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Aliases for TLR4 Gene

Aliases for TLR4 Gene

  • Toll Like Receptor 4 2 3 5
  • Toll-Like Receptor 4 2 3
  • HToll 3 4
  • Homolog Of Drosophila Toll 3
  • CD284 Antigen 4
  • ARMD10 3
  • CD284 3
  • TLR-4 3
  • TOLL 3

External Ids for TLR4 Gene

Previous GeneCards Identifiers for TLR4 Gene

  • GC09P111571
  • GC09P112113
  • GC09P113920
  • GC09P115842
  • GC09P117546
  • GC09P119506
  • GC09P120466
  • GC09P090084

Summaries for TLR4 Gene

Entrez Gene Summary for TLR4 Gene

  • The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

GeneCards Summary for TLR4 Gene

TLR4 (Toll Like Receptor 4) is a Protein Coding gene. Diseases associated with TLR4 include Macular Degeneration, Age-Related, 10 and Pertussis. Among its related pathways are MIF Action Through Endocytic Pathway and Rheumatoid arthritis. Gene Ontology (GO) annotations related to this gene include lipopolysaccharide binding. An important paralog of this gene is TLR8.

UniProtKB/Swiss-Prot for TLR4 Gene

  • Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) (PubMed:27022195). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (PubMed:9237759, PubMed:10835634, PubMed:27022195). Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate, and Ni(2+). Responses triggered by Ni(2+) require non-conserved histidines and are, therefore, species-specific (PubMed:20711192). Both M.tuberculosis HSP70 (dnaK) and HSP65 (groEL-2) act via this protein to stimulate NF-kappa-B expression (PubMed:15809303). In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to CD36. This event induces the formation of a heterodimer of TLR4 and TLR6, which is rapidly internalized and triggers inflammatory response, leading to the NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion. Binds electronegative LDL (LDL(-)) and mediates the cytokine release induced by LDL(-) (PubMed:23880187). Stimulation of monocytes in vitro with M.tuberculosis PstS1 induces p38 MAPK and ERK1/2 activation primarily via TLR2, but also partially via this receptor (PubMed:16622205).

Tocris Summary for TLR4 Gene

  • Toll-like receptors (TLRs) are single transmembrane cell-surface receptors, which have a key role in the innate immune system. TLRs generally exist as homodimers (heterodimers have been reported) and are found on immune cells; macrophages, B lymphocytes and mast cells.

Gene Wiki entry for TLR4 Gene

Additional gene information for TLR4 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TLR4 Gene

Genomics for TLR4 Gene

GeneHancer (GH) Regulatory Elements for TLR4 Gene

Promoters and enhancers for TLR4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J117702 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE dbSUPER 650.7 +0.8 761 4 CTCF TAF1 JUN MAX RAD21 YY1 POLR2A EGR1 ATF7 ETV6 ENSG00000285082 TLR4 RNU6-1082P GC09M117708
GH09J117714 Promoter/Enhancer 0.9 EPDnew dbSUPER 650.4 +10.3 10311 0.1 CTCF RAD21 TLR4 RNU6-1082P GC09M117708 ENSG00000285082 LOC105376244
GH09J117715 Promoter/Enhancer 0.7 EPDnew dbSUPER 650.4 +11.8 11798 0.1 TLR4 RNU6-1082P GC09M117708 ENSG00000285082 LOC105376244
GH09J117723 Enhancer 1.2 FANTOM5 Ensembl ENCODE dbSUPER 26.3 +20.8 20775 2.7 SP1 RXRA POLR2A HNF4A NR2F2 TLR4 GC09M117708 RNU6-1082P ENSG00000285082 LOC105376244
GH09J117744 Enhancer 0.6 FANTOM5 Ensembl 31 +40.8 40793 1.3 POLR2A TLR4 RNU6-1082P LOC105376244 GC09M117708 ENSG00000285082
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TLR4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TLR4 gene promoter:
  • AP-1
  • ATF-2
  • c-Jun
  • PPAR-alpha
  • Sp1
  • POU2F1
  • POU2F1a
  • AREB6

