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Aliases for TMPO Gene

Aliases for TMPO Gene

  • Thymopoietin 2 3 3 5
  • Thymopoietin-Related Peptide Isoforms Beta/Gamma 3 4
  • Thymopoietin-Related Peptide Isoform Alpha 3 4
  • LEM Domain Containing 4 2 3
  • TP Beta/Gamma 3 4
  • TP Alpha 3 4
  • LAP2 3 4
  • Thymopoietin, Isoforms Beta/Gamma 4
  • Lamina-Associated Polypeptide 2 3
  • Thymopoietin Isoform Alpha 4
  • TPRP Isoforms Beta/Gamma 4
  • TPRP Isoform Alpha 4
  • Thymopoietin Beta 3
  • PRO0868 3
  • CMD1T 3
  • LEMD4 3
  • TP 3

External Ids for TMPO Gene

Previous GeneCards Identifiers for TMPO Gene

  • GC12M098312
  • GC12P099412
  • GC12P098842
  • GC12P097411
  • GC12P098909
  • GC12P095970

Summaries for TMPO Gene

Entrez Gene Summary for TMPO Gene

  • The protein encoded by this gene resides in the nucleus and may play a role in the assembly of the nuclear lamina, and thus help maintain the structural organization of the nuclear envelope. It may function as a receptor for the attachment of lamin filaments to the inner nuclear membrane. Mutations in this gene are associated with dilated cardiomyopathy. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, May 2010]

GeneCards Summary for TMPO Gene

TMPO (Thymopoietin) is a Protein Coding gene. Diseases associated with TMPO include Dilated Cardiomyopathy 1T and Familial Isolated Dilated Cardiomyopathy. Among its related pathways are Mitotic Prophase and Transport of the SLBP independent Mature mRNA. Gene Ontology (GO) annotations related to this gene include lamin binding.

UniProtKB/Swiss-Prot for TMPO Gene

  • May be involved in the structural organization of the nucleus and in the post-mitotic nuclear assembly. Plays an important role, together with LMNA, in the nuclear anchorage of RB1.

  • TP and TP5 may play a role in T-cell development and function. TP5 is an immunomodulating pentapeptide.

  • May help direct the assembly of the nuclear lamina and thereby help maintain the structural organization of the nuclear envelope. Possible receptor for attachment of lamin filaments to the inner nuclear membrane. May be involved in the control of initiation of DNA replication through its interaction with NAKAP95.

  • Thymopoietin (TP) and Thymopentin (TP5) may play a role in T-cell development and function. TP5 is an immunomodulating pentapeptide.

Gene Wiki entry for TMPO Gene

Additional gene information for TMPO Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMPO Gene

Genomics for TMPO Gene

GeneHancer (GH) Regulatory Elements for TMPO Gene

Promoters and enhancers for TMPO Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12I098512 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 610.1 +0.6 607 7 FEZF1 DMAP1 YY1 E2F8 ZNF143 SP3 NFYC ZNF610 GLIS1 NBN TMPO TMPO-AS1 GC12P098518 GC12M098515 RNU4-41P SLC9A7P1 LINC02453
GH12I098592 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 52.8 +79.0 79004 4.3 PKNOX1 SMAD1 FOXA2 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC25A3 GC12M098595 TMPO IKBIP APAF1 TMPO-AS1
GH12I098643 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 21.7 +129.7 129654 4.1 FOXA2 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 POLR2B ZNF766 E2F8 IKBIP APAF1 TMPO SLC25A3 PPIAP8 GC12P098649
GH12I098502 Promoter/Enhancer 1.8 Ensembl ENCODE dbSUPER 18.1 -11.6 -11615 2.9 ZFP64 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 ZNF610 RCOR2 GC12P098505 LINC02453 TRD-GTC1-1 TRW-CCA4-1 TMPO SLC9A7P1 SLC25A3
GH12I098490 Enhancer 1.6 VISTA Ensembl ENCODE dbSUPER 17.1 -23.9 -23943 4.2 HDGF FOXA2 MLX ARNT ARID4B SIN3A DMAP1 IRF4 ETS1 YY1 TMPO RNU4-41P SLC9A7P1 GC12P098497 LINC02453 GC12M098479
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TMPO on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TMPO gene promoter:

