Aliases for TESK1 Gene
External Ids for TESK1 Gene
Previous GeneCards Identifiers for TESK1 Gene
This gene product is a serine/threonine protein kinase that contains an N-terminal protein kinase domain and a C-terminal proline-rich domain. Its protein kinase domain is most closely related to those of the LIM motif-containing protein kinases (LIMKs). The encoded protein can phosphorylate myelin basic protein and histone in vitro. The testicular germ cell-specific expression and developmental pattern of expression of the mouse gene suggests that this gene plays an important role at and after the meiotic phase of spermatogenesis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]
GeneCards Summary for TESK1 Gene
TESK1 (Testis Associated Actin Remodelling Kinase 1) is a Protein Coding gene. Diseases associated with TESK1 include Spermatogenic Failure 8. Among its related pathways are ERK Signaling and Cell junction organization. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is TESK2.
UniProtKB/Swiss-Prot Summary for TESK1 Gene
Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues (By similarity). Regulates the cellular cytoskeleton by enhancing actin stress fiber formation via phosphorylation of cofilin and by preventing microtubule breakdown via inhibition of TAOK1/MARKK kinase activity (By similarity). Probably plays a central role at and after the meiotic phase of spermatogenesis (By similarity).