Free for academic non-profit institutions. Other users need a Commercial license

Aliases for SEC62 Gene

Aliases for SEC62 Gene

  • SEC62 Homolog, Preprotein Translocation Factor 2 3 5
  • Translocation Protein 1 2 3 4
  • TLOC1 3 4
  • HTP-1 3 4
  • TP-1 3 4
  • Membrane Protein SEC62, S.Cerevisiae, Homolog Of 3
  • SEC62 Preprotein Translocation Factor 3
  • SEC62 Homolog (S. Cerevisiae) 2
  • Translocation Protein SEC62 3
  • Dtrp1 3
  • HTP1 3

External Ids for SEC62 Gene

Previous HGNC Symbols for SEC62 Gene

  • TLOC1

Previous GeneCards Identifiers for SEC62 Gene

  • GC03P171167
  • GC03P169681
  • GC03P167054
  • GC03P169684

Summaries for SEC62 Gene

Entrez Gene Summary for SEC62 Gene

  • The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. The protein encoded by this gene and SEC63 protein are found to be associated with ribosome-free SEC61 complex. It is speculated that Sec61-Sec62-Sec63 may perform post-translational protein translocation into the ER. The Sec61-Sec62-Sec63 complex might also perform the backward transport of ER proteins that are subject to the ubiquitin-proteasome-dependent degradation pathway. The encoded protein is an integral membrane protein located in the rough ER. [provided by RefSeq, Jul 2008]

GeneCards Summary for SEC62 Gene

SEC62 (SEC62 Homolog, Preprotein Translocation Factor) is a Protein Coding gene. Among its related pathways are Protein processing in endoplasmic reticulum and Protein export. Gene Ontology (GO) annotations related to this gene include ATPase activity, coupled to transmembrane movement of substances.

UniProtKB/Swiss-Prot for SEC62 Gene

  • Required for preprotein translocation.

Gene Wiki entry for SEC62 Gene

Additional gene information for SEC62 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SEC62 Gene

Genomics for SEC62 Gene

GeneHancer (GH) Regulatory Elements for SEC62 Gene

Promoters and enhancers for SEC62 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J169964 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 650.7 +0.3 312 3.9 PKNOX1 SMAD1 FOXA2 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ENSG00000239219 LOC100128164 SEC62 MYNN SEC62-AS1 LRRC31 GPR160 PHC3 RPL22L1
GH03J169944 Enhancer 1.3 Ensembl ENCODE dbSUPER 12.7 -21.1 -21092 2.3 PKNOX1 ATF1 ARNT IRF4 ZNF143 ATF7 RUNX3 JUNB ZNF592 ATF4 ENSG00000244193 ENSG00000239219 SEC62 LRRC31 GPR160 SAMD7 LRRIQ4 LRRC34 GC03P169939 LOC100128164
GH03J170043 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 11 +80.6 80588 7.8 PKNOX1 FOXA2 STAT5A BMI1 FEZF1 BATF ZBTB7B IRF4 ZBTB40 ATF7 GPR160 SEC62 ENSG00000239219 LRRC34 LRRIQ4 SKIL GC03P170058
GH03J169938 Enhancer 1.2 Ensembl ENCODE dbSUPER 12.6 -26.0 -25969 4.2 PKNOX1 SMAD1 STAT5A BMI1 BATF TCF12 GATA2 ATF7 ETV6 BCLAF1 GC03P169939 ENSG00000239219 SEC62 LRRC31 SAMD7 GPR160 LRRC34 LRRIQ4 ENSG00000244193
GH03J170002 Enhancer 1.3 Ensembl ENCODE dbSUPER 11.3 +36.9 36863 3 ELF3 FOXA2 MLX ZFP64 ARID4B THRB ZNF48 ZSCAN9 RARA ZNF614 ENSG00000239219 GPR160 RNU4-38P SEC62 LRRC31 LRRC34 LRRIQ4 SEC62-AS1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around SEC62 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SEC62 gene promoter:
  • TBP
  • Nkx6-1
  • Chx10
  • Pax-3
  • SRY
  • FOXD1
  • Evi-1
  • POU6F1 (c2)
  • FOXD3
  • c-Ets-1

