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Aliases for TRAPPC10 Gene

Aliases for TRAPPC10 Gene

  • Trafficking Protein Particle Complex 10 2 3 5
  • Trafficking Protein Particle Complex Subunit TMEM1 3 4
  • Trafficking Protein Particle Complex Subunit 130 2 3
  • Transport Protein Particle Subunit TMEM1 3 4
  • Transmembrane Protein 1 2 3
  • TRAPP 130 KDa Subunit 2 3
  • TRAPP Subunit TMEM1 3 4
  • EHOC-1 3 4
  • TMEM1 3 4
  • EHOC1 3 4
  • Trafficking Protein Particle Complex Subunit 10 3
  • Epilepsy Holoprosencephaly Candidate-1 Protein 3
  • Epilepsy Holoprosencephaly Candidate 1 Protein 4
  • Protein GT334 4
  • TRS130 3
  • GT334 3
  • TRS30 3

External Ids for TRAPPC10 Gene

Previous HGNC Symbols for TRAPPC10 Gene

  • TMEM1

Previous GeneCards Identifiers for TRAPPC10 Gene

  • GC00U913620
  • GC21P044257
  • GC21P045432
  • GC21P030802

Summaries for TRAPPC10 Gene

Entrez Gene Summary for TRAPPC10 Gene

  • The protein encoded by this gene is a transmembrane protein found in the cis-Golgi complex. The encoded protein is part of the multisubunit transport protein particle (TRAPP) complex and may be involved in vesicular transport from the endoplasmic reticulum to the Golgi. Mutations in this gene could be responsible for the Unverricht-Lundborg type of progressive myoclonus epilepsy, or for autoimmune polyglandular disease type 1. [provided by RefSeq, Jul 2008]

GeneCards Summary for TRAPPC10 Gene

TRAPPC10 (Trafficking Protein Particle Complex 10) is a Protein Coding gene. Diseases associated with TRAPPC10 include Holoprosencephaly and Autoimmune Polyendocrine Syndrome, Type I, With Or Without Reversible Metaphyseal Dysplasia. Among its related pathways are Transport to the Golgi and subsequent modification and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include sodium ion transmembrane transporter activity. An important paralog of this gene is LOC102724200.

UniProtKB/Swiss-Prot for TRAPPC10 Gene

  • May play a role in vesicular transport from endoplasmic reticulum to Golgi.

Gene Wiki entry for TRAPPC10 Gene

Additional gene information for TRAPPC10 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRAPPC10 Gene

Genomics for TRAPPC10 Gene

GeneHancer (GH) Regulatory Elements for TRAPPC10 Gene

Promoters and enhancers for TRAPPC10 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH21J044011 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 650.7 +0.9 897 4.1 HDGF PKNOX1 CLOCK SMAD1 ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B TRAPPC10 PWP2 RRP1B ENSG00000184441 U2AF1 H2AFZP1
GH21J044010 Enhancer 0.9 ENCODE dbSUPER 650.7 -1.7 -1664 0.2 TFAP4 SAP130 ARID4B ERF ZIC2 RAD21 RARA TEAD3 POLR2A NR2F6 TRAPPC10 PWP2 RNU6-1150P
GH21J043658 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 16.3 -352.1 -352146 2.8 HDGF SMAD1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 SLC30A9 POLR2B RRP1B HSF2BP PWP2 WDR4 U2AF1 ENSG00000184441 ENSG00000233754 PKNOX1 TRAPPC10 PDXK
GH21J043974 Enhancer 1.4 Ensembl ENCODE dbSUPER 22.4 -36.8 -36840 1 HDGF ATF1 ARNT SIN3A YBX1 GLI4 TCF12 ZNF280A POLR2B CBX5 RRP1B PWP2 U2AF1 TRAPPC10 AATBC SIK1 UBE2G2 RNU6-859P AGPAT3 RRP1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TRAPPC10 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TRAPPC10 gene promoter:
  • CREB
  • TBP
  • Pax-5
  • c-Ets-1
  • E47
  • Hand1
  • ATF
  • AhR

Genomic Locations for TRAPPC10 Gene

Genomic Locations for TRAPPC10 Gene
94,234 bases
Plus strand
94,234 bases
Plus strand

Genomic View for TRAPPC10 Gene

Genes around TRAPPC10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRAPPC10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRAPPC10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRAPPC10 Gene

Proteins for TRAPPC10 Gene

  • Protein details for TRAPPC10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Trafficking protein particle complex subunit 10
    Protein Accession:
    Secondary Accessions:
    • Q3MIR2
    • Q86SI7
    • Q9UMD4
    • Q9Y4L3