Genomic Locations for TLR4 Gene

Genomic Locations for TLR4 Gene
chr9:117,704,175-117,724,730
(GRCh38/hg38)
Size:
20,556 bases
Orientation:
Plus strand
chr9:120,466,460-120,479,768
(GRCh37/hg19)
Size:
13,309 bases
Orientation:
Plus strand

Genomic View for TLR4 Gene

Genes around TLR4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TLR4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TLR4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TLR4 Gene

Proteins for TLR4 Gene

  • Protein details for TLR4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00206-TLR4_HUMAN
    Recommended name:
    Toll-like receptor 4
    Protein Accession:
    O00206
    Secondary Accessions:
    • A8K1Y8
    • A9XLP9
    • A9XLQ0
    • A9XLQ1
    • B4E194
    • D1CS52
    • D1CS53
    • Q5VZI8
    • Q5VZI9
    • Q9UK78
    • Q9UM57

    Protein attributes for TLR4 Gene

    Size:
    839 amino acids
    Molecular mass:
    95680 Da
    Quaternary structure:
    • Belongs to the lipopolysaccharide (LPS) receptor, a multi-protein complex containing at least CD14, LY96 and TLR4 (PubMed:11274165). Binding to bacterial LPS leads to homodimerization. Interacts with LY96 via the extracellular domain (PubMed:17803912, PubMed:19252480). Interacts with MYD88 and TIRAP via their respective TIR domains (By similarity). Interacts with TICAM2 (PubMed:14519765, PubMed:25736436). Interacts with NOX4 (PubMed:15356101). Interacts with CNPY3 (By similarity). Interacts with HSP90B1. The interaction with both CNPY3 and HSP90B1 is required for proper folding in the endoplasmic reticulum. Interacts with MAP3K21; this interaction leads to negative regulation of TLR4 signaling (PubMed:21602844). Interacts with CD36, following CD36 stimulation by oxLDL or amyloid-beta 42, and forms a heterodimer with TLR6 (PubMed:20037584). The trimeric complex is internalized and triggers inflammatory response. LYN kinase activity facilitates TLR4-TLR6 heterodimerization and signal initiation. Interacts with TICAM1 in response to LPS in a WDFY1-dependent manner (PubMed:25736436). Interacts with WDFY1 in response to LPS (By similarity). Interacts with SMPDL3B (By similarity). Interacts with CEACAM1; upon lipopolysaccharide stimulation, forms a complex including TLR4 and the phosphorylated form of SYK and CEACAM1, which in turn, recruits PTPN6 that dephosphorylates SYK, reducing the production of reactive oxygen species (ROS) and lysosome disruption, which in turn, reduces the activity of the inflammasome (By similarity). Interacts with RFTN1; the interaction occurs in response to lipopolysaccharide stimulation (PubMed:27022195).
    Miscellaneous:
    • His-456 and His-458 are found in TLR4 of human and several other primate species and may be responsible for inflammatory responses triggered by nickel (Ni(2+)). Ni(2+) may cross-link the two receptor monomers through specific histidines, triggering the formation of a dimer that structurally resembles that induced by LPS. This process may be the basis for the development of contact allergy to Ni(2+). A mouse model of contact allergy to Ni(2+) in which TLR4-deficient mice expresses human TLR4 has been proposed.

    Three dimensional structures from OCA and Proteopedia for TLR4 Gene

    Alternative splice isoforms for TLR4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TLR4 Gene

Post-translational modifications for TLR4 Gene

  • N-glycosylated. Glycosylation of Asn-526 and Asn-575 seems to be necessary for the expression of TLR4 on the cell surface and the LPS-response. Likewise, mutants lacking two or more of the other N-glycosylation sites were deficient in interaction with LPS.
  • Glycosylation at posLast=630630, posLast=624624, posLast=575575, isoforms=2, 3526, isoforms=2, 3497, posLast=309309, isoforms=2, 3282, isoforms=2, 3205, isoforms=2173, and isoforms=35
  • Modification sites at PhosphoSitePlus

Other Protein References for TLR4 Gene

Antibody Products

No data available for DME Specific Peptides for TLR4 Gene

Domains & Families for TLR4 Gene

Gene Families for TLR4 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • CD markers
  • Predicted membrane proteins

Graphical View of Domain Structure for InterPro Entry

O00206

UniProtKB/Swiss-Prot:

