This gene product is a serine/threonine protein kinase that contains an N-terminal protein kinase domain and a C-terminal proline-rich domain. Its protein kinase domain is most closely related to those of the LIM motif-containing protein kinases (LIMKs). The encoded protein can phosphorylate myelin basic protein and histone in vitro. The testicular germ cell-specific expression... See more...

Aliases for TESK1 Gene

Aliases for TESK1 Gene

  • Testis Associated Actin Remodelling Kinase 1 2 3 5
  • Dual Specificity Testis-Specific Protein Kinase 1 3 4
  • Testicular Protein Kinase 1 3 4
  • Testis-Specific Kinase 1 2 3
  • Testis Specific Kinase-1 2
  • EC 2.7.12.1 4
  • TESK1 5

External Ids for TESK1 Gene

Previous GeneCards Identifiers for TESK1 Gene

  • GC09P035917
  • GC09P035774
  • GC09P035595
  • GC09P035561

Summaries for TESK1 Gene

Entrez Gene Summary for TESK1 Gene

  • This gene product is a serine/threonine protein kinase that contains an N-terminal protein kinase domain and a C-terminal proline-rich domain. Its protein kinase domain is most closely related to those of the LIM motif-containing protein kinases (LIMKs). The encoded protein can phosphorylate myelin basic protein and histone in vitro. The testicular germ cell-specific expression and developmental pattern of expression of the mouse gene suggests that this gene plays an important role at and after the meiotic phase of spermatogenesis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]

GeneCards Summary for TESK1 Gene

TESK1 (Testis Associated Actin Remodelling Kinase 1) is a Protein Coding gene. Diseases associated with TESK1 include Spermatogenic Failure 8. Among its related pathways are ERK Signaling and Cell junction organization. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is TESK2.

UniProtKB/Swiss-Prot Summary for TESK1 Gene

  • Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues (By similarity). Regulates the cellular cytoskeleton by enhancing actin stress fiber formation via phosphorylation of cofilin and by preventing microtubule breakdown via inhibition of TAOK1/MARKK kinase activity (By similarity). Probably plays a central role at and after the meiotic phase of spermatogenesis (By similarity).

Gene Wiki entry for TESK1 Gene

Additional gene information for TESK1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for TESK1 Gene

Genomics for TESK1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for TESK1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TESK1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for TESK1

Top Transcription factor binding sites by QIAGEN in the TESK1 gene promoter:
  • AML1a
  • AP-1
  • c-Fos
  • E47
  • ITF-2
  • MZF-1
  • RP58
  • STAT5A
  • Tal-1beta
  • Zic3

Genomic Locations for TESK1 Gene

Genomic Locations for TESK1 Gene
chr9:35,605,262-35,610,041
(GRCh38/hg38)
Size:
4,780 bases
Orientation:
Plus strand
chr9:35,605,281-35,610,038
(GRCh37/hg19)
Size:
4,758 bases
Orientation:
Plus strand

Genomic View for TESK1 Gene

Genes around TESK1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TESK1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TESK1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TESK1 Gene

Proteins for TESK1 Gene

  • Protein details for TESK1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15569-TESK1_HUMAN
    Recommended name:
    Dual specificity testis-specific protein kinase 1
    Protein Accession:
    Q15569
    Secondary Accessions:
    • Q8IXZ8

    Protein attributes for TESK1 Gene

    Size:
    626 amino acids
    Molecular mass:
    67684 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Cofactor:
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    • Interacts with SPRY4 (PubMed:12027893). Interacts with TAOK1; inhibits TAOK1 kinase activity (By similarity). Interacts with SPRED1 (via C-terminus); inhibits TESK1 kinase activity (PubMed:18216281).

neXtProt entry for TESK1 Gene

Post-translational modifications for TESK1 Gene

Other Protein References for TESK1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TESK1 Gene

Domains & Families for TESK1 Gene

Gene Families for TESK1 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for TESK1 Gene

InterPro:
Blocks:
  • Tyrosine protein kinase, active site
ProtoNet:

Suggested Antigen Peptide Sequences for TESK1 Gene

GenScript: Design optimal peptide antigens:
  • Testicular protein kinase 1 (TESK1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q15569