    Protein attributes for TRAPPC10 Gene

    1259 amino acids
    Molecular mass:
    142189 Da
    Quaternary structure:
    • Component of the multisubunit TRAPP (transport protein particle) complex, which includes at least TRAPPC2, TRAPPC2L, TRAPPC3, TRAPPC3L, TRAPPC4, TRAPPC5, TRAPPC8, TRAPPC9, TRAPPC10, TRAPPC11 and TRAPPC12.
    • Sequence=AAC50134.1; Type=Frameshift; Positions=1187; Evidence={ECO:0000305};

    Alternative splice isoforms for TRAPPC10 Gene


neXtProt entry for TRAPPC10 Gene

Post-translational modifications for TRAPPC10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TRAPPC10 Gene

Domains & Families for TRAPPC10 Gene

Gene Families for TRAPPC10 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for TRAPPC10 Gene


Suggested Antigen Peptide Sequences for TRAPPC10 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TMEM1 family.
  • Belongs to the TMEM1 family.
genes like me logo Genes that share domains with TRAPPC10: view

Function for TRAPPC10 Gene

Molecular function for TRAPPC10 Gene

UniProtKB/Swiss-Prot Function:
May play a role in vesicular transport from endoplasmic reticulum to Golgi.

Phenotypes From GWAS Catalog for TRAPPC10 Gene

Gene Ontology (GO) - Molecular Function for TRAPPC10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21273506
GO:0015081 sodium ion transmembrane transporter activity TAS 7633421
GO:0017112 Rab guanyl-nucleotide exchange factor activity TAS --
genes like me logo Genes that share ontologies with TRAPPC10: view
genes like me logo Genes that share phenotypes with TRAPPC10: view

Animal Models for TRAPPC10 Gene

MGI Knock Outs for TRAPPC10:

Animal Model Products

CRISPR Products

miRNA for TRAPPC10 Gene

miRTarBase miRNAs that target TRAPPC10

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TRAPPC10

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TRAPPC10 Gene

Localization for TRAPPC10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRAPPC10 Gene

Golgi apparatus, cis-Golgi network.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRAPPC10 gene
Compartment Confidence
cytosol 5
golgi apparatus 4
endosome 4
nucleus 3
peroxisome 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for TRAPPC10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005794 Golgi apparatus IEA --
GO:0005829 cytosol TAS --
GO:0016021 integral component of membrane TAS 9196060
GO:0030008 TRAPP complex IDA 21525244
genes like me logo Genes that share ontologies with TRAPPC10: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TRAPPC10 Gene

Pathways & Interactions for TRAPPC10 Gene

genes like me logo Genes that share pathways with TRAPPC10: view

Gene Ontology (GO) - Biological Process for TRAPPC10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006814 sodium ion transport TAS 7633421
GO:0006891 intra-Golgi vesicle-mediated transport IBA --
GO:0016192 vesicle-mediated transport IEA --
GO:0034498 early endosome to Golgi transport IBA --
GO:0035725 sodium ion transmembrane transport IEA --
genes like me logo Genes that share ontologies with TRAPPC10: view

No data available for SIGNOR curated interactions for TRAPPC10 Gene

Drugs & Compounds for TRAPPC10 Gene

(2) Drugs for TRAPPC10 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with TRAPPC10: view

Transcripts for TRAPPC10 Gene

Unigene Clusters for TRAPPC10 Gene

Trafficking protein particle complex 10:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TRAPPC10

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRAPPC10 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20a · 20b · 20c ^ 21a · 21b ^ 22 ^
SP1: - - - -
SP2: -
SP3: -
SP5: -

ExUns: 23 ^ 24 ^ 25

Relevant External Links for TRAPPC10 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TRAPPC10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TRAPPC10 Gene

Protein differential expression in normal tissues from HIPED for TRAPPC10 Gene

This gene is overexpressed in Urine (14.7), Peripheral blood mononuclear cells (10.8), and Lymph node (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TRAPPC10 Gene

Protein tissue co-expression partners for TRAPPC10 Gene

NURSA nuclear receptor signaling pathways regulating expression of TRAPPC10 Gene:


SOURCE GeneReport for Unigene cluster for TRAPPC10 Gene:


mRNA Expression by UniProt/SwissProt for TRAPPC10 Gene:

Tissue specificity: Expressed in all tissues examined.

