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Aliases for TIAL1 Gene

Aliases for TIAL1 Gene

  • TIA1 Cytotoxic Granule Associated RNA Binding Protein Like 1 2 3 5
  • TIA1 Cytotoxic Granule-Associated RNA-Binding Protein-Like 1 2
  • Aging-Associated Gene 7 Protein 3
  • T-Cluster Binding Protein 3
  • TIA-1-Related Nucleolysin 3
  • TIA-1-Related Protein 4
  • Nucleolysin TIAR 3
  • TCBP 3
  • TIAR 3

External Ids for TIAL1 Gene

Previous GeneCards Identifiers for TIAL1 Gene

  • GC10M120253
  • GC10M120578
  • GC10M121466
  • GC10M120999
  • GC10M121324
  • GC10M114963

Summaries for TIAL1 Gene

Entrez Gene Summary for TIAL1 Gene

  • The protein encoded by this gene is a member of a family of RNA-binding proteins, has three RNA recognition motifs (RRMs), and binds adenine and uridine-rich elements in mRNA and pre-mRNAs of a wide range of genes. It regulates various activities including translational control, splicing and apoptosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The different isoforms have been show to function differently with respect to post-transcriptional silencing. [provided by RefSeq, Jul 2008]

GeneCards Summary for TIAL1 Gene

TIAL1 (TIA1 Cytotoxic Granule Associated RNA Binding Protein Like 1) is a Protein Coding gene. Among its related pathways are Translational Control and Apoptosis and Autophagy. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is TIA1.

UniProtKB/Swiss-Prot for TIAL1 Gene

  • RNA-binding protein. Possesses nucleolytic activity against cytotoxic lymphocyte target cells. May be involved in apoptosis.

Gene Wiki entry for TIAL1 Gene

Additional gene information for TIAL1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TIAL1 Gene

Genomics for TIAL1 Gene

GeneHancer (GH) Regulatory Elements for TIAL1 Gene

Promoters and enhancers for TIAL1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J119594 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 686.3 +0.6 569 3.3 HDGF PKNOX1 CLOCK MLX ARID4B SIN3A DMAP1 ZNF2 ZBTB7B IRF4 TIAL1 GC10P119597 LOC105378512 SEC23IP MCMBP ENSG00000271353 RGS10
GH10J119598 Enhancer 0.7 ENCODE 650.7 -1.2 -1155 0.2 BATF IRF4 RELA POLR2A EED ZNF143 ETV6 IKZF2 RUNX3 CREM GC10P119597 TIAL1 ENSG00000271353 LOC105378512 GC10P119612
GH10J119650 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 32.7 -58.6 -58602 10.1 HDGF PKNOX1 FOXA2 ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B FOS BAG3 SEC23IP TIAL1 INPP5F MCMBP GRK5 TXNP1
GH10J119078 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 35.8 +516.8 516828 4 HDGF PKNOX1 FOXA2 SMAD1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 EIF3A GC10P119080 TIAL1 SEC23IP MCMBP NANOS1 RN7SL749P ENSG00000222588
GH10J119871 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 36 -275.6 -275588 3.2 PKNOX1 ARID4B SIN3A YY1 ZNF207 ZNF143 SP3 ZHX2 REST ZNF592 MCMBP TIAL1 WDR11 SEC23IP INPP5F ENSG00000282413
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TIAL1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TIAL1 gene promoter:
  • CHOP-10
  • C/EBPalpha
  • GR-beta
  • GR-alpha
  • GR
  • c-Myb
  • Meis-1a
  • Meis-1
  • Meis-1b
  • FOXJ2 (long isoform)

Genomic Locations for TIAL1 Gene

Genomic Locations for TIAL1 Gene
chr10:119,571,802-119,597,029
(GRCh38/hg38)
Size:
25,228 bases
Orientation:
Minus strand
chr10:121,332,977-121,356,541
(GRCh37/hg19)
Size:
23,565 bases
Orientation:
Minus strand

Genomic View for TIAL1 Gene

Genes around TIAL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TIAL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TIAL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TIAL1 Gene

Proteins for TIAL1 Gene

  • Protein details for TIAL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q01085-TIAR_HUMAN
    Recommended name:
    Nucleolysin TIAR
    Protein Accession:
    Q01085
    Secondary Accessions:
    • A8K3T0
    • A8K4L9

    Protein attributes for TIAL1 Gene

    Size:
    375 amino acids
    Molecular mass:
    41591 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for TIAL1 Gene

    Alternative splice isoforms for TIAL1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TIAL1 Gene

Post-translational modifications for TIAL1 Gene

  • Phosphorylated by MAPK14 following DNA damage, releasing TIAR from GADD45A mRNA.
  • Ubiquitination at isoforms=2203 and isoforms=2122
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TIAL1 Gene

Domains & Families for TIAL1 Gene

Gene Families for TIAL1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TIAL1: view

No data available for UniProtKB/Swiss-Prot for TIAL1 Gene

Function for TIAL1 Gene

Molecular function for TIAL1 Gene

UniProtKB/Swiss-Prot Function:
RNA-binding protein. Possesses nucleolytic activity against cytotoxic lymphocyte target cells. May be involved in apoptosis.

