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Aliases for TCP11 Gene

Aliases for TCP11 Gene

  • T-Complex 11 2 3 5
  • Fertilization-Promoting Peptide Receptor 2 3
  • T-Complex 11 (A Murine Tcp Homolog) 2 3
  • T-Complex 11, Testis-Specific 2 3
  • Testis Secretory Sperm-Binding Protein Li 222n 3
  • T-Complex Protein 11 Homolog 3
  • T-Complex 11 Homolog (Mouse) 2
  • T-Complex 11 Homolog 3
  • D6S230E 3
  • FPPR 3

External Ids for TCP11 Gene

Previous HGNC Symbols for TCP11 Gene

  • D6S230E

Previous GeneCards Identifiers for TCP11 Gene

  • GC06M035087
  • GC06M035132
  • GC06M035193
  • GC06M034807
  • GC06M035133
  • GC06M035240
  • GC06M035735
  • GC06M035594
  • GC06M035598
  • GC06M036293
  • GC06M036662
  • GC06M037015
  • GC06M037365
  • GC06M037721
  • GC06M038067

Summaries for TCP11 Gene

GeneCards Summary for TCP11 Gene

TCP11 (T-Complex 11) is a Protein Coding gene. An important paralog of this gene is TCP11X2.

UniProtKB/Swiss-Prot for TCP11 Gene

  • Plays a role in the process of sperm capacitation and acrosome reactions. Probable receptor for the putative fertilization-promoting peptide (FPP) at the sperm membrane that may modulate the activity of the adenylyl cyclase cAMP pathway.

Gene Wiki entry for TCP11 Gene

Additional gene information for TCP11 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TCP11 Gene

Genomics for TCP11 Gene

GeneHancer (GH) Regulatory Elements for TCP11 Gene

Promoters and enhancers for TCP11 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J035258 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE 661.2 -111.6 -111589 4.1 MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC ZNF76 TCP11 LOC101929285 GC06M038955 TAF11 ENSG00000272374 RPL10A ENSG00000219023 RPS10 DEF6
GH06J035140 Promoter/Enhancer 1.1 EPDnew Ensembl 670.5 +7.3 7343 0.9 USF1 RFX1 L3MBTL2 RNF2 BHLHE40 MAX USF2 REST IKZF1 VEZF1 TCP11 NUDT3 SCUBE3 UHRF1BP1 GC06M038652
GH06J035147 Enhancer 1 Ensembl ENCODE dbSUPER 650.7 +0.2 165 1 NANOG JUN BACH1 JUNB SIN3A BATF IRF4 SP1 FOSL1 JUND TCP11 UHRF1BP1 GC06M038652
GH06J035023 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 12.9 +123.3 123281 4.3 HDAC1 ATF1 FOXA2 KLF17 FEZF1 ZNF2 RFX5 ZNF335 ZNF366 SCRT2 HSPE1P11 TAF11 TCP11 UHRF1BP1 GC06M038960 ANKS1A
GH06J035317 Promoter/Enhancer 1.6 Ensembl ENCODE dbSUPER 11.8 -170.0 -170030 1.6 PKNOX1 ARID4B SIN3A DMAP1 ZNF2 ZNF48 SLC30A9 ZNF548 SP3 SP5 ZNF76 TAF11 ENSG00000272374 DEF6 PPARD TCP11 TEAD3 TULP1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around TCP11 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TCP11 gene promoter:
  • Meis-1b
  • Meis-1
  • HOXA9B
  • HOXA9
  • aMEF-2
  • MEF-2A
  • MIF-1
  • POU2F1a
  • POU2F1
  • FOXI1

Genomic Locations for TCP11 Gene

Genomic Locations for TCP11 Gene
chr6:35,118,071-35,148,610
(GRCh38/hg38)
Size:
30,540 bases
Orientation:
Minus strand
chr6:35,085,848-35,116,387
(GRCh37/hg19)
Size:
30,540 bases
Orientation:
Minus strand

Genomic View for TCP11 Gene

Genes around TCP11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TCP11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TCP11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TCP11 Gene

Proteins for TCP11 Gene

  • Protein details for TCP11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WWU5-TCP11_HUMAN
    Recommended name:
    T-complex protein 11 homolog
    Protein Accession:
    Q8WWU5
    Secondary Accessions:
    • B2RCE9
    • B3KQ27
    • B7Z7B5
    • B7Z7G1
    • B7Z7H4
    • B7Z7S8
    • E7EP29
    • J3KNG1
    • Q8NF85
    • Q9NQZ9
    • Q9NR39

    Protein attributes for TCP11 Gene

    Size:
    503 amino acids
    Molecular mass:
    56141 Da
    Quaternary structure:
    • Found in a complex at least composed of MROH2B, PRKACA isoform 2 and TCP11. Interacts with MROH2B. Interacts with PRKACA isoform 2 (By similarity). Isoform 2 and isoform 3 interact with ODF1 (via leucine zipper motif) (PubMed:21597245).