Evidence on tissue expression from TISSUES for TRAPPC10 Gene

  • Nervous system(4.4)
  • Liver(4.2)
genes like me logo Genes that share expression patterns with TRAPPC10: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRAPPC10 Gene

Orthologs for TRAPPC10 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TRAPPC10 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TRAPPC10 34 33
  • 99.52 (n)
(Canis familiaris)
Mammalia TRAPPC10 34 33
  • 87.66 (n)
(Bos Taurus)
Mammalia TRAPPC10 34 33
  • 86.18 (n)
(Ornithorhynchus anatinus)
Mammalia TRAPPC10 34
  • 86 (a)
(Monodelphis domestica)
Mammalia TRAPPC10 34
  • 86 (a)
(Mus musculus)
Mammalia Trappc10 16 34 33
  • 84.95 (n)
(Rattus norvegicus)
Mammalia Trappc10 33
  • 84.38 (n)
(Gallus gallus)
Aves TRAPPC10 34 33
  • 76.82 (n)
(Anolis carolinensis)
Reptilia TRAPPC10 34
  • 79 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia trappc10 33
  • 66.91 (n)
(Danio rerio)
Actinopterygii trappc10 33
  • 63.85 (n)
  • 61 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002242 33
  • 47.37 (n)
fruit fly
(Drosophila melanogaster)
Insecta SIDL 34 33
  • 45.17 (n)
(Caenorhabditis elegans)
Secernentea trpp-10 34
  • 18 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TRS130 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 41 (a)
Species where no ortholog for TRAPPC10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRAPPC10 Gene

Gene Tree for TRAPPC10 (if available)
Gene Tree for TRAPPC10 (if available)
Evolutionary constrained regions (ECRs) for TRAPPC10: view image

Paralogs for TRAPPC10 Gene

Paralogs for TRAPPC10 Gene

genes like me logo Genes that share paralogs with TRAPPC10: view

Variants for TRAPPC10 Gene

Sequence variations from dbSNP and Humsavar for TRAPPC10 Gene

SNP ID Clin Chr 21 pos Variation AA Info Type
rs386352376 uncertain-significance, not provided 44,091,981(+) A/G/T coding_sequence_variant, genic_downstream_transcript_variant, intron_variant, missense_variant, non_coding_transcript_variant
rs1000056650 -- 44,042,748(+) G/C genic_upstream_transcript_variant, intron_variant
rs1000087313 -- 44,030,253(+) G/C genic_upstream_transcript_variant, intron_variant
rs1000108698 -- 44,043,160(+) T/C genic_upstream_transcript_variant, intron_variant
rs1000136016 -- 44,054,864(+) G/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for TRAPPC10 Gene

Variant ID Type Subtype PubMed ID
esv25124 CNV gain 19812545
esv2723627 CNV deletion 23290073
esv33817 CNV loss 17666407
esv3557795 CNV deletion 23714750
esv3575397 CNV gain 25503493
nsv1063752 CNV gain 25217958
nsv1118936 CNV deletion 24896259
nsv1139033 CNV deletion 24896259
nsv1139034 CNV deletion 24896259
nsv587721 CNV loss 21841781
nsv587722 CNV loss 21841781

Variation tolerance for TRAPPC10 Gene

Residual Variation Intolerance Score: 15.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.72; 83.09% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TRAPPC10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRAPPC10 Gene

Disorders for TRAPPC10 Gene

MalaCards: The human disease database

(4) MalaCards diseases for TRAPPC10 Gene - From: DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for TRAPPC10

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with TRAPPC10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TRAPPC10 Gene

Publications for TRAPPC10 Gene

  1. Isolation and characterization of a candidate gene for progressive myoclonus epilepsy on 21q22.3. (PMID: 7633421) Yamakawa K … Korenberg JR (Human molecular genetics 1995) 2 3 4 22 58
  2. Genomic structure of the human GT334 (EHOC-1) gene mapping to 21q22.3. (PMID: 9370297) Lafrenière RG … Rouleau GA (Gene 1997) 3 4 22 58
  3. Genomic organization and complete nucleotide sequence of the TMEM1 gene on human chromosome 21q22.3. (PMID: 9196060) Nagamine K … Shimizu N (Biochemical and biophysical research communications 1997) 3 4 22 58
  4. C4orf41 and TTC-15 are mammalian TRAPP components with a role at an early stage in ER-to-Golgi trafficking. (PMID: 21525244) Scrivens PJ … Sacher M (Molecular biology of the cell 2011) 3 4 58
  5. L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms. (PMID: 20424473) Yokoyama K … Hosoya T (Nephron. Clinical practice 2010) 3 44 58

Products for TRAPPC10 Gene

Sources for TRAPPC10 Gene

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