Phenotypes From GWAS Catalog for TIAL1 Gene

Gene Ontology (GO) - Molecular Function for TIAL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003723 RNA binding HDA,IEA 22658674
GO:0017091 AU-rich element binding IEA --
genes like me logo Genes that share ontologies with TIAL1: view
genes like me logo Genes that share phenotypes with TIAL1: view

Animal Models for TIAL1 Gene

MGI Knock Outs for TIAL1:

Animal Model Products

CRISPR Products

miRNA for TIAL1 Gene

miRTarBase miRNAs that target TIAL1

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TIAL1

Clone Products

  • Addgene plasmids for TIAL1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TIAL1 Gene

Localization for TIAL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TIAL1 Gene

Cytoplasm. Nucleus. Cytoplasmic granule. Note=The cytoplasmic granules are stress granules which are a dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress. Colocalizes with NANOS3 in the stress granules (By similarity). Cytoplasmic granules of cytolytic T-lymphocytes. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TIAL1 gene
Compartment Confidence
extracellular 5
nucleus 5
lysosome 4
cytosol 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleus (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TIAL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm ISS --
GO:0005764 lysosome TAS 1326761
GO:0010494 cytoplasmic stress granule ISS --
genes like me logo Genes that share ontologies with TIAL1: view

Pathways & Interactions for TIAL1 Gene

genes like me logo Genes that share pathways with TIAL1: view

Pathways by source for TIAL1 Gene

Gene Ontology (GO) - Biological Process for TIAL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006357 regulation of transcription by RNA polymerase II TAS 9207209
GO:0006915 apoptotic process IEA,TAS --
GO:0006952 defense response TAS 1326761
GO:0007281 germ cell development IEA --
GO:0008284 positive regulation of cell proliferation IEA --
genes like me logo Genes that share ontologies with TIAL1: view

No data available for SIGNOR curated interactions for TIAL1 Gene

Drugs & Compounds for TIAL1 Gene

(3) Drugs for TIAL1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for TIAL1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TIAL1: view

Transcripts for TIAL1 Gene

Unigene Clusters for TIAL1 Gene

TIA1 cytotoxic granule-associated RNA binding protein-like 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TIAL1

Clone Products

  • Addgene plasmids for TIAL1

Alternative Splicing Database (ASD) splice patterns (SP) for TIAL1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15a · 15b ^
SP1: - - - - - - - -
SP2: - - - - - - -
SP3: - - - - - -
SP4: - - - - -
SP5: - -
SP6: - -
SP7: -
SP8: - -
SP9: -
SP10:
SP11:
SP12:

ExUns: 16a · 16b · 16c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for TIAL1 Gene

GeneLoc Exon Structure for
TIAL1
ECgene alternative splicing isoforms for
TIAL1

Expression for TIAL1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TIAL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TIAL1 Gene

This gene is overexpressed in Bone (10.5) and Peripheral blood mononuclear cells (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TIAL1 Gene



Protein tissue co-expression partners for TIAL1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TIAL1 Gene:

TIAL1

SOURCE GeneReport for Unigene cluster for TIAL1 Gene:

Hs.501203

Evidence on tissue expression from TISSUES for TIAL1 Gene

  • Lung(4.4)
  • Nervous system(3.3)
  • Blood(2.1)
  • Kidney(2.1)
  • Stomach(2)
genes like me logo Genes that share expression patterns with TIAL1: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TIAL1 Gene

