:
    • Forms a homodimer or heterodimer with other members of the family. All isoforms interact with several 14-3-3 proteins.
    • Sequence=BAD97351.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for TPD52 Gene

neXtProt entry for TPD52 Gene

Post-translational modifications for TPD52 Gene

  • Ubiquitination at posLast=149149 and isoforms=2, 3, 4, 5, 6, 7125
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Abcam antibodies for TPD52
  • Santa Cruz Biotechnology (SCBT) Antibodies for TPD52

No data available for DME Specific Peptides for TPD52 Gene

Domains & Families for TPD52 Gene

Gene Families for TPD52 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for TPD52 Gene


Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TPD52 family.
  • Belongs to the TPD52 family.
genes like me logo Genes that share domains with TPD52: view

Function for TPD52 Gene

Molecular function for TPD52 Gene

GENATLAS Biochemistry:
tumor protein D52,breast carcinoma associated

Phenotypes From GWAS Catalog for TPD52 Gene

Gene Ontology (GO) - Molecular Function for TPD52 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IDA 15576473
GO:0005515 protein binding IPI 9484778
GO:0042803 protein homodimerization activity IDA 9484778
GO:0046982 protein heterodimerization activity IDA 9484778
genes like me logo Genes that share ontologies with TPD52: view
genes like me logo Genes that share phenotypes with TPD52: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TPD52 Gene

Localization for TPD52 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TPD52 gene
Compartment Confidence
endoplasmic reticulum 5
cytosol 4
golgi apparatus 3
plasma membrane 2
nucleus 2
extracellular 1
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Golgi apparatus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TPD52 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 15576473
GO:0005783 endoplasmic reticulum IDA 10942595
GO:0048471 perinuclear region of cytoplasm IDA 16112108
genes like me logo Genes that share ontologies with TPD52: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TPD52 Gene

Pathways & Interactions for TPD52 Gene

genes like me logo Genes that share pathways with TPD52: view

SIGNOR curated interactions for TPD52 Gene

Other effect:

Gene Ontology (GO) - Biological Process for TPD52 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009653 anatomical structure morphogenesis TAS 8632896
GO:0030183 B cell differentiation IEP 15576473
GO:0046903 secretion TAS 15576473
genes like me logo Genes that share ontologies with TPD52: view

Drugs & Compounds for TPD52 Gene

(1) Additional Compounds for TPD52 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TPD52: view

Transcripts for TPD52 Gene

Unigene Clusters for TPD52 Gene

Tumor protein D52:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TPD52 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c · 13d · 13e · 13f · 13g · 13h
SP1: - - - - - - - -
SP2: - - - - - - - - - -
SP3: - - - - - - - - - - -
SP4: - - - - - - -
SP5: - - - - -
SP6: - - - -
SP7: - - - - - - - - - - - -
SP8: - - - - - -
SP9: - - - - - -
SP10: - - -
SP11: - -

Relevant External Links for TPD52 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TPD52 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TPD52 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TPD52 Gene

This gene is overexpressed in Oral epithelium (13.6), Salivary gland (9.0), and Islet of Langerhans (8.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TPD52 Gene

Protein tissue co-expression partners for TPD52 Gene

NURSA nuclear receptor signaling pathways regulating expression of TPD52 Gene:


SOURCE GeneReport for Unigene cluster for TPD52 Gene:


mRNA Expression by UniProt/SwissProt for TPD52 Gene:

Tissue specificity: Isoform 2 is expressed in colon, breast, prostate, pancreas and kidney tumor cell lines. Isoform 2 is expressed at high levels in kidney, prostate, brain, small intestine and pancreas, at moderate levels in placenta and colon, at low levels in lung, liver and heart, and at very low levels in spleen, thymus, peripheral mononuclear blood cells, testis and ovary.

Evidence on tissue expression from TISSUES for TPD52 Gene

  • Nervous system(4.9)
  • Intestine(4.6)
  • Liver(4.3)
  • Skin(4.3)
  • Spleen(4.3)
  • Pancreas(3.6)
  • Lung(2.6)
  • Stomach(2.4)
genes like me logo Genes that share expression patterns with TPD52: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TPD52 Gene

Orthologs for TPD52 Gene

This gene was present in the common ancestor of animals.

