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Aliases for TGFB1I1 Gene

Aliases for TGFB1I1 Gene

  • Transforming Growth Factor Beta 1 Induced Transcript 1 2 3 5
  • Androgen Receptor-Associated Protein Of 55 KDa 3 4
  • Androgen Receptor Coactivator 55 KDa Protein 3 4
  • Hydrogen Peroxide-Inducible Clone 5 Protein 3 4
  • Hydrogen Peroxide-Inducible Clone-5 2 3
  • HIC-5 3 4
  • ARA55 3 4
  • Transforming Growth Factor Beta-1-Induced Transcript 1 Protein 3
  • Androgen Receptor Coactivator ARA55 3
  • TSC-5 3
  • HIC5 3

External Ids for TGFB1I1 Gene

Previous GeneCards Identifiers for TGFB1I1 Gene

  • GC16P030566
  • GC16P031981
  • GC16P031480
  • GC16P031519
  • GC16P031390
  • GC16P029043

Summaries for TGFB1I1 Gene

Entrez Gene Summary for TGFB1I1 Gene

  • This gene encodes a coactivator of the androgen receptor, a transcription factor which is activated by androgen and has a key role in male sexual differentiation. The encoded protein is thought to regulate androgen receptor activity and may have a role to play in the treatment of prostate cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

GeneCards Summary for TGFB1I1 Gene

TGFB1I1 (Transforming Growth Factor Beta 1 Induced Transcript 1) is a Protein Coding gene. Diseases associated with TGFB1I1 include Prostate Cancer. Among its related pathways are ERK Signaling and CCR5 Pathway in Macrophages. Gene Ontology (GO) annotations related to this gene include transcription coactivator activity and I-SMAD binding. An important paralog of this gene is PXN.

UniProtKB/Swiss-Prot for TGFB1I1 Gene

  • Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. May also regulate SLC6A3 and SLC6A4 targeting to the plasma membrane hence regulating their activity. In the nucleus, functions as a nuclear receptor coactivator regulating glucocorticoid, androgen, mineralocorticoid and progesterone receptor transcriptional activity. May play a role in the processes of cell growth, proliferation, migration, differentiation and senescence. May have a zinc-dependent DNA-binding activity.

Gene Wiki entry for TGFB1I1 Gene

Additional gene information for TGFB1I1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TGFB1I1 Gene

Genomics for TGFB1I1 Gene

GeneHancer (GH) Regulatory Elements for TGFB1I1 Gene

Promoters and enhancers for TGFB1I1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16I031470 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 550.8 +1.4 1366 4.8 HDGF SIN3A ZNF121 GLIS2 GATA2 ZNF143 SP3 NFYC ZHX2 REST ENSG00000280132 TGFB1I1 ENSG00000260740 HERC2P4 SLC5A2
GH16I030566 Promoter/Enhancer 2.3 FANTOM5 Ensembl ENCODE dbSUPER 28.7 -901.7 -901711 6 ZFP64 FEZF1 DMAP1 YY1 ZNF213 E2F8 ZNF416 ZNF143 ZNF548 SP3 SETD1A SRCAP ENSG00000260267 FUS INO80E ZNF747 NPIPB13 ZNF764 SMG1P5 SMG1P2
GH16I031125 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 24 -340.4 -340447 10.7 HDGF CLOCK ARNT NEUROD1 SIN3A ZNF766 ZNF207 ZNF548 MCM3 SP3 ENSG00000261385 PRSS8 SRCAP SETD1A ENSG00000260267 SMG1P5 ZNF764 ENSG00000260304 KAT8 BCL7C
GH16I030525 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 19.2 -944.2 -944235 3.8 HDGF PKNOX1 CLOCK SMAD1 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B IRF4 ENSG00000278922 ZNF768 ENSG00000260267 BCL7C SRCAP SETD1A FUS INO80E SMG1P2 SMG1P5
GH16I030697 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 20.8 -772.5 -772450 3.8 CLOCK MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 SRCAP LOC730183 ZNF785 FUS SETD1A TAOK2 ENSG00000260267 ENSG00000260114 BCL7C SMG1P5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TGFB1I1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TGFB1I1 gene promoter:

Genomic Locations for TGFB1I1 Gene

Genomic Locations for TGFB1I1 Gene
chr16:31,471,585-31,477,960
(GRCh38/hg38)
Size:
6,376 bases
Orientation:
Plus strand
chr16:31,482,906-31,489,281
(GRCh37/hg19)

Genomic View for TGFB1I1 Gene

Genes around TGFB1I1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TGFB1I1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TGFB1I1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TGFB1I1 Gene

Proteins for TGFB1I1 Gene

  • Protein details for TGFB1I1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43294-TGFI1_HUMAN
    Recommended name:
    Transforming growth factor beta-1-induced transcript 1 protein
    Protein Accession:
    O43294
    Secondary Accessions:
    • B2R8D5
    • Q9BPW3
    • Q9Y2V5

    Protein attributes for TGFB1I1 Gene

    Size:
    461 amino acids
    Molecular mass:
    49814 Da
    Quaternary structure:
    • Homooligomer. Interacts with CRIP2, HSPB1, ILK, LIMS1, LIMS2, NCK2, NUDT16L1, PAK, PPARG, PTPN12, TCF3, TCF7L2 and VCL. Forms a complex with GIT1 and ARHGEF7. Interacts with AR/androgen receptor in a ligand-dependent manner. Interacts with CSK, LYN, MAPK15, NR3C1, PPARG, PTK2/FAK1, PTK2B/PYK2, SLC6A3, SLC6A4, SMAD3, SRC and talin. Interacts (via LIM zinc-binding domain 2) with CBLC (via RING-type zinc finger); the interaction is direct and enhances CBLC E3 ubiquitin-protein ligase activity.
    SequenceCaution:
    • Sequence=AAH32545.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for TGFB1I1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TGFB1I1 Gene

Post-translational modifications for TGFB1I1 Gene

  • Phosphorylated by gonadotropin-releasing hormone-activated SRC.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TGFB1I1 Gene

Domains & Families for TGFB1I1 Gene

Gene Families for TGFB1I1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TGFB1I1 Gene

Suggested Antigen Peptide Sequences for TGFB1I1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O43294

UniProtKB/Swiss-Prot:

TGFI1_HUMAN :
  • The LIM zinc-binding domains mediate glucocorticoid receptor coactivation and interaction with AR, CRIP2, ILK, LIMS1, NR3C1, PPARG, TCF3, TCF7L2, SLC6A3 and SMAD3. The LIM zinc-binding 2 and LIM zinc-binding 3 domains mediate targeting to focal adhesions and actin stress fibers. The LIM zinc-binding 3 and LIM zinc-binding 4 domains mediate interaction with TRAF4 and MAPK15. The LIM zinc-binding 4 domain mediates interaction with HSPB1, homooligomerization and targeting to the nuclear matrix. The LIM zinc-binding 3 domain mediates interaction with PTPN12.
  • Belongs to the paxillin family.
Domain:
  • The LIM zinc-binding domains mediate glucocorticoid receptor coactivation and interaction with AR, CRIP2, ILK, LIMS1, NR3C1, PPARG, TCF3, TCF7L2, SLC6A3 and SMAD3. The LIM zinc-binding 2 and LIM zinc-binding 3 domains mediate targeting to focal adhesions and actin stress fibers. The LIM zinc-binding 3 and LIM zinc-binding 4 domains mediate interaction with TRAF4 and MAPK15. The LIM zinc-binding 4 domain mediates interaction with HSPB1, homooligomerization and targeting to the nuclear matrix. The LIM zinc-binding 3 domain mediates interaction with PTPN12.
  • The LD (leucine and aspartate-rich) motif 3 mediates interaction with GIT1 and functions as a nuclear export signal.
Family:
  • Belongs to the paxillin family.
genes like me logo Genes that share domains with TGFB1I1: view

Function for TGFB1I1 Gene

Molecular function for TGFB1I1 Gene

UniProtKB/Swiss-Prot Function:
Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. May also regulate SLC6A3 and SLC6A4 targeting to the plasma membrane hence regulating their activity. In the nucleus, functions as a nuclear receptor coactivator regulating glucocorticoid, androgen, mineralocorticoid and progesterone receptor transcriptional activity. May play a role in the processes of cell growth, proliferation, migration, differentiation and senescence. May have a zinc-dependent DNA-binding activity.
UniProtKB/Swiss-Prot Induction:
Up-regulated by TNF and hydrogen peroxide.