Genomic Locations for TMPO Gene

Genomic Locations for TMPO Gene
chr12:98,515,512-98,550,379
(GRCh38/hg38)
Size:
34,868 bases
Orientation:
Plus strand
chr12:98,909,290-98,944,157
(GRCh37/hg19)

Genomic View for TMPO Gene

Genes around TMPO on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMPO Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMPO Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMPO Gene

Proteins for TMPO Gene

  • Protein details for TMPO Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P42166-LAP2A_HUMAN
    Recommended name:
    Lamina-associated polypeptide 2, isoform alpha
    Protein Accession:
    P42166
    Secondary Accessions:
    • P08918
    • P08919
    • Q14860
    • Q16295

    Protein attributes for TMPO Gene

    Size:
    694 amino acids
    Molecular mass:
    75492 Da
    Quaternary structure:
    • Interacts with LMNA, BANF1 and RB1 and with chromosomes. Associates directly or indirectly with lamins at specific cell-cycle stages.

    Three dimensional structures from OCA and Proteopedia for TMPO Gene

    Alternative splice isoforms for TMPO Gene

    UniProtKB/Swiss-Prot:
  • Protein details for TMPO Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P42167-LAP2B_HUMAN
    Recommended name:
    Lamina-associated polypeptide 2, isoforms beta/gamma
    Protein Accession:
    P42167
    Secondary Accessions:
    • A2T926
    • Q14861

    Protein attributes for TMPO Gene

    Size:
    454 amino acids
    Molecular mass:
    50670 Da
    Quaternary structure:
    • Interacts with LMNB1, LMNB2, BANF1, AKAP8L, GMCL and chromosomes (By similarity). Isoform Zeta interacts with BANF1/BAF and may sequester it in the cytoplasm.

    Alternative splice isoforms for TMPO Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMPO Gene

Post-translational modifications for TMPO Gene

  • Phosphorylated in a mitose-specific manner.
  • Citrullinated by PADI4.
  • Mitosis-specific phosphorylation specifically abolishes its binding to lamin B and chromosomes.
  • Ubiquitination at isoforms=2, 3213, posLast=346346, isoforms=2389, posLast=393393, and posLast=401401
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TMPO Gene

Domains & Families for TMPO Gene

Gene Families for TMPO Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins

Graphical View of Domain Structure for InterPro Entry

P42166

UniProtKB/Swiss-Prot:

LAP2B_HUMAN :
  • The N-terminal part contains two structurally independent, non-interacting domains: LEM-like (also called LAP2-N or LEM-D) and LEM (also called LAP2-C or LEM-B). LEM-like binds DNA while LEM interacts with BANF1.
  • Belongs to the LEM family.
Domain:
  • The N-terminal part contains two structurally independent, non-interacting domains: LEM-like (also called LAP2-N or LEM-D) and LEM (also called LAP2-C or LEM-B). LEM-like binds DNA while LEM interacts with BANF1.
  • The C-terminal domain forms a four-stranded coiled coil.
  • Has two structurally independent, non-interacting domains: LEM-like (also called LAP2-N or LEM-D) and LEM (also called LAP2-C or LEM-B). LEM-like binds DNA while LEM interacts with BANF1.
Family:
  • Belongs to the LEM family.
  • Belongs to the LEM family.
genes like me logo Genes that share domains with TMPO: view

Function for TMPO Gene

Molecular function for TMPO Gene

GENATLAS Biochemistry:
thymopoietin,nuclear precursor of subunits alpha (75kDa),beta (51kDa),gamma (39kDa),LAP2 (lamina-associated protein 2) family
UniProtKB/Swiss-Prot Function:
May be involved in the structural organization of the nucleus and in the post-mitotic nuclear assembly. Plays an important role, together with LMNA, in the nuclear anchorage of RB1.
UniProtKB/Swiss-Prot Function:
TP and TP5 may play a role in T-cell development and function. TP5 is an immunomodulating pentapeptide.
UniProtKB/Swiss-Prot Function:
May help direct the assembly of the nuclear lamina and thereby help maintain the structural organization of the nuclear envelope. Possible receptor for attachment of lamin filaments to the inner nuclear membrane. May be involved in the control of initiation of DNA replication through its interaction with NAKAP95.
UniProtKB/Swiss-Prot Function:
Thymopoietin (TP) and Thymopentin (TP5) may play a role in T-cell development and function. TP5 is an immunomodulating pentapeptide.

