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Aliases for TLE4 Gene

Aliases for TLE4 Gene

  • Transducin Like Enhancer Of Split 4 2 3 5
  • Transducin-Like Enhancer Of Split 4 (E(Sp1) Homolog, Drosophila) 2 3
  • Groucho-Related Protein 4 3 4
  • Grg-4 3 4
  • GRG4 3 4
  • Transducin-Like Enhancer Of Split 4, Homolog Of Drosophila E(Sp1) 3
  • Transducin-Like Enhancer Protein 4 3
  • Enhancer Of Split Groucho 4 3
  • B Lymphocyte Gene 1 3
  • KIAA1261 4
  • E(SpI) 3
  • BCE-1 3
  • BCE1 3
  • ESG4 3
  • ESG 3

External Ids for TLE4 Gene

Previous GeneCards Identifiers for TLE4 Gene

  • GC09P073246
  • GC09M074057
  • GC09P075756
  • GC09P077644
  • GC09P077643
  • GC09P079416
  • GC09P081376
  • GC09P082186
  • GC09P052018

Summaries for TLE4 Gene

GeneCards Summary for TLE4 Gene

TLE4 (Transducin Like Enhancer Of Split 4) is a Protein Coding gene. Among its related pathways are Signaling by Wnt and Wnt / Hedgehog / Notch. Gene Ontology (GO) annotations related to this gene include chromatin binding and transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding. An important paralog of this gene is TLE1.

UniProtKB/Swiss-Prot for TLE4 Gene

  • Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by PAX5, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Essential for the transcriptional repressor activity of SIX3 during retina and lens development and for SIX3 transcriptional auto-repression (By similarity).

Gene Wiki entry for TLE4 Gene

Additional gene information for TLE4 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TLE4 Gene

Genomics for TLE4 Gene

GeneHancer (GH) Regulatory Elements for TLE4 Gene

Promoters and enhancers for TLE4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J079570 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 650.7 +0.9 852 5.2 HDGF PKNOX1 FOXA2 SMAD1 ARID4B SIN3A FEZF1 YY1 POLR2B ZNF213 GC09P079572 GC09P079573 TLE4 GC09P079610
GH09J079609 Enhancer 2.3 VISTA UCNEbase FANTOM5 Ensembl ENCODE dbSUPER 20.2 +39.2 39212 3.6 FEZF1 BATF BRCA1 IRF4 RCOR1 ETV6 ATF7 IKZF2 CREM EGR2 GC09P079610 TLE4 GC09P079662
GH09J079659 Enhancer 1.4 VISTA Ensembl ENCODE dbSUPER 11.7 +90.2 90155 5.2 SCRT1 MXI1 ESRRA RFX1 ZNF843 SP1 GATA3 POLR2A ZNF692 SCRT2 GC09P079663 GC09P079662 TLE4 GC09P079610
GH09J079692 Enhancer 1 Ensembl ENCODE dbSUPER 15.8 +122.2 122227 3.9 SMARCE1 EBF1 BATF BRCA1 ZNF217 CTBP1 GATA3 ATF7 MLLT1 MAFK TLE4 ENSG00000240979 GC09P079663
GH09J079629 Enhancer 1.3 VISTA UCNEbase ENCODE 11.3 +59.1 59092 2 BACH1 EBF1 BMI1 BATF IRF4 RELA POLR2A EED ATF7 IKZF2 TLE4 GC09P079610 GC09P079662
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TLE4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TLE4 gene promoter:
  • Sp1
  • E2F
  • Sox5
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • TBP

Genomic Locations for TLE4 Gene

Genomic Locations for TLE4 Gene
chr9:79,571,773-79,726,882
(GRCh38/hg38)
Size:
155,110 bases
Orientation:
Plus strand
chr9:82,186,688-82,341,658
(GRCh37/hg19)
Size:
154,971 bases
Orientation:
Plus strand

Genomic View for TLE4 Gene

Genes around TLE4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TLE4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TLE4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TLE4 Gene

Proteins for TLE4 Gene

  • Protein details for TLE4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q04727-TLE4_HUMAN
    Recommended name:
    Transducin-like enhancer protein 4
    Protein Accession:
    Q04727
    Secondary Accessions:
    • F8W6T6
    • Q3ZCS1
    • Q5T1Y2
    • Q6PCB3
    • Q9BZ07
    • Q9BZ08
    • Q9BZ09
    • Q9NSL3
    • Q9ULF9

