Aliases for TCN1 Gene
External Ids for TCN1 Gene
Previous GeneCards Identifiers for TCN1 Gene
This gene encodes a member of the vitamin B12-binding protein family. This family of proteins, alternatively referred to as R binders, is expressed in various tissues and secretions. This protein is a major constituent of secondary granules in neutrophils and facilitates the transport of cobalamin into cells. [provided by RefSeq, Jul 2008]
GeneCards Summary for TCN1 Gene
TCN1 (Transcobalamin 1) is a Protein Coding gene. Diseases associated with TCN1 include Transcobalamin I Deficiency and Vitamin B12 Deficiency. Among its related pathways are Innate Immune System and Metabolism. Gene Ontology (GO) annotations related to this gene include cobalamin binding. An important paralog of this gene is GIF.
UniProtKB/Swiss-Prot for TCN1 Gene
Binds vitamin B12 with femtomolar affinity and protects it from the acidic environment of the stomach.