Aliases for ICAM5 Gene
External Ids for ICAM5 Gene
Previous HGNC Symbols for ICAM5 Gene
Previous GeneCards Identifiers for ICAM5 Gene
The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein is expressed on the surface of telencephalic neurons and displays two types of adhesion activity, homophilic binding between neurons and heterophilic binding between neurons and leukocytes. It may be a critical component in neuron-microglial cell interactions in the course of normal development or as part of neurodegenerative diseases. [provided by RefSeq, Jul 2008]
GeneCards Summary for ICAM5 Gene
ICAM5 (Intercellular Adhesion Molecule 5) is a Protein Coding gene. Diseases associated with ICAM5 include Holoprosencephaly. Among its related pathways are Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell and Degradation of the extracellular matrix. Gene Ontology (GO) annotations related to this gene include integrin binding. An important paralog of this gene is ICAM3.
UniProtKB/Swiss-Prot for ICAM5 Gene
ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2).