Orthologs for TIAL1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TIAL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TIAL1 34 33
  • 99.74 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TIAL1 34
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TIAL1 34 33
  • 97.28 (n)
OneToOne
cow
(Bos Taurus)
Mammalia TIAL1 34 33
  • 95.56 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TIAL1 34
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tial1 33
  • 94.98 (n)
mouse
(Mus musculus)
Mammalia Tial1 16 34 33
  • 94.81 (n)
chicken
(Gallus gallus)
Aves TIAR 34
  • 98 (a)
OneToOne
TIA1 33
  • 87.89 (n)
lizard
(Anolis carolinensis)
Reptilia TIAL1 34
  • 92 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia tial1-A-prov 33
zebrafish
(Danio rerio)
Actinopterygii tial1 34 33
  • 76.4 (n)
OneToOne
zgc66130 33
fruit fly
(Drosophila melanogaster)
Insecta CG4787 35
  • 62 (a)
Rox8 34 33
  • 55.84 (n)
ManyToMany
CG34354 34
  • 30 (a)
ManyToMany
CG34362 34
  • 20 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002335 33
  • 54.47 (n)
worm
(Caenorhabditis elegans)
Secernentea C18A3.5a 35
  • 51 (a)
C07A4.1 35
  • 46 (a)
C18A3.5b 35
  • 44 (a)
Y46G5A.13 35
  • 44 (a)
tiar-1 34
  • 39 (a)
ManyToMany
tiar-2 34
  • 34 (a)
ManyToMany
tiar-3 34
  • 26 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PUB1 34
  • 26 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons UBP1B 33
  • 52.01 (n)
rice
(Oryza sativa)
Liliopsida Os11g0620100 33
  • 53.14 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8430 34
  • 48 (a)
ManyToMany
-- 34
  • 30 (a)
ManyToMany
Cin.5046 33
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5046 33
Species where no ortholog for TIAL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TIAL1 Gene

ENSEMBL:
Gene Tree for TIAL1 (if available)
TreeFam:
Gene Tree for TIAL1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TIAL1: view image

Paralogs for TIAL1 Gene

Paralogs for TIAL1 Gene

(22) SIMAP similar genes for TIAL1 Gene using alignment to 6 proteins:

  • TIAR_HUMAN
  • A6NKZ9_HUMAN
  • E7ETC0_HUMAN
  • E7ETJ9_HUMAN
  • O15187_HUMAN
  • Q49AS9_HUMAN

Pseudogenes.org Pseudogenes for TIAL1 Gene

genes like me logo Genes that share paralogs with TIAL1: view

Variants for TIAL1 Gene

Sequence variations from dbSNP and Humsavar for TIAL1 Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1000047430 -- 119,583,780(-) C/G genic_downstream_transcript_variant, genic_upstream_transcript_variant, intron_variant
rs1000166312 -- 119,575,261(-) G/A 3_prime_UTR_variant, genic_downstream_transcript_variant, non_coding_transcript_variant
rs1000431168 -- 119,590,798(-) A/G genic_upstream_transcript_variant, intron_variant
rs1000500974 -- 119,573,585(-) G/C 3_prime_UTR_variant, genic_downstream_transcript_variant, non_coding_transcript_variant
rs1000651334 -- 119,582,083(-) G/A genic_downstream_transcript_variant, genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for TIAL1 Gene

Variant ID Type Subtype PubMed ID
nsv1044497 CNV gain 25217958
nsv552215 CNV loss 21841781

Variation tolerance for TIAL1 Gene

Residual Variation Intolerance Score: 27.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.14; 3.27% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TIAL1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TIAL1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TIAL1 Gene

Disorders for TIAL1 Gene

Additional Disease Information for TIAL1

No disorders were found for TIAL1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TIAL1 Gene

Publications for TIAL1 Gene

  1. Identification and functional characterization of a TIA-1-related nucleolysin. (PMID: 1326761) Kawakami A … Anderson P (Proceedings of the National Academy of Sciences of the United States of America 1992) 2 3 4 22 58
  2. DNA damage activates a spatially distinct late cytoplasmic cell-cycle checkpoint network controlled by MK2-mediated RNA stabilization. (PMID: 20932473) Reinhardt HC … Yaffe MB (Molecular cell 2010) 3 4 58
  3. A systematic analysis of intronic sequences downstream of 5' splice sites reveals a widespread role for U-rich motifs and TIA1/TIAL1 proteins in alternative splicing regulation. (PMID: 18456862) Aznarez I … Blencowe BJ (Genome research 2008) 3 22 58
  4. Two isoforms of the T-cell intracellular antigen 1 (TIA-1) splicing factor display distinct splicing regulation activities. Control of TIA-1 isoform ratio by TIA-1-related protein. (PMID: 17488725) Izquierdo JM … Valcárcel J (The Journal of biological chemistry 2007) 3 22 58
  5. Competitive binding of AUF1 and TIAR to MYC mRNA controls its translation. (PMID: 17486099) Liao B … Brewer G (Nature structural & molecular biology 2007) 3 22 58

Products for TIAL1 Gene

  • Addgene plasmids for TIAL1

Sources for TIAL1 Gene

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