TLR4_HUMAN :
  • The TIR domain mediates interaction with NOX4.
  • Belongs to the Toll-like receptor family.
Domain:
  • The TIR domain mediates interaction with NOX4.
Family:
  • Belongs to the Toll-like receptor family.
genes like me logo Genes that share domains with TLR4: view

Function for TLR4 Gene

Molecular function for TLR4 Gene

UniProtKB/Swiss-Prot Function:
Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) (PubMed:27022195). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (PubMed:9237759, PubMed:10835634, PubMed:27022195). Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate, and Ni(2+). Responses triggered by Ni(2+) require non-conserved histidines and are, therefore, species-specific (PubMed:20711192). Both M.tuberculosis HSP70 (dnaK) and HSP65 (groEL-2) act via this protein to stimulate NF-kappa-B expression (PubMed:15809303). In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to CD36. This event induces the formation of a heterodimer of TLR4 and TLR6, which is rapidly internalized and triggers inflammatory response, leading to the NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion. Binds electronegative LDL (LDL(-)) and mediates the cytokine release induced by LDL(-) (PubMed:23880187). Stimulation of monocytes in vitro with M.tuberculosis PstS1 induces p38 MAPK and ERK1/2 activation primarily via TLR2, but also partially via this receptor (PubMed:16622205).
GENATLAS Biochemistry:
Drosophila transmembrane receptor Toll homolog 4,specifically expressed in placenta,and on cells of the immune system binding directly to TLR2 and essential component of liposaccharides (LPS) receptor,inducing the LPS signaling pathway

Phenotypes From GWAS Catalog for TLR4 Gene

Gene Ontology (GO) - Molecular Function for TLR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001530 lipopolysaccharide binding IMP,NAS 10835634
GO:0001875 lipopolysaccharide receptor activity IDA 19252480
GO:0004888 transmembrane signaling receptor activity NAS 11970998
GO:0005102 signaling receptor binding IPI 20037584
GO:0005515 protein binding IPI 11441107
genes like me logo Genes that share ontologies with TLR4: view
genes like me logo Genes that share phenotypes with TLR4: view

Human Phenotype Ontology for TLR4 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for TLR4 Gene

MGI Knock Outs for TLR4:

Animal Model Products

Clone Products

  • Addgene plasmids for TLR4

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for TLR4 Gene

Localization for TLR4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TLR4 Gene

Cell membrane; Single-pass type I membrane protein. Early endosome. Note=Upon complex formation with CD36 and TLR6, internalized through dynamin-dependent endocytosis (PubMed:20037584). Colocalizes with RFTN1 at cell membrane and then together with RFTN1 moves to endosomes, upon lipopolysaccharide stimulation. {ECO:0000269 PubMed:20037584}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TLR4 gene
Compartment Confidence
plasma membrane 5
endosome 5
nucleus 4
extracellular 3
cytosol 3
cytoskeleton 2
mitochondrion 2
peroxisome 2
endoplasmic reticulum 2
lysosome 2
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (3)
  • Cytosol (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TLR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IPI 20037584
GO:0005737 cytoplasm IDA 19740627
GO:0005768 endosome IEA --
GO:0005769 early endosome IEA --
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with TLR4: view

Pathways & Interactions for TLR4 Gene

SuperPathway Contained pathways
1 Activated TLR4 signalling
2 Diseases associated with the TLR signaling cascade
3 Toll-like Receptor Signaling Pathway
4 IL-2 Pathway
5 Toll Comparative Pathway
genes like me logo Genes that share pathways with TLR4: view

SIGNOR curated interactions for TLR4 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for TLR4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000187 activation of MAPK activity ISS --
GO:0002218 activation of innate immune response IMP --
GO:0002224 toll-like receptor signaling pathway TAS --
GO:0002322 B cell proliferation involved in immune response IMP --
GO:0002376 immune system process IEA --
genes like me logo Genes that share ontologies with TLR4: view