    Protein attributes for TLE4 Gene

    Size:
    773 amino acids
    Molecular mass:
    83755 Da
    Quaternary structure:
    • Homooligomer and heterooligomer with other family members. Binds PAX5, LEF1, TCF7, TCF7L1 and TCF7L2. Interacts with ZNF703; TLE4 may mediate ZNF703 transcriptional repression. Interacts with SIX3 and SIX6 (By similarity). Interacts with PAX2.
    SequenceCaution:
    • Sequence=BAA86575.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAC22598.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAC22599.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI13644.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI13734.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI41315.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for TLE4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TLE4 Gene

Post-translational modifications for TLE4 Gene

No data available for DME Specific Peptides for TLE4 Gene

Domains & Families for TLE4 Gene

Gene Families for TLE4 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry

Q04727

UniProtKB/Swiss-Prot:

TLE4_HUMAN :
  • WD repeat Groucho/TLE family members are characterized by 5 regions, a glutamine-rich Q domain, a glycine/proline-rich GP domain, a central CcN domain, containing a nuclear localization signal, and a serine/proline-rich SP domain. The most highly conserved are the N-terminal Q domain and the C-terminal WD-repeat domain.
  • Belongs to the WD repeat Groucho/TLE family.
Domain:
  • WD repeat Groucho/TLE family members are characterized by 5 regions, a glutamine-rich Q domain, a glycine/proline-rich GP domain, a central CcN domain, containing a nuclear localization signal, and a serine/proline-rich SP domain. The most highly conserved are the N-terminal Q domain and the C-terminal WD-repeat domain.
Family:
  • Belongs to the WD repeat Groucho/TLE family.
genes like me logo Genes that share domains with TLE4: view

Function for TLE4 Gene

Molecular function for TLE4 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by PAX5, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Essential for the transcriptional repressor activity of SIX3 during retina and lens development and for SIX3 transcriptional auto-repression (By similarity).

Phenotypes From GWAS Catalog for TLE4 Gene

Gene Ontology (GO) - Molecular Function for TLE4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0003682 chromatin binding IEA --
GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding IEA --
GO:0003714 transcription corepressor activity IEA --
GO:0005515 protein binding IPI 24676634
genes like me logo Genes that share ontologies with TLE4: view
genes like me logo Genes that share phenotypes with TLE4: view

Animal Models for TLE4 Gene

MGI Knock Outs for TLE4:
  • Tle4 Tle4<tm1.2Dasw>

Animal Model Products

  • Taconic Biosciences Mouse Models for TLE4

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TLE4 Gene

Localization for TLE4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TLE4 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TLE4 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TLE4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,NAS 1303260
GO:0005654 nucleoplasm TAS --
GO:1990907 beta-catenin-TCF complex IDA 28296634
genes like me logo Genes that share ontologies with TLE4: view

Pathways & Interactions for TLE4 Gene

genes like me logo Genes that share pathways with TLE4: view

Gene Ontology (GO) - Biological Process for TLE4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0008150 biological_process ND --
GO:0016055 Wnt signaling pathway IEA --
genes like me logo Genes that share ontologies with TLE4: view

No data available for SIGNOR curated interactions for TLE4 Gene

Drugs & Compounds for TLE4 Gene

No Compound Related Data Available

Transcripts for TLE4 Gene

Unigene Clusters for TLE4 Gene

Transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TLE4 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c · 9d ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^
SP1: - - -
SP2: - - - -
SP3: - - - -
SP4: - - -
SP5:
SP6: -
SP7:
SP8: - - -
SP9: - - -
SP10:
SP11:

ExUns: 20
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for TLE4 Gene

GeneLoc Exon Structure for
TLE4
ECgene alternative splicing isoforms for
TLE4

Expression for TLE4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TLE4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TLE4 Gene

This gene is overexpressed in Testis (x4.8).

Protein differential expression in normal tissues from HIPED for TLE4 Gene

This gene is overexpressed in Testis (27.8), Ovary (24.1), and Heart (9.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TLE4 Gene



Protein tissue co-expression partners for TLE4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TLE4 Gene:

TLE4

SOURCE GeneReport for Unigene cluster for TLE4 Gene:

Hs.444213

mRNA Expression by UniProt/SwissProt for TLE4 Gene:

Q04727-TLE4_HUMAN
Tissue specificity: In all tissues examined, mostly in brain, and muscle.