Phenotypes From GWAS Catalog for TGFB1I1 Gene

Gene Ontology (GO) - Molecular Function for TGFB1I1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003713 transcription coactivator activity NAS 15572661
GO:0005515 protein binding IPI 9756887
GO:0046872 metal ion binding IEA --
GO:0048495 Roundabout binding IPI 19855388
GO:0050681 androgen receptor binding NAS 15572661
genes like me logo Genes that share ontologies with TGFB1I1: view
genes like me logo Genes that share phenotypes with TGFB1I1: view

Animal Models for TGFB1I1 Gene

MGI Knock Outs for TGFB1I1:

Animal Model Products

miRNA for TGFB1I1 Gene

miRTarBase miRNAs that target TGFB1I1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TGFB1I1 Gene

Localization for TGFB1I1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TGFB1I1 Gene

Cell junction, focal adhesion. Nucleus matrix. Cytoplasm, cytoskeleton. Note=Associated with the actin cytoskeleton; colocalizes with stress fibers.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TGFB1I1 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 4
extracellular 2
plasma membrane 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Focal adhesion sites (3)
  • Cytosol (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TGFB1I1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IDA 10075738
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
GO:0005925 focal adhesion HDA,IEA 21423176
genes like me logo Genes that share ontologies with TGFB1I1: view

Pathways & Interactions for TGFB1I1 Gene

genes like me logo Genes that share pathways with TGFB1I1: view

Pathways by source for TGFB1I1 Gene

2 Qiagen pathways for TGFB1I1 Gene
1 Cell Signaling Technology pathway for TGFB1I1 Gene

Gene Ontology (GO) - Biological Process for TGFB1I1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006366 transcription by RNA polymerase II TAS 10075738
GO:0007155 cell adhesion TAS 9422762
GO:0008285 negative regulation of cell proliferation TAS 7929412
GO:0009408 response to heat IEA --
GO:0010718 positive regulation of epithelial to mesenchymal transition IDA 18762808
genes like me logo Genes that share ontologies with TGFB1I1: view

No data available for SIGNOR curated interactions for TGFB1I1 Gene

Drugs & Compounds for TGFB1I1 Gene

(6) Drugs for TGFB1I1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(3) Additional Compounds for TGFB1I1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TGFB1I1: view

Transcripts for TGFB1I1 Gene

Unigene Clusters for TGFB1I1 Gene

Transforming growth factor beta 1 induced transcript 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TGFB1I1 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10a · 10b · 10c ^ 11a · 11b ^ 12 ^ 13
SP1: - - - -
SP2: - - - -
SP3: - - - - -
SP4: - -
SP5: - - -
SP6: -
SP7: -
SP8: - -
SP9: -
SP10: -
SP11:

Relevant External Links for TGFB1I1 Gene

GeneLoc Exon Structure for
TGFB1I1
ECgene alternative splicing isoforms for
TGFB1I1

Expression for TGFB1I1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TGFB1I1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TGFB1I1 Gene

This gene is overexpressed in Colon - Sigmoid (x4.2) and Esophagus - Muscularis (x4.0).

Protein differential expression in normal tissues from HIPED for TGFB1I1 Gene

This gene is overexpressed in Urinary Bladder (13.8), Bone marrow stromal cell (8.3), Prostate (8.3), and Rectum (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TGFB1I1 Gene



Protein tissue co-expression partners for TGFB1I1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TGFB1I1 Gene:

TGFB1I1

SOURCE GeneReport for Unigene cluster for TGFB1I1 Gene:

Hs.513530

mRNA Expression by UniProt/SwissProt for TGFB1I1 Gene:

O43294-TGFI1_HUMAN
Tissue specificity: Expressed in platelets, smooth muscle and prostate stromal cells (at protein level).