Drugs & Compounds for TLR4 Gene

(94) Drugs for TLR4 Gene - From: DrugBank, PharmGKB, ClinicalTrials, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
lauric acid Approved, Experimental Pharma Agonist, Target 0
Paclitaxel Approved, Vet_approved Pharma inhibitor, Biomarker, binder Tubulin and Bcl2 inhibitor, Taxanes 3027
Tacrolimus Approved, Investigational Pharma 1151
Imiquimod Approved, Investigational Pharma Agonist TLR-7 agonist,immunomodulator with antiviral and antitumor activity, Toll-like receptor 7 (TLR7) agonist 148
Mifamurtide Approved, Experimental Pharma Target, ligand 7

(49) Additional Compounds for TLR4 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(5) Tocris Compounds for TLR4 Gene

Compound Action Cas Number
Imiquimod Toll-like receptor 7 (TLR7) agonist 99011-02-6
Pam3CSK4 TLR1/2 agonist; induces cytokine production 112208-00-1
Poly(I:C) TLR3 agonist 24939-03-5
Resiquimod Toll-like receptor 7 (TLR7) agonist 144875-48-9
RWJ 21757 Toll-like receptor 7 (TLR7) agonist 121288-39-9
genes like me logo Genes that share compounds with TLR4: view

Transcripts for TLR4 Gene

mRNA/cDNA for TLR4 Gene

Unigene Clusters for TLR4 Gene

Toll-like receptor 4:
Representative Sequences:

Clone Products

  • Addgene plasmids for TLR4

Alternative Splicing Database (ASD) splice patterns (SP) for TLR4 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c
SP1: -
SP2: - -
SP3: - - -
SP4:

Relevant External Links for TLR4 Gene

GeneLoc Exon Structure for
TLR4
ECgene alternative splicing isoforms for
TLR4

Expression for TLR4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TLR4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TLR4 Gene

This gene is overexpressed in Whole Blood (x15.3).

Protein differential expression in normal tissues from HIPED for TLR4 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (18.1), Testis (14.9), Liver (13.5), Heart (12.5), and Monocytes (8.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TLR4 Gene



Protein tissue co-expression partners for TLR4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TLR4 Gene:

TLR4

SOURCE GeneReport for Unigene cluster for TLR4 Gene:

Hs.174312

mRNA Expression by UniProt/SwissProt for TLR4 Gene:

O00206-TLR4_HUMAN
Tissue specificity: Highly expressed in placenta, spleen and peripheral blood leukocytes (PubMed:9435236, PubMed:9237759). Detected in monocytes, macrophages, dendritic cells and several types of T-cells (PubMed:9237759, PubMed:27022195).

Evidence on tissue expression from TISSUES for TLR4 Gene

  • Spleen(4.8)
  • Blood(4.7)
  • Lung(4.7)
  • Nervous system(4.7)
  • Kidney(4.6)
  • Lymph node(3.4)
  • Intestine(3.3)
  • Heart(3.1)
  • Bone marrow(3)
  • Liver(3)
  • Muscle(2.7)
  • Skin(2.2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for TLR4 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • immune
  • integumentary
  • lymphatic
  • nervous
  • reproductive
  • skeletal muscle
  • skeleton
Regions:
Head and neck:
  • brain
  • cranial nerve
  • eye
  • face
  • head
  • meninges
  • mouth
  • neck
Thorax:
  • esophagus
Abdomen:
  • intestine
  • large intestine
  • small intestine
  • stomach
Pelvis:
  • penis
  • testicle
  • vagina
Limb:
  • ankle
  • digit
  • elbow
  • finger
  • foot
  • hand
  • hip
  • knee
  • lower limb
  • shoulder
  • toe
  • upper limb
  • wrist
General:
  • blood
  • blood vessel
  • bone marrow
  • coagulation system
  • hair
  • peripheral nerve
  • peripheral nervous system
  • skin
  • spinal cord
  • white blood cell
genes like me logo Genes that share expression patterns with TLR4: view

