Aliases for TCF12 Gene
External Ids for TCF12 Gene
Previous GeneCards Identifiers for TCF12 Gene
The protein encoded by this gene is a member of the basic helix-loop-helix (bHLH) E-protein family that recognizes the consensus binding site (E-box) CANNTG. This encoded protein is expressed in many tissues, among them skeletal muscle, thymus, B- and T-cells, and may participate in regulating lineage-specific gene expression through the formation of heterodimers with other bHLH E-proteins. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]
GeneCards Summary for TCF12 Gene
TCF12 (Transcription Factor 12) is a Protein Coding gene. Diseases associated with TCF12 include Craniosynostosis 3 and Isolated Brachycephaly. Among its related pathways are PAK Pathway and ERK Signaling. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and protein heterodimerization activity. An important paralog of this gene is TCF4.
UniProtKB/Swiss-Prot for TCF12 Gene
Transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5-CANNTG-3).