    Alternative splice isoforms for TCP11 Gene

neXtProt entry for TCP11 Gene

Post-translational modifications for TCP11 Gene

  • Constitutively phosphorylated on serine, threonine and tyrosine residues within the head and tail regions of noncapacitated spermatozoa. Phosphorylation on tyrosine residues increases upon sperm capacitation within the acrosomal region in a protein kinase A (PKA)-dependent signaling pathway.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TCP11 Gene

Domains & Families for TCP11 Gene

Gene Families for TCP11 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TCP11 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q8WWU5

UniProtKB/Swiss-Prot:

TCP11_HUMAN :
  • Belongs to the TCP11 family.
Family:
  • Belongs to the TCP11 family.
genes like me logo Genes that share domains with TCP11: view

Function for TCP11 Gene

Molecular function for TCP11 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in the process of sperm capacitation and acrosome reactions. Probable receptor for the putative fertilization-promoting peptide (FPP) at the sperm membrane that may modulate the activity of the adenylyl cyclase cAMP pathway.
GENATLAS Biochemistry:
T-complex 11 (murine tcp homolog)

Phenotypes From GWAS Catalog for TCP11 Gene

genes like me logo Genes that share phenotypes with TCP11: view

Animal Models for TCP11 Gene

MGI Knock Outs for TCP11:
  • Tcp11 Tcp11<tm1a(EUCOMM)Wtsi>

Animal Model Products

miRNA for TCP11 Gene

miRTarBase miRNAs that target TCP11

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TCP11 Gene

Localization for TCP11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TCP11 Gene

Membrane; Single-pass membrane protein. Cell projection, cilium, flagellum. Cytoplasmic vesicle, secretory vesicle, acrosome. Note=Localizes on the acrosomal cap region of acrosome-intact, but not acrosome-reacted sperm. Colocalizes with MROH2B and PRKACA on the acrosome and tail regions in round spermatids and spermatozoa regardless of the capacitation status of the sperm. {ECO:0000250 UniProtKB:Q01755}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TCP11 gene
Compartment Confidence
cytosol 2
plasma membrane 1
extracellular 1
mitochondrion 1
peroxisome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for TCP11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001669 acrosomal vesicle ISS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0031410 cytoplasmic vesicle IEA --
GO:0036126 sperm flagellum ISS --
genes like me logo Genes that share ontologies with TCP11: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TCP11 Gene

Pathways & Interactions for TCP11 Gene

SuperPathways for TCP11 Gene

No Data Available

Interacting Proteins for TCP11 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000308708%0d%0a9606.ENSP00000301072%0d%0a9606.ENSP00000301071%0d%0a9606.ENSP00000248437%0d%0a9606.ENSP00000336799%0d%0a9606.ENSP00000326042%0d%0a
Selected Interacting proteins: ENSP00000308708 Q8WWU5-TCP11_HUMAN for TCP11 Gene via STRING IID

Gene Ontology (GO) - Biological Process for TCP11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development TAS 1893875
GO:0007283 spermatogenesis IEA --
GO:0010737 protein kinase A signaling ISS --
GO:0030154 cell differentiation IEA --
GO:0043949 regulation of cAMP-mediated signaling ISS --
genes like me logo Genes that share ontologies with TCP11: view

No data available for Pathways by source and SIGNOR curated interactions for TCP11 Gene

Drugs & Compounds for TCP11 Gene

(1) Additional Compounds for TCP11 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with TCP11: view

Transcripts for TCP11 Gene

Unigene Clusters for TCP11 Gene

T-complex 11, testis-specific:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TCP11 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8a · 8b · 8c · 8d · 8e ^ 9a · 9b · 9c · 9d ^ 10 ^
SP1: - -
SP2: - - -
SP3: - - - - -
SP4: - - - -
SP5: - - - - - - - - - -
SP6: - - - - - - - - -
SP7: - - - - - -
SP8: - - - - - -
SP9: - - - - -
SP10: - - - - - - - - - - -
SP11: - -
SP12: - - - - - - - -
SP13: - - - - - - -
SP14: - - - - - - -
SP15: - - - - - -
SP16: - - - - - - - - -
SP17: - - - -
SP18:

ExUns: 11a · 11b · 11c ^ 12 ^ 13
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:

Relevant External Links for TCP11 Gene

GeneLoc Exon Structure for
TCP11
ECgene alternative splicing isoforms for
TCP11

Expression for TCP11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TCP11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TCP11 Gene

This gene is overexpressed in Testis (x51.5).