Evidence on tissue expression from TISSUES for TLE4 Gene

  • Nervous system(4.7)
  • Liver(4.1)
genes like me logo Genes that share expression patterns with TLE4: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for TLE4 Gene

Orthologs for TLE4 Gene

This gene was present in the common ancestor of animals.

Orthologs for TLE4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TLE4 34 33
  • 99.5 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TLE4 34
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TLE4 34 33
  • 93.1 (n)
OneToOne
dog
(Canis familiaris)
Mammalia TLE4 34 33
  • 92.66 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Tle4 16 34 33
  • 92.32 (n)
rat
(Rattus norvegicus)
Mammalia Tle4 33
  • 91.72 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TLE4 34
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves TLE4 34 33
  • 86.63 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TLE4 34
  • 99 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tle4 33
  • 84 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.15157 33
zebrafish
(Danio rerio)
Actinopterygii tle2 34
  • 71 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta gro 34
  • 67 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010324 33
  • 60.93 (n)
worm
(Caenorhabditis elegans)
Secernentea unc-37 34
  • 41 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8664 34
  • 57 (a)
ManyToMany
CSA.10712 34
  • 53 (a)
ManyToMany
Species where no ortholog for TLE4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TLE4 Gene

ENSEMBL:
Gene Tree for TLE4 (if available)
TreeFam:
Gene Tree for TLE4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TLE4: view image

Paralogs for TLE4 Gene

Paralogs for TLE4 Gene

(6) SIMAP similar genes for TLE4 Gene using alignment to 15 proteins:

  • TLE4_HUMAN
  • B3KQ29_HUMAN
  • E7EQH3_HUMAN
  • F8W6T6_HUMAN
  • F8W9R0_HUMAN
  • F8WAY5_HUMAN
  • G8JLG4_HUMAN
  • H0Y5S0_HUMAN
  • H7C4E4_HUMAN
  • H7C4P7_HUMAN
  • H7C4W5_HUMAN
  • Q5JSY7_HUMAN
  • Q5JSY8_HUMAN
  • Q5JSZ1_HUMAN
  • Q5JSZ2_HUMAN

Pseudogenes.org Pseudogenes for TLE4 Gene

genes like me logo Genes that share paralogs with TLE4: view

Variants for TLE4 Gene

Sequence variations from dbSNP and Humsavar for TLE4 Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1000018449 -- 79,701,962(+) A/G genic_upstream_transcript_variant, intron_variant
rs1000025647 -- 79,652,253(+) C/G genic_upstream_transcript_variant, intron_variant
rs1000069629 -- 79,624,075(+) G/T genic_upstream_transcript_variant, intron_variant
rs1000083736 -- 79,617,226(+) C/T genic_upstream_transcript_variant, intron_variant
rs1000126914 -- 79,584,252(+) A/T genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TLE4 Gene

Variant ID Type Subtype PubMed ID
esv3450741 CNV insertion 20981092
nsv1048899 CNV gain 25217958
nsv831634 CNV loss 17160897

Variation tolerance for TLE4 Gene

Residual Variation Intolerance Score: 8.05% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.05; 37.65% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TLE4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TLE4

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TLE4 Gene

Disorders for TLE4 Gene

Additional Disease Information for TLE4

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for TLE4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TLE4 Gene

Publications for TLE4 Gene

  1. Mutations in PAX2 associate with adult-onset FSGS. (PMID: 24676634) Barua M … Pollak MR (Journal of the American Society of Nephrology : JASN 2014) 3 4 58
  2. Propensity score-based nonparametric test revealing genetic variants underlying bipolar disorder. (PMID: 21254220) Jiang Y … Zhang H (Genetic epidemiology 2011) 3 44 58
  3. Analyses of shared genetic factors between asthma and obesity in children. (PMID: 20816195) Melén E … Lasky-Su J (The Journal of allergy and clinical immunology 2010) 3 44 58
  4. Genome-wide association study implicates chromosome 9q21.31 as a susceptibility locus for asthma in mexican children. (PMID: 19714205) Hancock DB … London SJ (PLoS genetics 2009) 3 44 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58

Products for TLE4 Gene

Sources for TLE4 Gene

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