Genomic Locations for SEC62 Gene

Genomic Locations for SEC62 Gene
chr3:169,966,635-169,998,373
(GRCh38/hg38)
Size:
31,739 bases
Orientation:
Plus strand
chr3:169,684,423-169,716,161
(GRCh37/hg19)
Size:
31,739 bases
Orientation:
Plus strand

Genomic View for SEC62 Gene

Genes around SEC62 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SEC62 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SEC62 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SEC62 Gene

Proteins for SEC62 Gene

  • Protein details for SEC62 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99442-SEC62_HUMAN
    Recommended name:
    Translocation protein SEC62
    Protein Accession:
    Q99442
    Secondary Accessions:
    • D3DNQ0
    • O00682
    • O00729

    Protein attributes for SEC62 Gene

    Size:
    399 amino acids
    Molecular mass:
    45862 Da
    Quaternary structure:
    • Part of a complex that contains SEC61, SEC62 and SEC63. Interacts with SEC61B.

neXtProt entry for SEC62 Gene

Post-translational modifications for SEC62 Gene

  • Ubiquitination at posLast=6060, isoforms=51, and isoforms=19
  • Modification sites at PhosphoSitePlus

Other Protein References for SEC62 Gene

No data available for DME Specific Peptides for SEC62 Gene

Domains & Families for SEC62 Gene

Gene Families for SEC62 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for SEC62 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q99442

UniProtKB/Swiss-Prot:

SEC62_HUMAN :
  • Belongs to the SEC62 family.
Family:
  • Belongs to the SEC62 family.
genes like me logo Genes that share domains with SEC62: view

Function for SEC62 Gene

Molecular function for SEC62 Gene

UniProtKB/Swiss-Prot Function:
Required for preprotein translocation.

Phenotypes From GWAS Catalog for SEC62 Gene

Gene Ontology (GO) - Molecular Function for SEC62 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0038023 signaling receptor activity TAS 9020021
genes like me logo Genes that share ontologies with SEC62: view
genes like me logo Genes that share phenotypes with SEC62: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SEC62

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for SEC62 Gene

Localization for SEC62 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SEC62 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SEC62 gene
Compartment Confidence
endoplasmic reticulum 5
cytosol 5
plasma membrane 3
cytoskeleton 2
nucleus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (2)
  • Intermediate filaments (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SEC62 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum TAS 9020021
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0005791 rough endoplasmic reticulum ISS --
GO:0005829 cytosol TAS --
GO:0016020 membrane IDA 22375059
genes like me logo Genes that share ontologies with SEC62: view

Pathways & Interactions for SEC62 Gene

genes like me logo Genes that share pathways with SEC62: view

Gene Ontology (GO) - Biological Process for SEC62 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006613 cotranslational protein targeting to membrane TAS 9020021
GO:0006620 posttranslational protein targeting to endoplasmic reticulum membrane IMP 22375059
GO:0015031 protein transport IEA --
GO:0036498 IRE1-mediated unfolded protein response TAS --
genes like me logo Genes that share ontologies with SEC62: view

No data available for SIGNOR curated interactions for SEC62 Gene

Drugs & Compounds for SEC62 Gene

No Compound Related Data Available

Transcripts for SEC62 Gene

mRNA/cDNA for SEC62 Gene

Unigene Clusters for SEC62 Gene

SEC62 homolog (S. cerevisiae):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for SEC62

Alternative Splicing Database (ASD) splice patterns (SP) for SEC62 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b
SP1:
SP2:

Relevant External Links for SEC62 Gene

GeneLoc Exon Structure for
SEC62
ECgene alternative splicing isoforms for
SEC62

Expression for SEC62 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SEC62 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for SEC62 Gene

This gene is overexpressed in Nasal epithelium (41.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for SEC62 Gene



Protein tissue co-expression partners for SEC62 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SEC62 Gene:

SEC62

SOURCE GeneReport for Unigene cluster for SEC62 Gene:

Hs.744859

Evidence on tissue expression from TISSUES for SEC62 Gene

  • Liver(4.4)
  • Nervous system(3.6)
  • Kidney(2.7)
  • Lung(2.5)
genes like me logo Genes that share expression patterns with SEC62: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for SEC62 Gene

Orthologs for SEC62 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for SEC62 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SEC62 34 33
  • 99.92 (n)
OneToOne
dog
(Canis familiaris)
Mammalia -- 34
  • 98 (a)
OneToMany
SEC62 33
  • 94.82 (n)
-- 34
  • 92 (a)
OneToMany
cow
(Bos Taurus)
Mammalia SEC62 34 33
  • 95.41 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Sec62 33
  • 91.04 (n)
mouse
(Mus musculus)
Mammalia Sec62 16 34 33
  • 90.79 (n)
oppossum
(Monodelphis domestica)
Mammalia SEC62 34
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SEC62 34
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves SEC62 34 33
  • 82.45 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SEC62 34
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia sec62 33
  • 76.62 (n)
Str.3285 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.23749 33
zebrafish
(Danio rerio)
Actinopterygii sec62 34 33
  • 71.91 (n)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.14146 33
fruit fly
(Drosophila melanogaster)
Insecta Trp1 34
  • 34 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea C18E9.2 34
  • 38 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SEC62 36 34
  • 23 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9471 34
  • 31 (a)
OneToOne
Species where no ortholog for SEC62 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SEC62 Gene

ENSEMBL:
Gene Tree for SEC62 (if available)
TreeFam:
Gene Tree for SEC62 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for SEC62: view image

Paralogs for SEC62 Gene

(1) SIMAP similar genes for SEC62 Gene using alignment to 6 proteins:

  • SEC62_HUMAN
  • A0JLN5_HUMAN
  • F8WCJ7_HUMAN
  • F8WDG8_HUMAN
  • F8WF48_HUMAN
  • Q3KR08_HUMAN
genes like me logo Genes that share paralogs with SEC62: view

No data available for Paralogs for SEC62 Gene

Variants for SEC62 Gene

Sequence variations from dbSNP and Humsavar for SEC62 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000075558 -- 169,988,496(+) A/C intron_variant
rs1000136105 -- 169,995,935(+) A/G 3_prime_UTR_variant
rs1000335840 -- 169,968,415(+) A/G intron_variant
rs1000451966 -- 169,967,995(+) A/G intron_variant
rs1000530971 -- 169,981,223(+) A/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SEC62 Gene

Variant ID Type Subtype PubMed ID
esv2494675 CNV insertion 19546169
esv3310578 CNV novel sequence insertion 20981092
esv3338146 CNV insertion 20981092
esv3396477 CNV duplication 20981092
nsv7356 OTHER inversion 18451855

Variation tolerance for SEC62 Gene

Residual Variation Intolerance Score: 32% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.68; 46.01% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SEC62 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
SEC62

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SEC62 Gene

Disorders for SEC62 Gene

Additional Disease Information for SEC62

No disorders were found for SEC62 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for SEC62 Gene

Publications for SEC62 Gene

  1. Identification of a human cDNA homologue to the Drosophila translocation protein 1 (Dtrp1). (PMID: 9020021) Daimon M … Sasaki H (Biochemical and biophysical research communications 1997) 2 3 4 22 58
  2. Mammalian Sec61 is associated with Sec62 and Sec63. (PMID: 10799540) Meyer HA … Hartmann E (The Journal of biological chemistry 2000) 2 3 4 58
  3. Fine structure of the human translocation protein 1 (HTP1/TLOC1) gene. (PMID: 10683767) Daimon M … Kato T (IUBMB life 1999) 3 4 22 58
  4. Different effects of Sec61α, Sec62 and Sec63 depletion on transport of polypeptides into the endoplasmic reticulum of mammalian cells. (PMID: 22375059) Lang S … Dudek J (Journal of cell science 2012) 2 3 58
  5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 58

Products for SEC62 Gene

Sources for SEC62 Gene

Content
Loading form....