Gene Ontology (GO) - Molecular Function for TMPO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI --
GO:0005521 lamin binding TAS 8530026
GO:0045296 cadherin binding IDA 25468996
genes like me logo Genes that share ontologies with TMPO: view
genes like me logo Genes that share phenotypes with TMPO: view

Human Phenotype Ontology for TMPO Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for TMPO Gene

MGI Knock Outs for TMPO:

Clone Products

  • Addgene plasmids for TMPO

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Transcription Factor Targets and HOMER Transcription for TMPO Gene

Localization for TMPO Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMPO Gene

Nucleus. Chromosome. Note=Expressed diffusely throughout the nucleus.
Nucleus inner membrane; Single-pass type II membrane protein. Note=Tightly associated with the nuclear lamina.
Isoform Zeta: Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMPO gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear membrane (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TMPO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000785 chromatin IDA 17284516
GO:0005634 nucleus TAS,IDA 17284516
GO:0005635 nuclear envelope IDA,IEA --
GO:0005637 nuclear inner membrane IEA --
GO:0005694 chromosome IEA --
genes like me logo Genes that share ontologies with TMPO: view

Pathways & Interactions for TMPO Gene

genes like me logo Genes that share pathways with TMPO: view

Gene Ontology (GO) - Biological Process for TMPO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with TMPO: view

No data available for SIGNOR curated interactions for TMPO Gene

Drugs & Compounds for TMPO Gene

(18) Drugs for TMPO Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(16) Additional Compounds for TMPO Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TMPO: view

Transcripts for TMPO Gene

Unigene Clusters for TMPO Gene

Thymopoietin:
Representative Sequences:

Clone Products

  • Addgene plasmids for TMPO

Alternative Splicing Database (ASD) splice patterns (SP) for TMPO Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b
SP1: - - -
SP2: - - - - - -
SP3: -
SP4:
SP5:

Relevant External Links for TMPO Gene

GeneLoc Exon Structure for
TMPO
ECgene alternative splicing isoforms for
TMPO

Expression for TMPO Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMPO Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TMPO Gene



Protein tissue co-expression partners for TMPO Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TMPO Gene:

TMPO

SOURCE GeneReport for Unigene cluster for TMPO Gene:

Hs.11355

mRNA Expression by UniProt/SwissProt for TMPO Gene:

P42166-LAP2A_HUMAN
Tissue specificity: Expressed in many tissues. Most abundant in adult thymus and fetal liver.

Evidence on tissue expression from TISSUES for TMPO Gene

  • Nervous system(4.8)
  • Blood(4.4)
  • Eye(4.3)
  • Liver(4.3)
  • Spleen(2.7)
  • Bone marrow(2.5)

Phenotype-based relationships between genes and organs from Gene ORGANizer for TMPO Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • nervous
  • respiratory
  • skeletal muscle
Regions:
Head and neck:
  • brain
  • ear
  • head
Thorax:
  • heart
  • heart valve
  • lung
Limb:
  • lower limb
  • upper limb
General:
  • blood
  • blood vessel
  • coagulation system
  • red blood cell
  • spinal cord
genes like me logo Genes that share expression patterns with TMPO: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein differential expression in normal tissues for TMPO Gene