UniProtKB/Swiss-Prot:

TESK1_HUMAN :
  • The extracatalytic C-terminal part is highly rich in proline residues.
  • Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.
Domain:
  • The extracatalytic C-terminal part is highly rich in proline residues.
Family:
  • Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.
genes like me logo Genes that share domains with TESK1: view

Function for TESK1 Gene

Molecular function for TESK1 Gene

UniProtKB/Swiss-Prot Function:
Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues (By similarity). Regulates the cellular cytoskeleton by enhancing actin stress fiber formation via phosphorylation of cofilin and by preventing microtubule breakdown via inhibition of TAOK1/MARKK kinase activity (By similarity). Probably plays a central role at and after the meiotic phase of spermatogenesis (By similarity).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.12.1;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.12.1;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.12.1;.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by autophosphorylation on Ser-220. Kinase activity is inhibited by SPRED1 (By similarity).
GENATLAS Biochemistry:
testis specific protein kinase 1,putatively involved in signal transduction

Enzyme Numbers (IUBMB) for TESK1 Gene

Gene Ontology (GO) - Molecular Function for TESK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity TAS,IBA 21873635
GO:0004712 protein serine/threonine/tyrosine kinase activity IEA --
GO:0004713 protein tyrosine kinase activity IEA --
genes like me logo Genes that share ontologies with TESK1: view
genes like me logo Genes that share phenotypes with TESK1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TESK1

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TESK1

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TESK1 Gene

Localization for TESK1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TESK1 gene
Compartment Confidence
nucleus 4
cytosol 4
plasma membrane 2
cytoskeleton 2
extracellular 1
mitochondrion 1
endosome 1
peroxisome 0

Gene Ontology (GO) - Cellular Components for TESK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA 21873635
GO:0005737 cytoplasm IBA 21873635
GO:0005829 cytosol TAS --
GO:0031410 colocalizes_with cytoplasmic vesicle ISS 18216281
genes like me logo Genes that share ontologies with TESK1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for TESK1 Gene

Pathways & Interactions for TESK1 Gene

genes like me logo Genes that share pathways with TESK1: view

Pathways by source for TESK1 Gene

1 Cell Signaling Technology pathway for TESK1 Gene

SIGNOR curated interactions for TESK1 Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for TESK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0007283 spermatogenesis TAS,IEA --
GO:0016310 phosphorylation IEA --
GO:0018108 peptidyl-tyrosine phosphorylation IEA --
GO:0030036 actin cytoskeleton organization IBA 21873635
genes like me logo Genes that share ontologies with TESK1: view

Drugs & Compounds for TESK1 Gene

(8) Drugs for TESK1 Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
fostamatinib Approved, Investigational Pharma Target, inhibitor Kinase Inhibitors 0
Magnesium Approved, Experimental, Investigational Pharma 0
Manganese Approved Nutra 56
ATP Investigational Nutra Agonist, Activator, Partial agonist, Antagonist, Full agonist, Gating inhibitor, Pore Blocker, Potentiation 0

(1) Additional Compounds for TESK1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Agonist, Full agonist, Partial agonist, Gating inhibitor, Antagonist 58-64-0
genes like me logo Genes that share compounds with TESK1: view

Transcripts for TESK1 Gene

mRNA/cDNA for TESK1 Gene

2 REFSEQ mRNAs :
15 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for TESK1

Alternative Splicing Database (ASD) splice patterns (SP) for TESK1 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10
SP1: -
SP2: -
SP3: -

Relevant External Links for TESK1 Gene

GeneLoc Exon Structure for
TESK1

Expression for TESK1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TESK1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TESK1 Gene

This gene is overexpressed in Pancreas (61.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TESK1 Gene



Protein tissue co-expression partners for TESK1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for TESK1

SOURCE GeneReport for Unigene cluster for TESK1 Gene:

Hs.708096

Evidence on tissue expression from TISSUES for TESK1 Gene

  • Nervous system(4.6)
  • Eye(4)
  • Muscle(3)
  • Kidney(2.5)
  • Heart(2.1)
genes like me logo Genes that share expression patterns with TESK1: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TESK1 Gene

Orthologs for TESK1 Gene

This gene was present in the common ancestor of animals.