Orthologs for TPD52 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TPD52 34 33
  • 99.87 (n)
(Bos Taurus)
Mammalia TPD52 34 33
  • 91.82 (n)
(Canis familiaris)
Mammalia TPD52 34
  • 85 (a)
(Rattus norvegicus)
Mammalia Tpd52 33
  • 84.23 (n)
(Mus musculus)
Mammalia Tpd52 16 34 33
  • 82.31 (n)
(Ornithorhynchus anatinus)
Mammalia TPD52 34
  • 58 (a)
(Monodelphis domestica)
Mammalia TPD52 34
  • 48 (a)
(Gallus gallus)
Aves TPD52 34 33
  • 78.21 (n)
(Anolis carolinensis)
Reptilia TPD52 34
  • 77 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tpd52 33
  • 70.26 (n)
Str.17690 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.10244 33
(Danio rerio)
Actinopterygii tpd52 34 33
  • 64.68 (n)
Dr.14430 33
fruit fly
(Drosophila melanogaster)
Insecta CG5174 34
  • 18 (a)
(Caenorhabditis elegans)
Secernentea F13E6.1 34
  • 31 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9626 34
  • 37 (a)
Species where no ortholog for TPD52 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TPD52 Gene

Gene Tree for TPD52 (if available)
Gene Tree for TPD52 (if available)
Evolutionary constrained regions (ECRs) for TPD52: view image

Paralogs for TPD52 Gene

Paralogs for TPD52 Gene

(6) SIMAP similar genes for TPD52 Gene using alignment to 7 proteins:

  • E5RJ27_HUMAN
  • E5RK35_HUMAN
  • F5H0B0_HUMAN
  • H0YC44_HUMAN
genes like me logo Genes that share paralogs with TPD52: view

Variants for TPD52 Gene

Sequence variations from dbSNP and Humsavar for TPD52 Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000049557 -- 80,168,908(-) T/C genic_upstream_transcript_variant, intron_variant
rs1000128862 -- 80,053,889(-) C/T intron_variant
rs1000130481 -- 80,057,843(-) A/T intron_variant
rs1000149959 -- 80,139,877(-) T/C genic_upstream_transcript_variant, intron_variant
rs1000192958 -- 80,141,357(-) A/T genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TPD52 Gene

Variant ID Type Subtype PubMed ID
esv2737216 CNV deletion 23290073
esv33694 CNV gain 17666407
esv3413156 CNV insertion 20981092
esv3543725 CNV deletion 23714750
esv3617769 CNV loss 21293372
esv3617771 CNV loss 21293372
esv9040 CNV gain 19470904
nsv1128432 CNV deletion 24896259
nsv518684 CNV gain 19592680

Variation tolerance for TPD52 Gene

Residual Variation Intolerance Score: 66.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.32; 53.47% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TPD52 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TPD52 Gene

Disorders for TPD52 Gene

MalaCards: The human disease database

(2) MalaCards diseases for TPD52 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
lung squamous cell carcinoma
  • epidermoid cell carcinoma of the lung
nodular malignant melanoma
  • nodular melanoma
- elite association - COSMIC cancer census association via MalaCards
Search TPD52 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for TPD52

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with TPD52: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TPD52 Gene

Publications for TPD52 Gene

  1. PrLZ, a novel prostate-specific and androgen-responsive gene of the TPD52 family, amplified in chromosome 8q21.1 and overexpressed in human prostate cancer. (PMID: 14996714) Wang R … Chung LW (Cancer research 2004) 3 4 22 58
  2. Identification of homo- and heteromeric interactions between members of the breast carcinoma-associated D52 protein family using the yeast two-hybrid system. (PMID: 9484778) Byrne JA … Gunning P (Oncogene 1998) 3 4 22 58
  3. A screening method to identify genes commonly overexpressed in carcinomas and the identification of a novel complementary DNA sequence. (PMID: 7796418) Byrne JA … Basset P (Cancer research 1995) 2 3 4 58
  4. Polymorphisms in predicted miRNA binding sites and osteoporosis. (PMID: 20641033) Lei SF … Deng HW (Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2011) 3 44 58
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58

Products for TPD52 Gene

Sources for TPD52 Gene

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