Orthologs for TMPO Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMPO Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMPO 33 34
  • 99.71 (n)
dog
(Canis familiaris)
Mammalia TMPO 33 34
  • 94.78 (n)
mouse
(Mus musculus)
Mammalia Tmpo 33 16 34
  • 89.75 (n)
rat
(Rattus norvegicus)
Mammalia Tmpo 33
  • 89.75 (n)
cow
(Bos Taurus)
Mammalia TMPO 33 34
  • 75.45 (n)
oppossum
(Monodelphis domestica)
Mammalia TMPO 34
  • 42 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMPO 34
  • 38 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMPO 33 34
  • 80.26 (n)
lizard
(Anolis carolinensis)
Reptilia TMPO 34
  • 37 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmpo 33
  • 69.58 (n)
MGC75950 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.464 33
zebrafish
(Danio rerio)
Actinopterygii tmpoa 33 34
  • 59.21 (n)
tmpob 34
  • 30 (a)
OneToMany
TMPO (3 of 3) 34
  • 28 (a)
OneToMany
tmpo 33
Species where no ortholog for TMPO was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMPO Gene

ENSEMBL:
Gene Tree for TMPO (if available)
TreeFam:
Gene Tree for TMPO (if available)

Paralogs for TMPO Gene

genes like me logo Genes that share paralogs with TMPO: view

No data available for Paralogs for TMPO Gene

Variants for TMPO Gene

Sequence variations from dbSNP and Humsavar for TMPO Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1024759923 uncertain-significance, Dilated Cardiomyopathy, Dominant 98,533,975(+) A/G coding_sequence_variant, intron_variant, missense_variant
rs1060499573 uncertain-significance, Dilated cardiomyopathy 1T 98,533,555(+) G/A/C coding_sequence_variant, intron_variant, missense_variant
rs1060502979 uncertain-significance, Loeys-Dietz syndrome 2 98,533,710(+) A/G coding_sequence_variant, intron_variant, missense_variant
rs1060502980 uncertain-significance, Loeys-Dietz syndrome 2 98,533,413(+) G/A coding_sequence_variant, intron_variant, missense_variant
rs1085307099 uncertain-significance, Dilated cardiomyopathy 1T 98,533,795(+) T/ coding_sequence_variant, frameshift, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TMPO Gene

Variant ID Type Subtype PubMed ID
esv2601754 CNV deletion 19546169
esv2761763 CNV loss 21179565
nsv1040329 CNV gain 25217958
nsv1138163 CNV deletion 24896259
nsv7234 OTHER inversion 18451855
nsv975655 CNV duplication 23825009

Variation tolerance for TMPO Gene

Residual Variation Intolerance Score: 63.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.64; 78.34% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMPO Gene

Human Gene Mutation Database (HGMD)
TMPO
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMPO

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMPO Gene

Disorders for TMPO Gene

MalaCards: The human disease database

(12) MalaCards diseases for TMPO Gene - From: HGMD, GTR, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
dilated cardiomyopathy 1t
  • cmd1t
familial isolated dilated cardiomyopathy
  • familial or idiopathic dilated cardiomyopathy
dilated cardiomyopathy
  • cardiomyopathy, familial idiopathic
alopecia totalis
  • loss of all scalp hair
dysentery
  • infectious diarrhea
- elite association - COSMIC cancer census association via MalaCards
Search TMPO in MalaCards View complete list of genes associated with diseases

Additional Disease Information for TMPO

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with TMPO: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TMPO Gene

Publications for TMPO Gene

  1. Three distinct human thymopoietins are derived from alternatively spliced mRNAs. (PMID: 7517549) Harris CA … Goldstein G (Proceedings of the National Academy of Sciences of the United States of America 1994) 2 3 4 22 58
  2. Structure and mapping of the human thymopoietin (TMPO) gene and relationship of human TMPO beta to rat lamin-associated polypeptide 2. (PMID: 8530026) Harris CA … Goldstein G (Genomics 1995) 3 4 22 58
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  4. Genome-wide SNP genotyping study using pooled DNA to identify candidate markers mediating susceptibility to end-stage renal disease attributed to Type 1 diabetes. (PMID: 19929986) Craig DW … DiStefano JK (Diabetic medicine : a journal of the British Diabetic Association 2009) 3 44 58
  5. LAP2zeta binds BAF and suppresses LAP2beta-mediated transcriptional repression. (PMID: 18403046) Shaklai S … Rechavi G (European journal of cell biology 2008) 3 4 58

Products for TMPO Gene

  • Addgene plasmids for TMPO

Sources for TMPO Gene