Evidence on tissue expression from TISSUES for TGFB1I1 Gene

  • Nervous system(4.6)
  • Muscle(4.4)
  • Liver(4.1)
genes like me logo Genes that share expression patterns with TGFB1I1: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for TGFB1I1 Gene

Orthologs for TGFB1I1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TGFB1I1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TGFB1I1 34 33
  • 99.57 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TGFB1I1 34
  • 92 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TGFB1I1 33 34
  • 90.13 (n)
dog
(Canis familiaris)
Mammalia TGFB1I1 33 34
  • 89.73 (n)
mouse
(Mus musculus)
Mammalia Tgfb1i1 33 16 34
  • 87.16 (n)
rat
(Rattus norvegicus)
Mammalia Tgfb1i1 33
  • 87.06 (n)
oppossum
(Monodelphis domestica)
Mammalia TGFB1I1 34
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TGFB1I1 34
  • 58 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii ldb3a 34
  • 17 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Pax 35 34
  • 57 (a)
worm
(Caenorhabditis elegans)
Secernentea C28H8.6 35
  • 51 (a)
pxl-1 34
  • 38 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes LRG1 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9134 34
  • 42 (a)
OneToMany
Species where no ortholog for TGFB1I1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TGFB1I1 Gene

ENSEMBL:
Gene Tree for TGFB1I1 (if available)
TreeFam:
Gene Tree for TGFB1I1 (if available)

Paralogs for TGFB1I1 Gene

(8) SIMAP similar genes for TGFB1I1 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with TGFB1I1: view

Variants for TGFB1I1 Gene

Sequence variations from dbSNP and Humsavar for TGFB1I1 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000574636 -- 31,477,548(+) A/G coding_sequence_variant, missense_variant
rs1000749458 -- 31,477,152(+) C/T intron_variant
rs1002209755 -- 31,475,740(+) A/T intron_variant
rs1002244053 -- 31,475,709(+) G/A/C intron_variant
rs1002422226 -- 31,475,313(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TGFB1I1 Gene

Variant ID Type Subtype PubMed ID
esv3570465 CNV gain 25503493
nsv833194 CNV loss 17160897

Variation tolerance for TGFB1I1 Gene

Residual Variation Intolerance Score: 31.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.81; 47.70% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TGFB1I1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TGFB1I1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TGFB1I1 Gene

Disorders for TGFB1I1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TGFB1I1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
prostate cancer
  • prostate cancer, susceptibility to
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for TGFB1I1

genes like me logo Genes that share disorders with TGFB1I1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TGFB1I1 Gene

Publications for TGFB1I1 Gene

  1. Cloning and characterization of androgen receptor coactivator, ARA55, in human prostate. (PMID: 10075738) Fujimoto N … Chang C (The Journal of biological chemistry 1999) 2 3 4 22 58
  2. Cell adhesion kinase beta forms a complex with a new member, Hic-5, of proteins localized at focal adhesions. (PMID: 9422762) Matsuya M … Sasaki T (The Journal of biological chemistry 1998) 2 3 4 22 58
  3. ERK8 down-regulates transactivation of the glucocorticoid receptor through Hic-5. (PMID: 16624805) Saelzler MP … Abe MK (The Journal of biological chemistry 2006) 3 4 22 58
  4. Novel function of androgen receptor-associated protein 55/Hic-5 as a negative regulator of Smad3 signaling. (PMID: 15561701) Wang H … Danielpour D (The Journal of biological chemistry 2005) 3 4 22 58
  5. Hic-5 regulates an epithelial program mediated by PPARgamma. (PMID: 15687259) Drori S … Spiegelman BM (Genes & development 2005) 3 4 22 58

Products for TGFB1I1 Gene

Sources for TGFB1I1 Gene

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