Orthologs for TESK1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia TESK1 30 31
  • 99.47 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia TESK1 30 31
  • 90.82 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Tesk1 30 17 31
  • 89.38 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia TESK1 30 31
  • 89.07 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Tesk1 30
  • 89 (n)
Oppossum
(Monodelphis domestica)
Mammalia TESK1 31
  • 62 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia TESK1 31
  • 61 (a)
OneToOne
Chicken
(Gallus gallus)
Aves TESK1 30 31
  • 67.25 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia TESK1 31
  • 53 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii si:ch211-113e8.3 30
  • 64.24 (n)
TESK1 (1 of 2) 31
  • 46 (a)
OneToMany
TESK1 (2 of 2) 31
  • 44 (a)
OneToMany
Dr.12054 30
Fruit Fly
(Drosophila melanogaster)
Insecta cdi 31
  • 21 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea T25B9.5 31
  • 17 (a)
ManyToMany
Y69E1A.3 31
  • 17 (a)
ManyToMany
K09B11.5 31
  • 17 (a)
ManyToMany
Y52D5A.2 31
  • 16 (a)
ManyToMany
kin-21 31
  • 16 (a)
ManyToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 51 (a)
OneToMany
Species where no ortholog for TESK1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)

Evolution for TESK1 Gene

ENSEMBL:
Gene Tree for TESK1 (if available)
TreeFam:
Gene Tree for TESK1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TESK1: view image

Paralogs for TESK1 Gene

(1) SIMAP similar genes for TESK1 Gene using alignment to 1 proteins:

  • TESK1_HUMAN
genes like me logo Genes that share paralogs with TESK1: view

Variants for TESK1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for TESK1 Gene

SNP ID Clinical significance and condition Chr 09 pos Variation AA Info Type
rs1373248755 Breast cancer samples p.His539Tyr
rs55673450 - p.Gly574Ser

Additional dbSNP identifiers (rs#s) for TESK1 Gene

Structural Variations from Database of Genomic Variants (DGV) for TESK1 Gene

Variant ID Type Subtype PubMed ID
esv25703 CNV loss 19812545
nsv1119196 CNV deletion 24896259
nsv1125318 OTHER inversion 24896259
nsv528256 CNV loss 19592680
nsv614164 CNV gain 21841781
nsv614165 CNV gain 21841781

Variation tolerance for TESK1 Gene

Residual Variation Intolerance Score: 24.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.97; 36.40% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TESK1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TESK1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TESK1 Gene

Disorders for TESK1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TESK1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
spermatogenic failure 8
  • spgf8
- elite association - COSMIC cancer census association via MalaCards
Search TESK1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for TESK1

genes like me logo Genes that share disorders with TESK1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TESK1 Gene

Publications for TESK1 Gene

  1. Identification and characterization of a novel protein kinase, TESK1, specifically expressed in testicular germ cells. (PMID: 8537404) Toshima J … Mizuno K (The Journal of biological chemistry 1995) 2 3 4 23
  2. Human sprouty 4, a new ras antagonist on 5q31, interacts with the dual specificity kinase TESK1. (PMID: 12027893) Leeksma OC … de Vries CJ (European journal of biochemistry 2002) 3 4 23
  3. Cofilin phosphorylation by protein kinase testicular protein kinase 1 and its role in integrin-mediated actin reorganization and focal adhesion formation. (PMID: 11294912) Toshima J … Mizuno K (Molecular biology of the cell 2001) 2 3 23
  4. Spred1 and TESK1--two new interaction partners of the kinase MARKK/TAO1 that link the microtubule and actin cytoskeleton. (PMID: 18216281) Johne C … Mandelkow EM (Molecular biology of the cell 2008) 3 4
  5. Actopaxin interacts with TESK1 to regulate cell spreading on fibronectin. (PMID: 15817463) LaLonde DP … Turner CE (The Journal of biological chemistry 2005) 3 23

Products for TESK1 Gene

Sources for TESK1 Gene