Orthologs for TLR4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TLR4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TLR4 34 33
  • 99.76 (n)
OneToOne
dog
(Canis familiaris)
Mammalia TLR4 34 33
  • 82.28 (n)
OneToOne
cow
(Bos Taurus)
Mammalia TLR4 34 33
  • 81.58 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tlr4 33
  • 75.19 (n)
mouse
(Mus musculus)
Mammalia Tlr4 16 34 33
  • 75.16 (n)
oppossum
(Monodelphis domestica)
Mammalia TLR4 34
  • 55 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TLR4 34
  • 53 (a)
OneToOne
chicken
(Gallus gallus)
Aves TLR4 34 33
  • 55.84 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TLR4 34
  • 44 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii tlr4ba 34 33
  • 50.6 (n)
OneToMany
tlr4bb 34
  • 38 (a)
OneToMany
tlr4al 34
  • 38 (a)
OneToMany
Species where no ortholog for TLR4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TLR4 Gene

ENSEMBL:
Gene Tree for TLR4 (if available)
TreeFam:
Gene Tree for TLR4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TLR4: view image

Paralogs for TLR4 Gene

Paralogs for TLR4 Gene

(2) SIMAP similar genes for TLR4 Gene using alignment to 10 proteins:

  • TLR4_HUMAN
  • D1CS55_HUMAN
  • D2JYI2_HUMAN
  • D2JYI3_HUMAN
  • D2JYI4_HUMAN
  • D2JYI5_HUMAN
  • D2JYI6_HUMAN
  • D2JYI7_HUMAN
  • D2JYI8_HUMAN
  • D2JYI9_HUMAN
genes like me logo Genes that share paralogs with TLR4: view

Variants for TLR4 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for TLR4 Gene

TLR4_HUMAN-O00206
Allele TLR4*B (Gly-299, Ile-399) is associated with a blunted response to inhaled LPS.

Sequence variations from dbSNP and Humsavar for TLR4 Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs4986790 benign, TLR4 POLYMORPHISM 117,713,024(+) A/G/T coding_sequence_variant, missense_variant
rs4986791 benign, not-provided, TLR4 POLYMORPHISM, not provided 117,713,324(+) C/T coding_sequence_variant, missense_variant
rs137853920 not-provided, not provided 117,712,970(+) G/A coding_sequence_variant, missense_variant
rs1000071461 -- 117,711,708(+) T/A intron_variant
rs1000456320 -- 117,716,773(+) A/G 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for TLR4 Gene

Variant ID Type Subtype PubMed ID
nsv7434 OTHER inversion 18451855
nsv831706 CNV gain 17160897

Variation tolerance for TLR4 Gene

Residual Variation Intolerance Score: 87.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.17; 61.75% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TLR4 Gene

Human Gene Mutation Database (HGMD)
TLR4
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TLR4

SNP Genotyping and Copy Number Assay Products

Disorders for TLR4 Gene

MalaCards: The human disease database

(96) MalaCards diseases for TLR4 Gene - From: HGMD, GTR, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
macular degeneration, age-related, 10
  • armd10
pertussis
  • bordetella infection
pyelonephritis
suppurative otitis media
  • otitis media with effusion - purulent
cysticercosis
  • intestinal taenia solium infection
- elite association - COSMIC cancer census association via MalaCards
Search TLR4 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for TLR4

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with TLR4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TLR4 Gene

Publications for TLR4 Gene

  1. Toll-like receptor 4 variant D299G is associated with susceptibility to age-related macular degeneration. (PMID: 15829498) Zareparsi S … Swaroop A (Human molecular genetics 2005) 3 4 22 44 58
  2. Gene polymorphisms in association with emerging cardiovascular risk markers in adult women. (PMID: 20078877) Fan AZ … Mokdad AH (BMC medical genetics 2010) 3 22 44 58
  3. Toll-like receptor 4 and inducible nitric oxide synthase gene polymorphisms are associated with Type 2 diabetes. (PMID: 19395279) Bagarolli RA … Saad ST (Journal of diabetes and its complications 2010) 3 22 44 58
  4. A functional nonsynonymous toll-like receptor 4 gene polymorphism is associated with metabolic syndrome, surrogates of insulin resistance, and syndromes of lipid accumulation. (PMID: 19922963) Steinhardt AP … Taverna MJ (Metabolism: clinical and experimental 2010) 3 22 44 58
  5. The structural basis of lipopolysaccharide recognition by the TLR4-MD-2 complex. (PMID: 19252480) Park BS … Lee JO (Nature 2009) 3 4 22 58

Products for TLR4 Gene

  • Addgene plasmids for TLR4

Sources for TLR4 Gene

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