Aliases for TCEA2 Gene
- Transcription Elongation Factor A2 2 3 5
- Transcription Elongation Factor S-II Protein 2 3 4
- Transcription Elongation Factor A (SII), 2 2 3
- Transcription Elongation Factor TFIIS.L 3 4
- Testis-Specific S-II 3 4
- Transcription Elongation Factor A Protein 2 3
- Transcription Elongation Factor TFIIS.1 3
- TFIIS 3
External Ids for TCEA2 Gene
Previous GeneCards Identifiers for TCEA2 Gene
The protein encoded by this gene is found in the nucleus, where it functions as an SII class transcription elongation factor. Elongation factors in this class are responsible for releasing RNA polymerase II ternary complexes from transcriptional arrest at template-encoded arresting sites. The encoded protein has been shown to interact with general transcription factor IIB, a basal transcription factor. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for TCEA2 Gene
TCEA2 (Transcription Elongation Factor A2) is a Protein Coding gene. Diseases associated with TCEA2 include Hypotrichosis-Lymphedema-Telangiectasia Syndrome. Among its related pathways are RNA Polymerase II Transcription Initiation And Promoter Clearance. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and translation elongation factor activity. An important paralog of this gene is TCEA1.
UniProtKB/Swiss-Prot for TCEA2 Gene
Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3-terminus.