Aliases for TNFAIP1 Gene
- TNF Alpha Induced Protein 1 2 3 5
- Tumor Necrosis Factor, Alpha-Induced Protein 1 (Endothelial) 2 3
- BTB/POZ Domain-Containing Protein TNFAIP1 3 4
- HBACURD2 3 4
- EDP1 3 4
- BTB/POZ Domain-Containing Adapter For CUL3-Mediated RhoA Degradation Protein 2 3
- Tumor Necrosis Factor, Alpha-Induced Protein 1, Endothelial 4
External Ids for TNFAIP1 Gene
Previous HGNC Symbols for TNFAIP1 Gene
Previous GeneCards Identifiers for TNFAIP1 Gene
This gene was identified as a gene whose expression can be induced by the tumor necrosis factor alpha (TNF) in umbilical vein endothelial cells. Studies of a similar gene in mouse suggest that the expression of this gene is developmentally regulated in a tissue-specific manner. [provided by RefSeq, Jul 2008]
GeneCards Summary for TNFAIP1 Gene
TNFAIP1 (TNF Alpha Induced Protein 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include ubiquitin-protein transferase activity and GTP-Rho binding. An important paralog of this gene is KCTD10.
UniProtKB/Swiss-Prot for TNFAIP1 Gene
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in regulation of cytoskeleton structure. The BCR(TNFAIP1) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration. Its interaction with RHOB may regulate apoptosis. May enhance the PCNA-dependent DNA polymerase delta activity.