Protein differential expression in normal tissues from HIPED for TCP11 Gene

This gene is overexpressed in Plasma (51.0), Testis (11.4), and Heart (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TCP11 Gene



Protein tissue co-expression partners for TCP11 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TCP11 Gene:

TCP11

SOURCE GeneReport for Unigene cluster for TCP11 Gene:

Hs.435371

mRNA Expression by UniProt/SwissProt for TCP11 Gene:

Q8WWU5-TCP11_HUMAN
Tissue specificity: Isoform 2 and isoform 3 are expressed in sperm. Isoform 1 is not detected in sperm (at protein level) (PubMed:21597245). Testis-specific (PubMed:11756566). Isoform 1, isoform 2 and isoform 3 are expressed in sperm (PubMed:21597245).

Evidence on tissue expression from TISSUES for TCP11 Gene

  • Nervous system(4.6)
genes like me logo Genes that share expression patterns with TCP11: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for TCP11 Gene

Orthologs for TCP11 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TCP11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TCP11 34 33
  • 99.71 (n)
OneToOne
dog
(Canis familiaris)
Mammalia TCP11 34 33
  • 86.22 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Tcp11 16 34 33
  • 77.78 (n)
rat
(Rattus norvegicus)
Mammalia Tcp11 33
  • 76.2 (n)
cow
(Bos Taurus)
Mammalia TCP11 34
  • 71 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 58 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 54 (a)
ManyToMany
-- 34
  • 53 (a)
ManyToMany
chicken
(Gallus gallus)
Aves TCP11 33
  • 59.71 (n)
-- 34
  • 46 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 47 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG16721 34
  • 26 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea M05D6.2 34
  • 23 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SOK1 34
  • 12 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 21 (a)
OneToMany
Species where no ortholog for TCP11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for TCP11 Gene

ENSEMBL:
Gene Tree for TCP11 (if available)
TreeFam:
Gene Tree for TCP11 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for TCP11: view image

Paralogs for TCP11 Gene

Paralogs for TCP11 Gene

(4) SIMAP similar genes for TCP11 Gene using alignment to 13 proteins:

  • TCP11_HUMAN
  • D6R8Y5_HUMAN
  • D6R989_HUMAN
  • D6R9D8_HUMAN
  • D6R9R9_HUMAN
  • D6RAC0_HUMAN
  • D6RBE4_HUMAN
  • D6RFY8_HUMAN
  • D6RG02_HUMAN
  • D6RGC0_HUMAN
  • D6RGY5_HUMAN
  • D6RIW4_HUMAN
  • H0Y8T8_HUMAN
genes like me logo Genes that share paralogs with TCP11: view

Variants for TCP11 Gene

Sequence variations from dbSNP and Humsavar for TCP11 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000157570 -- 35,141,931(-) G/C upstream_transcript_variant
rs1000264480 -- 35,135,429(-) A/G intron_variant
rs1000314905 -- 35,140,817(-) G/C/T 5_prime_UTR_variant, coding_sequence_variant, intron_variant, synonymous_variant
rs1000603265 -- 35,140,692(-) C/T intron_variant
rs1000897337 -- 35,120,735(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TCP11 Gene

Variant ID Type Subtype PubMed ID
esv1001098 CNV deletion 20482838
esv1533887 CNV deletion 17803354
esv2633690 CNV deletion 19546169
nsv1119079 CNV deletion 24896259
nsv349272 CNV deletion 16902084
nsv511879 CNV loss 21212237

Variation tolerance for TCP11 Gene

Residual Variation Intolerance Score: 74% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.37; 76.92% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TCP11 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TCP11

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TCP11 Gene

Disorders for TCP11 Gene

Additional Disease Information for TCP11

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for TCP11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TCP11 Gene

Publications for TCP11 Gene

  1. Human t-complex protein 11 (TCP11), a testis-specific gene product, is a potential determinant of the sperm morphology. (PMID: 21597245) Liu Y … Ma Y (The Tohoku journal of experimental medicine 2011) 2 3 4 58
  2. Molecular characterization of the TCP11 gene which is the human homologue of the mouse gene encoding the receptor of fertilization promoting peptide. (PMID: 11756566) Ma Y … Milunsky A (Molecular human reproduction 2002) 2 3 4 58
  3. A testis-expressed Zn finger gene (ZNF76) in human 6p21.3 centromeric to the MHC is closely linked to the human homolog of the t-complex gene tcp-11. (PMID: 1427894) Ragoussis J … Trowsdale J (Genomics 1992) 2 3 22 58
  4. The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature. (PMID: 20546612) Zhao J … Grant SF (BMC medical genetics 2010) 3 44 58
  5. Many sequence variants affecting diversity of adult human height. (PMID: 18391951) Gudbjartsson DF … Stefansson K (Nature genetics 2008) 3 44 58

Products for TCP11 Gene

Sources for TCP11 Gene

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